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| 1 | Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum fibrogenesis marker, YKL-40, in patients with HCV-associated liver disease显示文摘AIM: To evaluate the clinical utility of serum fibrosis markers,including YKL-40, in patients with HCV-associated liver disease.METHODS: A total of 109 patients with HCV-associated liver disease were enrolled. We measured serum type Ⅳ collagen, amino-terminal peptide of type Ⅲ procollagen (PⅢP),hyaluronic acid (HA), YKL-40 levels and biochemical.Parameters by RIA or ELISA. Eighty-eight patients underwent liver biopsy, and 67 of 109 patients received interferon (IFN)therapy. We also investigated the relationship between the concentrations of serum fibrosis markers and histological fibrosis scores (METAVIR), and evaluated the changes of the levels of fibrosis markers before and after the IFN therapy.RESULTS: The increase in serum levels of all markers,particularly HA, was correlated with the progression of liver fibrosis (for type Ⅳ collagen, F= 9.076, P<0.0001; for PⅢP,F= 9.636, P<0.0001; for HA, F= 13.128, P<0.0001; and for YKL-40, F= 8.016, P<0.0001). YKL-40 had strong correlation with HA (r= 0.536, P<0.0001). Based on the receiver operating curve (ROC), the ability of serum HA exceeded the abilities of other serum markers to determine fibrosis score 4 from fibrosis score 0-3 (AUC = 0.854). While YKL-40 was superior to other fibrosis markers for predicting severe fibrosis (F2-F4) from mild fibrosis (F0-F1) (YKL-40, AUC = 0.809;HA, AUC = 0.805). After IFN therapy, only YKL-40 values significantly decreased not only in the responder group,but also in the nonresponder group (P = 0.03).CONCLUSION: YKL-40 may be a useful non-invasive serum marker to estimate the degree of liver fibrosis and to evaluate the efficacy of IFN therapies in patients with HCV-associated liver disease. | Yukiko Saitou Katsuya Shiraki Yutaka Yamanaka Yumi Yamaguchi Tomoyuki Kawakita Norihiko Yamamoto Kazushi Sugimoto Kazumoto Murata Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，4： | 21 |
| 2 | Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy显示文摘AIM To compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor(PPI)-based therapies to treat Helicobacter pylori(H. pylori).METHODS We retrospectively analysed data from first-line(vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d)(n = 1353) and second-line(vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d)(n = 261) eradication treatments for H. pylori- positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related factors.RESULTS After the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9%(95%CI: 84.9%-90.5%), 71.6%(95%CI: 67.5%-75.5%), 62.9%(95%CI: 52.0%-72.9%), and 57.3%(95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs(P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group(P = 0.34), whereas it decreased the rates in the PPI groups(P = 0.013). The incidence of adverse events in the vonop-razan group was not different from the PPI group(P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based therapy.CONCLUSION Vonoprazan might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events. | Kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 3 | 西那卡塞降低血液透析患者钙性尿毒症小动脉病变的发生显示文摘终末期肾病(ESRD)患者未控制的继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT),是钙性尿毒症小动脉病变(calcific uremic arteriolopathy,CUA,即钙化防御)的危险因素。CUA是相对罕见的综合症,1年生存率仅为45%;其主要病变是皮肤和脂肪组织小动脉和中动脉壁的中层钙化,导致进行性和极其痛苦的皮肤溃疡、感染,是CUA高死亡率的主要原因。CUA很少见于肾功能正常的患者,大多数CUA都局限于晚期CKD尤其是ESRD患者。在所有ESRD患者中CUA的患病率估计为1%到4%。 | Jürgen Floege Yumi Kubo Anna Floege 王建中 | 2015 | 中华肾病研究电子杂志2015，4，3： | 13 |
| 4 | Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization显示文摘AIM: To detect the expression of a proliferation-related ligand on human hepatocellular carcinoma (HCC) cell lines (SK-Hep1, HLE and HepG2) and in culture medium.METHODS: APRIL expression was analyzed by Western blotting in HCC cell lines. Effects of APRIL to cell count and angiogenesis were analyzed, too.RESULTS: Recombinant human APRIL (rhAPRIL) increased cell viability of HepG2 cells and, in HUVEC, rhAPRIL provided slight tolerance to cell death from serum starvation. Soluble APRIL (sAPRIL) from HLE cells increased after serum starvation, but did not change in SK-Hep1 or HepG2 cells. These cells showed down-regulation of VEGF after incubation with anti-APRIL antibody.Furthermore, culture medium from the HCC cells treated with anti-APRIL antibody treatment inhibited tube formation of HUVECs.CONCLUSION: Functional expression of APRIL might contribute to neovascularization via an upregulation of VEGF in HCC. | Hiroshi Okano Katsuya Shiraki Yutaka Yamanaka Hidekazu Inoue Tomoyuki Kawakita Yukiko Saitou Yumi Yamaguchi Naoyuki Enokimura Keiichi Ito Norihiko Yamamoto Kazushi Sugimoto Kazumoto Murata Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，30： | 13 |
| 5 | Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review显示文摘BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes.AIM To investigate the effectiveness of conventional therapy for MS-IBD.METHODS A systematic review with no time limit was conducted in July 2017 through the Cochrane Collaboration, MEDLINE, and LILACS databases. The inclusion criteria encompassed meta-analyses, systematic reviews, randomized clinical trials, observational and case-control studies concerning conventional therapy in adult patients with MS-IBD, including Crohn's disease(CD) and ulcerative colitis(UC). Corticosteroids(prednisone, hydrocortisone, budesonide, prednisolone,dexamethasone), 5-aminosalicylic acid(5-ASA) derivatives(mesalazine and sulfasalazine) and immunosuppressants [azathioprine(AZA), methotrexate(MTX), mycophenolate, cyclosporine, tacrolimus, 6-mercaptopurine(6-MP)] were considered conventional therapy. The exclusion criteria were sample size below50; narrative reviews; specific subpopulations(e.g., pregnant women,comorbidities); studies on postoperative IBD; and languages other than English,Spanish, French or Portuguese. The primary outcome measures were clinical remission(induction or maintenance), clinical response and mucosal healing. As secondary outcomes, fecal calprotectin, hospitalization, death, and surgeries were analyzed. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTS The search strategy identified 1995 citations, of which 27 were considered eligible(7 meta-analyses, 20 individual studies). For induction of clinical remission, four meta-analyses were selected(AZA and 6-MP showed no advantage over placebo,MTX or 5-ASA in CD; MTX showed no statistically significant difference versus placebo, 6-MP, or 5-ASA in UC; tacrolimus was superior to placebo for UC in two meta-analyses). Only one meta-analysis evaluated clinical remission maintenance, showing no statistically significant difference between MTX and placebo, 5-ASA, or 6-MP in UC. AZA and 6-MP had no advantage over placebo in induction of clinical response in CD. Three meta-analyses showed the superiority of tacrolimus vs placebo for induction of clinical response in UC. The clinical response rates for cyclosporine were 41.7% in randomized controlled trials(RCTs) and 55.4% in non-RCTs for UC. For induction of mucosal healing,one meta-analysis showed a favorable rate with tacrolimus versus placebo for UC. For secondary outcomes, no meta-analyses specifically evaluated fecal calprotectin, hospitalization or death. Two meta-analyses were retrieved evaluating colectomy rates for tacrolimus and cyclosporine in UC. Most of the twenty individual studies retrieved contained a low or very low quality of evidence.CONCLUSION High-quality evidence assessing conventional therapy in MS-IBD treatment is scarce, especially for remission maintenance, mucosal healing and fecal calprotectin. | Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa | 2019 | World Journal of Gastroenterology2019，25，9： | 13 |
| 6 | GIGANTEA and EARLY FLOWERING 4 in Arabidopsis Exhibit Differential Phase-Specific Genetic Influences over a Diurnal Cycle显示文摘内长的生理节奏的钟调整与工厂幸存和适应性有关的许多生理的过程。GIGANTEA (官方补给) ,联系钟的蛋白质,贡献生理节奏的时期长度和振幅的维护,并且也响应白天调整 flowering 时间和胚轴生长长度。同样,早 FLOWERING 4 (ELF4 ) ,另一个钟管理者,也贡献这些过程。然而,很少对也被知道在之间的基因或分子的相互作用官方补给并且在 Arabidopsis 的 ELF4。在这研究,我们调查了在之间的基因相互作用官方补给并且在生理节奏的控制钟的产量的规定的 ELF4。我们的变异的分析显示出那官方补给是到在 flowering 时间决心的 ELF4 的 epistatic,当 ELF4 是 epistatic 到时在胚轴生长官方补给规定。而且,官方补给并且 ELF4 在内长的钟规定上有 synergistic 或添加剂效果。介绍的基因表示官方补给, elf4,和官方补给的 elf4 异种进一步建立了那官方补给并且 ELF4 有差别对在黄昏和黎明的生理节奏的生理的产量的主导的影响分别地。这分阶段执行官方补给并且 ELF4 影响提供一个潜在的工具在生理节奏的生理的产量的规定完成差异,包括 flowering 时间和胚轴生长。 | Yumi Kim Miji Yeom Hyunmin Kim Junhyun Lim Hee Jung Koo Daehee Hwang David Somers Hong Gil Nam | 2012 | Molecular Plant2012，5，3： | 7 |
| 7 | Short-term effects of di-(2-ethylhexyl) phthalate on testes,liver, kidneys and pancreas in mice显示文摘瞄准:决定 di-(2-ethylhexyl ) 的生物化学的效果在生精的上皮的退化的过程的白天 10 上的睾丸,肝,肾和胰上的 phthalate (DEHP ) 。方法:包含 2% DEHP 的食谱被给男 Crlj : CD1 (ICR ) 老鼠 for10 天。DEHP 的剂量是 0.90 ± 0.52 mg/mouse/day。他们的睾丸,肝,肾 andpancreata 为察觉被检验单音 --(2-ethylhexyl ) phthalate (MEHP ) ,氮氧化物(NOx ) 生产了由每氮的氧化物的氧化(没有) 与自由激进分子,和类脂化合物一起每自由激进分子的链反应导致的氧化。结果:组织学的观察和浆液分析显示出严重 spermatogenic 骚乱, Leydig 房间机能障碍,肝机能障碍和脱水的存在。出人意料地,在睾丸的 MEHP 的集中在肝与那相比是极其低的。然而,在睾丸的 NOx 的集中象肝的集中一样高。而且,免费导致激进分子的类脂化合物组织化学地在睾丸然而并非在肝每氧化被检测。结论:结果显示阴囊的纸巾的高敏感引起到传播 MEHP 的 MEHP 而非特定的累积或举起进睾丸的那导致 DEHP 的 aspermatogenesisis。 | Yumi Miura Munekazu Naito Maira Ablake Hayato Terayama Shuang-Qin Yi Ning Qu Lin-Xian Cheng Shigeru Suna Fumihiko Jitsunari Masahiro Itoh | 2007 | Asian Journal of Andrology2007，9，2： | 6 |
| 8 | Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma显示文摘AIM: To investigate the role of angiopoietin (Ang) -1, -2 and -4 and its receptors, Tie-1 and -2, in the growth and differentiation of gastrointestinal stromal tumors (GISTs).METHODS: Thirty GISTs, seventeen leiomyomas and six schwannomas were examined by immunohistochemistry in this study.RESULTS: Ang-1, -2 and -4 proteins were expressed in the cytoplasm of tumor cells, and Tie-1 and -2 were expressed both in the cytoplasm and on the membrane of all tumors. Immunohistochemical staining revealed that 66.7% of GISTs (20 of 30), 76.5% of leiomyomas (13 of 17) and 83.3% of schwannomas (5 of 6) were positive for Ang-1. 83.3% of GISTs (25 of 30), 82.4% of leiomyomas (14 of 17) and 100% of schwannomas (6 of 6) were positive for Ang-2. 36.7% of GISTs (11 of 30), 58.8% of leiomyomas (10 of 17) and 83.3% of schwannomas (5 of 6) were positive for Ang-4. 60.0% of GISTs (18 of 30), 82.4% of leiomyomas and 100% of schwannomas (6 of 6) were positive for Tie-1. 10.0% of GISTs (3 of 30), 94.1% of leiomyomas (16 of 17) and 33.3% of schwannomas (2 of 6) were positive for Tie-2. Tie-2 expression was statistically different between GISTs and leiomyomas (P < 0.001). However, there was no correlation between expression of angiopoietin pathway components and clinical risk categories.CONCLUSION: Our results suggest that the angiopoietin pathway plays an important role in the differentiation of GISTs, leiomyomas and schwannomas. | Toshiyuki Nakayama Maki Inaba Shinji Naito Yumi Mihara Shiro Miura Mitsuru Taba Ayumi Yoshizaki Chun-Yang Wen Ichiro Sekine | 2007 | World Journal of Gastroenterology2007，13，33： | 6 |
| 9 | Magnifying narrow-band imaging with acetic acid to diagnose early colorectal cancer显示文摘AIM:To evaluate the diagnostic characteristics of magnifying endoscopy with acetic acid spray and narrowband imaging(MA-NBI)for early colorectal cancer.METHODS:We conducted a prospective study to evaluate the diagnostic characteristics of MA-NBI in differentiating early colorectal adenocarcinomas from adenomas.To compare the results,we used magnifying endoscopy with NBI(M-NBI)and magnifying endoscopy with crystal violet staining(M-CV).The study was performed in 2 phases.In phase 1,10 colonoscopists at our institution were shown still photographs of 35colorectal polyps(24 adenocarcinomas and 11 adenomas)in M-NBI,MA-NBI,and M-CV.They made diagnostic predictions using a five-grade scoring evaluation.We plotted receiver operating characteristic curves and compared the areas under the curves(AUCs).In phase2,colorectal polyps measuring≥8 mm were prospectively enrolled.During real-time colonoscopy,one ofthe 7 colonoscopists scored the lesion as an adenocarcinoma or an adenoma and assigned a level of confidence to the prediction(high or low).We calculated the accuracy,sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)for each method and compared the proportions of highconfidence predictions.RESULTS:In phase 1,the mean±SD AUCs were 0.64±0.031 in M-NBI,0.71±0.066 in MA-NBI,and 0.76±0.059 in M-CV(P<0.05 for M-NBI vs MA-NBI,P<0.001 for M-NBI vs M-CV,and not significant for MANBI vs M-CV).In phase 2,84 patients with 91 lesions(46 adenocarcinomas and 45 adenomas)were enrolled.The diagnostic characteristics were as follows:73%accuracy,85%sensitivity,60%specificity,68%PPV,and 79%NPV in M-NBI;73%accuracy,80%sensitivity,64%specificity,70%PPV,and 76%NPV in MA-NBI;and 73%accuracy,83%sensitivity,62%specificity,69%PPV,and 78%NPV in M-CV.The proportions of high-confidence predictions were 57%in M-NBI,75%in MA-NBI,and 76%in M-CV(P<0.005 for M-NBI vs MA-NBI,P<0.0005 for M-NBI vs M-CV,and P=1.0 for MA-NBI vs M-CV).CONCLUSION:MA-NBI is useful for differentiating early colorectal adenocarcinomas from adenomas. | Norihiro Goto Toshihiro Kusaka Yumi Tomita Hideyuki Tanaka Yoshio Itokawa Yorimitsu Koshikawa Daisuke Yamaguchi Yoshitaka Nakai Shigehiko Fujii Hiroyuki Kokuryu | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 10 | Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC. | Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel | 2017 | World Journal of Stem Cells2017，9，9： | 4 |
| 11 | Risk factors for the recurrence of hepatocellular carcinoma after radiofrequency ablation of hepatocellular carcinoma in patients with hepatitis C显示文摘AIM: To analyze the risk factors of hepatocellular carcinoma (HCC) recurrence after radiofrequency ablation (RFA) treatment with HCV-associated hepatitis. METHODS: Twenty-six patients with HCV-associated HCC who were followed-up for more than 12 mo were selected for this study. Risk factors for distant intrahepatic recurrences of HCC were evaluated for patients in whom complete coagulation was achieved without recurrence in the same subsegment as the primary nodule. Twelve clinical and tumoral factors were examined: Age, gender, nodule diameter, number of primary HCC nodule, Child-Pugh classification, serum platelet, serum albumin, serum AST, post RFA AST, serum ALT, post RFA ALT, post RFA treatment.RESULTS: Distant recurrences of HCC in remnant liver after RFA were observed in 14 cases and in the number of primary HCC nodules (P = 0.047), and the serum platelets (P = 0.030), the clear difference came out by the recurrence group and the non-recurrence group. The cumulative recurrence rates after 1 and 2 years were30.8% and 86.8%, respectively for primary multinodular HCC, and 15.4% and 29.5% respectively, for primary uninodular HCC. In addition the 1-year recurrence rates for patients with serum albumin more than 3.4 g/dL and less than 3.4 g/dL were 23.1% for both, but the 2-years recurrence rates were 89.0% and 23.1%, respectively. The number of primary HCC nodules (relative risk, 6.970; P = 0.016) were found to be a statistically significant predictor for poor distant intrahepatic recurrence by univariate analysis.CONCLUSION: Patients who have multiple HCC nodules, low serum platelets and low serum albumin accompanied by HCV infection, should be carefully followed because of the high incidence of new HCC lesions in the remnant liver, even if coagulation RFA is complete. | Yutaka Yamanaka Katsuya Shiraki Kazumi Miyashita Tomoko Inoue Tomoyuki Kawakita Yumi Yamaguchi Yukiko Saitou Norihiko Yamamoto Takeshi Nakano Atsuhiro Nakatsuka Koichiro Yamakado Kan Takeda | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 12 | Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps显示文摘Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin. | Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba | 2009 | World Journal of Gastroenterology2009，15，17： | 4 |
| 13 | Augmentation of tumor necrosis factor family-induced apoptosis by E3330 in human hepatocellular carcinoma cell lines via inhibition of NFκB显示文摘AIM: To investigate the reduction of cell viability in human hepatocellular carcinoma (HCC) cell lines induced by inhibition of nuclear factor κB (NFκB). METHODS: HLE, SKHep1, and HepG2 were incubated and E3330 was used to compare the stimulation of some chemotherapeutic drugs with that of TNF family, Fas ligand, TNFα and TNF-related apoptosis-inducing ligand (TRAIL) at the point of the reduction of cell viability by inhibiting NFκB. RESULTS: E3330 decreased NFκB levels in HLE cells stimulated by TNF and TRAIL. The cytotoxicity of the combination of TRAIL, TNFα, Fas ligand, and E3330 increased synergistically in a dose-dependent manner compared to either E3330 alone in all HCC cell lines by MTT assay. However, the combination of some chemotherapeutic drugs and E3330 did not decrease the cell viability. CONCLUSION: Inhibition of NFκB sensitizes human HCC cell lines to TNF-mediated apoptosis including TRAIL, and TRAIL-based tumor therapy might be a powerful potential therapeutic tool in the treatment of human HCC. | Yukiko Saitou Katsuya Shiraki Takenari Yamanaka Kazumi Miyashita Tomoko Inoue Yutaka Yamanaka Yumi Yamaguchi Naoyuki Enokimura Norihiko Yamamoto Keiichi Itou Kazushi Sugimoto Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 14 | Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection—association between TGF-β1 polymorphisms and hepatocellular carcinoma显示文摘 | Kiyoshi Migita Seiji Miyazoe Yumi Maeda Manabu Daikoku Seigo Abiru Tshihito Ueki Koji Yano Shinya Nagaoka Takehiro Matsumoto Kazuhiko Nakao Keisuke Hamasaki Hiroshi Yatsuhashi Hiromi Ishibashi Katsumi Eguchi | 2004 | Journal of Hepatology2004，，4： | 3 |
| 15 | A pilot study to assess the safety and efficacy of carbon dioxide insufflation during colorectal endoscopic submucosal dissection with the patient under conscious sedation显示文摘 | Yutaka Saito Toshio Uraoka Takahisa Matsuda Fabian Emura Hisatomo Ikehara Yumi Mashimo Tsuyoshi Kikuchi Takahiro Kozu Daizo Saito | 2007 | Gastrointestinal Endoscopy2007，，3： | 3 |
| 16 | Chemical induction of disease resistance in rice is correlated with the expression of a gene encoding a nucleotide binding site and leucine-rich repeats显示文摘 | Koji S Yuichi T Yumi Y | 1999 | Plant Molecular Biology1999，40，： | 2 |
| 17 | Effectiveness of therapeutic barium enema for diverticular hemorrhage显示文摘AIM:To evaluate the effectiveness of barium impaction therapy for patients with colonic diverticular bleeding.METHODS:We reviewed the clinical charts of patients in whom therapeutic barium enema was performed for the control of diverticular bleeding between August2010 and March 2012 at Yokohama Rosai Hospital.Twenty patients were included in the review,consisting of 14 men and 6 women.The median age of the patients was 73.5 years.The duration of the followup period ranged from 1 to 19 mo(median:9.8 mo).Among the 20 patients were 11 patients who required the procedure for re-bleeding during hospitalization,6patients who required it for re-bleeding that developed after the patient left the hospital,and 3 patients who required the procedure for the prevention of rebleeding.Barium(concentration:150 w%/v%)was administered per the rectum,and the leading edge of the contrast medium was followed up to the cecum by fluoroscopy.After confirmation that the ascending colon and cecum were filled with barium,the enema tube was withdrawn,and the patient’s position was changed every 20 min for 3 h.RESULTS:Twelve patients remained free of rebleeding during the follow-up period(range:1-19mo)after the therapeutic barium enema,including 9men and 3 women with a median age of 72.0 years.Re-bleeding occurred in 8 patients including 5 men and 3 women with a median age of 68.5 years:4developed early re-bleeding,defined as re-bleeding that occurs within one week after the procedure,and the remaining 4 developed late re-bleeding.The DFI(disease-free interval)decreased 0.4 for 12 mo.Only one patient developed a complication from therapeutic barium enema(colonic perforation).CONCLUSION:Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. | Mizue Matsuura Masahiko Inamori Atsushi Nakajima Yasuhiko Komiya Yumi Inoh Keigo Kawasima Mai Naitoh Yuji Fujita Akiko Eduka Noriyoshi Kanazawa Shiori Uchiyama Rie Tani Kennichi Kawana Setsuya Ohtani Hajime Nagase | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 18 | Combined use of T2-weighted and diffusion-weighted 3-T MR imaging for differentiating uterine sarcomas from benign leiomyomas显示文摘 | Tomohiro Namimoto Yasuyuki Yamashita Kazuo Awai Takeshi Nakaura Yumi Yanaga Toshinori Hirai Tetsuo Saito Hidetaka Katabuchi | 2009 | European Radiology2009，，： | 2 |
| 19 | 显示文摘 | Shigeo I Yumi H | 1998 | J Antibact Antifung Agents1998，26，3： | 2 |
| 20 | The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial显示文摘 | Yumie Takeshita Toshinari Takamura Masao Honda Yuki Kita Yoh Zen Ken-ichiro Kato Hirofumi Misu Tsuguhito Ota Mikiko Nakamura Kazutoshi Yamada Hajime Sunagozaka Kuniaki Arai Tatsuya Yamashita Eishiro Mizukoshi Shuichi Kaneko | 2014 | Diabetologia2014，，5： | 2 |
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