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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice显示文摘In the present study,we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice.Immunofluorescence staining revealed that the number of newly generated(BrdU+)cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation,and there was also a significant increase in the number of BrdU+/DCX+neuroblasts in these animals.Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well.Furthermore,adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice.Based on these findings,we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice,thereby facilitating functional recovery. | Yufang Yan Tuo Ma Kai Gong Qiang Ao Xiufang Zhang Yao Gong | 2014 | Neural Regeneration Research2014，9，8： | 16 |
| 3 | AntarcticaLC2000:The new Antarctic land cover database for the year 2000显示文摘Antarctica plays a key role in global energy balance and sea level change.It has been conventionally viewed as a whole ice body with high albedo in General Circulation Models or Regional Climate Models and the differences of land cover has usually been overlooked.Land cover in Antarctica is one of the most important drivers of changes in the Earth system.Detailed land cover information over the Antarctic region is necessary as spatial resolution improves in land process models.However,there is a lack of complete Antarctic land cover dataset derived from a consistent data source.To fill this data gap,we have produced a database named Antarctic Land Cover Database for the Year 2000(AntarcticaLC2000) using Landsat Enhanced Thematic Mapper Plus(ETM+) data acquired around 2000 and Moderate Resolution Imaging Spectrometer(MODIS) images acquired in the austral summer of 2003/2004 according to the criteria for the 1:100000-scale.Three land cover types were included in this map,separately,ice-free rocks,blue ice,and snow/firn.This classification legend was determined based on a review of the land cover systems in Antarctica(LCCSA) and an analysis of different land surface types and the potential of satellite data.Image classification was conducted through a combined usage of computer-aided and manual interpretation methods.A total of 4067 validation sample units were collected through visual interpretation in a stratified random sampling manner.An overall accuracy of 92.3%and the Kappa coefficient of 0.836 were achieved.Results show that the areas and percentages of ice-free rocks,blue ice,and snow/firn are 73268.81 km2(0.537%),225937.26 km2(1.656%),and 13345460.41 km2(97.807%),respectively.The comparisons with other different data proved a higher accuracy of our product and a more advantageous data quality.These indicate that AntarcticaLC2000,the new land cover dataset for Antarctica entirely derived from satellite data,is a reliable product for a broad spectrum of applications. | HUI FengMing KANG Jing LIU Yan CHENG Xiao GONG Peng WANG Fang LI Zhan YE YuFang GUO ZiQi | 2017 | Science China Earth Sciences2017，60，4： | 5 |
| 4 | An improved Landsat Image Mosaic of Antarctica显示文摘A revised Landsat Image Mosaic of Antarctica (LIMA) is presented, using the 1073 multi-band scenes of the original Landsat-7 ETM+ LIMA image collection available at the United States Geological Survey (USGS: http://gffzza64998f73d704ee0hkv6nv5f0vqob6kpf.ffgz.tsg.suse.edu.cn/). Three improvements have been applied during the data processing: (1) DN saturation is adjusted by adopting a linear regression, which has a lower root mean square error than the ratio regression used by LIMA; (2) solar elevation angle is calculated using pixel-level latitude/longitude and the acquisition time and date of the central pixel of the scene, improving slightly upon the bilinear interpolation of the solar elevation angles of scene corners applied in LIMA; and (3) two additional image bands, Band 5 and Band 7, are sharpened using the panchromatic band (Band 8) and a Gram-Schmidt Spectral Sharpening algorithm to more easily distinguish snow, cloud and exposed rocks. The final planetary reflectance product is stored in 16-bit bands to preserve the full radiometric content of the scenes. A comparative statistical analysis among 12 sample regions indicates that the new mosaic has enhanced visual qualities, information entropy, and information content for land cover classification relative to LIMA. | HUI FengMing CHENG Xiao LIU Yan ZHANG YanMei YE YuFang WANG XianWei LI Zhan WANG Kun ZHAN ZhiFei GUO JianHong HUANG HuaBing LI XiuHong GUO ZiQi GONG Peng | 2013 | Science China Earth Sciences2013，56，1： | 4 |
| 5 | Detail control strategies for topology optimization in architectural design and development显示文摘With the ability to generate forms with high efficiency and elegant geometry,topology optimization has been increasingly used in architectural and structural designs.However,the conventional topology optimization techniques aim at achieving the structurally most efficient solution without any potential for architects or designers to control the design details.This paper introduces three strategies based on Bi-directional Evolutionary Structural Optimization(BESO)method to artificially pre-design the topological optimized structures.These strategies have been successfully applied in the computational morphogenesis of various structures for solving practical design problems.The results demonstrate that the developed methodology can provide the designer with structurally efficient and topologically different solutions according to their proposed designs with multi-filter radii,multi-volume fractions,and multi-weighting coefficients.This work establishes a general approach to integrating objective topology optimization methods with subjective human design preferences,which has great potential for practical applications in architecture and engineering industry. | Xin Yan Dingwen Bao Yufang Zhou Yimin Xie Tong Cui | 2022 | Frontiers of Architectural Research2022，11，2： | 4 |
| 6 | TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis ina Chinese population显示文摘 | YuFang Lu Zhang Gang-qiao Zhou Zhi-fu Wang Kai Feng Zhi-yi Lou Wei Pang Lei Li Yan Ling Yu-xia Li Bao-chi Liu | 2010 | World Journal of Emergency Medicine2010，1，3： | 3 |
| 7 | Production of human lysozyme-transgenic cloned porcine embryos by somatic nuclear transfer显示文摘Due to their physiology and organ size, pigs have significant potential as human disease models and as organ transplantation donors. Genetic modification of pigs could provide benefits for both agriculture and human medicine. In this study, five fetal pig fibroblast cell lines from two species (Wuzhishan and Landrace pigs) were transfected using double-marked human lysozyme (HLY) plasmids (pBC1-HLY-GFP-NEO) by a liposome-mediated method. The ratio of green fluorescent protein (GFP)-expressing cells was >95% in sw7, sw8, slw3 and slw6 cell lines, but only 49.3% in slw9 cells. Cells from the four highly transgenic lines were used as nuclear donors to construct embryos, which were then cultured after fusion and activation by electric stimulation. The rate of cleavage was 76.7%, 48 h after activation. After 7 days, 18.5% of cleaved eggs had developed to the blastocyst stage and 93.3% of blastocysts were GFP-positive. These results indicate that transgenic fetal pig flbroblast cell lines could be obtained by a liposome-mediated method, though the transfection efficiency varied between cell lines. Reconstructed embryos derived from transgenic cells could successfully develop into blastocysts, most of which were GFP-positive. | Qiuyan Li Hengxi Wei Ying Guo Yan Li Rui Zhao Yufang Ma Zhengquan Yu Bo Tang Lei Zhang Yunping Dai Ning Li | 2009 | Progress in Natural Science:Materials International2009，19，6： | 2 |
| 8 | Highly selective oxidation of amines to imines by Mn2O3 catalyst under eco-friendly conditions显示文摘Enhancing the selectivity of imines for the oxidative self-coupling of primary amines was found to be challenging in the heterogeneous catalysis.Three different manganese oxides(M-3,M-4,M-5) were synthesized by controlling the calcination temperature using a simple template-free oxalate route.The prepared manganese oxides were systematically characterized using XRD,N2 sorption,SEM,TEM,XPS,H2-TPR techniques.M-4 gave 96.2% selectivity of imine at 100% conversion of benzylamine,which was far more superior than other existing protocols.Mn^3+/Mn^4+ ratio was found to affect the selectivity of the imines.The probable reaction pathway for amines oxidation catalyzed by manganese oxides was proposed for the first time. | Fushan Chen Tao Yang Songlin Zhao Taotao Jiang Lu Yu Houfeng Xiong Chuankun Guo Yufang Rao Yan Liu Liu Liu Jian Zhou Pengxiang Tu Jun Ni Qunfeng Zhang Xiaonian Li | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 9 | Novel cyanine dyes as fluorescent pH sensors: PET, ICT mechanism or resonance effect?显示文摘 | Yufang Xu Yan Liu Xuhong Qian | 2007 | Journal of Photochemistry & Photobiology, A: Chemistry2007，，1： | 1 |
| 10 | Preparation and ap- plication of melanmine formaldehyde pootoehromie microeapsules 显示文摘 | Zhou Yuehua Yan Yufang Du Yang et td | 2013 | Sens~ rs and Act uators B : Chemk''al2013，188，： | 1 |
| 11 | A fluorometric assay for acetylcholinesterase activity and inhibitor detection based on DNA-templated copper/silver nanoclusters显示文摘 | Wenhua Li Wang Li Yufang Hu Yalin Xia Qinpeng Shen Zhou Nie Yan Huang Shouzhuo Yao | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 12 | Alleviative effects of a novel strain Bacillus coagulans XY2 on copper-induced toxicity in zebrafish larvae显示文摘Copper (Cu) is a kind of micronutrient element that is essential for human metabolism.However,it is also considered as an environmental pollutant which is toxic to organisms at a high concentration level.Probiotics,regarded as beneficial microorganisms for promoting human health,have functions of antioxidant capacity,immune-enhancing properties,intestinal barrier protection and regulation.Several studies have reported that probiotics show positive effects on alleviating and intervening heavy metals toxicity.However,evidence for relieving copper-induced toxicity by probiotics is still limited.In this study,we firstly conducted a zebrafish larvae model to screen out microorganisms which are helpful for CuSO_(4)toxicity resistance and one novel strain named as Bacillus coagulans XY2 was discovered with the best protective activity.B.coagulans XY2 significantly reduced the mortality of zebrafish larvae exposed to 10μmol/L CuSO_(4)for 96 hr,as well as alleviated the neutrophils infiltration in the larvae lateral line under a 2 hr exposure.B.coagulans XY2 exhibited a high in vitro antioxidant activity and against CuSO_(4)-induced oxidative stress in zebrafish larvae by up-regulating sod1,gstp1 and cat gene transcriptional levels and relevant enzymatic activities.CuSO_(4)stimulated the inflammation process resulting in obvious increases of gene il-1βand il-10 transcription,which were suppressed by B.coagulans XY2 intervention.Overall,our results underline the bio-function of B.coagulans XY2 on protecting zebrafish larvae from copper toxicity,suggesting the potential application values of probiotics in copper toxicity alleviation on human and the environment. | Fang Ai Xuedi Huang Yalan Wu Chen Ji Yufang Gao Ting Yu Fujie Yan | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 13 | Construction Progress of Chinese Meridian Project PhaseⅡ显示文摘The Chinese Meridian Project(CMP)is the Space Environment Ground Based Comprehensive Monitoring Network of China,a national major science and technology infrastructure project.The CMP consists of the Space Environment Monitoring System,Data Communication System,and Science Application System.Its construction has been divided into two steps:the PhaseⅠwas from 2008 to 2012;the PhaseⅡstarted at the end of 2019,expected to be completed at the end of 2023.Beyond 2023,the CMP as a whole will be in operation to make observations.This report introduces the construction progress of CMP PhaseⅡin the past two years,covering the construction progress of both the Data Communication System and the Science Application System.As for the Space Environment Monitoring System,this report mainly gives an introduction to the construction progress of large-scale advanced monitoring equipment,such as,the solar radio telescope,interplanetary scintillation telescope,incoherent scatter radar,high frequency radar,MST radar,and large-aperture Helium Lidar.In addition,this paper presents the construction plan for the next two years and the future outlook as well. | WANG Chi XU Jiyao LÜDaren YUE Xinan XUE Xianghui CHEN Gang YAN Jingye YAN Yihua LAN Ailan WANG Jiangyan WANG Xin TIAN Yufang | 2022 | 空间科学学报2022，42，4： | 1 |
| 14 | Effect of leptin on oocyte maturation and subsequent pregnancy rate of cloned embryos reconstructed by somatic cell nuclear transfer in pigs显示文摘由原子转移(SCNT ) 有的体的房间克隆猪在基本研究,人的药和农业生产的宽应用。到改善克隆效率,二基本成熟媒介的效果, NCSU-23 和 TCM199,被比较,并且 TCM199 为有 leptin 的下列实验被选择。我们系统地在 vitro 成熟(IVM ) 在卵母细胞上学习了 leptin 补充的效果,在激活的单性生殖的联盟者(PA ) 和 SCNT 胚胎的 vitro 开发并且在在胚胎转移(et ) 以后的 SCNT 胚胎的 vivo 开发。结果证明进成熟媒介的 100 或 200 ng/ml leptin 的补充极大地没影响 PA 和 SCNT 的卵母细胞,或劈开率的原子成熟(P >
0.05 ) 。当 100 或 200 ng/ml leptin 在 PA 胚囊被加到房间的成熟媒介,和数字时, PA 和 SCNT 胚胎的胚囊率显著地被改进也被改进(P <
0.05 ) 。在 SCNT 的胚囊的房间的数字被改进,当 100 ng/ml leptin 被增加时(P <
0.05 ) 。而且,到 IVM 媒介的 100 或 200 ng/ml leptin 的补充可以在猪克隆改进怀孕率和交货率。 | Hengxi Wei Qiuyan Li Jun Li Yan Li Yunping Dai Yufang Ma Kai Xue Ning Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 1 |
| 15 | Smurf participates in Helicoverpa armigera diapause by regulating the transforming growth factor-βsignaling pathway显示文摘Diapause,an important strategy used by insects to avoid adverse environments,is regulated by various cell signaling pathways.The results of our previous studies demonstrated that the transforming growth factor-β(TGF-β)signaling pathway regulated pupal diapause in Helicoverpa armigera,which was accompanied by downregulation of proteins in TGF-βsignaling.However,to date the mechanism underlying this phenomenon remains unknown.Here,we cloned the E3 ubiquitin ligases gene Smurf.In vitro experiments showed that Smurf directly bound to TGF-βreceptor type I(TGFβRI)and Smad2.Overexpressing Smurf promoted ubiquitination of TGFβRI and Smad2,thereby downregulating their protein levels.Conversely,silencing of the Smurf gene suppressed ubiquitination of TGFβRI and Smad2 thereby increasing their protein levels.Results from in vivo co-immunoprecipitation assays revealed that the binding of Smurf to TGFβRI or Smad2 was stronger in diapause pupae than in nondiapause pupae.Injection of Smurf inhibitor A01 into diapause pupae markedly upregulated expression of TGFβRI and Smad2 proteins,leading to resumption of development in diapause pupae.Taken together,these findings suggested that ubiquitin ligase E3 Smurf participated in H.armigera diapause by regulating TGF-βsignaling,and thus could be playing a crucial role in insect diapause. | Haiyin Li Qin Lu Yan Li Yufang Yan Zhiyong Yin Jianjun Guo Weihua Xu | 2022 | Insect Science2022，29，5： | 0 |
| 16 | Microinvasive analysis of textile relics from an ancient Silk Road turquoise mining site显示文摘The Xinjiang region,with its unique location and climate,exhibits well-preserved relics of great academic interest.This paper focuses on the microinvasive analysis of textile samples obtained from an ancient turquoise mining site in the Heishanling region of Xinjiang,active between 820 and 400 BC.Various analytical techniques,including optical microscopy,scanning electron microscopy,Fourier-transform infrared spectroscopy with attenuated total reflection,and liquid chromatography-mass spectrometry,were employed to investigate these textiles.The results revealed that the textiles were composed of wool and dyed using indigo and purpurin.The bluegrass and madder-derived dyes were likely sourced locally or imported from wetter regions such as the Chinese Central Plains.The infrared deconvolution spectra and the results demonstrated that red and blue dyes considerably influenced the movement of wool fiber chains,leading to a more rapid decay of dyed fibers compared to those that were undyed.In addition,the medium dyeing process and Ke techniques were employed to create unique color shades and special patterns.This scientific and technological analysis of the textiles provides essential data for elucidating the materials available to ancient laborers.Furthermore,it offers scientific evidence supporting the cultural exchange between the western regions and the Central Plains and integration along the Silk Road. | XIAO Wei XIAN YiHeng YU Chun WANG Yan SUN LiJuan LI YuFang | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
| 17 | Numerical and Experimental Study on Performance of a Low-Backpressure Polyhedral Thermoelectric Generator for Waste Heat Recovery显示文摘Optimized fin arrangement and dimension of heat exchanger can improve the maximum output power of thermoelectric generator(TEG)system which converts the wasted heat into electricity with thermoelectric modules(TEMs).Considering that the geometric symmetry contributes to the temperature uniformity improvement and convenient TEMs arrangement,a low-backpressure TEG system based on a polyhedral-shape heat exchanger was developed.To assess the effect of inner topology and fin parameters on the heat transfer and output power of the TEG system,a realizable k-?turbulence based numerical model was established and validated to perform numerical simulations.The results demonstrate that increasing fin length,fin width and fin intersection angle are beneficial to the average surface temperature,temperature distribution uniformity and maximum output power of the TEG system.Moreover,decreasing fin spacing distance contributes to the enhanced average surface temperature and maximum power of TEG system,and has insignificant effect on its temperature uniformity.The inserted fins with optimal length,width,intersection angle and spacing distance enhance higher output power,whereas result in increasing backpressure.The maximum difference between the experimental and simulation results is 3.2%,which validates the feasibility of the established numerical model.It also provides a theoretical reference to the optimal design and performance analysis of low-backpressure TEG systems used in automobile exhaust heat recovery. | QUAN Rui LI Yangxin LI Tao CHANG Yufang YAN Huaicheng | 2023 | Journal of Thermal Science2023，32，1： | 0 |
| 18 | SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection显示文摘The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of life.Here we analyzed a prospective cohort of 121 recovered COVID-19 patients from Xiangyang,China at 1-year after diagnosis.Among them,chemiluminescence immunoassay-based screening showed 99%(95%CI,98–100%)seroprevalence 10–12 months after infection,comparing to 0.8%(95%CI,0.7–0.9%)in the general population.Total anti-receptor-binding domain(RBD)antibodies remained stable since discharge,while anti-RBD IgG and neutralization levels decreased over time.A predictive model estimates 17%(95%CI,11–24%)and 87%(95%CI,80–92%)participants were still 50%protected against detectable and severe re-infection of WT SARS-CoV-2,respectively,while neutralization levels against B.1.1.7 and B.1.351 variants were significantly reduced.All non-severe patients showed normal chest CT and 21%reported COVID-19-related symptoms.In contrast,53%severe patients had abnormal chest CT,decreased pulmonary function or cardiac involvement and 79%were still symptomatic.Our findings suggest long-lasting immune protection after SARS-CoV-2 infection,while also highlight the risk of immune evasive variants and long-term consequences for COVID-19 survivors. | Yan Zhan Yufang Zhu Shanshan Wang Shijun Jia Yunling Gao Yingying Lu Caili Zhou Ran Liang Dingwen Sun Xiaobo Wang Zhibing Hou Qiaoqiao Hu Peng Du Hao Yu Chang Liu Miao Cui Gangling Tong Zhihua Zheng Yunsheng Xu Linyu Zhu Jin Cheng Feng Wu Yulan Zheng Peijun Liu Peng Hong | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 19 | A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway显示文摘Glioma is characterized by rapid cell proliferation,aggressive invasion,altered apoptosis and a poor prognosis.β-Sitosterol,a kind of phytosterol,has been shown to possess anticancer activities.Our current study aims to in-vestigate the effects ofβ-sitosterol on gliomas and reveal the underlying mechanisms.Our results show thatβ-sitosterol effectively inhibits the growth of U87 cells by inhibiting proliferation and inducing G2/M phase arrest and apoptosis.In addition,β-sitosterol inhibits migration by downregulating markers of epithelial-mesenchymal tran-sition(EMT).Mechanistically,network pharmacology and transcriptomics approaches illustrate that the EGFR/MAPK signaling pathway may be responsible for the inhibitory effect ofβ-sitosterol on glioma.Afterward,the results show thatβ-sitosterol effectively suppresses the EGFR/MAPK signaling pathway.Moreover,β-sitosterol significantly inhibits tumor growth in a U87 xenograft nude mouse model.β-Sitosterol inhibits U87 cell proliferation and migration and induces apoptosis and cell cycle arrest in U87 cells by blocking the EGFR/MAPK signaling pathway.These results suggest thatβ-sitosterol may be a promising therapeutic agent for the treatment of glioma. | Yufang Xie Zhijian Chen Shuang Li Meijuan Yan Wenjun He Li Li Junqiang Si Yan Wang Xinzhi Li Ketao Ma | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 20 | Seasonal influence on the development of parthenotes and cloned embryos in pigs显示文摘Seasonal influence on the developmental ability of porcine embryos was studied by comparisons of the number of cumulus-oocytes-complexes (COCs) per ovary pair and meiotic maturation ability of oocytes in different seasons; and by the observations on developmental competence of the parthenogenetic oocytes and cloned embryos collected from different seasons. We found that the number of COCs per ovary pairs was significantly higher in spring compared to the other seasons (P<0.05). However, no significant difference was found in the rate of oocytes progressing to MⅡ in four seasons (P<0.05). In addition, the rate of blastocyst formation of parthenogenetic embryos in summer was obviously declined compared to the other seasons (P<0.05), and an increased blastocyst rate of cloned porcine embryos was found in spring compared to autumn and winter (P<0.05). The results suggest that there should be a seasonal influence on the developmental competence of porcine embryos. | Zhang Kun Zhang Yunhai Pan Dengke Ma Yufang Wei Hengxi Zhang Jian Li Xuyang Wang Shaohua Li Yan Dai Yunping Li Ning | 2007 | Progress in Natural Science:Materials International2007，17，10： | 0 |
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