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| 1 | Experimental long-distance quantum secure direct communication显示文摘Quantum secure direct communication(QSDC) is an important quantum communication branch, which realizes the secure information transmission directly without encryption and decryption processes.Recently, two table-top experiments have demonstrated the principle of QSDC. Here, we report the first long-distance QSDC experiment, including the security test, information encoding, fiber transmission and decoding. After the fiber transmission of 0.5 km, quantum state fidelities of the two polarization entangled Bell states are 91% and 88%, respectively, which are used for information coding. We theoretically analyze the performance of the QSDC system based on current optical communication technologies,showing that QSDC over fiber links of several tens kilometers could be expected. It demonstrates the potential of long-distance QSDC and supports its future applications on quantum communication networks. | Feng Zhu Wei Zhang Yubo Sheng Yidong Huang | 2017 | Science Bulletin2017，62，22： | 25 |
| 2 | Passive source range estimation with a single receiver in shallow water显示文摘An approach for long-range passive impulsive source ranging with a single receiver in shallow water is proposed,which utilizes the frequency spectrum of the warped signal autocorrelation function via warping transform.For an ideal waveguide,there are invariable frequency features both in the frequency spectrum of the warped signal corresponding to modal cut-off frequencies and the warped signal autocorrelation function due to modal interference.These intrinsic frequency features can be used to passive source ranging.So,the approximate relationship between the frequency of warped signal at an unknown source range and the intrinsic frequency extracted by the time warping transform is derived.These rules can be generalized to an actual shallow water waveguide.Employing an acoustic model to offer the invariable frequency spectrum features,the impulsive signal data collected by a single hydrophone in the North Yellow Sea in December 2011 are analyzed to verify the proposed source ranging approach.The estimated ranges are in good agreement with the ranges measured by GPS,and the mean relative error of range estimation is less than 10%. | QI Yubo ZHOU Shihong REN Yun WANG Dejun LIU Jianjun FENG Xiqiang | 2015 | Chinese Journal of Acoustics2015，34，1： | 13 |
| 3 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 4 | Laminar shear stress delivers cell cycle arrest and anti-apoptosis to mesenchymal stem cells显示文摘Biomechanical 力量作为房间功能的批评管理者正在出现,液体流动是一个有势力机械刺激。尽管对液体作出回应的造骨细胞和 osteocytes 的机制流动被阐明,很少对怎么被知道 osteoprogenitors,间充质的干细胞(MSC ) ,对液体作出回应流动。这里,我们检验了 laminar 的效果砍在 vitro 的 MSC 上的应力(LSS ) 。从 SpragueDawley 老鼠的骨头髓的 MSC 被孤立,净化,并且使遭到了到 LSS 的生理的层次。DNA 合成和房间周期被测量通过[3H ] thymidine 并且由流动 cytometry,分别地检测细胞的增长。Annexin V immunostaining 和 Bcl-2/Bax mRNA 表示被评估在 MSC apoptosis 上决定 LSS 的效果。结果证明液体砍与房间的多数引起 MSC 的增长率的剂量相关的减小的应力在 G0 或 G1 阶段正在被逮捕。而且, LSS 的生理的层次在 MSC apoptosis 上施加了有势力抑制效果,这被发现。在摘要,这些数据在维持 MSC 的静止揭示了 LSS 的一个关键角色。 | Wei Luo Wei Xiong Jun Zhou Zhong Fang Wenjian Chen Yubo Fan Feng Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 4 |
| 5 | Ultrasound speed and attenuation in progressive trypsin digested articular cartilage显示文摘Subtle changes of articular cartilage(AC) can lead to tissue degeneration and even osteoarthritis(OA).The early degeneration of AC is closely related to a change in proteoglycans(PG) content.The observation of PG is therefore an appropriate way of studying OA and evaluating the degree of AC degeneration.In this study,20 cartilage-bone samples were prepared from normal porcine femoral condyle cartilage and 10 samples were digested over 2 h using 0.25% trypsin solution.The dynamic process of PG-digestion was explored using a conventional A-mode ultrasound(US) experimental system with a 10 MHz center frequency.Quantitative acoustic parameters were calculated from ultrasonic radio-frequency echo signals and included US speed(USS),US amplitude attenuation coefficient(UAA) and broadband US attenuation coefficient(BUA).The experimental results showed that the conventional A-mode ultrasound is valuable for tracking the degree of PG-digestion.Histology also confirmed the validity of the ultrasound observations.For every AC sample,the degree of PG-digestion within a given time was different and was affected by individual differences.After two hours of degeneration,USS showed a mean decrease of 0.4%(P<0.05).UAA was significantly lower after a two-hour PG depletion period(from(2.45±0.23) to(2.28±0.41) dB mm?1).BUA showed no significant differences during this process.In conclusion,conventional ultrasound can provide useful information about trypsin-induced progressive PG depletion in AC and can reflect variations of PG content via the quantitative acoustic parameters USS and UAA.The results of this study may be used to identify an indirect indicator of cartilage matrix integrity and OA disease progression. | NIU HaiJun LI LiFeng SUN Feng YAN Yan WANG YueXiang LI DeYu FAN YuBo | 2011 | Science China(Life Sciences)2011，54，11： | 3 |
| 6 | Biomechanism of impact resistance in the woodpecker's head and its application显示文摘The woodpecker does not suffer head/eye impact injuries while drumming on a tree trunk with high acceleration(more than 1000×g) and high frequency.The mechanism that protects the woodpecker's head has aroused the interest of ornithologists,biologists and scientists in the areas of mechanical engineering,material science and electronics engineering.This article reviews the literature on the biomechanisms and materials responsible for protecting the woodpecker from head impact injury and their applications in engineering and human protection. | WANG LiZhen LU Shan LIU XiaoYu NIU XuFeng WANG Chao NI YiKun ZHAO MeiYa FENG ChengLong ZHANG Ming FAN YuBo | 2013 | Science China(Life Sciences)2013，56，8： | 3 |
| 7 | Genome-wide association study and genomic prediction of Fusarium ear rot resistance in tropical maize germplasm显示文摘Fusarium ear rot(FER)is a destructive maize fungal disease worldwide.In this study,three tropical maize populations consisting of 874 inbred lines were used to perform genomewide association study(GWAS)and genomic prediction(GP)analyses of FER resistance.Broad phenotypic variation and high heritability for FER were observed,although it was highly influenced by large genotype-by-environment interactions.In the 874 inbred lines,GWAS with general linear model(GLM)identified 3034 single-nucleotide polymorphisms(SNPs)significantly associated with FER resistance at the P-value threshold of 1×10^(-5),the average phenotypic variation explained(PVE)by these associations was 3%with a range from 2.33%to 6.92%,and 49 of these associations had PVE values greater than 5%.The GWAS analysis with mixed linear model(MLM)identified 19 significantly associated SNPs at the P-value threshold of 1×10^(-4),the average PVE of these associations was 1.60%with a range from 1.39%to 2.04%.Within each of the three populations,the number of significantly associated SNPs identified by GLM and MLM ranged from 25 to 41,and from 5 to 22,respectively.Overlapping SNP associations across populations were rare.A few stable genomic regions conferring FER resistance were identified,which located in bins 3.04/05,7.02/04,9.00/01,9.04,9.06/07,and 10.03/04.The genomic regions in bins 9.00/01 and 9.04 are new.GP produced moderate accuracies with genome-wide markers,and relatively high accuracies with SNP associations detected from GWAS.Moderate prediction accuracies were observed when the training and validation sets were closely related.These results implied that FER resistance in maize is controlled by minor QTL with small effects,and highly influenced by the genetic background of the populations studied.Genomic selection(GS)by incorporating SNP associations detected from GWAS is a promising tool for improving FER resistance in maize. | Yubo Liu Guanghui Hu Ao Zhang Alexander Loladze Yingxiong Hu Hui Wang Jingtao Qu Xuecai Zhang Michael Olsen Felix San Vicente Jose Crossa Feng Lin Boddupalli M.Prasanna | 2021 | The Crop Journal2021，9，2： | 3 |
| 8 | From CO Oxidation to CO2 Activation: An Unexpected Catalytic Activity of Polymer-Supported Nanogold 显示文摘 | Feng Shi Qinghua Zhang Yubo Ma | 2005 | J Am Chem Soc2005，127，12： | 1 |
| 9 | Shape-enhanced maximum intensity projection显示文摘 | Zhou Zhiguang Tao Yubo Lin Hai Dong Feng Clapworthy G | | 0，，6： | 1 |
| 10 | Simulated Microgravity Combined with Polyglycolic Acid Scaffold Culture Conditions Improves the Function of Pancreatic Islets显示文摘 | Yimin Song Zheng Wei Chun Song Shanshan Xie Jinfa Feng Jiehou Fan Zengling Zhang Yubo Shi Manoor Prakash Hande | 2013 | <journal-title>BioMed Research International2013，，： | 1 |
| 11 | Investigation on thermo-mechanical behavior of reinforced concrete energy pile with large cross-section in saturated sandy soil by model experiments显示文摘Energy piles are a new type of heat exchange systems with buried pipes in a pile foundation,which optimize a ground source heat pump system for the utilization of shallow geothermal energy.In this study,based on the principle of similarity,the thermo-mechanical behavior of the model energy pile with a large cross-section in saturated sandy soil was experimentally evaluated.The pre-cast model concrete pile with a diameter of 0.2 m and length of 1.5 m was buried in saturated sand in a steel box with dimensions of 2.5 m×2.5 m×2.0 m(length×width×height).The pile was heated using water in the polyethylene(PE)pipe,which was connected to a water cycle temperature controller.At a constant inlet water temperature of 55℃,three thermal cycles were carried out with the same heating and cooling periods and different water flow rates.The temperature distributions in the pile and soil,in addition to the pore pressure,soil pressure,and displacement of the pile,were monitored to clarify the thermo-mechanical behavior of the pile and soil.The heat transfer efficiency was analyzed based on the temperature difference and water flow rates.The measured strain at different locations in the pile under cyclic thermal loading revealed that the uneven strain that developed in a pile body should be considered for its long-term application.Furthermore,focus should be directed toward the long-term unrecoverable displacement of the energy pile due to the thermal plastic strain and thermal consolidation of the soil. | Xiaohua Bao Yubo Li Tangjie Feng Hongzhi Cui Xiangsheng Chen | 2020 | Underground Space2020，5，3： | 1 |
| 12 | From CO oxidation to CO2 activation:An unexpected catalytic activity of polymer-supported nanogold显示文摘 | ZHANG Qinghua MA Yubo | 2005 | J Am Chem Soc2005，127，12： | 1 |
| 13 | Improved PCR-based subtractive hybridization, a shortcut to clone cell differential expression novel genes 显示文摘 | Feng Z Yubo C | 2000 | Biotechniques2000，292，2： | 1 |
| 14 | The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo显示文摘 | Xiaoming Li Haifeng Liu Xufeng Niu Bo Yu Yubo Fan Qingling Feng Fu-zhai Cui Fumio Watari | 2012 | Biomaterials2012，，19： | 1 |
| 15 | Cloning and biological comparison of Restin, novel member of Mage superfamily显示文摘 | Zhongliang Zhao Fan Lu Feng Zhu Hui Yang Yubo Chai Sumin Chen | 2002 | Science in China Series C: Life Sciences2002，，4： | 1 |
| 16 | Improved PCR-based subtrac- tive hybridization, a shortcut to clone cell differential expression novel genes显示文摘 | Zhu Feng Yah W Chai Yubo | 2000 | Biotechniques2000，29，2： | 1 |
| 17 | Effect of mechanical stretching and substrate stiffness on the morphology,cytoskeleton and nuclear shape of corneal endothelial cells显示文摘Due to the limited capacity of corneal endothelial cells(CECs)division,corneal endothelial diseases have become a great challenge.The cornea is subjected to various mechanical stimuli in vivo,which may have a positive or negative influence.Thus,it is significant to gain an insight into the mechanism of mechanobiology of CECs for seeking more possible treatment.The purpose of this study was to determine the impacts of mechanical stretch and substrate stiffness on the morphology and fundamental cell behavior of CECs.Rabbit corneal endothelial cells(RCECs)were subjected to a 5%mechanical stretch or cultured on substrates of different stiffness.The impacts of mechanical stimulus on cell area,aspect ratio,circularity,cell density,nuclear shape,cytoskeleton,and cell viability were investigated.The expressions of the corneal endothelium-related markers ZO-1 and Na^(+)/K^(+) ATPase were also evaluated by confocal immunofluorescence microscopy in the stiffness group.Our results suggested that mechanical stretch promoted the rearrangement of the cytoskeleton while decreasing the cell circularity,nuclear area,and cell density as well as cell viability.RCECs cultured on 10 kPa substrates,which was close to the physiological stiffness of rabbit Descemet's membrane(DM),showed better cell morphology,more stable actin cytoskeleton assembly,and more robust expression of the functional marker compared with other softer or stiffer substrates.In summary,mechanical stretch and substrate stiffness have profound influences on the morphology and function of CECs,which may have implications for the understanding and possible treatment of corneal endothelial diseases. | Ruotian Du Dongyan Li Yan Huang Hui Xiao Jindong Xue Jing Ji Yun Feng Yubo Fan | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
| 18 | New Splitting Methods for Convection-Dominated Diffusion Problems and Navier-Stokes Equations显示文摘We present a new splitting method for time-dependent convention-dominated diffusion problems.The original convention diffusion system is split into two sub-systems:a pure convection system and a diffusion system.At each time step,a convection problem and a diffusion problem are solved successively.A few important features of the scheme lie in the facts that the convection subproblem is solved explicitly and multistep techniques can be used to essentially enlarge the stability region so that the resulting scheme behaves like an unconditionally stable scheme;while the diffusion subproblem is always self-adjoint and coercive so that they can be solved efficiently using many existing optimal preconditioned iterative solvers.The scheme can be extended for solving the Navier-Stokes equations,where the nonlinearity is resolved by a linear explicit multistep scheme at the convection step,while only a generalized Stokes problem is needed to solve at the diffusion step and the major stiffness matrix stays invariant in the time marching process.Numerical simulations are presented to demonstrate the stability,convergence and performance of the single-step and multistep variants of the new scheme. | Feng Shi Guoping Liang Yubo Zhao Jun Zou | 2014 | Communications in Computational Physics2014，16，10： | 0 |
| 19 | Novel thieno[2,3-b]quinoline-procaine hybrid molecules:A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors显示文摘Small molecule activators could equally provide powerful tools as inhibitors do for interrogating cellular signal transduction.However,targeted protein activation is chemically challenging.Developing activators against Src homology region 2 domain-containing phosphatase-1(SHP-1)to block STAT3 pathway represents a promising strategy for DLBCL therapy.Here we reported a new class of thieno[2,3-b]quinolineprocaine hybrid molecules as SHP-1 allosteric activators.The representative hybrid compound 3b displayed SHP-1 activating effect with EC50 of 5.48±0.28μmol/L.Further investigations confirmed that 3b allosterically interacted with SHP-1,switched it from close to open conformation,blocked SHP-1/p-STAT3 pathway,induced apoptosis and inhibited ABC-DLBCL cell proliferation in vitro,and delayed tumor growth in the xenograft model of SU-DHL-2.Overall,this work offered a novel paradigm to develop SHP-1 allosteric activators through chemical space evolution of PTPs inhibitors,and firstly validated the therapeutic strategy that directly activating SHP-1 alone could be a potential therapy against ABC-DLBCL via blocking STAT3 pathway. | Lei Xu Xuyang Mu Minmin Liu Zhijia Wang Chao Shen Qianwen Mu Bo Feng Yechun Xu Tingjun Hou Lixin Gao Haini Jiang Jia Li Yubo Zhou Wenlong Wang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 20 | The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency显示文摘The development of small-diameter vascular grafts that can meet the long-term patency required for implementation in clinical practice presents a key challenge to the research field.Although techniques such as the braiding of scaffolds can offer a tunable platform for fabricating vascular grafts,the effects of braided silk fiber skeletons on the porosity,remodeling,and patency in vivo have not been thoroughly investigated. | Xili Ding Weirong Zhang Peng Xu Wentao Feng Xiaokai Tang Xianda Yang Lizhen Wang Linhao Li Yan Huang Jing Ji Diansheng Chen Haifeng Liu Yubo Fan | 2023 | Research2023，，2： | 0 |
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