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您的检索式：作者名="Yungang Deng"
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| 1 | Proteasomal and lysosomal degradation for specific and durable suppression of immunotherapeutic targets显示文摘Cancer immunotherapy harness the body's immune system to eliminate cancer,by using a broad panel of soluble and membrane proteins as therapeutic targets.Immunosuppression signaling mediated by ligand-receptor interaction may be blocked by monoclonal antibodies,but because of repopulation of the membranevia intracellular organelles,targets must be eliminated in whole cells.Targeted protein degradation,as exemplified in proteolysis targeting chimera(PROTAC)studies,is a promising strategy for selective inhibition of target proteins.The recently reported use of lysosomal targeting molecules to eliminate immune checkpoint proteins has paved the way for targeted degradation of membrane proteins as crucial anti-cancer targets.Further studies on these molecules'modes of action,target-binding'warheads',lysosomal sorting signals,and linker design should facilitate their rational design.Modifications and derivatives may improve their cell-penetrating ability and thein vivo stability of these pro-drugs.These studies suggest the promise of alternative strategies for cancer immunotherapy,with the aim of achieving more potent and durable suppression of tumor growth.Here,the successes and limitations of antibody inhibitorsin cancer immunotherapy,as well as research progress on PROTAC-and lysosomal-dependent degradation of target proteins,are reviewed. | Yungang Wang Shouyan Deng Jie Xu | 2020 | Cancer Biology & Medicine2020，17，3： | 1 |
| 2 | Toughness improvement mechanism and evaluation of cement concrete for road pavement:A review显示文摘Traditional cement concrete has the disadvantages of low tensile strength,poor toughness,and rapid development of cracks while cracking,which causes a significantly negative influence on the safety and durability of concrete road pavement.This paper presents a state-of-the-art review of toughness improvement mechanisms and evaluation methods of cement concrete for road pavement.The review indicates that(i)The performance of concrete material depends on its material composition and internal structure.Aggregate size,cement properties and admixtures are the main factors of concrete toughness.(ii)The incorporation of rubber or fiber in pavement concrete improves the toughness of concrete materials.However,these additions must be maintained within a reasonable range.The amount of rubber and fiber are encouraged not more than 30%of the volume of fine aggregate and 2%of the volume of concrete,respectively.(iii)The toughness of pavement concrete material includes the toughness regarding bending,impact and fracture.The toughness of cement concrete for highway and municipal pavement is generally evaluated by bending and fracture toughness,while the toughness of airfield pavement concrete is more focused on impact toughness.(iv)The toughening measures of cement concrete for road pavement are mainly mixed with rubber or fiber,while these two materials have their defects,and the application of hightoughness cement concrete in the actual road still faces many challenges.For example,the synergistic effect of rubber and fiber,the development and application of new flexible admixtures,and the formulation of the toughness index of pavement cement concrete materials need further research. | Mingjing Fang Yiming Chen Yungang Deng Zhe Wang Mengjun Zhu | 2023 | Journal of Road Engineering2023，3，2： | 1 |
| 3 | The expression and function of microRNA-203 in lung cancer显示文摘 | Jianhua Jin Jianzhong Deng Fang Wang Xiyi Xia Tiefeng Qiu Wenbin Lu Xianwen Li Hua Zhang Xiaoyan Gu Yungang Liu Weiguo Cao Wenlong Shao | 2013 | Tumor Biology2013，，： | 1 |
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