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| 1 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Body diffusion-weighted MR imaging of uterine endometrial cancer: Is it helpful in the detection of cancer in nonenhanced MR imaging?显示文摘 | Yuki Inada Mitsuru Matsuki Go Nakai Fuminari Tatsugami Masato Tanikake Isamu Narabayashi Takashi Yamada Motomu Tsuji | 2007 | European Journal of Radiology2007，，1： | 2 |
| 3 | Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity显示文摘 | Yuki Kawakami Tomoko Hosokawa Tomoko Morinaka Shioka Irino Shiori Hirano Hirokazu Kobayashi Akiko Yoshioka Toshiko Suzuki-Yamamoto Miyuki Yokoro Masumi Kimoto Hideaki Tsuji Hiromi Yamashita Shinobu Doi Chikao Yutani Rina Kato Hiroyuki Itabe Teruyuki Kanad | 2011 | Food Chemistry2011，，4： | 1 |
| 4 | Identification of genes expressed during spore germination of Mycosphaerella pinodes显示文摘 | Hiroyuki Takahara Kazuhiro Toyoda Gento Tsuji Yasuyuki Kubo Yoshishige Inagaki Yuki Ichinose Tomonori Shiraishi | 2005 | Journal of General Plant Pathology2005，，3： | 1 |
| 5 | An immunologic abnormality common to Bickerstaffs Brainstem and Fisher's syndrome显示文摘 | Yuki N Sato S Tsuji S | 1993 | J Neurol Sci1993，188，1： | 1 |
| 6 | Syntheses of Silver Nanofilms,Nanoreds,Andnanowires by a Microwavepolyol Method in the Presence of Pt Seeds and Polyvinylpyrrolidone显示文摘 | Yuki Nishizawa Masayuki Hashimoto | 2004 | Chemistry Letters2004，33，4： | 1 |
| 7 | An immunological abnormality common to Bickerstaff's brain stem and Fisher's syndrome 显示文摘 | Yuki N Sato S Tsuji S | 2001 | J Neurol Sci2001，188，1： | 1 |
| 8 | Syntheses of silver nanofilms,nanorods,and nanowires by a microwave-polyol method in the presence of Pt seeds and polyvinylpyrrolidone显示文摘 | Masaharu Tsuji Yuki Nishizawa Masayuki Hashimoto | 2004 | Chemistry Letters2004，33，4： | 1 |
| 9 | Agrobacterium tumefaciens-mediated transformation as a tool for random mutagenesis of Colletotrichum trifolii显示文摘 | Hiroyuki Takahara Gento Tsuji Yasuyuki Kubo Mikihiro Yamamoto Kazuhiro Toyoda Yoshishige Inagaki Yuki Ichinose Tomonori Shiraishi | 2004 | Journal of General Plant Pathology2004，，2： | 1 |
| 10 | An immunologic abnor- mality common to Bickerstaffg brain stem enecphalitis and Fisher's syndrome 显示文摘 | Yuki N Sato S Tsuji S | 1993 | J Neurol Sei1993，118，1： | 1 |
| 11 | An immunological abnormality common to Bickerstaff′s biainstem and Fisher′s syndrome显示文摘 | YuKi N Sato S Tsuji S | 1993 | J Neurolsci1993，188，1： | 1 |
| 12 | By using either endogenous or transplanted stem cells,which could you prefer for neural regeneration?显示文摘Neural regeneration by stem cells transplantation:Tissue regeneration and homeostasis are principally dependent on tissue stem cells which possess abilities of self-renewal and differentiation into multidirectional specialized cell types.In general,stem cells are critical for normal tissue renewal as well as repair after tissue injury.For example,mesenchymal stromal cells and endothelial progenitor cells identified in bone marrow | satoru matsuda yukie nakagawa kumi amano yuka ikeda ai tsuji yasuko kitagishi | 2018 | Neural Regeneration Research2018，13，10： | 1 |
| 13 | Development of an efficient gene targeting system in Colletotrichum higginsianum using a non-homologous end-joining mutant and Agrobacterium tumefaciens -mediated gene transfer显示文摘 | Takuma Ushimaru Hiroshi Terada Kie Tsuboi Yuki Kogou Ayumu Sakaguchi Gento Tsuji Yasuyuki Kubo | 2010 | Molecular Genetics and Genomics2010，，5： | 1 |
| 14 | Microwave-assisted synthesis of metallic nanostructures in solution显示文摘 | Masaharu Tsuji Masayuki Hashimoto Yuki Nishizawa | 2005 | Chemistry-A European Journal2005，11，2： | 1 |
| 15 | Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging显示文摘 | Sumitaka Hasegawa Yukie Morokoshi Atsushi B. Tsuji Toshiaki Kokubo Ichio Aoki Takako Furukawa Ming-Rong Zhang Tsuneo Saga | 2014 | Molecular Oncology2014，，： | 1 |
| 16 | An immunologic abnormality common to Bickerstaff's brain stem encephalitis and Fisher's syn- drome显示文摘 | Yuki N Sato S Tsuji S | 1993 | J Neuro Sci1993，118，1： | 1 |
| 17 | Agrobacterium tumefaciens-mediated transformation as a tool for random mutagenesis of Colletotrichum trifolii显示文摘 | Hiroyuki Takahara Gento Tsuji Yasuyuki Kubo Mikihiro Yamamoto Kazuhiro Toyoda Yoshishige Inagaki Yuki Ichinose Tomonori Shiraishi | 2004 | Journal of General Plant Pathology2004，，2： | 1 |
| 18 | Agrobacterium tumefaciens-mediated transformation as a tool for random mutagenesis of Colletotrichum trifolii显示文摘 | Hiroyuki Takahara Gento Tsuji Yasuyuki Kubo Mikihiro Yamamoto Kazuhiro Toyoda Yoshishige Inagaki Yuki Ichinose Tomonori Shiraishi | | 0，，： | 1 |
| 19 | Association between ADAMTS13 activity-VWF antigen imbalance and the therapeutic effect of HAIC in patients with hepatocellular carcinoma显示文摘BACKGROUND Prediction of HAIC treatment response is important for improving the prognosis in patients with hepatocellular carcinoma(HCC).The progression of HCC is related to hypercoagulability and angiogenesis.It is known that ADAMTS13 and von Willebrand factor(VWF)are related to hypercoagulability.In addition,previous study reported that the association between ADAMTS13 and VWF,and angiogenesis via vascular endothelial growth factor(VEGF).Recently,ADAMTS13 and VWF have been associated with the prognosis in patients with various kinds of cancer undergoing chemotherapy.AIM To investigate whether ADAMTS13 and VWF become useful biomarkers of treatment response in HCC patients before the initiation of HAIC treatment.METHODS Seventy-two patients were enrolled in this study.ADAMTS13 activity(ADAMTS13:AC),VWF antigen(VWF:Ag)and VEGF levels were determined via enzyme-linked immunosorbent assay.Univariable and multivariable analyses were performed to determine the predictive factors of treatment response in patients with HCC undergoing HAIC treatment.RESULTS ADAMTS13:AC levels in HCC patients with stable disease(SD)+partial response(PR)of HAIC treatment were significantly higher than those with progressive disease(PD)(P<0.05).In contrast,VWF:Ag/ADAMTS13:AC ratio and VEGF levels in HCC patients with SD+PR were significantly lower than those with PD(both P<0.05).Patients with high VWF:Ag/ADAMTS13:AC ratio(>2.7)had higher VEGF levels than those with low ratio(≤2.7).Multivariable analysis revealed that VWF:Ag/ADAMTS13:AC ratio was a predictive factor of HAIC treatment response.CONCLUSION VWF:Ag/ADAMTS13:AC ratio may become a useful biomarker of treatment response in HCC patients before the initiation of HAIC treatment. | Hiroaki Takaya Tadashi Namisaki Kei Moriya Naotaka Shimozato Kosuke Kaji Hiroyuki Ogawa Koji Ishida Yuki Tsuji Daisuke Kaya Hirotestu Takagi Yukihisa Fujinaga Norihisa Nishimura Yasuhiko Sawada Hideto Kawaratani Takemi Akahane Masanori Matsumoto Hitoshi Yoshiji | 2020 | World Journal of Gastroenterology2020，26，45： | 0 |
| 20 | Plasma copeptin concentration is a predictor of tolvaptan efficacy in patients with hepatic ascites显示文摘Aims:No solid evidence-based opinion was raised regarding predictors of the degree of ascites reduction with tolvaptan.This retrospective cohort study aimed to examine whether serum copeptin concentration is a useful predictor of this.Methods:The study population consisted of 80 patients with liver cirrhosis treated with tolvaptan for hepatic ascites effusions at Nara Medical University Hospital from May 2014 to December 2018.Forty-three patients who lost>1.5 kg of body weight in the first week after starting tolvaptan were classified as good responders and the remaining 37 as poor responders.Various laboratory parameters were measured immediately before the start of tolvaptan therapy to examine factors associated with predicting its efficacy.Results:In the univariate analysis,no significant differences with respect to age(67.6 vs.69.8 years,p>0.05),sex,body mass index(24.8 vs.23.7 kg/m^(2),p>0.05),Child-Pugh score(9.4 vs.9.7,p>0.05),and Model for End-stage Liver Disease score(11 vs.12,p>0.05)were found between the two groups.Conversely,aspartate transferase and alanine transaminase(ALT)levels were significantly lower in the good response group(52.9±56.3 vs.68.8±50.7 U/L,p<0.05;26.2±30.6 vs.40.5±33.5 U/L,p<0.01),whereas serum copeptin and serum sodium concentrations were significantly higher(57.1±15.0 vs.45.8±16.0 pg/mL,p<0.01;136.3±3.4 vs.133.8±5.8 mEq/L,p<0.05).In the multivariate analysis,serum copeptin concentration and ALT were statistically significant factors(p<0.01,p<0.05).Regression analysis of the association between the tolvaptan efficacy for refractory ascites and pretreatment serum copeptin concentration showed that a copeptin concentration cutoff of 45.9 pg/mL could predict treatment efficacy with a sensitivity,specificity,and area under the curve of 76.7%,59.5%,and 0.71%,respectively.Conclusion:Serum copeptin concentration may be a predictor of tolvaptan efficacy for refractory ascites effusion in Japanese patients with liver cirrhosis. | Fumimasa Tomooka Kei Moriya Takahiro Kubo Akihiko Shibamoto Jyunya Suzuki Satoshi Iwai Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Yuki Tsuji Yukihisa Fujinaga Koh Kitagawa Norihisa Nishimura Hiroaki Takaya Kosuke Kaji Hideto Kawaratani Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
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