|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94显示文摘A bicyclic depsipeptide, chromopeptide A(1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K_α radiation(λ ? 0.71073 ?) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC_(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively. | Zhenfang Zhou Xin Wang Hui Zhang Jingya Sun Linghui Zheng Hongchun Liu Jidong Wang Aijun Shen Meiyu Geng Yuewei Guo | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 6 |
| 2 | Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis显示文摘Eight cembrane-type diterpenoids, namely,(t)-(6 R)-6-hydroxyisosarcophytoxide(1),(t)-(6 R)-6-acetoxyisosarcophytoxide(2),(t)-17-hydroxyisosarcophytoxide(3), sarcomililatins A–D(4–7), and sarcomililatol(8), were isolated from the soft coral Sarcophyton mililatensis collected from Weizhou Island, Guangxi Autonomous Region, together with 2 known related analogues,(t)-isosarcophytoxide(9) and(t)-isosarcophine(10). The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data.The absolute configuration of compound 1 was established by the modified Mosher's method, while the absolute configurations of compounds 4 and 5 were assigned by electronic circular dichroism(ECD)spectroscopy and that of compound 8 was established by time-dependent density functional theory electronic circular dichroism(TD-DFT ECD) calculation. In in vitro bioassays, compound 9 displayed significant cytotoxicity against the human cancer cell lines human promyelocytic leukemia cells(HL-60)and human lung adenocarcinoma cells(A-549) with IC_(50) values of 0.7870.21 and 1.2670.80 μmol/L,respectively. Compounds 4 and 9 also showed moderate inhibitory effects on the TNFα-induced Nuclear factor kappa B(NF-κB, a therapeutical target in cancer) activation, showing IC_(50) values of 35.23712.42 and 22.5274.44 μmol/L, respectively. | Songwei Li Fei Ye Zhengdan Zhu Hui Huang Shuichun Mao Yuewei Guo | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 3 |
| 3 | Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry显示文摘Five novel biscembranoids,ximaolides H-L(1-5),along with four known related compounds(6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum.The structures of the new compounds were determined by extensive spectroscopic analysis,quantum chemical calculations,and/or by comparing their CD spectra with those of the known compounds.Compounds 1 and 2 are the first examples of biscembranoids bearing a 1,35-bridged lactone moiety,4 is the first biscembranoid comprising an uncommon oxetane ring,and 5 represents the first 36-peroxyl biscembranoid.Ximaolides Ⅰ(2),K(4) and F(9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release in RAW264.7 macrophages. | Yufen Li Songwei Li Cristina Cuadrado Chenglong Gao Qihao Wu Xiaolu Li Tao Pang Antonio Hernandez Daranas Yuewei Guo Xuwen Li | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 4 | Sartrolides A-G and bissartrolide, new cembranolides from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller 显示文摘 | LIANG Linfu LAN Lefu GUO Yuewei | 2013 | Tetrahedron2013，69，35： | 1 |
| 5 | Biscembranoids formed from an α, β-unsaturated y-lactone ring as a dienophile: structure revision and establishment of their absolute configurations using theoretical calculations of electronic circular diehroism spectra 显示文摘 | JIA Rui Zhang Wen Guo Yuewei | 2013 | J Org Chem2013，78，7： | 1 |
| 6 | Efficient Total Synthesis of (S)-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide显示文摘与 trans-resorcylide dimethyl 醚(2b ) 一起的(S)-dihydroresorcylide (1a ) 的有效合成,被完成在线性从有象在合成顺序的关键步的酯化作用, carbonylation,和关上戒指的换位(RCM ) 的商业地可得到的 orcinol 一水化物(6 ) 的 9 步。 | Li Zhang Wenquan Ma Lili Xu Fei Deng Yuewei Guo | 2013 | Chinese Journal of Chemistry2013，31，3： | 1 |
| 7 | Secondary metabolites from the South China Sea invertebrates: chemistry and biological activity 显示文摘 | ZHANG Wen GUO Yuewei GU Yueheng | 2006 | Curr Med Chem2006，13，7： | 1 |
| 8 | Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision显示文摘High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases.Current non-invasive neuromodulation methods offer limited precision at the milimeter level.Here,we report opticallygenerated focused ultrasound(OFUS)for non-invasive brain stimulation with ultrahigh precision.OFUS is generated by a soft optoacoustic pad(SOAP)fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film.SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83μm,which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound(tFUS).Here,we show effective OFUS neurostimulation in vitro with a single ultrasound cycle.We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo.An acoustic energy of 0.6 mJ/cm?,four orders of magnitude less than that of tFUS,is suffcient for successful OFUS neurostimulation.OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision noninvasively. | Yueming Li Ying Jiang Lu Lan Xiaowei Ge Ran Cheng Yuewei Zhan Guo Chen Linli Shi Runyu Wang Nan Zheng Chen Yang Ji-Xin Cheng | 2022 | Light(Science & Applications)2022，11，11： | 1 |
| 9 | Gymnorrhizol, an unusual macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza 显示文摘 | Sun Yanqiu Guo Yuewei | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 10 | Crystal structure of 1,2, 6,7,11 , 12-hexathia-cyclopentadecane, C9H18S6显示文摘 | Sun Yanqiu Sun Jie Guo Yuewei | 2004 | New Cryst Struct2004，219，： | 1 |
| 11 | Simulation of nonlinear vibration responses of cab system subject to suspension damper complete failure for trucks显示文摘The strong vibration responses of the cab system can be restrained by the damper force and the friction of the suspensions for trucks.After the failures of dampers,especially in the case of the complete failure,the anti vibration effect of the friction is prominent.However,the nonlinear vibration response characteristics of the cab subject to the damper complete failure have not been revealed.In order to reveal the nonlinear vibration response characteristics,a dynamic model of the cab system was established and its vibration equations were given.The friction forces existing in the suspensions were determined by the bench test.The influences of the friction forces on the cab vibration under different amplitude harmonic inputs were investigated when the dampers completely fail.The cab vertical displacement changes with the excitation amplitude and the vibration represents various motion states,including the periodic motion,the quasi-periodic motion,and the chaotic motion.The simulation results show that when the dampers fail,the proper friction forces help to suppress the quasi-periodic motion and the chaotic motion of the cab and to reduce the amplitude of the periodic motion.The proper friction forces can make the cab movement far away from the chaos area.They also help to avoid the fatigue damage of the cab floor and suspension parts to improve the service life of the suspension parts and to reduce the maintenance cost of the cab suspensions. | Leilei Zhao Jian Guo Yuewei Yu Xiaohan Li Changcheng Zhou | 2020 | International Journal of Modeling, Simulation, and Scientific Computing2020，11，2： | 0 |
| 12 | Yonarolide A, an unprecedented furanobutenolide-containing norcembranoid derivative formed by photoinduced intramolecular[2+2] cycloaddition显示文摘Eight polycyclic furanobutenolide-containing norcembrane diterpenoids featuring C19 frameworks(1–8)were rapidly recognized and isolated from the Hainan soft coral Sinularia sp. by the HSQC-based small molecule accurate recognition technology. Yonarolide A(1a), featuring an unprecedented 5/6/4/4/7 pentacyclic ring skeleton, was surprisingly obtained as a transformed product by leaving compound 1 under indoor natural light, and was further proved to be a [2 + 2] cycloaddition product of 1 by photochemical reaction. The absolute stereochemistry of 1a and the three known norcembrane diterpenoids 1, 4, and7 were determined by using X-ray diffraction(XRD) analyses. Further, with the aid of XRD analysis, the structure of scabrolide B(2), which was previously reported of possessing 5/6/7 tricyclic skeleton, was firmly revised as 2a with the rare inelegane skeleton featured by the highly oxygenated 5/7/6 tricyclic carbocycle. | Yeqing Du Ligong Yao Xuwen Li Yuewei Guo | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 13 | A Novel Sarsolenane Diterpene as a PTPIB Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller显示文摘 | Linfu Liang Jinan Wang Xiaoxuan Shi Yinghua Zhu Jia Li Weiliang Zhu Heyao Wang Yuewei Guo | 2017 | Chinese Journal of Chemistry2017，35，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员