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| 1 | Impact of Accessibility on Housing Prices in Dalian City of China Based on a Geographically Weighted Regression Model显示文摘This paper studies the relationship between accessibility and housing prices in Dalian by using an improved geographically weighted regression model and house prices, traffic, remote sensing images, etc. Multi-source data improves the accuracy of the spatial differentiation that reflects the impact of traffic accessibility on house prices. The results are as follows: first, the average house price is 12 436 yuan(RMB)/m^2, and reveals a declining trend from coastal areas to inland areas. The exception was Guilin Street, which demonstrates a local peak of house prices that decreases from the center of the street to its periphery. Second, the accessibility value is 33 minutes on average, excluding northern and eastern fringe areas, which was over 50 minutes. Third, the significant spatial correlation coefficient between accessibility and house prices is 0.423, and the coefficient increases in the southeastern direction. The strongest impact of accessibility on house prices is in the southeastern coast, and can be seen in the Lehua, Yingke, and Hushan communities, while the weakest impact is in the northwestern fringe, and can be seen in the Yingchengzi, Xixiaomo, and Daheishi community areas. | YANG Jun BAO Yajun ZHANG Yuqing LI Xueming GE Quansheng | 2018 | Chinese Geographical Science2018，28，3： | 10 |
| 2 | Expert consensus on early childhood caries management显示文摘Early childhood caries(ECC)is a significant chronic disease of childhood and a rising public health burden worldwide.ECC may cause a higher risk of new caries lesions in both primary and permanent dentition,affecting lifelong oral health.The occurrence of ECC has been closely related to the core microbiome change in the oral cavity,which may be influenced by diet habits,oral health management,fluoride use,and dental manipulations.So,it is essential to improve parental oral health and awareness of health care,to establish a dental home at the early stage of childhood,and make an individualized caries management plan.Dental interventions according to the minimally invasive concept should be carried out to treat dental caries.This expert consensus mainly discusses the etiology of ECC,caries-risk assessment of children,prevention and treatment plan of ECC,aiming to achieve lifelong oral health. | Jing Zou Qin Du Lihong Ge Jun Wang Xiaojing Wang Yuqing Li Guangtai Song Wei Zhao Xu Chen Beizhan Jiang Yufeng Mei Yang Huang Shuli Deng Hongmei Zhang Yanhong Li Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，3： | 5 |
| 3 | Aquaporin-1 Expressed in Cultured Human Trabecular Meshwork Cells显示文摘Objective:To determine if aquaporin-1 could be detected in cultures of human trabecularshwork cells. Methods: Using primers specific for aquaporin-1, reverse transcription combined withpolymerase chain reaction (RT-PCR) yielded a product and its size with total RNAprepared from the human trabecular meshwork cells. SDS-PAGE and immunoblottingwere also used in this study to detect the specific water channel.Results: The presence of this product and its size (298 base pairs) are consistent withthat of an aquaporin-1 message in these cells. A band of 28 kD in agreement with themolecular size of aquaporin-1 was showed in a film by immunoblotting.Conclusion: The presence of aquaporin-1 in human trabecular meshwork cells, thepredominant cell-type of the primary outflow region of the human eye, suggests that waterchannels may be involved in the movement of aqueous fluid out of the eye. In addition,the existence of aquaporin-1 on cultures of human trabecular meshwork cells provides anin vitro model to study the endogenous expression of aquaporin-1 and its possible role inthe regulation of aqueous outflow. | Mingkai Lin, Jian Ge, Yehong Zhuo, Yuqing Lan, Keming Yu, Jianliang ZhengZhongshan Ophthalmic center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | Eye Science2002，18，1X： | 2 |
| 4 | Phacoemulsification in Patients with Secondary Glaucoma Caused by Uveitis显示文摘Purposes: To evaluate the effect of phacoemulsification in the patients with uveitis,secondary glaucoma and complicated cataract.
Methods: Phacoemulsification and implantation of a foldable intraocular len was performed in 12 patients(13 eyes) with uveitis, secondary glaucoma and complicated cataract. The complications, intraocular pressures (IOP), and visual acuity were observed postoperatively.
Results: No severe complication was found in the patients postoperatively or within the operation procedure. The visual acuity was improved after the operation ( P < 0.05) .The intraocular pressures and/or the number of antiglaucoma medications reduced in 3months of the follow-up time.
Conclusion: phacoemulsification is the best way to treat the patients with secondary glaucoma and complicated cataract caused by uveitis. Eye Science 2001; 17: 8 ~ 10. | Mingkai Lin, Jian Ge, Yizhi Liu, Yuqing Lan, Yehong ZhouZhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences. Guangzhou, 510060, China | 2001 | Eye Science2001，17，1： | 1 |
| 5 | Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E显示文摘 | Yuqing Ge Rubin Cheng Yuhong Zhou Jianping Shen Laijun Peng Xiaofeng Xu Qun Dai Pei Liu Haibing Wang Xiaoqiong Ma Jia Jia Zhe Chen | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 6 | The Preliminary Study of Interferon-γ Gene Transfection to Human Tenon's Capsule Fibroblasts in Vitro显示文摘 | Yuqing Lan, Jian Ge, Mingkai Lin, Jianliang Zheng, Huiyi Chen, Haiquan Liu, Jing Wei , Yanyan LiZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China Sun Yat-Sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510120, China | 2000 | 眼科学报2000，16，3： | 1 |
| 7 | A 3D bio-printed spheroids based perfusion in vitro liver on chip for drug toxicity assays显示文摘Liver is the foremost organ of human being for drug metabolism,and it played a significant role in toxicity evaluation of drugs.Establishing a liver model in vitro can accelerate the process of the drug screening and new drug research and development.We provide a 3D printing based hepatic sinusoid-on-a-chip microdevice that reconstitutes organ-level liver functions to create a drug screening model of toxicity evaluation on chip.The microfluidic device,which recapitulates the hepatic sinusoid microenvironment,consists of PET polyporous membranes which mimic the perisinusoidal space,and experience fluid flow to mimic the hepatic arterial capillaries.The PET membrane was used to separate the hepatocyte and endotheliocyte.The endotheliocyte was cultured on the downside of the membrane and the hepatocyte were 3D seeded on the membrane via the 3D printer.This device was used to reproduce the in vitro liver model for drug toxicity assays.The expression of several biomarkers of liver was compared with the monoculture and 2D cultured conditions,and the results reveal that this organ-on-a-chip microdevice mimics the drug hepatoxicity that has not been possible by 2D cell-based and animal models,providing a useful platform for screening the drugs and developing an effective therapy in hepatopathy. | Tian Tian Yuhan Ho Chen Chen Hebin Sun Janan Hui Panhui Yang Yuqing Ge Ting Liu Jian Yang Hongju Mao | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 8 | Down-regulation of β1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis 显示文摘 | Yuanyan Wei Dan Liu Yuqing Ge | 2008 | Cancer Letters2008，267，1： | 1 |
| 9 | Immunosenescence:molecular mechanisms and diseases显示文摘Infection susceptibility,poor vaccination efficacy,age-related disease onset,and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging(known as immunosenescence).During aging,organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers,termed inflammaging.This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases.Thymic involution,naïve/memory cell ratio imbalance,dysregulated metabolism,and epigenetic alterations are striking features of immunosenescence.Disturbed T-cell pools and chronic antigen stimulation mediate premature senescence of immune cells,and senescent immune cells develop a proinflammatory senescence-associated secretory phenotype that exacerbates inflammaging.Although the underlying molecular mechanisms remain to be addressed,it is well documented that senescent T cells and inflammaging might be major driving forces in immunosenescence.Potential counteractive measures will be discussed,including intervention of cellular senescence and metabolic-epigenetic axes to mitigate immunosenescence.In recent years,immunosenescence has attracted increasing attention for its role in tumor development.As a result of the limited participation of elderly patients,the impact of immunosenescence on cancer immunotherapy is unclear.Despite some surprising results from clinical trials and drugs,it is necessary to investigate the role of immunosenescence in cancer and other age-related diseases. | Zaoqu Liu Qimeng Liang Yuqing Ren Chunguang Guo Xiaoyong Ge Libo Wang Quan Cheng Peng Luo Yi Zhang Xinwei Han | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 10 | Functionalized anodic aluminum oxide (AAO) membranes for affinity protein separation显示文摘 | Wei Shi Yuqing Shen Dongtao Ge Maoqiang Xue Huihui Cao Sanqing Huang Jixiao Wang Guoliang Zhang Fengbao Zhang | 2008 | Journal of Membrane Science2008，，2： | 1 |
| 11 | Establishment of correlation between reaction kinetics and carbon structures in the char gasification process显示文摘For a gasification process,the char-CO_(2)gasification is the controlling step worthwhile to be deeply investigated.The article chosen corn stalk(CS),poplar sawdust(PS)and bagasse residue(BR)as the typical waste species derived from agricultural,forestal and industrial sources.The char-CO_(2)gasification behavior,reaction kinetics and carbon structure were studied to reveal the intrinsic factors determining the reaction kinetics.Generally,the carbon conversion and maximum conversion rate were influenced by the feedstocks species and char preparation temperatures,as influenced by ash proportion,potassium content in ash and carbon structure of char.The char-CO_(2)reaction for CS was subject more to the catalytic effect of alkali compositions,while pore structure affected more the gasification reaction for PS char.The isoconversional kinetic analysis indicated that the gasification reaction became stable at carbon conversion of 0.5.Subsequently,sectionalized kinetic parameters were calculated for the initial gasification temperature to the temperature reaching 50%conversion.The result showed that high initial gasification temperature increased the char-CO_(2)gasification barrier to hardly start the reaction but accelerate the reaction rate.The carbon structure analyses further clarified that the reaction activation energy was highly related to the microcrystalline structure of carbon,while the reaction rate was more determined by carbon pore structure. | Zefeng Ge Xi Cao Zhenting Zha Yuna Ma Mingxun Zeng Yuqing Wu Zenghui Hou Huiyan Zhang | 2023 | Carbon Resources Conversion2023，6，2： | 0 |
| 12 | Quality assurance measures of bridge construction concrete technology显示文摘In recent years,with the development of the economy,drives Our country's transport industry,To increase the number of bridge construction projects,During the construction of a bridge project,The concrete process is a Key technology,It has an important impact on the quality of bridge engineering,other,The quality of bridge construction has a direct impact on social development in some degree.,and so on.,to the bridge Strict control of construction requirements.in the construction of Bridges,Concrete occupies a very large proportion,and its quality directly affects the quality of the entire bridge project,so,To enforce Quality control of concrete process in bridge engineering,The quality of the bridge works well..is based on this,First,the factors influencing the quality of concrete process during bridge construction are described.,and the quality control measures. | Ge Yong Wu Yuqing | 2018 | Concrete Technology2018，7，1： | 0 |
| 13 | SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication显示文摘Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe disease.However,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus transmission.Studying how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its infection.Here,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N protein.We found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’t.Further study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and mice.Mechanistically,N protein specifically interacted with anti-apoptotic protein MCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of MCL-1,which stabilized this protein and promoted it to hijack Bak in mitochondria.Importantly,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a MCL-1 specific inhibitor,S63845.Altogether,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral replication.These may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other viruses.We anticipate that abrogating the N/MCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses. | Pan Pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 14 | Anthropogenic influence on the extreme drought in eastern China in 2022 and its future risk显示文摘2022年夏季中国东部地区遭遇了一次持续性极端高温干旱事件.本文利用CMIP6检测归因比较计划(DAMIP)数据,量化了人为强迫对类2022年极端干旱事件发生概率的影响,并基于未来不同增暖情景试验给出了此类极端干旱事件的未来变化预估.通过分析不同外强迫因子作用下此类极端干旱事件的发生概率变化,发现人为强迫使此类极端干旱事件的发生概率提高约56%,这主要与人为强迫下中国东部平均水汽减少和平均上升运动减弱有关.进一步通过分析此类极端干旱事件对不同温室气体排放情景(SSP1-2.6,SSP2-4.5,SSP5-8.5)的响应,发现在低排放情景下类2022年极端干旱事件的发生概率较当今气候显著下降,这主要与中国东部平均水汽的增加和平均环流的变化有关,而在高排放情景(SSP5-8.5)下,此类极端干旱事件的发生概率较当今气候增加约79%,这主要与高排放情景下平均下沉运动增强有关.该研究表明,人为强迫通过调制气候平均背景场从而引起极端事件发生频次的变化是人类活动影响极端气候事件的重要途径之一,极端干旱事件对温室气体排放量的响应可能是非线性的. | Yinjun Zhang Lin Chen Yuqing Li Zi-An Ge | 2024 | Atmospheric and Oceanic Science Letters2024，17，1： | 0 |
| 15 | N,S-Doped Carbon Dots as Additive for Suppression of Zinc Dendrites in Alkaline Electrolyte显示文摘The severe dendrite growth on zinc anode in alkaline electrolyte brings great challenge to the development of zinc-based batteries.It is a simple and effective strategy to inhibit zinc dendrite formation by introducing additives into the electrolyte.In this study,N,S-doped carbon dots(TU-CQDs)were synthesized and used as additives to regulate zinc deposition in a typical KOH electrolyte.The experimental and three-dimensional transient nucleation model disclosed that the special functional groups of carbon dots can change the electrode surface state and the coordination behaviors of zinc species in the electrolyte.Therefore,TU-CQDs can not only inhibit the hydrogen evolution reaction,but also achieve uniform zinc deposition.The in-situ synchrotron radiation X-ray imaging elucidated that TU-CQDs can effectively inhibit the dendrite growth and improve the reversibility of zinc plating/stripping process.This work provides a feasible route for regulating the reversibility of zinc metal anode in alkaline electrolyte. | Shan Cai Ge Chang Jiugang Hu Jiae Wu Yuqing Luo Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2023 | Chinese Journal of Chemistry2023，41，14： | 0 |
| 16 | Anthropogenic influence on the occurrence of extreme drought like that in eastern China in 2019显示文摘2019年夏秋季中国东部遭遇了七十年一遇的强持续性极端干旱事件.本文借助于CMIP6检测归因模式比较计划(DAMIP)数据,量化了人为强迫对类似2019年极端干旱事件发生概率的影响.通过比较不同外强迫因子作用下此类极端干旱事件的发生概率,发现人为强迫可使此类极端干旱事件的发生概率提高8倍左右.进一步研究发现人为强迫引起的海表温度增暖是经向不均匀的,对应海洋大陆附近存在一个增暖大值中心,从而增强海洋大陆地区平均上升环流,通过局地Hadley环流作用导致中国东部地区平均垂直环流出现异常下沉,最终有利于中国东部极端干旱事件发生概率增加.该研究表明,人为强迫通过调制气候平均背景场从而引起极端事件发生频次的变化是人类活动影响极端气候事件的重要途径之一. | Yuqing Li Lin Chen Yinjun Zhang Xiaojun Wei Ming Sun Zi-An Ge | 2023 | Atmospheric and Oceanic Science Letters2023，16，3： | 0 |
| 17 | Research Progress of circRNAs during Epithelial- Mesenchymal Transition of Hepatocellular Carcinoma显示文摘Hepatocellular carcinoma is prone to invasion and metastasis.It often receives a low diagnosis rate in the early stage but has an extremely high mortality rate.Epithelial-mesenchymal transformation(EMT)is a key factor in promoting tumor cell invasion and metastasis.Circular RNA(circRNA)is involved in regulating EMT in hepatocarcinoma cells through multiple pathways,thereby affecting the occurrence and progression of hepatocellular carcinoma.This article mainly reviews the research progress of circRNA related to EMT core transcription factors,circRNA that promotes EMT in liver cancer,and circRNA that inhibits EMT in liver cancer. | Yuqing Li Cuicui Ren Yu Cai Chang Tian Yuanyuan Jia Ge Wu | 2024 | Proceedings of Anticancer Research2024，8，2： | 0 |
| 18 | Generation of coherent blue light via bichromatic pumping in cesium vapor显示文摘Diode-pumped alkali lasers,possessing high efficiency and narrow linewidth,can provide feasible solutions for wavelength ranges difficult to reach by commercial lasers.In this study,we investigate a generation of coherent blue light(CBL)via four-wave mixing(FWM)-based up-conversion processes in cesium(Cs)vapor.A bichromatic pumping scheme with 852-and 917-nm lasers drives the Cs atoms to the 6D5/2 excited level,followed by cascaded decay of 6D5/2→7 P3/2→6 S1/2,producing 456-nm CBL under phase matching conditions.The fluorescence in multiple bands from blue to near-and far-infrared in the FWM process is demonstrated under different experimental conditions.To optimize the experimental parameters,we investigate the dependence of 456-nm CBL on the vapor temperature,frequency,and intensity of the two pump lasers.A maximum power of 2.94 mW is achieved with pump powers of 430 mW(for 852 nm)and 470 mW(for 917 nm).The corresponding conversion efficiency is 1.5%/W,three-fold higher than those in previous studies.Our results can contribute to fundamental research on atom–photon interactions and quantum metrology. | Guiyuan Ge Li Tian Guoqing Zhang Ningxuan Zheng Wenliang Liu Vladimir Sovkov Jizhou Wu Yuqing Li Yongming Fu Peng Li Jie Ma Liantuan Xiao Suotang Jia | 2023 | Frontiers of physics2023，18，4： | 0 |
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