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| 1 | Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells显示文摘Aim: To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods: The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3,-8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results: GA inhibited cell growth in a time-and dose-dependent manner. GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting. Conclusions: GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle. | Jingyan Xu Min Zhou Jian Ouyang Jing Wang Qiguo Zhang Yong Xu Yueyi Xu Qian Zhang Xihui Xu Hui Zeng | 2013 | Chinese Journal of Cancer Research2013，25，2： | 18 |
| 2 | Relationship between the number of tapping-induced secondary laticifer lines and rubber yield among Hevea germplasm显示文摘The lack of suitable early selection parameters means that traditional rubber breeding for yield is time consuming and inefficient. Laticifer is a tissue specific fo natural rubber biosynthesis and storage in rubber tree. The number of the secondary laticifers in the trunk bark tissues is positively correlated with rubber yield in the matured rubber trees that are regularly tapped. In the present study the rubber yield from 280 of 4–5 year-old virgin trees from7 cross combinations was compared with the number o newly differentiated secondary laticifers caused by tapping. Results showed that the number of tapping induced lines of secondary laticifers varied in differen germplasm and was positively related to the rubber yield indicating this could be used as a suitable parameter fo early evaluation of yield potential of rubber trees. | Yueyi CHEN Xinsheng GAO Xiaofei ZHANG Weimin TIAN | 2016 | Frontiers of Agricultural Science and Engineering2016，3，4： | 9 |
| 3 | Lipid metabolism in cartilage and its diseases:a concise review of the research progress显示文摘The homeostasis of the vertebrate body depends on anabolic and catabolic activities that are closely linked the inside and outside of the cell.Lipid metabolism plays an essential role in these metabolic activities.Although a large amount of evidence shows that normal lipid metabolism guarantees the conventional physiological activities of organs in the vertebrate body and that abnormal lipid metabolism plays an important role in the occurrence and deterioration of cardiovascular-related diseases,such as obesity,atherosclerosis,and type II diabetes,little is known about the role of lipid metabolism in cartilage and its diseases.This review aims to summarize the latest advances about the function of lipid metabolism in cartilage and its diseases including osteoarthritis,rheumatoid arthritis,and cartilage tumors.With the gradual in-depth understanding of lipid metabolism in cartilage,treatment methods could be explored to focus on this metabolic process in various cartilage diseases. | Yueyi Yang Jieya Wei Jiachi Li Yujia Cui Xuedong Zhou Jing Xie | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 7 |
| 4 | Complementary transmissive ultra-thin meta-deflectors for broadband polarization-independent refractions in the microwave region显示文摘Polarization manipulation is a significant issue for artificial modulation of the electromagnetic(EM) wave, but general mechanisms all suffer the restriction of inherent symmetric properties between opposite handedness.Herein, a strategy to independently and arbitrarily manipulate the EM wave with orthogonal circular polarizations based on a metasurface is proposed, which effectually breaks through traditional symmetrical characteristics between orthogonal handedness. By synthesizing the propagation phase and geometric phase, the appropriate Jones matrix is calculated to obtain independent wavefront manipulation of EM waves with opposite circular polarizations. Two transmissive ultra-thin meta-deflectors are proposed to demonstrate the asymmetrical refraction of transmitted circularly polarized waves in the microwave region. Simulated transmitted phase front and measured far-field intensity distributions are in excellent agreement, indicating that the transmitted wave with different polarizations can be refracted into arbitrary and independent directions within a wide frequency band(relative bandwidth of 25%). The results presented in this paper provide more freedom for the manipulation of EM waves, and motivate the realizations of various polarization-independent properties for all frequency spectra. | YUEYI YUAN KUANG ZHANG XUMIN DING BADREDDINE RATNI SHAH NAWAZ BUROKUR QUN WU | 2019 | Photonics Research2019，7，1： | 5 |
| 5 | Transforming growth factor-β1-induced N-cadherin drives cell–cell communication through connexin43 in osteoblast lineage显示文摘Gap junction(GJ)has been indicated to have an intimate correlation with adhesion junction.However,the direct interaction between them partially remains elusive.In the current study,we aimed to elucidate the role of N-cadherin,one of the core components in adhesion junction,in mediating connexin 43,one of the functional constituents in gap junction,via transforming growth factor-β1(TGF-β1)induction in osteoblasts.We first elucidated the expressions of N-cadherin induced by TGF-β1 and also confirmed the upregulation of Cx43,and the enhancement of functional gap junctional intercellular communication(GJIC)triggered by TGF-β1 in both primary osteoblasts and MC3T3 cell line.Colocalization analysis and Co-IP experimentation showed that N-cadherin interacts with Cx43 at the site of cell–cell contact.Knockdown of N-cadherin by siRNA interference decreased the Cx43 expression and abolished the promoting effect of TGF-β1 on Cx43.Functional GJICs in living primary osteoblasts and MC3T3 cell line were also reduced.TGF-β1-induced increase in N-cadherin and Cx43 was via Smad3 activation,whereas knockdown of Smad3 signaling by using siRNA decreased the expressions of both N-cadherin and Cx43.Overall,these data indicate the direct interactions between N-cadherin and Cx43,and reveal the intervention of adhesion junction in functional gap junction in living osteoblasts. | Yueyi Yang Wenjing Liu JieYa Wei Yujia Cui Demao Zhang Jing Xie | 2021 | International Journal of Oral Science2021，13，2： | 4 |
| 6 | Runxl protects against the pathological progression of osteoarthritis显示文摘Runt-related transcription factor-1(Runxl)is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.However,the potential role of Runxl in joint diseases is not well known.In the current study,we aimed to explore the role of Runxl in osteoarthritis induced by anterior cruciate ligament transaction(ACLT)surgery.We showed that chondrocyte-specific Runxl knockout(Runx1f/fCol2a1-Cre)aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis.Moreover,we observed thinning and ossification of the growth plate,a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis.We overexpressed Runxl by adeno-associated virus(AAV)in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis.ChIP-seq analysis identified new targets that interacted with Runxl in cartilage pathology,and we confirmed the direct interactions of these factors with Runxl by ChIP-qPCR.This study helps us to understand the function of Runxl in osteoarthritis and provides new clues for targeted osteoarthritis therapy. | Chenchen Zhou Yujia Cui Yueyi Yang Daimo Guo Demao Zhang Yi Fan Xiaobing Li Jing Zou Jing Xie | 2021 | Bone Research2021，9，4： | 4 |
| 7 | Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients显示文摘IgA nephropathy(IgAN)is a leading cause of chronic kidney disease(CKD),which are commonly accompanied by dyslipidemia.Obesity is also associated with dyslipidemia and risk of CKD,but the relation of the dyslipidemia patterns with obesity and disease progression in IgAN patients remains unknown.Traditional Chinese medicine(TCM)and the combined treatment with corticosteroids and TCM have been shown to be of benefit for IgAN patients,but predictive markers for guiding these treatments are lacking.Here,we quantified 545 lipid species in the plasma from 196 participants,including 140 IgAN patients and 56 healthy volunteers,and revealed an altered plasma lipidome in IgAN patients as compared to healthy participants.Association analysis showed that a subgroup of glycerides,particularly triacylglycerols(TGs)containing docosahexaenoic acid,were positively associated with high body mass index(BMI)in under-or normal-weight IgAN patients,while several free fatty acids and sphingomyelins were positively associated with high BMI in overweight or obese IgAN patients.Further,our study suggested that elevated levels of eight lipids,mainly TG species containing linolenic acid,were independent risk factors for IgAN progression and also reported the prospective association of circulating lipids with treatment outcomes in IgAN.Taken together,our findings may not only help to achieve precision medicine but also provide a knowledge base for dietary intervention in the treatment of IgAN. | Yueyi Deng Qingqing Wu Wanjia Chen Li Zhu Wangyi Liu Fangying Xia Liang Sun Xu Lin Rong Zeng | 2021 | Journal of Molecular Cell Biology2021，13，8： | 2 |
| 8 | Research progress of rare earth separation methods and technologies显示文摘Strategical elements,such as rare earth elements,play a crucial role in the industry,especially in producing high-tech materials.Major global industries have developed a strong dependence on rare earth materials.Every year,there are innovations in industries such as modern technology,green energy,or communications technology,which need more strategic metals to improve investment profitability.This article reviews advances in rare earth separation methods and techniques to guide and recommend the best extractants,depending on leaching conditions and the final target product.Each method for separating and extracting agents is individually revised in terms of the mechanism and interaction of providing rare earth elements.This paper also evaluates past and current trends of these methods and technical extractants and identifies their strengths and weaknesses. | Mory Traore Aijun Gong Yiwen Wang Lina Qiu Yuzhen Bai Weiyu Zhao Yang Liu Yi Chen Ying Liu Huilin Wu Shuli Li Yueyi You | 2023 | Journal of Rare Earths2023，41，2： | 2 |
| 9 | Effect of morphine preconditioning on neuronal apoptosis following cerebral ischemia/reperfusion injury显示文摘Apoptosis,a form of neuronal damage,takes place following cerebral ischemia/reperfusion injury,and caspase-3 plays an important role in apoptosis.Studies have shown that morphine preconditioning influences neuronal apoptosis and related protein expression following cerebral ischemia/reperfusion injury.In the present study,neuronal degeneration was attenuated,and the number of apoptotic cells and caspase-3 expression decreased following morphine preconditioning in a rat model of cerebral ischemia/reperfusion injury.Moreover,pathological changes were attenuated with increasing morphine doses,as well as the number of apoptotic cells and caspase-3 expression.Results from the present study revealed that morphine preconditioning reduced ischemic brain injury and improved cerebral ischemic tolerance in a dose-dependent manner.The anti-apoptotic mechanism of morphine is closely related to Caspase-3. | He Dong Xiangyu Ji Dong Wang Yueyi Ren Shiduan Wang Jianfang Song | 2010 | Neural Regeneration Research2010，5，15： | 2 |
| 10 | Developing China's roadmap for air quality improvement:A review on technology development and future prospects显示文摘Air pollution control policies in China have been experiencing profound changes,highlighting a strategic transformation from total pollutant emission control to air quality improvement,along with the shifting targets starting from acid rain and NO_(x)emissions to PM_(2.5)pollution,and then the emerging O_(3)challenges.The marvelous achievements have been made with the dramatic decrease of SO_(2)emission and fundamental improvement of PM_(2.5)concentration.Despite these achievements,China has proposed Beautiful China target through 2035 and the goal of 2030 carbon peak and 2060 carbon neutrality,which impose stricter requirements on air quality and synergistic mitigation with Greenhouse Gas(GHG)emissions.Against this background,an integrated multi-objective and multi-benefit roadmap is required to provide decision support for China’s long-term air quality improvement strategy.This paper systematically reviews the technical system for developing the air quality improvement roadmap,which was integrated from the research output of China’s National Key R&D Program for Research on Atmospheric Pollution Factors and Control Technologies(hereafter Special NKP),covering mid-and long-term air quality target setting techniques,quantitative analysis techniques for emission reduction targets corresponding to air quality targets,and pathway optimization techniques for realizing reduction targets.The experience and lessons derived from the reviews have implications for the reformation of China’s air quality improvement roadmap in facing challenges of synergistic mitigation of PM_(2.5)and O_(3),and the coupling with climate change mitigation. | Yueyi Feng Miao Ning Wenbo Xue Miaomiao Cheng Yu Lei | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 11 | Phylogenetic analysis of porcine epidemic diarrhea virus field strains prevailing recently in China显示文摘 | Yueyi Gao Qiuwen Kou Xinna Ge Lei Zhou Xin Guo Hanchun Yang | 2013 | Archives of Virology2013，，3： | 1 |
| 12 | Lack of association between the polymorphisms of β-site APP-cleaving enzyme 2 (BACE2) 5'-flanking region and sporadic Alzheimer's disease显示文摘 | Yueyi Y Jianping J | 2009 | Brain Res2009，1257，： | 1 |
| 13 | Property investigation of calcium-silicate-hydrate (C-S-H) gel in cementitious composites显示文摘 | HU Chuanlin HAN Yunge GAO Yueyi | 2014 | Mater Charact2014，95，： | 1 |
| 14 | Population structure and association mapping to detect QTL controlling tomato spotted wilt virus resistance in cultivated peanuts显示文摘Tomato spotted wilt(TSW)is a serious virus disease of peanut in the United States.Breeding for TSWV resistance would be facilitated by the implementation of marker-assisted selection in breeding programs;however,genes associated with resistance have not been identified.Association mapping is a type of genetic mapping that can exploit relationships between markers and traits in many lineages.The objectives of this study were to examine genetic diversity and population structure in the U.S.peanut mini-core collection using simple sequence repeat(SSR)markers,and to conduct association mapping between SSR markers and TSWV resistance in cultivated peanuts.One hundred and thirty-three SSR markers were used for genotyping 104 accessions.Four subpopulations,generally corresponding to botanical varieties,were classified by population structure analysis.Association mapping analysis indicated that five markers:pP GPseq5D5,GM1135,GM1991,TC23C08,and TC24C06,were consistently associated with TSW resistance by the Q,PCA,Q+K,and PCA+K models.These markers together explained 36.4%of the phenotypic variance.Moreover,pP GPseq5D5 and GM1991 were associated with both visual symptoms of TSWV and ELISA values with a high R^2.The potential of these markers for use in a marker-assisted selection program to breed peanut for resistance to TSWV is discussed. | Jing Li Yueyi Tang Alana L.Jacobson Phat M.Dang Xiao Li Ming Li Wang Austin Hagan Charles Y.Chen | 2018 | The Crop Journal2018，6，5： | 1 |
| 15 | Finishing advanced surface of magnesium alloy tube based on abrasive belt grinding technology显示文摘 | Huang Zhi Huang Yun Wu Yueyi | 2009 | Materials Science Forum2009，，1： | 1 |
| 16 | Transthoracic device closure of ventricular septal defects without cardiopulmonary bypass: experience in infants weighting less than 8 kg显示文摘 | Quansheng Xing Qin Wu Silin Pan Yueyi Ren Hao Wan | 2011 | European Journal of Cardio-Thoracic Surgery2011，，3： | 1 |
| 17 | System dynamics modeling for urban energy consumption and CO2 emis-sions:a case study of Beijing,China显示文摘 | FENG Yueyi CHEN Shaoqing ZHANG Lixiao | 2012 | Ecol Model2012，252，1： | 1 |
| 18 | Efficacy and Safety of Traditional Chinese Medicine (Shenqi Particle) for Patients With Idiopathic Membranous Nephropathy: A Multicenter Randomized Controlled Clinical Trial显示文摘 | Yiping Chen Yueyi Deng Zhaohui Ni Nan Chen Xiangmei Chen Wei Shi Yongli Zhan Fahuan Yuan Wei Deng Yifei Zhong | 2013 | American Journal of Kidney Diseases2013，，： | 1 |
| 19 | Phylogenetic analysis of porcine epidemic diarrhea virus field strains prevailing recently in China显示文摘 | Yueyi Gao Qiuwen Kou Xinna Ge | 2013 | Arch Virol2013，158，： | 1 |
| 20 | Phylogenetic analysis of porcine epidemic diarrhea virus field strains prevailing recently in China显示文摘 | Yueyi Gao Qiuwen Kou Xinna Ge | 2013 | Arch Virol2013，158，3： | 1 |
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