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| 1 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 2 | Association of nonalcoholic fatty liver disease with type 2 diabetes: clinical features and independent risk factors in diabetic fatty liver patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common chronic liver disease in China, of which diabetic fatty liver (DFL) accounts for a large proportion in clinic. DFL is a disease without specific clinical features and lacking of confirmatory laboratory tests, and the etiology of hepatic steatosis remains poorly understood. The aim of this paper was to explore the clinical characteristics and to determine associated risk factors in type 2 diabetes patients with fatty liver. METHODS: A total of 166 patients, 53 in DFL group and 113 in NDFL(diabetes without fatty liver) group participated in this study. Serum fasting blood glucose (FBG), alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphate (AKP), gamma glutamyl transpeptidase (GGT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured in both groups. And these variables were analyzed by using Student’ s t test and logistic regression model. RESULTS:A progressive increase in the level of FBG, ALT, AST, AKP, GGT, TG( P<0.05) and a decrease of HDL-C(P<0.01)were observed from DFL group to NDFL group. And there was no statistical difference in the level of TC between the two groups. CONCLUSIONS:Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. The successive escalation of serum ALT and TG levels and the lower HDL-C level are the independent risk factors of DFL. | Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Jin HB, Gu ZY, Yu CH and Li YM) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 3 | Determination of the second autoproteolytic cleavage site of cephalosporin C acylase and the effect of deleting its flanking residues in the alpha-C-terminal region 显示文摘 | Zhang J Yu HM Wang Y Luo H Shen ZY | 2014 | J Biotechnol2014，184，： | 1 |
| 4 | Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats显示文摘 | Tian DS Xie MJ Yu ZY | 2007 | Brain Res2007，1135，1： | 1 |
| 5 | Recurrence after resection of alpha-fetoprotein positive hepatocellular carcinoma显示文摘 | Zhou XD Tang ZY Yu YQ | 1994 | J Cancer Res Clin Oncol1994，120，6： | 1 |
| 6 | Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants显示文摘 | Yu H Wang DD Wang Y Liu T Lee FS Chen ZY | 2012 | J Neurosci2012，32，12： | 1 |
| 7 | Rat focal cerebral ischemia induced astrocyte proliferation and delayed neuronal death are attenuated by cyclindependent kinase inhibition显示文摘 | Wang W Redecker C Yu ZY | | 0，，03： | 1 |
| 8 | An important approach to pro-longing survival further after radical resection of AFP positive hepatocellular carcinoma显示文摘 | Tang ZY Yu YQ Zhou XD | 1984 | J Exp Clin Cancer Res1984，3，4： | 1 |
| 9 | Characteristic of immobilized cephalosporin C acylase and its application in one-step enzymatic conversion of cephalosporin C to 7-aminocephalosporanic acid 显示文摘 | Zhu XW Luo H Chang YH Su HB Li QA Yu HM Shen ZY | 2011 | World J Microb Biotechnol2011，27，4： | 1 |
| 10 | Inhibition of G protein- coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain 显示文摘 | Li N Lu ZY Yu LH | 2014 | Mol Pain2014，10，： | 1 |
| 11 | Improved survival with resection after transcatheler arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma 显示文摘 | Fan J Tang ZY Yu YQ | 1998 | Dig Surg1998，15，6： | 1 |
| 12 | Inter- and intraspecific variations of cadmium accumulation of 13 leafy vegetable species in a greenhouse experiment显示文摘 | Wang JL Fang W Yang ZY Yuan JG Zhu Y Yu H | 2007 | Journal of Agricultural and Food Chemistry2007，55，： | 1 |
| 13 | Dose-dependent association between UGT1A1*28 polymorphism and irinotecan-induced diarrhoea:A meta-analysis显示文摘 | Hu ZY Yu Q Zhao YS | 2010 | Eur J Cancer2010，46，10： | 1 |
| 14 | Intraoral one-stage curved osteotomy forthe prominent mandibular angle:a clinical study of 407 cases显示文摘 | Gui L Yu D Zhang ZY | 2005 | Aesthetic Plast Surg2005，29，6： | 1 |
| 15 | Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia:an experience from a single neonatal intensive care unit显示文摘 | Lin ZL Yu HM Lin J Chen SQ Liang ZQ Zhang ZY | 2006 | J Perinatol2006，26，3： | 1 |
| 16 | Subclinical hepatocellular carcinoma: an analysis of 391 patients显示文摘 | Tang ZY Yu YQ Zhou XD | 1993 | J Surg Oncol Suppl1993，3，： | 1 |
| 17 | Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial- mesenchymal transition in gastric cancer显示文摘 | Xu ZY Yu QM Du YA | 2013 | Int J Biol Sci2013，9，6： | 1 |
| 18 | IL-6 rescues enterocytes hemorrhage induced apoptosis in vivo and in vitro by a Bcl-2 mediated mechanism显示文摘 | Rollwagen FM Yu ZY Li YY | 1998 | Clin Immunol Immunopathol1998，89，3： | 1 |
| 19 | Three decades, experience in surgery of hepatocellular carcinoma显示文摘 | Tang ZY Yu YQ Zhou XD | 1997 | Can To Kagaku Ryoho1997，24，1： | 1 |
| 20 | Micro-EDM for three-dimensional cavities-Development of uniform wear method显示文摘 | Yu ZY Masuzawa T Fujino M | 1998 | Annals of the CIRP1998，47，1： | 1 |
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