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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Methane aromatization in the absence of oxygen over extruded and molded MoO_3/ZSM-5 catalysts:Influences of binder and molding method显示文摘The influences of binder and molding method on the catalytic performance of methane aromatization in the absence of O2 over MoO3/ZSM-5 catalysts were investigated.SEM,NH3-TPD,FT-IR of adsorbed pyridine,N2 adsorption-desorption,cyclohexane adsorption and XPS were employed to characterize the physical and chemical properties of the catalysts.It was found that SiO2 was a suitable binder for the catalyst due to its appropriate weak acidity.The laminar catalyst comprising of an inert spherical core and a MoO3/ZSM-5 laminar shell with 0.1 0.2 mm in thickness showed a better catalytic performance than the extruded catalyst.The improved activity of the laminar catalyst could be attributed to the easy carbonization of Mo species and the quick removal of reaction products from the catalyst surface. | Dongmei Ren Xiangsheng Wang Gang Li Xiaojing Cheng Huayun Long Lidong Chen | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 7 |
| 3 | Research on Combined Construction Technology for Cross-Subway Tunnels in Underground Spaces显示文摘 | Xiangsheng Chen | 2018 | Engineering2018，4，1： | 3 |
| 4 | Prediction of geological characteristics from shield operational parameters by integrating grid search and K-fold cross validation into stacking classification algorithm显示文摘This study presents a framework for predicting geological characteristics based on integrating a stacking classification algorithm(SCA) with a grid search(GS) and K-fold cross validation(K-CV). The SCA includes two learner layers: a primary learner’s layer and meta-classifier layer. The accuracy of the SCA can be improved by using the GS and K-CV. The GS was developed to match the hyper-parameters and optimise complicated problems. The K-CV is commonly applied to changing the validation set in a training set. In general, a GS is usually combined with K-CV to produce a corresponding evaluation index and select the best hyper-parameters. The torque penetration index(TPI) and field penetration index(FPI) are proposed based on shield parameters to express the geological characteristics. The elbow method(EM) and silhouette coefficient(Si) are employed to determine the types of geological characteristics(K) in a Kmeans++ algorithm. A case study on mixed ground in Guangzhou is adopted to validate the applicability of the developed model. The results show that with the developed framework, the four selected parameters, i.e. thrust, advance rate, cutterhead rotation speed and cutterhead torque, can be used to effectively predict the corresponding geological characteristics. | Tao Yan Shui-Long Shen Annan Zhou Xiangsheng Chen | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 3 |
| 5 | Numerical study on transverse deformation characteristics of shield tunnel subject to local soil loosening显示文摘In this study,a refined numerical model for segmental lining of a shield tunnel,which contains detailed models of reinforcement and connecting bolts,is established using finite element software.The model is first validated by the results from a full-scale model test.Then,based on the load-structure method,this numerical model is adopted to investigate the internal force distribution and the transverse deformation characteristics of the shield tunnel when it is subject to local soil loosening.The influence of loosening position,loosening range,and loosening extent on the mechanical response is extensively studied through comprehensive numerical analyses.The results show that the main influence of local soil loosening on the ring is to disturb the force balance and change the constraint conditions,thus changing the deformation pattern and force state.After the loosening occurs,the bending moment of the ring in the loosening range increases and the axial force decreases.The vertical convergence of the ring is the largest and the equivalent stiffness of the ring is the smallest when the local soil loosened at the haunch and the loosening range a is 90°.The vertical convergence of the ring increases with increasing of the loosening extent,and the equivalent stiffness decreases linearly with increasing of the loosening extent.The results can enhance our understanding of mechanical behaviors of segmental lining associated soil loosening,and will show a possible way for detecting soil loosening based on the measured deformation and internal forces. | Dong Su Weijie Chen Xuetao Wang Maolong Huang Xiaochao Pang Xiangsheng Chen | 2022 | Underground Space2022，7，1： | 2 |
| 6 | Towards a Leprosy-Free Country--China,2011−2018显示文摘Summary What is already known about this topic?Leprosy is a chronic infectious disease that is endemic in several countries.Control of leprosy has had targets set by World Health Organization’s(WHO)Global Strategy 2016–2020 and by China through a national leprosy-control plan(2011–2020).What is added by this report?Data from the Leprosy Management Information System in China was analyzed and showed a national prevalence of 0.178 per 100,000 and detection rate of 0.037 per 100,000 residents in 2018.In addition,all the main targets for 2020 have been met by 2018 except for the proportion of counties or cities to reach a prevalence of less than 1/100,000 and the proportion of children cases with grade 2 disability(G2D).What are the implications for public health practice?There are still challenges remaining to close the gaps between current progress and the targets set forth by the WHO and China.However,lessons learned in China in developing and implementing the national program may be invaluable for future plans to achieve and sustain elimination of leprosy at global and country level. | Meiwen Yu Peiwen Sun Le Wang Hongsheng Wang Heng Gu Xiangsheng Chen | 2020 | China CDC weekly2020，2，4： | 2 |
| 7 | Hot deformation behavior and processing map of coarse-grained Mg–Gd–Y–Nd–Zr alloy显示文摘 | Xiangsheng Xia Qiang Chen Kui Zhang Zude Zhao Minglong Ma Xinggang Li Yongjun Li | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 8 | Characterization of hot deformation behavior of as-extruded Mg–Gd–Y–Zn–Zr alloy显示文摘 | Xiangsheng Xia Qiang Chen Jianping Li Dayu Shu Chuankai Hu Shuhai Huang Zude Zhao | 2014 | Journal of Alloys and Compounds2014，，： | 2 |
| 9 | Classification of facial wrinkles among Chinese women显示文摘It is generally recognized that Caucasians and Asians have different skin aging features.The aim of this study was to develop a facial wrinkle grading scale for Chinese women.Standard photographs were taken of 242 Chinese women.Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected,including grading scales for resting and hyperkinetic crow's feet,frontalis lines,glabellar frown lines,and nasolabial folds.To identify the scale by objective quantitative measurement,skin surface measurements from the Visioscan~ VC98 were used.To test the reliability and validity of our wrinkle scale,a multi-rater consensus method was used.A double-blind,randomized,vehicle-controlled 12-week study was conducted to use this clinical photo-score to evaluate the efficacy and safety of Centella triterpenes cream~ in treating crow's feet.A newly developed 10-point photographic and descriptive scale emerged from this study.The final atlas of these photographs contained a total of 6 sets with 10 pictures each.From 0 to 9,surface evaluation of smoothness(SEsm) parametric measurements decreased progressively,indicating that the scale increased inversely.Weighted kappa coefficients for intra-assessor were between 0.75-0.87.The overall Kendall's coefficient is 0.86 on the first rating and 0.87 on the second rating.Thirtysix volunteers were recruited and 35 subjects completed a 12-week trial.Clinical photo-score by investigator showed a significant difference(P < 0.05) between the treatment side and control side after 4 weeks.Use of these scales in clinical settings to evaluate facial wrinkles in Asians individuals is recommended. | Jiechen Zhang Wei Hou Suying Feng Xiangsheng Chen Hongwei Wang | 2017 | The Journal of Biomedical Research2017，31，2： | 2 |
| 10 | Evaluation and prediction of earth pressure balance shield performance in complex rock strata:A case study in Dalian,China显示文摘This research explores the potential for the evaluation and prediction of earth pressure balance shield performance based on a gray system model.The research focuses on a shield tunnel excavated for Metro Line 2 in Dalian,China.Due to the large error between the initial geological exploration data and real strata,the project construction is extremely difficult.In view of the current situation regarding the project,a quantitative method for evaluating the tunneling efficiency was proposed using cutterhead rotation(R),advance speed(S),total thrust(F)and torque(T).A total of 80 datasets with three input parameters and one output variable(F or T)were collected from this project,and a prediction framework based gray system model was established.Based on the prediction model,five prediction schemes were set up.Through error analysis,the optimal prediction scheme was obtained from the five schemes.The parametric investigation performed indicates that the relationships between F and the three input variables in the gray system model harmonize with the theoretical explanation.The case shows that the shield tunneling performance and efficiency are improved by the tunneling parameter prediction model based on the gray system model. | Xiang Shen Dajun Yuan Xing-Tao Lin Xiangsheng Chen Yuansheng Peng | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，6： | 1 |
| 11 | Separate deposition of gold and palladium nanoparticles on ordered mesoporous carbon and evaluation of their catalytic activity for cinnamaldehyde hydrogenation under atmospheric condition显示文摘 | Gu Huizi Xu Xiangsheng Chen Aoang | 2013 | Catalysis Communications2013，41，： | 1 |
| 12 | Analysis and simplification of three-dimensional space vector PWM for three-phase four-leg inverters显示文摘 | Li Xiangsheng Deng Zhiquan Chen Zhida | 2011 | IEEE Industrial Electronics Society2011，2，2： | 1 |
| 13 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 14 | Cold-adaptive alkaline protease from the psychrophilic Planomicrobium sp.547: enzyme characterization and gene cloning显示文摘A psychrophilic bacterium strain 547 producing cold-adaptive alkaline protease was isolated from the deep sea sediment of Prydz Bay,Antarctica.The organism was identified as a Planomicrobium species by 16S rRNA analysis.The optimal and highest growth temperatures for strain 547 were 15℃ and 30℃,respectively.The extracellular protease was purified by ammonium sulfate precipitation and DEAE cellulose-52 chromatography.The optimal temperature and pH for the activity of the purified enzyme were 35℃ and pH 9.0,respectively.The enzyme retained approximately 40% of its activity after 2 h of incubation at 50℃.The enzymatic activity was inhibited by 1 mmol/L phenylmethyl sulfonylfluoride (PMSF) and hydrochloride 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF),indicating that it was a serine protease.The presence of Ca2+ and Mn2+ increased the activity of the enzyme.The protease gene with a size of 1 269 bp was cloned from Planomicrobium sp.547 using primers designed based on the conserved sequences of proteases in GenBank.The Planomicrobium sp.547 protease contained a domain belonging to the peptidase S8 family,which has a length of 309 amino acid (AA) residues.The alignment and phylogenetic analysis of the AA sequence indicated that the protease belonged to the subtilisin family. | YANG XiangSheng CHEN XingLin XU XianZhong ZENG RunYing | 2011 | Chinese Journal of Polar Science2011，22，1： | 1 |
| 15 | Analysis and simplification of three-dimensional space vector PWM for three-phase four-leg inverters 显示文摘 | Li Xiangsheng Zhiquan Deng Chen Zhida | 2011 | IEEE Transactions on Industrial Electronics2011，58，2： | 1 |
| 16 | Hydroconversion of n-octane over nanoscale HZSM-5 zeolites promoted by 12- molybdo Phosphoric acid and Ni显示文摘 | Chen Lidong Wang Xiangsheng Guo Hongchen | 2007 | Catalysis Communications2007，8，： | 1 |
| 17 | Investigation on thermo-mechanical behavior of reinforced concrete energy pile with large cross-section in saturated sandy soil by model experiments显示文摘Energy piles are a new type of heat exchange systems with buried pipes in a pile foundation,which optimize a ground source heat pump system for the utilization of shallow geothermal energy.In this study,based on the principle of similarity,the thermo-mechanical behavior of the model energy pile with a large cross-section in saturated sandy soil was experimentally evaluated.The pre-cast model concrete pile with a diameter of 0.2 m and length of 1.5 m was buried in saturated sand in a steel box with dimensions of 2.5 m×2.5 m×2.0 m(length×width×height).The pile was heated using water in the polyethylene(PE)pipe,which was connected to a water cycle temperature controller.At a constant inlet water temperature of 55℃,three thermal cycles were carried out with the same heating and cooling periods and different water flow rates.The temperature distributions in the pile and soil,in addition to the pore pressure,soil pressure,and displacement of the pile,were monitored to clarify the thermo-mechanical behavior of the pile and soil.The heat transfer efficiency was analyzed based on the temperature difference and water flow rates.The measured strain at different locations in the pile under cyclic thermal loading revealed that the uneven strain that developed in a pile body should be considered for its long-term application.Furthermore,focus should be directed toward the long-term unrecoverable displacement of the energy pile due to the thermal plastic strain and thermal consolidation of the soil. | Xiaohua Bao Yubo Li Tangjie Feng Hongzhi Cui Xiangsheng Chen | 2020 | Underground Space2020，5，3： | 1 |
| 18 | Microstructure and mechanical properties of isothermal multi-axial forging formed AZ61 Mg alloy 显示文摘 | Xia Xiangsheng Chen Ming Lu Yongjin | 2013 | Transactions of Nonferrous Metals Society of China2013，11，： | 1 |
| 19 | A Model of Distributed OS Automatic Generating System显示文摘Nowadays,there are some problems in the area of distributed operating system(DOS)and its research methods.To solve these problems,we have provided a Distributed Operat-ing System Auto-generating System(DOSAGS)model,which is characterized by intelli-gence,integration and moldability.DOSAGS’ system structure,functions,work principlesand key problems in its implementation are presented.It is obvious that the DOS generatedby DOSAGS is a real new generation distributed OS. | He Yanxiang Xia Xunbin Chen Yantao Sun Xiangsheng (Department of Computer Science,Wuhan University Wuhan 430072,P.R.China) | 1995 | High Technology Letters1995，1，1： | 1 |
| 20 | Microstruc- ture evolution and mechanical properties of 7A09 high strength aluminium alloy processed by backward extrusion at room tem- perature显示文摘 | Chen QiangtXia Xiangsheng Yuan Baoguo | 2013 | Materials Science and Engineering:A2013，588，12： | 1 |
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