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| 1 | Parameter determination to calculate water environmental capacity in Zhangweinan Canal Sub-basin in China显示文摘Zhangweinan canal sub-basin (ZWN) has the most serious water resource shortage and water pollution problems in north of China.To calculate the water environmental capacity in ZWN,determination methods for design flow rates and degradation coefficients were discussed in this study.Results showed that 90% and 50% hydrological guarantee flow rates were suitable to be the design flow rates for rainy and dry seasons,respectively.Degradation coefficients of COD Mn and NH 3 -N were 0.25 day -1 and 0.15 day -1 for branch streams and 0.5 day -1 and 0.25 day -1 for mainstreams,respectively in ZWN.With one-dimensional water quality simulation model,water environmental capacities were calculated to be 82,139 tons/yr for COD Mn and 2394 tons/yr for NH 3 -N in ZWN. | Yingxia Li ,Ruzhi Qiu,Zhifeng Yang,Chunhui Li,Jingshan Yu State Key Laboratory of Water Environment Simulation,School of Environment,Beijing Normal University,Beijing,100875,China. | 2010 | Journal of Environmental Sciences2010，22，6： | 23 |
| 2 | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway显示文摘Whether and how garlic-derived S-allylmercaptocysteine(SAMC) inhibits hepatocellular carcinoma(HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor(LDLR)-related protein 6(LRP6) in HCC progression and the anti-HCC mechanism of SAMC was examined in clinical sample, cell model and xenograft/orthotopic mouse models. We demonstrated that SAMC inhibited cell proliferation and tumorigenesis, while induced apoptosis of human HCC cells without influencing normal hepatocytes. SAMC directly interacted with Wnt-pathway co-receptor LRP6 on the cell membrane. LRP6 was frequently over-expressed in the tumor tissue of human HCC patients(66.7% of 48 patients) and its overexpression only correlated with the over-expression of β-catenin, but not with age, gender, tumor size, stage and metastasis. Deficiency or over-expression of LRP6 in hepatoma cells could partly mimic or counteract the anti-tumor properties of SAMC, respectively. In vivo administration of SAMC significantly suppressed the growth of Huh-7 xenograft/orthotopic HCC tumor without causing undesirable side effects. In addition, stable down-regulation of LRP6 in Huh-7 facilitated the anti-HCC effects of SAMC. In conclusion, LRP6 can be a potential therapeutic target of HCC. SAMC is a promising specific anti-tumor agent for treating HCC subtypes with Wnt activation at the hepatoma cell surface. | Jia Xiao Feiyue Xing Yingxia Liu Yi Lv Xiaogang Wang Ming-Tat Ling Hao Gao Songying Ouyang Min Yang Jiang Zhu Yu Xia Kwok-Fai So George L.Tipoe | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 3 | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling显示文摘Alcoholic liver disease(ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of S-allylmercaptocysteine(SAMC) from aged garlic on liver cell injury. A chronic ethanol-fed ALD in vivo model(the NIAAA model) was used to test the protective functions of SAMC. It was observed that SAMC(300 mg/kg, by gavage method) effectively ameliorated ALD-induced body weight reduction, steatosis,insulin resistance, and inflammation without affecting the health status of the control mice, as demonstrated by histological, biochemical, and molecular biology assays. By using biophysical assays and molecular docking, we demonstrated that SAMC directly targeted insulin receptor(INSR) protein on the cell membrane and then restored downstream IRS-1/AKT/GSK3 b signaling. Liver-specific knock-down in mice and siRNA-mediated knock-down in AML-12 cells of Insr significantly impaired SAMC(250 mmol/L in cells)-mediated protection. Restoration of the IRS-1/AKT signaling partly recovered hepatic injury and further contributed to SAMC’s beneficial effects. Continuous administration of AKT agonist and recombinant IGF-1 in combination with SAMC showed hepato-protection in the mice model.Long-term(90-day) administration of SAMC had no obvious adverse effect on healthy mice. We conclude that SAMC is an effective and safe hepato-protective complimentary agent against ALD partly through the direct binding of INSR and partial regulation of the IRS-1/AKT/GSK3 b pathway. | Pingping Luo Ming Zheng Rui Zhang Hong Zhang Yingxia Liu Wei Li Xiaoming Sun Qian Yu George LTipoe Jia Xiao | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 4 |
| 4 | Research about the Effect of Ultrasonic Impact on the Fatigue Properties of Cruciform Joints of 16MnR Steel显示文摘Surface impact treatment was carried out on the cruciform joint weldment of 16MnR steel by using the HJ-II-type ultrasonic impact machine.The ultrasonic impact current is 1.2 A,the impact amplitude is 30?m and ultrasonic impacting time is 30 and 60 min,respectively.Fatigue experiments were carried out for both treated specimen and un-treated specimen by using EHF-EM200K2-070-1A fatigue testing machine.The fatigue fractures were observed with the scanning electron microscope of 6360LA type and the microstructure of ultrasonic impact treating surface layer was analyzed by using high resolution transmission electron microscope of JEM-2100 type.The experimental results show that the microstructure of ultrasonic impact surface layer has been successfully nanocrystallized.The fatigue life of welded cruciform joints of 16MnR steel can be significantly improved through the ultrasonic impact treatment.The main reasons are that the ultrasonic impact treating can reduces the stress concentration in the weld toe,decrease the tensile stress,and even change to compressive stress in the weldment,the grain size in the welded joint can be refined.The longer the impact time,the greater increasing range of fatigue life will be.Compared to the sample without treatment,its fatigue life was increased 210.37%,362.48%,respectively,when the impact time was 30,60 min,respectively. | He Bolin Yu Yingxia Liu Jing Zhang Xiaodong Shi Jianping | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 5 | ^(40)Ar/^(39)Ar analysis of supergene yavapaiite and preliminary investigation on Ar closure temperature显示文摘Yavapaiite (KFe(SO4)2) is a new sulfate mineral with high potassium content, discovered in the oxidation zone of non-ferrous metal mining in the Tu-Ha Basin, Xinjiang Uygur Autonomous Region, northwestern China.Dating of this mineral by the K-Ar and 40Ar/39Ar method allows us to study the time and process of the region's aridity, and further we can provide some insight into the influence of not only the Tibetan Plateau uplift but also formation and evolution of polar ice caps on climate of this region.However, as the temperature of this region is up to 60℃ in summer, it is still questionable whether this high temperature causes the diffusive loss of 40Ar from yavapaiite in a long time, or whether the fine grain of the mineral can lead to diffusive loss of 40Ar from yavapaiite.These are important for interpreting the mineral age data.According to diffusion theory, we use 40Ar/39Ar step heating experiment to determine the apparent Ar diffusivity.Then we present a simple model of diffusive loss and radiogenic in-growth to evaluate the effect of extreme high ambient temperature and the grain size upon the Ar age.The experimental results show that the diffusion parameters as follows: the activation energy Ea is 71.30 kcal/mol and the frequency factor logD0/a2 is 13.71/s, the corresponding closure temperature Tc is 294℃ (assuming a cooling rate of 10℃/Ma), and the activation energy and closure temperature are very high.The simulation results show that the high ambient temperature and the grain size have no effect on the Ar age after yavapaiite was precipitated.Furthermore, the reproducibility of the age attests to the suitability of supergene yavapaiite for K-Ar and 40Ar/39Ar dating. | YANG Jing ZHENG DeWen LI DaMing XU YingXia YU ShuYan | 2012 | Science China Earth Sciences2012，55，12： | 2 |
| 6 | Meiotic Chromosome Behavior in a Human Male t(8;15)Carrier显示文摘Reciprocal translocation is one of the most common structural chromosomal rearrangements in human beings;it is widely recognized to be associated with male infertility.This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers.However,the underlying mechanisms are not completely known.Here we report a reciprocal translocation carrier of t(8;15),who is oligozoospermic due to apoptosis of primary spermatocytes and to premature germ cell desquamation from seminiferous tubules.Further analysis showed abnormal synapsis and recombination frequency in this patient,indicating a connection between chromosome behavior and apoptosis of primary spermatocytes.We also compared these observations with recently reported findings on spermatogenesis defects in reciprocal translocation carriers,and discuss the possible mechanisms underlying bom common and unique phenotypes of reciprocal translocations involving different chromosomes with the aim of further understanding the regulation of human spermatogenesis. | Hanwei Jiang Liu Wang Yingxia Cui Zhipeng Xu Tonghang Guo Dongkai Cheng Peng Xu Wen Yu Qinghua Shi | 2014 | Journal of Genetics and Genomics2014，41，3： | 2 |
| 7 | Preparation of CS/GPTMS hybrid molecularly imprinted membrane for efficient chiral resolution of phenylalanine isomers显示文摘 | Jiang Zhongyi Yu Yingxia Wu Hong | 2006 | Journal of Membrane Science2006，280，12： | 1 |
| 8 | Calculation about the Effect of Stress Concentration Coefficient on the Fatigue Properties for Welded Cruciform Joints of 16MnR Steel 显示文摘 | YU Yingxia HE Bolin ZHANG Xiaodong | 2012 | Applied Mechanics and Materials2012，189，： | 1 |
| 9 | Research and Prospects of Improving the Fatigue Life of Welded Train Bogie Structure 显示文摘 | HE Bolin YU Yingxia LIU Jing | 2011 | Advanced Materials Research2011，189，： | 1 |
| 10 | Preparation of CS/GPTMS hy- brid molecularly imprinted membrane for efficient chiral resolution ofphenylalanineisomers显示文摘 | Jiang Zhongyi Yu yingxia Wu Hong | 2006 | Journal of Membrane Science2006，280，12： | 1 |
| 11 | Preparation ofCS/GPTMS hybrid molecularly imprinted membrane forefficient chiral resolution of phenylalanine isomers 显示文摘 | Zhongyi Jiang Yingxia Yu Hong Wu | 2006 | Journal of Membrane Science2006，280，12： | 1 |
| 12 | Occurrence and possible sources of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) along the Chao River, China显示文摘 | Yang Yu Yingxia Li Zhenyao Shen Zhifeng Yang Li Mo Yanhong Kong Inchio Lou | 2014 | Chemosphere2014，，： | 1 |
| 13 | Preparation of CS/GPTMS hybrid molecularly imprinted membrane for efficient chiral resolution of phenylalanine isomers显示文摘 | Jiang Zhongyi Yu Yingxia Wu Hong | 2006 | Journal of Membrane Science2006，280，12： | 1 |
| 14 | Atmosphere CO2 increased concentration against lush membrane sponge stay显示文摘under lab conditions , studied the atmosphere CO2 effect of elevated concentrations on the filtration function of the lowest-equal multicellular animal sponge . in mock atmosphere CO2 Elevated concentrations of ecosystems , review CO2 concentration for 387, 750, 1000 mg/l under the environment , Lush film Sponge Hymeniacidonperlevis Stop sterilization of total organic carbon in seawater ( TOC) Capabilities . results show : in impersonation CO 2 concentration is 387 , 750, 1000 mg/l under the condition of Lush film sponge in H Clear seawater inside TOC The efficiency of IS 8%,67.6%, 50.0% and 15.4%, in the 24h to TOC The average drag retention rate for is (1.90±0.20 ,( 2.13±0.06 ,( 1.69±0.08 ,( 0.43± 0.11 mgkh-g Sponge ), The average purge rate is ( 0.025±0.002 ,( 0.033±0.001 ,( 0.019±0.001 ,( 0.004±0.001 mlkh.g sponge ), See Atmospher CO2 concentration from approximately 387 mg/l elevated to mg/l ,promotes lush film sponges prevent seawate from being in the sea TOC Ability , When the concentration is elevated to 750 mg/l suppresses the lush membrane sponge to stay TOC Capabilities , When the concentration is further elevation to 1000 mg/l , The causes the lush membrane sponge to almost lose its resistance to the seawater.TOC Capabilities . This study can be used for atmospheric 一: concentration The elevation of the effect of the sponge filtration function of intertidal zone and its possible ecological problems in nearshore waters . | Xu Hui Liu Hongwen Anzongfo Sheng Yu Line Du Yingxia | 2018 | Journal of Atmosphere and Oceanography Environment2018，6，1： | 0 |
| 15 | The Research on Growth Temperature of Ge/Si Thin Films Grown by Magnetron Sputtering显示文摘The films of Ge and Si were grown on the substrate Si (100) by magnetron sputtering at 2.5 Pa Ar pressure.The growth temperature of films was 100℃,250℃,400℃and 550℃.The structure and composition were analysised by Raman scattering.The poly-crystal peak and crystal peak of Ge were observed in these films.The results indicate that the single crystal film of Ge was prepared at the substrate temperature of 400℃.The peak of acoustic phonons of Ge was 98 cm^(-1) and that of Si was 170 cm^(-1). | Xu Mao Yingxia Jin Zhenlai Zhou YU Yang Xinghui Wu Fuxue Zhang | 2006 | 稀有金属材料与工程2006，35，A03： | 0 |
| 16 | Identification and quantification of lead source in sediment in the northern East China Sea using stable lead isotopes显示文摘Stable Pb isotopes in surface and core sediments were determined to identify the sources of Pb contaminants in the northern East China Sea(ECS).The Bayesian stable isotope mixing model was used to quantify the contributions of Pb sources.The results show that since the late 1980 s,ratios of^(207)Pb/^(206)Pb and^(208)Pb/^(206)Pb increased in the top 34-cm sediment shown in the coastal core samples,reflecting elevated anthropogenic Pb input in coastal sea.Seaward increase of^(207)Pb/^(206)Pb and^(208)Pb/^(206)Pb ratios in surface sediments reveals that anthropogenic Pb came mainly via atmospheric transmission into the ECS.Anthropogenic sources accounted for 12.0%-21.1%of the total Pb in sediments after the 1990 s.Coal combustion was the largest anthropogenic contributor(47.5%±18.8%),and Pb mining and smelting,cement production,and vehicle exhaust/gasoline contributed 23.2%±7.1%,19.0%±13.0%,and 10.3%±6.9%,respectively.The proportions of the anthropogenic sources gradually increased while geogenic source(riverine sediment)decreased from the coast to the outer shelf.This study demonstrated that the significant influence of atmospheric input of Pb contaminants into the ECS,and also the urgent need to control coal combustion and Pb discharge from industrial dust and fume emission in China.It also highlights the promising application of the Simmr model to quantify the proportions of multiple sources of trace elements in an environment. | Yu YU Yingxia LI Bing LI Yichao REN Xiaoyu DONG | 2021 | Journal of Oceanology and Limnology2021，39，5： | 0 |
| 17 | IndRT-GCNets: Knowledge Reasoning with Independent Recurrent Temporal Graph Convolutional Representations显示文摘Due to the structural dependencies among concurrent events in the knowledge graph and the substantial amount of sequential correlation information carried by temporally adjacent events,we propose an Independent Recurrent Temporal Graph Convolution Networks(IndRT-GCNets)framework to efficiently and accurately capture event attribute information.The framework models the knowledge graph sequences to learn the evolutionary represen-tations of entities and relations within each period.Firstly,by utilizing the temporal graph convolution module in the evolutionary representation unit,the framework captures the structural dependency relationships within the knowledge graph in each period.Meanwhile,to achieve better event representation and establish effective correlations,an independent recurrent neural network is employed to implement auto-regressive modeling.Furthermore,static attributes of entities in the entity-relation events are constrained andmerged using a static graph constraint to obtain optimal entity representations.Finally,the evolution of entity and relation representations is utilized to predict events in the next subsequent step.On multiple real-world datasets such as Freebase13(FB13),Freebase 15k(FB15K),WordNet11(WN11),WordNet18(WN18),FB15K-237,WN18RR,YAGO3-10,and Nell-995,the results of multiple evaluation indicators show that our proposed IndRT-GCNets framework outperforms most existing models on knowledge reasoning tasks,which validates the effectiveness and robustness. | Yajing Ma Gulila Altenbek Yingxia Yu | 2024 | Computers, Materials & Continua2024，78，1： | 0 |
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