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| 1 | Analysis of the binding sites with NL-101 to amino acids and peptides by HPLC/MS/MS显示文摘The binding between NL-101, a novel nitrogen mustard anti-cancer drug, with amino acids and peptides has been investigated by high performance liquid chromatography electrospray tandem mass spectrometry(HPLC/ESI-MS/MS). This study offers supporting data of the interaction among drug and amino acids and peptides, which could potentially explain the cytotoxic and mutagenic effects of the drug. Collision-induced dissociation(CID) experiment demonstrated that under the same collision energy, the amino group combined with NL-101 adducts are sensitive and often produce more fragment ions; the carboxyl group combined with NL-101 adducts are hard to break and display fewer fragment ions. In addition, when other group(like sulfhydryl group) of amino acids binds to NL-101, CID spectra show different fragmentation pattern. These differences could display structural information about the drug adducts and be utilized as location of the authentic binding sites. | Lingzi Dai Nian Guo Yaqin Liu Shanshan Shen Qiufu Ge Yuanjiang Pan | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 2 | Tip-assisted ambient electric arc ionization mass spectrometry for rapid detection of trace organophosphorus pesticides in strawberry显示文摘In this study,an ambient mass spectrometry(AMS)based method was developed for rapid detection of organophosphorus pesticides in strawberry.This method combines an electric arc and a microsyringe tip to realize tip-assisted ambient electric arc ionization(TAAEAI).A high-voltage electric arc can be applied to the microsyringe tip to generate an electric field,which results in corona discharge at the microsyringe tip.The juiced strawberry sample loaded on the tip could be directly ionized with TAAEAI and then analyzed by a mass spectrometer.TAAEAI-MS was successfully applied to analyze 6 organophosphorus pesticides in three strawberry samples.Malathion and profenofos were detected from the investigated strawberry samples.This method could quantitatively determine the contents of organophosphorus pesticides in strawberry with high reproducibility,high precision,and high sensitivity.Sample matrices did not interfere with the pesticide analysis.The recoveries of organophosphorus pesticides spiked in strawberry samples varied between 82.6%and 116%with relative standard deviations(RSDs)less than 9.2%.The limits of detection(LODs)varied between 0.0124µg/g and 0.0245µg/g,while the limits of quantification(LOQs)varied between 0.0413µg/g and 0.0817µg/g.The coefficients of determination(R2)of the method were determined to be>0.995.The method established here may have potential application in the detection of organophosphorus pesticides in vegetables and fruits. | Zihan Ma Yuanji Gao Fengjian Chu Yunli Tong Yuwen He Yuan Li Zhan Gao Weiwei Chen Shuheng Zhang Yuanjiang Pan | 2022 | Chinese Chemical Letters2022，33，9： | 2 |
| 3 | Separation of rosin acids by molecular recognition: crystal structure of the complex of neoabietic acid with 2-amino-6-methyl-pyridine显示文摘 | Zhimin Jin Yuanjiang Pan Jiageng Liu Duanjun Xu | 2000 | Journal of Chemical Crystallography2000，，3： | 1 |
| 4 | In vitro and in vivo mmunosupp ressive activity of Spica Prunellae ethanol extract on the immune responses in mice显示文摘 | Sun Hongxiang Qin Feng Pan Yuanjiang | 2005 | Journal of ethnopharmacology2005，101，10： | 1 |
| 5 | I- solation and Purification of Antioxidative isomerie polyphenols from the roots of parthenoe- issus laetevirens by counter-current chromatog- raphy 显示文摘 | He Shan Lu Yanbin Pan Yuanjiang | 2007 | Journal of Chromatography A2007，1151，12： | 1 |
| 6 | Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease(CCVD)and non-CCVD patients显示文摘Cardio-cerebrovascular disease(CCVD)is a major comorbidity of coronavirus disease 2019(COVID-19).However,the clinical characteristics and outcomes remain unclear.In this study,102 cases of COVID-19 from January 22,2020 to March 26,2020 in Xixi Hospital of Hangzhou were included.Twenty cases had pre-existing CCVD.Results showed that compared with non-CCVD patients,those with CCVD are more likely to develop severe disease(15%versus 1%),and the proportion of pneumonia severity index grade IV was significantly higher(25%versus 3.6%).Computed tomography images demonstrated that the proportion of multiple lobe lesion involvement was significantly higher in the CCVD group than in the non-CCVD group(90%versus 63.4%).Compared with non-CCVD group,the levels of C-reactive protein,fibrinogen,D-dimer,and serum amyloid-A were higher,whereas the total protein and arterial partial Pa02 were lower in the CCVD group.Although no statistical difference was observed in the outcomes between groups,CCVD patients received more intensive comprehensive treatment to improve COVID-19 symptoms compared with non-CCVD patients.Integrated Chinese and Western medicine treatments have certain advantages in controlling the severe conversion rate and mortality of COVID-19.In addition,given that COVID-19 patients are usually related to coagulation disorders and thrombosis risk,the application of Chinese medicine in promoting blood circulation and removing stasis should be strengthened. | Yu Wang Lan Li Yuanjiang Pan Yu He Zuhua Chen Yunhao Xun Yuhan Xu Yilei Guo Jiehong Yang Jianchun Guo Haitong Wan | 2021 | Frontiers of Medicine2021，15，4： | 1 |
| 7 | Isolation, purification and structural investigation of a water-soluble polysaccharide from Solarium lyratum Thunb显示文摘 | WU Yaling PAN Yuanjiang SUN Cuirong | 2005 | International Journal of Biological Macromolecules2005，36，4： | 1 |
| 8 | Sesquiterpenoid with new skeleton from Chloranthus henryi 显示文摘 | Wu Bin He Shan Pan Yuanjiang | 2007 | Tetrahedron Lett2007，48，： | 1 |
| 9 | Applications of ambient electric arc ionization mass spectrometry in saline samples显示文摘Salinity tolerance of ambient electric arc ionization(AEAI)was evaluated by comparing electrospray ionization for various samples at NaCl concentrations from 0 to 1000 mmol/L.AEAI-mass spectrometry(AEAI-MS)exhibited an excellent signal intensity even at NaCl concentrations of 1000 mmol/L,while the ESI-MS had no signal because high salinity has a strong inhibitory effect on analytes.The sodium adduct was verified using LiCl instead of NaCl.AEAI-MS successfully quantified saline samples with an excellent quantitative ability(R^(2)≥0.998).We also achieved some analytical samples in the buffer solution at a very high concentration and even in a saturated salt solution.Overall,AEAI-MS has protonated ions for most target analytes.In addition,the relationship between auxiliary temperature and the distance from the sample to the arc was investigated,and the results indicated that thermal desorption plays an important role in AEAI source. | Yuan Li Yuanji Gao Binpeng Zhan Weiwei Chen Fengjian Chu Hongru Feng Zhan Gao Zihan Ma Yuanjiang Pan | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 10 | Studies on stereoselective synthesis of phenylglycine using D-gluco- pyranosylimine as chiral template 显示文摘 | ZHOU Guobin ZHANG Pengfei PAN Yuanjiang | 2004 | Chem J Internet2004，6，： | 1 |
| 11 | Isolation and characterization of a mannoglucan from edible Cordyceps sinensis mycelium显示文摘 | Yalin Wu Nan Hu Yuanjiang Pan | 2007 | Carbohydrate Research2007，342，： | 1 |
| 12 | Carboxylic Acids from Phyllanthus urinaria显示文摘 | Wanxing Wei Yuanjiang Pan Yaozu Chen Cuiwu Lin Tengyou Wei Shukai Zhao | 2005 | Chemistry of Natural Compounds2005，，1： | 1 |
| 13 | A novel method for synthesis of arylacetic acids from aldehydes,N-(2,3,4,6-tetra-O-pivaloylated-D-glucopyranosyl)amine and trimethylsi lylcyanide显示文摘 | Guobin Zhou Pengfei Zhang Yuanjiang Pan | 2005 | Tetrahedron2005，61，： | 1 |
| 14 | Carboxylic Acids from Phyllanthus Urinaria显示文摘 | Wangxing Wei Yuanjiang Pan Yaozu Chen | 2005 | Chemistry of natural compounds2005，41，1： | 1 |
| 15 | Isolation,purification and structural investigation of a water-soluble polysaccharide from Solanum lyratum Thunb显示文摘 | Wu Yalin Pan Yuanjiang Sun Cuirong | 2005 | International Journal of Biological Macromolecules2005，36，： | 1 |
| 16 | Detection,isolation,and characterization of a novel impurity from several folic acid products显示文摘Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods. | Qirong SHEN Quan HE Yuanjiang PAN Cuirong SUN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，7： | 0 |
| 17 | Intrinsic effects of precursor functional groups on the Na storage performance in carbon anodes显示文摘The oxygen-containing functional groups in disordered carbon anodes have been widely reported to influence the Na storage performance.However,the effect of original oxygen-containing groups in the precursors on the final structures and electrochemical performance is rarely studied.Herein,we used the anthraquinone derivatives with different oxygen-containing functional groups as precursors to make the disordered carbon anodes for Na-ion batteries(NIBs).Through comprehensive structural and electrochemical analyses,we found that the different types of functional groups in carbon precursors directly affect the cross-linking process during carbonization.The original precursors containing enough inter-chain oxygen or oxygen-containing functional groups with unsaturated bonds unattached to the ring are beneficial for the oxygen atoms to remain or cross-link in structure to result in more C–O–C group,forming nanovoids and disordered structure,which then determine the high performance of the carbon anodes in NIBs.This work highlights the importance of the type/content of functional groups in precursor and provides guidance for the future design of carbon anodes in NIBs from the perspective of precursor selection. | Xiaohan Tang Fei Xie Yaxiang Lu Zhao Chen Xiangfei Li Hong Li Xuejie Huang Liquan Chen Yuanjiang Pan Yong-Sheng Hu | 2023 | Nano Research2023，16，11： | 0 |
| 18 | The effect of cation size(H^+, Li^+, Na^+, and K^+) on McLafferty-type rearrangement of even-electron ions in mass spectrometry显示文摘Protonation and alkali-metal cation adduction are the most important ionization processes in soft-ionization mass spectrometry.Studies on the fragmentation mechanism of protonated and alkali-metal-cationized compounds in tandem mass spectrometry are essential and helpful for structural analysis.In some cases,it was often observed that a compound attached by different alkali-metal cations(or proton)exhibits similar fragmentation patterns but the relative abundances of product ions are different.This difference was considered to derive from the different electrostatic interactions of alkali-metal cations(or the bonded effect of proton)with the analyte.The alkali-metal cation with a smaller ionic radius shows stronger electrostatic interaction with the molecule because of its higher charge density.In addition,the bonded effect of the proton is stronger than the electrostatic interaction of the alkali-metal cation.In the present study,which used McLafferty-type rearrangements of even-electron ions([M+Cat]+,Cat=H,Li,Na,K)as model reactions,the effect of cation size in mass spectrometric fragmentation reactions is highlighted.These considerations were also successfully applied to interpret the similar but distinct fragmentation behavior of proton and alkali-metal cation adducts of a synthetic compound(2-(acetamido(phenyl)methyl)-3-oxobutanoate)and a drug(entecavir). | CHAI YunFeng PAN YuanJiang | 2014 | Science China Chemistry2014，57，5： | 0 |
| 19 | Fragmentation mechanism of product ions from protonated proline-containing tripeptides in electrospray ionization mass spectrometry显示文摘The dissociation chemistry of primary fragment ions from the protonated proline-containing tripeptides glycylprolylglycine,prolylglycylglycine,and prolylprolylglycine was investigated by electrospray ionization multi-stage mass spectrometry.Calcula-tions showed the a 2 ions generated from b 2 ions were cyclic,which is energetically more favorable than the linear form.The prolyl residue in the structure affected the energy hypersurface of the dissociation reaction from the b 2 ion to the a 2 ion.In the fragmen-tation of a 2 ions,the iminium-imine complex corresponding to loss of CO from the a 2 ion was suggested to be an ion-neutral com-plex (INC).The a 1 ion was generated from direct separation of this INC,and the internal iminium ion,which was absent in PGG,was generated from another INC that was formed from the first INC via proton-bridged complex-mediated intramolecular proton transfer.Although these intermediates are unstable,their existence is supported by experiments and density functional theory calculations. | YOU ZhuShuang WEN YongJun JIANG KeZhi PAN YuanJiang | 2012 | Chinese Science Bulletin2012，57，17： | 0 |
| 20 | In Situ Analysis of Tobacco Leaves Based on Microwave Plasma Torch Desorption Ionization Mass Spectrometry显示文摘Tobacco is an important economic crop worldwide.Tobacco leaves contain a large number of natural products.Therefore,the analysis of tobacco composition is crucial for the control of tobacco safety and quality assessment.Microwave plasma torch desorption ionization mass spectrometry(MPT-MS) is an emerging ambient mass spectrometry(AMS) technique that can be used for rapid real-time analysis of s amples without pretreatment.Our work focuses on the chemical composition analysis of tobacco using MPT-MS,and 14 compounds were detected in green flue-cured tobacco leaves,while 30 compounds were detected in cured flue-cured tobacco leaves,which confirms that curing can enhance the flavor of cigarettes.Furthermore,we successfully in situ identified characteristic fragment ions of α/β-CBD(α/β-cembranoids),an important aroma compound in tobacco by MPT-MS.The results demonstrate the capability of MPT-MS for in situ analysis of tobacco components and its potential for evaluating tobacco quality. | He Tang Yonggang Zhang Zhiguang Reng Junchen Zhu Yue Xie Xiaobin Zhang Hongru Feng Kailong Yuan Yuanjiang Pan | 2024 | Journal of Analysis and Testing2024，8，1： | 0 |
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