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| 1 | TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer显示文摘Tumor necrosis factor receptor-associated protein 1(TRAP1), an important member of mitochondrial heat shock protein 90 family, is involved in multiple biological processes in several types of tumors. However, its pathological role in esophageal squamous cell cancer(ESCC) remains unknown. Herein, we demonstrated the clinical value of TRAP1, and its role in apoptosis and motility in ESCC. The clinical potential of TRAP1 was investigated through immunohistochemical analysis in 328 ESCC samples, which revealed that strong TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis. Expression of TRAP1 was found to be an independent prognostic factor for patients with ESCC. Additionally, the upregulation of TRAP1 antagonized cisplatin-induced apoptosis while its downregulation sensitized cells to cisplatin-induced apoptosis. As revealed by the transwell assay, TRAP1 overexpression promoted cellular migration and invasion as compared to the control groups. In contrast,silencing of endogenous TRAP1 expression attenuated the ability of migration and invasion. Finally, the molecular mechanism investigated in the present study demonstrated that TRAP1-mediated migration and invasion occurred through STAT3/MMP2 signaling pathway. In conclusion, TRAP1 may be considered as a molecular predictive marker for prognosis and a novel molecular candidate for therapeutic target in ESCC. | Yunwei Ou Lingyan Liu Liyan Xue Wei Zhou Zitong Zhao Bainan Xu Yongmei Song Qimin Zhan | 2014 | Journal of Genetics and Genomics2014，41，10： | 8 |
| 2 | Suppressor of RNA silencing encoded by Rice gall dwarf virus genome segment 11显示文摘Rice gall dwarf virus(RGDV)is an important rice pathogen in China and Southeast Asia.However,little is known about the molecular mechanisms of RGDV interactions with plant cells.Here,we have identi-fied an RGDV protein,Pns11,which acts as a suppressor of RNA silencing in coinfiltration assays with the reporter,green fluorescent protein(GFP)in transgenic Nicotiana benthamiana line 16c carrying GFP.Pns11 suppressed local and systemic silencing induced by sense RNA.The spread of mobile RNA si-lencing signals was blocked or inactivated by Pns11.Expression of Pns11 also enhanced Potato virus X pathogenicity in N.benthamiana.This suppressor could reduce,but not eliminate,siRNA in the local and systemic RNA silencing suppression assays,suggesting that Pns11 functions by interfering with initial stages of RNA silencing. | LIU FuXiu ZHAO Qin RUAN XiaoLei HE YunWei LI HuaPing | 2008 | Chinese Science Bulletin2008，53，3： | 8 |
| 3 | Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings:A positive feedback loop regulation显示文摘Glioma is the most common type of primary brain tumors in the central nervous system(CNS). Migfilin occurs in human glioma and enhances cellular motility via the epidermal growth factor receptor(EGFR)pathway. However, the underlying molecular mechanism is not fully understood. In this study, we found that Migfilin promoted matrix metalloproteinase-2(MMP-2) activity, and restrained the expression of tissue inhibitor of metalloproteinase 2(TIMP2), which is an MMP-2 inhibitor. Functional and structural studies showed that the LIM1 domain of Migfilin was required for Migfilin-mediated TIMP2 expression inhibition and MMP-2 activity, and was also necessary in promoting cell motility. Furthermore, Migfilininduced EGFR phosphorylation was greatly reduced by MMP-2 inhibitor(GM6001) or si RNA, while Migfilin-induced MMP-2 activation was also blocked by the EGFR inhibitor(AG1478) or si RNA. MMP-2 and EGFR inhibitors and their si RNAs can block Migfilin-induced migration and invasion, respectively.These results demonstrated that EGFR and MMP-2 signalings may form a positive feedback loop to enhance Migfilin-induced migration and invasion. Finally, we detected that the expression of Migfilin,EGFR phosphorylation(Tyr1173) and MMP-2 activity had a positive correlation in the clinical glioma sample. Taken together, these results suggest that Migfilin is a critical regulator in cellular motility by driving the EGFR-MMP-2 feedback loop, and may be considered as a potential therapeutic target in glioma. | Yunwei Ou Qingnan Wu Chuanyue Wu Xuefeng Liu Yongmei Song Qimin Zhan | 2017 | Journal of Genetics and Genomics2017，44，12： | 7 |
| 4 | A dynamic Bayesian networks modeling of human factors on offshore blowouts显示文摘 | Baoping Cai Yonghong Liu Yunwei Zhang Qian Fan Zengkai Liu Xiaojie Tian | 2013 | Journal of Loss Prevention in the Process Industries2013，，4： | 2 |
| 5 | Formation of the beef flavour precursors and their correlation with chemical parameters during the controlled thermal oxidation of tallow显示文摘 | Shiqing Song Xiaoming Zhang Khizar Hayat Ping Liu Chengsheng Jia Shuqin Xia Zuobing Xiao Huaixiang Tian Yunwei Niu | 2010 | Food Chemistry2010，，1： | 2 |
| 6 | Strength-Toughening Model of Eutectic Ceramic Composite with Inherent Defects显示文摘Strengthening and toughening mechanisms in composite ceramics is complex. A change in a single parameter induces multiple property variations. The multiple changes in properties are often incompletely represented in theoretical models. This incompleteness in the parameter chosen fails to explain the mechanism of failure in composite ceramics. The exponential toughness function is used to represent the pull-out toughening mechanism, which dominates the crack growth resistance curve(R-curve). The strengthening-toughening model is established based on the Mori-Tanaka method(M-T method). The influence of inherent defects on toughness function and strength is analyzed by using this model. The theoretical result is compared with the experiment data. This model exactly reflects the change in strength. The theoretical result indicates that defects change the toughness function. Moreover, micro-cracks increase toughness size ac, and the strength of crack instable extensions acutely decreases as defect content increases. This presented model establishes the relationship among the important mechanical parameters of defect, strength, elastic modulus, and the R-curve. | FU Yunwei ZHANG Long NI Xinhua LIU Xiequan CHEN Cheng ZHAO Siyuan | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 2 |
| 7 | Damage and fracture model for eutectic composite ceramics显示文摘Study of damage and fracture models to analyze the fracture mechanism of eutectic composite ceramics is of considerable importance because no accurate fracture models are available for these materials. Eutectic composite ceramics are composed of microcells with random direction. We present herein a model that predicts the damage and fracture of eutectic composite ceramics based on analysis of defect stability and the damage localization band. Firstly, given the microstructure of eutectic composite ceramics, a mesodomain and a microcell model are constructed. The local stress field in the mesodomain is then analyzed based on the interaction direct derivative estimate. Secondly, the stability of a defect around particles in a microcell is analyzed, and the stress intensity factor of an annular defect under the applied stress field and the residual stress field in the particle are calculated. The stress intensity factor of a defect is controlled by the residual stress when the defect extension is small. However, it is controlled by the applied stress when the defect extension is large. Finally, a model for the damage localization band at the crack tip is constructed based on the Dugdale-Barenblatt model. The residual intensity is the important factor affecting the length of the damage localization band. When the damage variables reach their largest value, the residual in ten sity and the length of the damage localization band attain their minimum value. This work provides the theoretical basis for further study of the damage mechanics of eutectic composite ceramics and guides the engineering applications of these materials. | Jinfeng Yu Xinhua Ni Xiequan Liu Yunwei Fu Zhihong Du | 2019 | Acta Mechanica Sinica2019，35，1： | 2 |
| 8 | Rapid measuring and modelling flavour quality changes of oxidised chicken fat by electronic nose profiles through the partial least squares regression analysis显示文摘 | Shiqing Song Lin Yuan Xiaoming Zhang Khizar Hayat Huangnv Chen Fang Liu Zuobing Xiao Yunwei Niu | 2013 | Food Chemistry2013，，： | 1 |
| 9 | Contribution of beef base to aroma characteristics of beeflike process flavour assessed by descriptive sensory analysis and gas chromatography olfactometry and partial least squares regression显示文摘 | Shiqing Song Xiaoming Zhang Khizar Hayat Meigui Huang Ping Liu Eric Karangwa Fenglin Gu Chengsheng Jia Shuqin Xia Zuobing Xiao Yunwei Niu | 2010 | Journal of Chromatography A2010，，49： | 1 |
| 10 | Effects of Plant-derived Humic Acid Organic Fertilizer on Selenium Content of Rice in Northern Guangxi显示文摘This study was to find out the suitable application amount of plant-derived humic acid organic fertilizer for selenium-rich rice production in northern Guilin area by applying the fertilizer at different amounts.The results showed that plant-derived humic acid organic fertilizer could effectively activate selenium in selenium-rich soil,and then promote the uptake of selenium by rice.With costs,selenium enrichment and rice yield as the main evaluation indicators,A4 was chosen as the best treatment,that is,the application of 4 500 kg/hm^2 of plant-derived humic acid organic fertilizer as base fertilizer could achieve the best benefit. | Yunwei JIANG Lixiu HUANG Dongmei WANG Liping PAN Qianchi MO Ri MING Zongji ZHANG Jinping CHEN Hengzhi ZHAO Youxing YANG Xiongying JIANG Dayong FAN Yongxian LIU | 2019 | Agricultural Biotechnology2019，8，3： | 1 |
| 11 | Effect of space flight factors on alfalfa seeds显示文摘 | Ren Weibo Zhang Yunwei Deng Bo Guo Huiqin Chen Li- bo Liu Yaxue | 2010 | African Journal of Biotechnology2010，9，43： | 1 |
| 12 | Virus-phytoplankton adhesion:a new WSSV transmission route to zooplankton显示文摘The pathogenicity of white spot syndrome virus(WSSV)to zooplankton species,rotifer Brachionus urceus(Linnaeus),copepod Acartia clausi(Giesbrecht)and mysid shrimp Neomysis awatschensis(Brandt),was estimated by immersion challenge and virus-phytoplankton adhesion route to investigate a potential new transmission route of WSSV to zooplankton.WSSV succeeded in infecting these zooplankton species and nested-PCR revealed positive results for the virus-phytoplankton adhesion route,whereas WSSV cannot infect zooplankton by immersion challenge.These results indicated that virus-phytoplankton adhesion route is a successful new transmission route of WSSV to zooplankton and also implied that phytoplankton could be a carrier in WSSV transmission. | ZHANG Jiasong DONG Shuanglin TIAN Xiangli DONG Yunwei LIU Xiangyi YAN Dongchun | 2007 | Acta Oceanologica Sinica2007，26，6： | 1 |
| 13 | Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice显示文摘 | Wenjin Xi Yejia Hu Yugang Liu Jiao Zhang Lei Wang Yunwei Lou Zhonghua Qu Jian Cui Guizhong Zhang Xiaohong Liang Chunhong Ma Chengjiang Gao Youhai Chen Suxia Liu | 2011 | Molecular Immunology2011，，9： | 1 |
| 14 | A dynamic Bayesian networks modeling of human factors on off- shore blowouts显示文摘 | Cai Baoping Liu Yonghong Zhang Yunwei | 2013 | Journal of Loss Prevention in the Process Industries2013，26，： | 1 |
| 15 | Influence of two inlets of the Luzon overflow on the deep circulation in the northern South China Sea显示文摘An inverse reduced-gravity model is used to simulate the deep South China Sea(SCS)circulation.A set of experiments are conducted using this model to study the influence of the Luzon overflow through the two inlets on the deep circulation in the northern SCS.Model results suggest that the relative contribution of these inlets largely depends on the magnitude of the input transport of the overflow,but the northern inlet is more efficient than the southern inlet in driving the deep circulation in the northern SCS.When all of the Luzon overflow occurs through the northern inlet the deep circulation in the northern SCS is enhanced.Conversely,when all of the Luzon overflow occurs through the southern inlet the circulation in the northern SCS is weakened.A Lagrangian trajectory model is also developed and applied to these cases.The Lagrangian results indicate that the location of the Luzon overflow likely has impacts upon the sediment transport into the northern SCS. | Muping Zhou Changlin Chen Yunwei Yan Wenhu Liu | 2020 | Acta Oceanologica Sinica2020，39，11： | 1 |
| 16 | A dynamicBayesian networks modeling of human factors on offshore blowouts显示文摘 | CAI Baoping LIU Yonghong ZHANG Yunwei | 2013 | Journal of Loss Prevention in the Process Industries2013，26，4： | 1 |
| 17 | Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk显示文摘Silk has been widely used in the clothing industry due to their soft and smooth features,good biocompatibility,good heat dissipation,warmth and ultraviolet resistance.The application of fragrance to silk can significantly improve the performance of silk.However,there are two key scientific problems that need to be solved:slowing down the release rate of fragrances and increasing the scent lasting time of silk.In this study,cationic and temperature-sensitive liposomes were designed and prepared to encapsulate eugenol.These fragrance-loaded liposomes significantly slowed down the release rate of the fragrance and controlled the release rate of the fragrance in a thermo-sensitive manner.The liposomes adhered to the silk through electrostatic adsorption interaction.The positive charge on the fragranceloaded liposomes neutralized much negative charge on silk and thereby increasing the adhesion efficiency. | Zhiguo Lu Xiangyu Wang Tianlu Zhang Luyao Zhang Jun Yang Yan Li Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Guiying Liu Xin Zhang | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 18 | Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis显示文摘Background:Excessive alcohol intake with hepatitis B virus(HBV)infection accelerates chronic liver disease progression and patients with HBV infection are more susceptible to alcohol-induced liver disease.Hepatitis B virus X protein(HBx)plays a crucial role in disease pathogenesis,while its specific role in alcoholic liver disease(ALD)progression has not yet been elucidated.Here,we studied the role of HBx on the development of ALD.Methods:HBx-transgenic(HBx-Tg)mice and their wild-type littermates were exposed to chronic plus binge alcohol feeding.Primary hepatocytes,cell lines,and human samples were used to investigate the interaction between HBx and acetaldehyde dehydrogenase 2(ALDH2).Lipid profiles in mouse livers and cells were assessed by using liquid chromatography–mass spectrometry.Results:We identified that HBx significantly aggravated alcohol-induced steatohepatitis,oxidative stress,and lipid peroxidation in mice.In addition,HBx induced worse lipid profiles with high lysophospholipids generation in alcoholic steatohepatitis,as shown by using lipidomic analysis.Importantly,serum and liver acetaldehyde were markedly higher in alcoholfed HBx-Tg mice.Acetaldehyde induced lysophospholipids generation through oxidative stress in hepatocytes.Mechanistically,HBx directly bound to mitochondrial ALDH2 to induce its ubiquitin–proteasome degradation,resulting in acetaldehyde accumulation.More importantly,we also identified that patients with HBV infection reduced ALDH2 protein levels in the liver.Conclusions:Our study demonstrated that HBx-induced ubiquitin-dependent degradation of mitochondrial ALDH2 aggravates alcoholic steatohepatitis. | Haoxiong Zhou Sizhe Wan Yujun Luo Huiling Liu Jie Jiang Yunwei Guo Jia Xiao Bin Wu | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 19 | Reactive nano-essential oils for sustained release of essential oils and application to wallpaper显示文摘Essential oils are a volatile and aromatic substance with a variety of active biological activities.However,the excessive volatility and inconvenience of the use of essential oils limit their applications.In this study,we developed a reactive mesoporous silica nanoparticle(rMSNs)based on cyanuric chloride modification for essential oil encapsulation and commodity adhesion.The large pore volume and specific surface area of rMSNs facilitate the nanoparticles adhering to a large amount of essential oil and achieve the sustained release of essential oil,thus prolonging the fragrance retention time of essential oils.The reactive nanoessential oils can form covalent bonds with the wallpaper,thereby remarkably improving the adhesion of the reactive nano-essential oils on the wallpaper and preventing the reactive nano-essential oil from deadhering from the wallpaper.The active nano essential oil simultaneously overcomes the intense volatility of the essential oil and inconvenience in use,has a simple preparation process and low cost,and has great application potential. | Qiulian Hao Huan Peng Ruichen Zhao Jianze Wang Zhiguo Lu Jingwen Wang Jie Shen Yunwei Niu Zuobing Xiao Guiying Liu Jifu Hao Xin Zhang | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 20 | Research Trends and Emerging Hotspots of Lung Cancer Surgery during 2012-2021:A 10-Year Bibliometric and Network Analysis显示文摘Background. Lung cancer remains the leading cause of death because of cancer globally in the past years. To inspire researcherswith new targets and path-breaking directions for lung cancer research, this study is aimed at exploring the research trends andemerging hotspots in the lung cancer surgery literature in the recent decade. Methods. This cross-sectional study combinedbibliometric and network analysis techniques to undertake a quantitative analysis of lung cancer surgery literature. Dimensionsdatabase was searched using keywords in a 10-year period (2012-2021). Publications were characterized by publication year,research countries, field citation ratio, cooperation status, research area, and emerging hotspots. Results. Overall, globalscholarly outputs of lung cancer surgery had almost doubled during the recent decade, with China, Japan, and the UnitedStates leading the way, while Denmark and Belgium predominated in terms of scientific influence. Network analysis showedthat international cooperation accounted for a relatively small portion in lung cancer surgery research, and the United States,China, and Europe were the prominent centers of international cooperation network. In the recent decade, research of lungcancer surgery majored in prevention, biomedical imaging, rehabilitation, and genetics, and the emerging research hotspotstransformed into immunotherapy. Research on immunotherapy showed a considerable increase in scientific influence in thelatest year. Conclusions. The study findings are expected to provide researchers and policymakers with interesting insights intothe changing trends of lung cancer surgery research and further generate evidence to support decision-making in improvingprognosis for patients with lung cancer. | Jingyi Wu Chenlu Bao Ganwei Liu Shushi Meng Yunwei Lu Pengfei Li Jian Zhou | 2022 | Health Data Science2022，，1： | 0 |
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