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| 1 | A Randomized Controlled Trial of Radiofrequency Ablation With Ethanol Injection for Small Hepatocellular Carcinoma显示文摘 | Shuichiro Shiina Takuma Teratani Shuntaro Obi Shinpei Sato Ryosuke Tateishi Tomonori Fujishima Takashi Ishikawa Yukihiro Koike Haruhiko Yoshida Takao Kawabe Masao Omata | 2005 | Gastroenterology2005，，1： | 1 |
| 2 | Relationship between outcomes and relative dose intensity of lenvatinib treatment in patients with advanced hepatocellular carcinoma显示文摘Background and aims:Lenvatinib(LEN)is a newly developed tyrosine kinase inhibitor,and is approved as a first-line treatment for advanced hepatocellular carcinoma(HCC)in Japan.This retrospective multi-center study investigated the effect of the relative dose intensity(RDI)of LEN on response rate,progression-free survival(PFS),and overall survival(OS).Methods:This retrospective study enrolled 123 patients with advanced HCC who were treated with LEN at six hospitals in Japan between March 2018 and December 2019.These patients were divided into two groups:RDI≥70%(RDI 70 group,N=70)or RDI<70%(control group,N=53)in the first 30 days.The following data were compared between groups:patient backgrounds,adverse events,treatment out-comes,PFS,and OS.PFS and OS were analyzed using the Kaplan-Meier method,followed by the log-rank test.To identify significant factors that contributed to response,PFS,and OS,multivariate analysis was performed using factors for which P-values were<0.10 in univariate analysis.Results:The proportion of patients with Child-Pugh class 5A was significantly greater in the RDI 70 group than that in the control group(64.3%vs.28.3%,P<0.01).Dose interruption due to adverse events was significantly more common in the control group.The response rate was significantly higher in the RDI 70 group than that in the control group(35.7%vs.11.3%,P<0.01).Median PFS was significantly longer in the RDI 70 group(9.4 vs.4.7 months,P<0.01).Multivariate analysis showed that RDI≥70%(hazard ratio(HR)=0.55,P=0.025),hypertension grade≥2(HR=0.47,P=0.019),and response(HR=0.52,P=0.033)were independently associated with improved PFS.Median OS was also significantly longer in the RDI 70 group(20.0 vs.13.3 months,P=0.045).Multivariate analysis showed that female sex(HR=0.33,P=0.034)and disease control(HR=0.31,P<0.01)were independently associated with improved OS.RDI≥70%was not statistically significant in multivariate analysis.Conclusions:Our study revealed the importance of achieving RDI≥70%in the first 30 days of treatment to maximize the effects of LEN。 | Takamasa Ohki Koki Sato Mayuko Kondo Eriko Goto Takahisa Sato Yuji Kondo Masatoshi Akamatsu Shinpei Sato Hideo Yoshida Yukihiro Koike Shuntaro Obi | 2020 | Liver Research2020，4，4： | 1 |
| 3 | Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus—An analysis of 236 consecutive patients with a single lesion显示文摘 | Yukihiro Koike Yasushi Shiratori Shinpei Sato Shuntaro Obi Takuma Teratani Masatoshi Imamura Keisuke Hamamura Yasuo Imai Haruhiko Yoshida Shuichiro Shiina Masao Omata | 2000 | Hepatology2000，，6： | 1 |
| 4 | Gallbladder carcinoma with a tumor thrombus in the common bile duct: An unusual cause of obstructive jaundice显示文摘 | Yutaka Midorikawa Keiichi Kubota Yutaka Komatsu Kiyoshi Hasegawa Yukihiro Koike Masaya Mori Masatoshi Makuuchi | 2000 | Surgery2000，，4： | 1 |
| 5 | Laparoscopic surgery for small-bowel obstruction caused by Meckel's diverticulum显示文摘A 26-year-old woman was referred to our hospital because of abdominal distention and vomiting. Contrastenhanced computed tomography showed a blind loop of the bowel extending to near the uterus and a fibrotic band connecting the mesentery to the top of the bowel,suggestive of Meckel's diverticulum(MD) and a mesodiverticular band(MDB). After intestinal decompression,elective laparoscopic surgery was carried out. Using three 5-mm ports,MD was dissected from the surrounding adhesion and MDB was divided intracorporeally. And subsequent Meckel's diverticulectomy was performed. The presence of heterotopic gastric mucosa was confirmed histologically. The patient had an uneventful postoperative course and was discharged 5 d after the operation. She has remained healthy and symptom-free during 4 years of follow-up. This was considered to be an unusual case of preoperatively diagnosed and laparoscopically treated small-bowel obstruction due to MD in a young adult woman. | Takatsugu Matsumoto Motoki Nagai Daisuke Koike Yukihiro Nomura Nobutaka Tanaka | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 1 |
| 6 | A Randomized Controlled Trial of Radiofrequency Ablation With Ethanol Injection for Small Hepatocellular Carcinoma显示文摘 | Shuichiro Shiina Takuma Teratani Shuntaro Obi Shinpei Sato Ryosuke Tateishi Tomonori Fujishima Takashi Ishikawa Yukihiro Koike Haruhiko Yoshida Takao Kawabe Masao Omata | 2005 | Gastroenterology2005，，1： | 1 |
| 7 | Anchor-wire technique for multiple plastic biliary stents to prevent stent dislocation显示文摘In endoscopic placement of multiple plastic biliary stents (PBSs),we sometimes experience proximal dislocation of the first PBS at the time of subsequent PBS insertion.We describe the case of a 79-year-old male with obstructive jaundice caused by cholangiocarcinoma who needed to receive multiple PBS placements for management of cholangitis.Although proximal dislocation of the first PBS was observed,we prevented the dislocation via our technique of using guidewire inserted from the distal end of the first PBS to the side hole as the anchor-wire.We could complete this technique only by inserting guidewire through the side hole of the first PBS during the process of releasing the first PBS and pulling out the guidewire and the inner sheath.It did not matter whether the anchor-wire went towards the third portion of the duodenum or the duodenal bulb.Here we introduce this 'anchor-wire technique',which is useful for the prevention of PBS proximal dislocation in placing multiple PBSs. | Tsuyoshi Hamada Yousuke Nakai Saburo Matsubara Hiroyuki Isayama Akiko Narita Kazuhiro Watanabe Yukihiro Koike Shigeo Matsukawa Tateo Kawase Kazuhiko Koike | 2011 | World Journal of Gastroenterology2011，17，28： | 0 |
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