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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 3 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 4 | Synthesis and Characterization of Nanocrystalline Ni-Ti and Ni-Cr Powders by Mechanical Alloying显示文摘Nanocrystalline powders in the Ni-Ti and Ni-Cr systems were prepared by mechanical alloying (MA) of elemental crystalline powders in an inert atmosphere. The microstructure of the mechanically alloyed powders were characterized by XRD and TEM. The ball-milling process results in a drastic decrease of the crystallite size to the nanometer scale. X-ray diffraction analysis reveals that in the Ni-Cr system, no diffraction peaks from NiCr compound were observed even after 20 h of ball milling; while the lattice parameter of Ni increased with the milling time. In the Ni-Ti system, amorphous alloy was formed. Crystalline intermetallic compounds were obtained by post heat treatment of the amorphous alloy.The crystallization temperature of the amorphous NiTi alloy was obtained be DSC measurement. | Chen, SQ Zhou, YC Li, YY He, SH | 1997 | Journal of Materials Science & Technology1997，13，2： | 2 |
| 5 | Expression of a cytotox cationic antibacterial peptide in Eschedchia coli using two fu- sion partners 显示文摘 | Chen YQ Zhang SQ Li BC | 2008 | Protein Expression and Purification2008，57，2： | 1 |
| 6 | Effect of different depths ofanesthesia on perioperative stress response in children undergoingadenoidectomy and tonsillectomy显示文摘 | Yang LQ Li JJ Chen SQ | 2013 | CNS Neurosci Ther2013，19，2： | 1 |
| 7 | Combination transcatheter hepatic arterial chemoembolization with thymosin alpha 1 on recurrence prevention of hepatocellular carcinoma显示文摘 | Cheng SQ Wu MC Chen H | 2004 | Hepatogastroenterology2004，51，59： | 1 |
| 8 | Nutrients removal from municipal wastewater by chemicalprecipitation in a moving bed biofilm reactor 显示文摘 | Wang X J Xia SQ Chen L | 2006 | Process Biochemistry2006，41，： | 1 |
| 9 | Laparoscopy-assisted surgery for neonatal intestinal atresia and stenosis: a report of 35 cases 显示文摘 | Li B Chen WB Wang SQ | 2012 | Pediatr Surg Int2012，28，12： | 1 |
| 10 | Lipoprotein-associ- ated phospholipase A2 gene V279F polymorphisms and coronary heart disease : a meta-analysis显示文摘 | Zheng GH Chen HY Xiong SQ | 2011 | Mol Biol Rep2011，38，6： | 1 |
| 11 | The risk factors for hypoxemia in children younger than 5 years old undergoing rigid bronchoscopy for foreign body removal 显示文摘 | Chen LH Zhang X Li SQ | 2009 | Anesth Analg2009，109，4： | 1 |
| 12 | Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis显示文摘 | Yao SQ Rojanasakul LW Chen ZY | 2011 | Apoptosis2011，16，12： | 1 |
| 13 | Carboxymethylated chitosan stimulates proliferation of Schwann cells in vitro via the activation of the ERK and Akt signaling pathways显示文摘 | He B Liu SQ Chen Q | 2011 | Eur J Pharmacol2011，667，13： | 1 |
| 14 | Propofol pretreatment reduces ce- ramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats 显示文摘 | Liu KX Chen SQ Huang WQ | 2008 | Anesth Analg2008，107，6： | 1 |
| 15 | Carboxymethylated chitosan stimulates proliferation of Schwann cells in vitro via the activation of the ERK and Akt signaling pathways 显示文摘 | He B Liu SQ Chen Q | 2011 | Eur J Pharmacol2011，667，： | 1 |
| 16 | G-CSF-primed haploidentical marrow transplantation without ex vivo T cell depletion: an excellent alternative for high-risk leukemia 显示文摘 | Ji SQ Chen HR Wang HX | 2002 | Bone Marrow Transplant2002，30，12： | 1 |
| 17 | Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1显示文摘 | Vassilev LT Tovar C Chen SQ | 2006 | Proc Natl Acad Sci USA2006，103，10： | 1 |
| 18 | The prognostic value of pul- monary embolism severity index in acute pulmonary embolism: a meta-analysis显示文摘 | Zhou XY Ben SQ Chen HL | 2012 | Respir Res2012，13，12： | 1 |
| 19 | The Cretaceous Duimiangou adakite-like intrusion from the Chifeng region, northern North China Craton: Crustal contamination of basaltic magma in an intracontinental extensional environment显示文摘 | Fu L B Wei J H Kusky M T Chen H Y Tan J Li Y J Shi W J Chen C Zhao SQ | 2012 | Lithosphere2012，，： | 1 |
| 20 | Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis显示文摘 | Chen FJ Sun M Li SQ | 2013 | Mol Carcinog2013，52，11： | 1 |
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