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| 1 | Mapping epistasis and environment × QTX interaction based on four-omics genotypes for the detected QTX loci controlling complex traits in tobacco显示文摘Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation. | Liyuan Zhou Ruiyuan Li Longjiang Fan Yuewei Shi Zhihong Wang Shengdong Xie Yijie Gui Xueliang Ren Jun Zhu | 2013 | The Crop Journal2013，1，2： | 4 |
| 2 | Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision显示文摘High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases.Current non-invasive neuromodulation methods offer limited precision at the milimeter level.Here,we report opticallygenerated focused ultrasound(OFUS)for non-invasive brain stimulation with ultrahigh precision.OFUS is generated by a soft optoacoustic pad(SOAP)fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film.SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83μm,which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound(tFUS).Here,we show effective OFUS neurostimulation in vitro with a single ultrasound cycle.We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo.An acoustic energy of 0.6 mJ/cm?,four orders of magnitude less than that of tFUS,is suffcient for successful OFUS neurostimulation.OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision noninvasively. | Yueming Li Ying Jiang Lu Lan Xiaowei Ge Ran Cheng Yuewei Zhan Guo Chen Linli Shi Runyu Wang Nan Zheng Chen Yang Ji-Xin Cheng | 2022 | Light(Science & Applications)2022，11，11： | 1 |
| 3 | The Application of BP Neural Networks to Analysis the National Vulnerability显示文摘Climate change is the main factor affecting the country’s vulnerability,meanwhile,it is also a complicated and nonlinear dynamic system.In order to solve this complex problem,this paper first uses the analytic hierarchy process(AHP)and natural breakpoint method(NBM)to implement an AHP-NBM comprehensive evaluation model to assess the national vulnerability.By using ArcGIS,national vulnerability scores are classified and the country’s vulnerability is divided into three levels:fragile,vulnerable,and stable.Then,a BP neural network prediction model which is based on multivariate linear regression is used to predict the critical point of vulnerability.The function of the critical point of vulnerability and time is established through multiple linear regression analysis to obtain the regression equation.And the proportion of each factor in the equation is established by using the partial least-squares regression to select the main factors affecting the country’s vulnerability,and using the neural network algorithm to perform the fitting.Lastly,the BP neural network prediction model is optimized by genetic algorithm to get the chaotic time series BP neural network prediction model.In order to verify the practicability of the model,Cambodia is selected to be an example to analyze the critical point of the national vulnerability index. | Guodong Zhao Yuewei Zhang Yiqi Shi Haiyan Lan Qing Yang | 2019 | Computers, Materials & Continua2019，，2： | 1 |
| 4 | A Novel Sarsolenane Diterpene as a PTPIB Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller显示文摘 | Linfu Liang Jinan Wang Xiaoxuan Shi Yinghua Zhu Jia Li Weiliang Zhu Heyao Wang Yuewei Guo | 2017 | Chinese Journal of Chemistry2017，35，8： | 0 |
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