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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than Gemcitabine 显示文摘 | Cuirong Zhao Bin Yue Huiping Liu Cuicui Sun Wenbao Li Xianjun Qu | 2012 | Toxicology and Applied Pharmacology2012，262，： | 1 |
| 3 | Isolation, purification and structural investigation of a water-soluble polysaccharide from Solarium lyratum Thunb显示文摘 | WU Yaling PAN Yuanjiang SUN Cuirong | 2005 | International Journal of Biological Macromolecules2005，36，4： | 1 |
| 4 | Characteriza- tion of impurities in semi-synthetic vinorelbine bitartrate by HPLC-MS with mass spectrometric shift technique 显示文摘 | Xiaoji Cao Yuanpo Tai Cuirong Sun | 2005 | Journal of Pharmaceutical rout Biomedical Analysis2005，，39： | 1 |
| 5 | Isolation, purification and structural investigation of a water-soluble polysaccharide from Solanum lyratum Thunb显示文摘 | WU Yalin PAN Yuanjuan SUN Cuirong | 2005 | International Journal of Biological Macromolecules2005，36，4： | 1 |
| 6 | RMHSForest:Relative Mass and Half-Space Tree Based Forest for Anomaly Detection显示文摘Anomaly detection refers to identify the true anomalies from a given data set.We present an ensemble anomaly detection method called Relative mass and half-space tree based forest(RMHSForest),which detect anomalies,including global and local anomalies,based on relative mass estimation and halfspace tree.Different from density or distance based measure,RMHSForest utilizes a novel relative mass estimation to improve the detection of local anomaly.Meanwhile,half-space tree based on augmented mass can estimate a mass distribution efficiently without density or distance calculations or clustering.Our empirical results show that RMHSForest outperforms the current popular anomaly detection algorithms in terms of AUC and processing time in the test data sets. | LYU Yanxia LI Wenjie WANG Yue SUN Siqi WANG Cuirong | 2020 | Chinese Journal of Electronics2020，29，6： | 1 |
| 7 | On-line HPLC methodfor screening of antioxidants against superoxide anion radical fromcomplex mixtures显示文摘 | SUN Cuirong FU Jindi CHEN Juanjuan | 2010 | Journal of Seperation Science2010，33，8： | 1 |
| 8 | Isolation,purification and structural investigation of a water-soluble polysaccharide from Solanum lyratum Thunb显示文摘 | Wu Yalin Pan Yuanjiang Sun Cuirong | 2005 | International Journal of Biological Macromolecules2005，36，： | 1 |
| 9 | Detection,isolation,and characterization of a novel impurity from several folic acid products显示文摘Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods. | Qirong SHEN Quan HE Yuanjiang PAN Cuirong SUN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，7： | 0 |
| 10 | Identification of quantitative trait loci for growth traits in red swamp crayfish(Procambarus clarkii)显示文摘Genetic breeding is an important approach to improve the economic traits of aquaculture animals.Unfortunately,the genetic basis for important economic traits of red swamp crayfish,including growth-related traits,has not yet been reported.In the present study,two full-sib families and two natural populations were employed to identify quantitative trait loci(QTLs)for growth-related traits of red swamp crayfish.In total,28 QTLs for five growth-related traits,including body weight,body length,carapace length,carapace width,and abdomen length,were repeatedly identified in more than two families/populations,by means of association analysis;nine of these displayed a heterosis effect.The phenotypic variations of the five investigated traits explained by the 28 QTLs ranged from 4.2%to 19.0%.Eight additive and three heterosis QTLs were further successfully validated using comparative analysis of favoured alleles between the small and big size crayfish groups in the natural population.In conclusion,this study investigated the genetic basis of growth-related traits in red swamp crayfish,which is of great significance for their application in the future molecular breeding of the species. | Junxiao Sun Cuirong Luo Bo Peng Guohui Peng Yunfei Tan Xufeng Bai | 2023 | Aquaculture and Fisheries2023，8，6： | 0 |
| 11 | Effectiveness of Post-Traumatic Growth Intervention to Promote Positive Post-Traumatic Traits in Chinese Breast Cancer Patients:A Randomized Controlled Trial显示文摘Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomized control trial of a psychological group intervention based on PTG model.Methods:The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264.A total of 92 patients with breast cancer were recruited.The participants were randomly assigned to the experimental group(n=46)and the control group(n=46).A six-session psychological group intervention based on PTG model was implemented in the experimental group,and a six-session health education was implemented in the control group.The outcomes weremeasured at baseline(pre-intervention),3 weeks,6 weeks after the intervention.The primary outcome was posttraumatic growth assessed by the Chinese version of the Post-Traumatic Growth Inventory(PTGI);Secondary outcomes included psychological resilience,family resilience,rumination,and self-disclosure.Results:A total of 87 patients with breast cancer completed this study,including 44 patients in the experimental group and 43 patients in the control group.There was no significant difference in baseline data of breast cancer patients between the two groups except for the treatment regimen(p>0.05).The two groups were compared after the intervention;the interaction effects between the total scores of posttraumatic growth,family resilience,and self-disclosure and the time term were statistically significant(p<0.05),indicating that the trend of change in total scores of post-traumatic growth,family resilience,and self-disclosure differed between the experimental and control groups over time,and the scores improved in the experimental group were significantly higher than those in the control group.The comparison of psychological resilience and total score of rumination at each time point was statistically significant(p<0.05),indicating that group intervention based on the PTG model could improve the psychological recovery ability and rumination level of the experimental group.Conclusion:The psychological group intervention based on the PTG model significantly improved post-traumatic growth,family resilience,and self-disclosure in patients with breast cancer.However,the impact on psychological resilience and rumination was relatively small.Long-term intervention is needed to further test the effect of the PTG model on psychological resilience and rumination. | Cuirong Xu Han Yan Dawei Xu Guanjie Chen Qian Xu Kunpeng Li Yehao Rui Zanmin Song Neeraj Gill Jing Sun | 2023 | International Journal of Mental Health Promotion2023，25，10： | 0 |
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