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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 3 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 4 | Standard CMOS implementation of a novel, fully differential optoelectronic integrated receiver 显示文摘 | YU C L MAO L H XIAO X D | 2009 | J of Optoelectronics Laser2009，20，4： | 1 |
| 5 | IgC, anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes 显示文摘 | Li Y L Yu C L Yu H S | 2000 | J Invest Dermatol2000，115，6： | 1 |
| 6 | A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation显示文摘 | Hang H C Yu C Kato D L | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 7 | Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality 显示文摘 | Kuo C F See L C Yu K H | 2013 | Rheumatology(Oxford)2013，52，1： | 1 |
| 8 | Hierarchical streamline bundles显示文摘 | Shene C K Wang C L Yu H F | 2012 | IEEE Transactions on Visualization and Computer Graphics2012，18，8： | 1 |
| 9 | Expression pattern genomic struc- ture, and promoter analysis of the gene encoding stilbene synthase from Chinese wild Vitis pseudoreticulata显示文摘 | XU W R YU Y H ZHOU Q DING J H DAI L M XIE X Q XU Y ZHANG C H WANG Y J | 2011 | Journal of Experimen- tal Botany2011，62，8： | 1 |
| 10 | The Effects of Firm-initiated Clawback Provisions on Earnings Quality and Au- ditor Behavior显示文摘 | Chan L H Chen K C W Chen T Y Yu Y X | 2012 | Journal of Accounting and Economics2012，，54： | 1 |
| 11 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | Mierostructure and Properties of TiAISiN Coatings Prepared by Hybrid PVD Technology 显示文摘 | Yu D H Wang C Y Cheng X L | 2009 | Thin Solid Films2009，517，： | 1 |
| 13 | Expected k-Coverage in Wireless Sensor Networks 显示文摘 | Yen L H Wu Yu C & Cheng Y-M | 2006 | Ad Hoc Networks2006，5，4： | 1 |
| 14 | A novel density-tunable nanoeomposites of CdTe quantum dots linked to dendrimer-tethered multiwall carbon nanotubes显示文摘 | Zeng Y L Tang C R Wang H W Jiang J H Tian M N Shen G L Yu R Q | 2008 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2008，70，5： | 1 |
| 15 | cDNA cloning and ex- pression of a novel estrogen receptor β-subtype in goldfish (Carassius auratus) 显示文摘 | Ma C H Dong K W Yu K L | 2000 | Biochim Biophys Acta2000，1490，： | 1 |
| 16 | Study on the growth mechanism of silver nanorods in the nanowire-seeding polyol process 显示文摘 | CHEN C WANG L YU H J | 2008 | Mater Chcm Phys2008，107，1： | 1 |
| 17 | A study of the constituents of Millettia reticulate显示文摘 | Chen C C Chen Y L Yu H P | 1983 | Taiwan Yaoxue Zazhi1983，35，1： | 1 |
| 18 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history 显示文摘 | Chen F H Yu Z C Yang M L | 2008 | Quaternary Science Reviews2008，27，： | 1 |
| 19 | The bioaccessibility of lead (Pb) from vacuumed house dust on carpets in urban residences 显示文摘 | Yu C H Yiin L M Paul J L | 2006 | Risk Analysis2006，26，1： | 1 |
| 20 | Enhanced paclitaxel production induced by the combination of elicitors in cell suspension cultures of Taxus chinensis 显示文摘 | Zhang C H Mei X G Yu L J | 2000 | Biotechnol Lett2000，22，19： | 1 |
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