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| 1 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 2 | Damage Identification in Simply Supported Bridge Based on Rotational-Angle Influence Lines Method显示文摘To locate and quantify local damage in a simply supported bridge, in this study, we derived a rotational-angle influence line equation of a simply supported beam model with local damage. Using the diagram multiplication method, we introduce an analytical formula for a novel damage-identification indicator, namely the diff erence of rotational-angle influence linescurvature(DRAIL-C). If the initial stiff ness of the simply supported beam is known, the analytical formula can be effectively used to determine the extent of damage under certain circumstances. We determined the effectiveness and anti-noise performance of this new damage-identification method using numerical examples of a simply supported beam, a simply supported hollow-slab bridge, and a simply supported truss bridge. The results show that the DRAIL-C is directly proportional to the moving concentrated load and inversely proportional to the distance between the bridge support and the concentrated load and the distance between the damaged truss girder and the angle measuring points. The DRAIL-C indicator is more sensitive to the damage in a steel-truss-bridge bottom chord than it is to the other elements. | Yu Zhou Shengkui Di Changsheng Xiang Wanrun Li Lixian Wang | 2018 | Transactions of Tianjin University2018，24，6： | 10 |
| 3 | Recent advances of metal phosphides for Li-S chemistry显示文摘Li-S batteries have been considered as one of advanced next-generation energy storage systems owing to their remarkable theoretical capacity(1672 m Ah g^(-1))and high energy density(2600 Wh kg^(-1)).However,critical issues,mainly pertaining to lithium polysulfide shuttle and slow sulfur reaction kinetics,have posed a fatal threat to the electrochemical performances of Li-S batteries.The situation is even worse for high sulfur-loaded and flexible cathodes,which are the essential components for practical Li-S batteries.In response,the use of metal compounds as electrocatalysts in Li-S systems have been confirmed as an effective strategy to date.Particularly,recent years have witnessed many progresses in phosphidesoptimized Li-S chemistry.This has been motivated by the superior electron conductivity and high electrocatalytic activity of phosphides.In this tutorial review,we offer a systematic summary of active metal phosphides as promoters for Li-S chemistry,aiming at helping to understanding the working mechanism of phosphide electrocatalysts and guiding the construction of advanced Li-S batteries. | Songlin Yu Wenlong Cai Le Chen Lixian Song Yingze Song | 2021 | Journal of Energy Chemistry2021，30，4： | 3 |
| 4 | Benefits of redundant channels in observer-based H∞ control for discrete-time switched linear systems显示文摘In this paper, the H∞ control problem is investigated for a class of discrete-time switched linear systems with modal persistent dwell-time(MPDT) switching. The redundant channels are considered to use in the data transmission to benefit the capability of overcoming the fragility of networks commonly configured by a single channel in the communication networks subject to random packet losses. In light of a new class of Lyapunov functions, the desired observer-based quasi-time-dependent controllers, which have less conservatism than the time-independent ones, are designed such that the resulting closed-loop system is exponentially mean-square stable with a guaranteed H_∞ disturbance attenuation performance. The MPDT can be minimized while ensuring the existence of such a class of observer-based controllers for a given period of persistence. An example of DC-DC boost converter is provided to verify the effectiveness of theoretical findings. | ZHU YanZheng ZHANG LiXian LIN WeiYang LI Zhan YU ShuYou | 2016 | Science China(Technological Sciences)2016，59，1： | 2 |
| 5 | Orbit induced spin squeezing in a spin-orbit coupled Bose-Einstein condensate]显示文摘 | LIAN Jinling YU Lixian LIANG J Q | 2013 | Sci Rep2013，3，1： | 1 |
| 6 | Dual Inhibition of Bcr-Abl and Hsp90by C086 Potently Inhibits the Proliferation of Imatinib-Resistant CML Cells显示文摘 | Lixian Wu Jing Yu Ruijia Chen | 2015 | Clinical Cancer Research2015，21，4： | 1 |
| 7 | Orbit-induced spin squeezing in a spin-orbit coupled Bose-Einstein condensate显示文摘 | Lian Jinling Yu Lixian Liang J Q | 2013 | Sci Rep2013，，4： | 1 |
| 8 | Single-cell RNA Sequencing Reveals Thoracolumbar Vertebra Heterogeneity and Rib-genesis in Pigs显示文摘Development of thoracolumbar vertebra(TLV)and rib primordium(RP)is a common evolutionary feature across vertebrates,although whole-organism analysis of the expression dynamics of TLV-and RP-related genes has been lacking.Here,we investigated the single-cell transcriptome landscape of thoracic vertebra(TV),lumbar vertebra(LV),and RP cells from a pig embryo at 27 days post-fertilization(dpf)and identified six cell types with distinct gene expression signatures.In-depth dissection of the gene expression dynamics and RNA velocity revealed a coupled process of osteogenesis and angiogenesis during TLV and RP development.Further analysis of cell type-specific and strand-specific expression uncovered the extremely high level of HOXA103′-UTR sequence specific to osteoblasts of LV cells,which may function as anti-HOXA10-antisense by counteracting the HOXA10-antisense effect to determine TLV transition.Thus,this work provides a valuable resource for understanding embryonic osteogenesis and angiogenesis underlying vertebrate TLV and RP development at the cell type-specific resolution,which serves as a comprehensive view on the transcriptional profile of animal embryo development. | Jianbo Li Ligang Wang Dawei Yu Junfeng Hao Longchao Zhang Adeniyi C.Adeola Bingyu Mao Yun Gao Shifang Wu Chunling Zhu Yongqing Zhang Jilong Ren Changgai Mu David M.Irwin Lixian Wang Tang Hai Haibing Xie Yaping Zhang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 9 | Effect of artmether,hemin and Fe^(3+) on recombinant lactate dehydrogenase from Schistosoma japonicum显示文摘Objective:To explore antischitosome effects of artemether,hemin and Fe on S/LDH.Methods: Enzyme activity of rS/LDH was assayed in the standard reaction system by adding different concentration of reagents(0.00-0.10 mM artemether,0.00-0.02 mM hemin,0.00-0.50 mM Fe3+). Same solvents of the each reagent were used as control.Results:There was no enzyme activity inhibition observed at 0.10 mM artemther:obivious inhibition for lactate oxidation reaction and pyruvate reduction reaction were detected at 0.002 mM and 0.004 mM of hemin,respectively: comparing with that of the control(P<0.05).The relative enzymatic activity inhibitions for pyruvate reduction reaction and lactate oxidation reaction at 0.02 mM hemin were 93.48%and 100.00%,respectively,comparing with that of the control(P<0.01):both pyruvate reduction and lactate oxidation reaction were inhibited completely at 0.50 mM Fe3+,comparing with that of the control(P<0.01).Conclusions:The results implied that SjLDH was not the direct molecular target of artemether.Hemin and Fe are inhibitors of SjLDH. | Gang Lu Xuchu Hu Can Huang Yajun Lu Lixian Wu Lihua Li Jing Xu Xinbing Yu | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 1 |
| 10 | Multi-loop node line states in ternary MgSrSi-type crystals显示文摘Node line band-touchings protected by mirror symmetry(named as m-NLs),the product of inversion and time reversal symmetry S=PT(named as s-NLs),or nonsymmorphic symmetry are nontrivial topological objects of topological semimetals in the Brillouin Zone.In this work,we screened a family of MgSrSi-type crystals using first principles calculations,and discovered that more than 70 members are node-line semimetals.A new type of multi-loop structure was found in AsRhTi that a s-NL touches robustly with a m-NL at some“nexus point”,and in the meanwhile a second m-NL crosses with the s-NL to form a Hopf-link.Unlike the previously proposed Hopf-link formed by two s-NLs or two m-NLs,a Hopf-link formed by a s-NL and a m-NL requires a minimal three-band model to characterize its essential electronic structure.The associated topological surface states on different surfaces of AsRhTi crystal were also obtained.Even more complicated and exotic multi-loop structure of NLs were predicted in AsFeNb and PNiNb.Our work may shed light on search for exotic multi-loop node-line semimetals in real materials. | Jinling Lian Lixian Yu Qi-Feng Liang Jian Zhou Rui Yu Hongming Weng | 2019 | npj Computational Materials2019，，1： | 1 |
| 11 | Stabilized multifunctional phase change materials based on carbonized Cu-coated melamine foam/reduced graphene oxide framework for multiple energy conversion and storage显示文摘The leakage of organic phase change materials(OPCMs)at temperatures above their melting point severely limits their large-scale application.The introduction of porous supports has been identified as an efficient leakageproofing method.In this study,a novel carbonized Cu-coated melamine foam(MF)/reduced graphene oxide(rGO)framework(MF/rGO/Cu-C)is constructed as a support for fabricating stabilized multifunctional OPCMs.MF serves as the supporting material,while rGO and Cu act as functional reinforcements.As a thermal energy storage material,polyethylene glycol(PEG)is encapsulated into MF/rGO/Cu-C through a vacuum-assisted impregnation method to obtain PEG@MF/rGO/Cu-C composite with excellent comprehensive performance.PEG@MF/rGO/Cu-C exhibits high phase change enthalpies of 148.3 J g^(-1)(melting)and 143.9 J g^(-1)(crystallization),corresponding to a high energy storage capability of 92.7%.Simultaneously,MF/rGO/Cu-C endues the composite with an enhanced thermal conductivity of 0.4621Wm^(-1) K^(-1),which increases by 463%compared to that of PEG@MF.Furthermore,PEG@MF/rGO/Cu-C displays great light-to-thermal and electric-to-thermal conversion capabilities,thermal cycle stability,light-tothermal cycle stability,and shape stability,showing promising application prospects in different aspects. | Zhicong Hu Yongjin Zou Cuili Xiang Lixian Sun Fen Xu Menghe Jiang Sensen Yu | 2022 | Carbon Energy2022，4，6： | 0 |
| 12 | Sequence modulation of tunneling barrier and charge transport across histidine doped oligo-alanine molecular junctions显示文摘Series tunneling across peptides composed of various amino acids is one of the main charge transport mechanisms for realizing the function of protein. Histidine, more frequently found in redox active proteins, has been proved to be efficient tunneling mediator. While how it exactly modulates charge transport in a long peptide sequence remains poorly explored. In this work, we studied charge transport of a model peptide junction, where oligo-alanine peptide was doped by histidine at different position,and the series of peptides were self-assembled into a monolayer on gold electrode with soft EGa In as top electrode to form molecular junction. It was found that histidine increased the overall conductance of the peptide, meanwhile, its position modulated the conductance as well. Quantitative analysis by transport model and ultraviolet photoelectron spectroscopy(UPS) indicated a sequence dependent energy landscape of the tunneling barrier of the junction. Density-functional theory(DFT) calculation on the electronic structure of histidine doped oligo-alanine peptides revealed localized highest occupied molecular orbital(HOMO) on imidazole group of the histidine, which decreased charge transport barrier. | Baili Li Xuan Ji Lixian Tian Xianneng Song Ziyan Wang Hira Khalid Xi Yu Lejia Wang Wenping Hu | 2021 | Chinese Chemical Letters2021，32，12： | 0 |
| 13 | Study on Top Grafting Technology of Bare Scions of Walnut Trees in Eastern Hebei显示文摘[Objectives]To accelerate the improvement of walnut varieties and change the cultivation status of low yield and poor quality.[Methods]Through experimenting on the optimization technology of walnut trees,this paper studied the suitable top grafting period and scientific top grafting protection measures of walnut trees in Eastern Hebei,and established the top grafting technology system of walnut.Moreover,this paper explored the impact of different time and scientific management and protection measures on the survival rate and growth of bare scion top grafting of walnut trees.[Results]The grafting time had a great impact on the growth of new shoots,and there were significant differences in the survival rate among different grafting periods.The highest grafting survival rate was 96.97%on April 27 and the lowest grafting survival rate was 66.67%on May 4;the average survival rate was 78.10%.Among them,the survival rate of top grafting was the highest on April 20 and April 27.The growth of new shoots grafted in the early stage was greater than that in the late stage.The growth of new shoots and branches on April 8 and April 20 were the largest,with lengths of 160.3 and 143.7 cm;the thickness was 1.72 and 1.43 cm;the branch lengths were 79.8 and 63.4 cm;the branch thickness was 0.98 and 0.82 cm;the growth index was also the highest on April 8 and April 20 at 10,20,30 d after grafting,which was significantly different from other time periods.[Conclusions]Walnut trees with early grafting in Eastern Hebei can quickly restore their crown growth and had higher yield,thus this technology can be widely applied in Eastern Hebei or Yanshan area. | Jinli LIU Qiuxiang YU Lixian CUI Jing LIU Zhongkui BAI | 2022 | Asian Agricultural Research2022，14，6： | 0 |
| 14 | Achieving High-Performance Molecular Rectification through Fast Screening Alkanethiol Carboxylate- Metal Complexes Electroactive Units显示文摘Achieving high performance in molecular scale diode devices remains a formidable challenge due to the complexity of the charge transport process and the difficulty in device structure modulation.Herein,we demonstrated a low-cost and fast screening strategy to search for proper electroactive units and construct high performance self-assembled monolayer(SAM)-based molecular diodes.The strategy is based on off-the-shelf carboxylate-terminated alkane thiols and simple carboxylate-metal ion complexes,structures denoted as Au-S-(CH2)n-1COO−Mm+(Cn+Mm+),where n=11,12,13,14,16,18,and Mm+=Ca^(2+),Mn^(2+),Fe_(2)+,Fe3+,Co^(2+),Ni^(2+),Cu^(2+),and Zn^(2+),as the library of functional SAM layers on gold substrate.Combing the fast screening measurements using a eutectic indium-gallium alloy top contact(EGaIn),C18+Ca^(2+)and C18+Zn^(2+)structures were found to afford record high rectification ratio(RR)>700 at±1.5 V.Theoretical analysis based on a single level tunneling model shows that the C18+Ca^(2+)and C18+Zn^(2+)devices possessed an optimized combination of asymmetric voltage division,energy offset,and coupling of carboxylate-metal complexes with the electrode.This newly developed method represents a general strategy for fast,inexpensive,and effective exploration of the functional metal complex chemical space,and can largely accelerate the development of practical high performance molecular diode devices. | Lixian Tian Aiqing Fan Xi Yu Wenping Hu | 2023 | CCS Chemistry2023，5，4： | 0 |
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