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| 1 | Process engineering in electrochemical energy devices innovation显示文摘This review focuses on the application of process engineering in electrochemical energy conversion and storage devices innovation. For polymer electrolyte based devices, it highlights that a strategic simple switch from proton exchange membranes(PEMs) to hydroxide exchange membranes(HEMs) may lead to a new-generation of affordable electrochemical energy devices including fuel cells, electrolyzers, and solar hydrogen generators. For lithium-ion batteries, a series of advancements in design and chemistry are required for electric vehicle and energy storage applications. Manufacturing process development and optimization of the LiF eP O_4/C cathode materials and several emerging novel anode materials are also discussed using the authors' work as examples.Design and manufacturing process of lithium-ion battery electrodes are introduced in detail, and modeling and optimization of large-scale lithium-ion batteries are also presented. Electrochemical energy materials and device innovations can be further prompted by better understanding of the fundamental transport phenomena involved in unit operations. | Yingying Xie Weimin Zhang Shuang Gu Yushan Yan Zi-Feng Ma | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 5 |
| 2 | Influence of Sanao Tang on urine volume and expression of aquaporin 2 in rats with respiratory function impairment induced by passive smoking and lipopolysaccharide显示文摘OBJECTIVE: To investigate the effect of Sanao Tang(SAT) on urine volume and the expression of aquaporin-2(AQP2) in rats with lung dysfunction induced by passive smoking and lipopolysaccharide.METHODS: Totally 45 healthy Specific pathogen Free Wistar Rats were randomized into 3 groups:normal control group, model group and SAT group.A rat model of respiratory dysfunction induced by exposure to cigarette smoking and lipopolysaccharide(LPS). Lavage of decoction of the Chinese medicine was performed for rats in the SAT group. Anires 2005 System was used to analyze the pulmonary function. Urine of rats was collected through metabolism cage method. Enzyme-linked immunosorbent assay(ELISA) was used to determine content of antidiuretic hormone(ADH), angiotensin Ⅱ(AngⅡ), atrial natriuretic factor(ANP), endothelin 1(ET-1), nitric oxide(NO) and prostaglandin E2(PGE2) in serum, lung and kidney. The expression of AQP2 in rat renal tissue was determined with real-time fluorescence quantitative PCR(RT-PCR).RESULTS:(a) In comparison with the normal control, It was found that enforced vital capacity(FVC),1-second forced expiratory volume/forced vital capacity%(FEV1/FVC%), 24 h urine volume content of NO and PGE2 were decreased, while AQP2 m RNA level and content of ADH, Agn Ⅱ, ANP and ET-1were increased in the model group with statistical significance(P < 0.05).(b) In comparison with the model group, It was found that FVC, FEV1, FEV1/FVC%, 24 h urine volume, content of PGE2 and NO decreased, while AQP2 m RNA level, content of ANP,ADH and AngⅡ decreased in the SAT group with statistical significance(P < 0.05).CONCLUSION: SAT might effectively regulate the urine volume in the modeled rats; ADH, Ang Ⅱ,ANP, ET-1, NO and PGE2 might play an important role in the regulation on urine volume by lungs.This might be the mechanisms underpinning the function of lung governing water passage in terms of the theory of Traditional Chinese Medicine. | Zhang Jinchao Sun Yan Zhang Shujing Gao Yushan Wang Zhenyi Liu Xiaolei Yang Jiamin Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 2 |
| 3 | Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula显示文摘Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. | Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，4： | 2 |
| 4 | Zeolite thin films; from computer chips to space stations显示文摘 | Lew C M Cai Rui Yan Yushan | 2009 | Accounts of Chemical Research2009，43，2： | 1 |
| 5 | Colloidal suspensions of template - removed zeolite nanocrystals 显示文摘 | Wang Huanting Wang Zhengbao Yan Yushan | 2000 | Chemical Communications2000，，23： | 1 |
| 6 | High-performance zeolite NaA membranes on polymer-zeolite composite hollow fiber suppor- ts 显示文摘 | Ge Qinqin Wang Zhengbao Yan Yushan | 2009 | Journal of the American Chemical Society2009，131，17： | 1 |
| 7 | Interfacial polymerization of thin film nanocomposites : A newconcept for reverse osmosis membranes 显示文摘 | JEONG Byeong Heon HOEK Ericm V YAN Yushan | 2007 | Journal of Mem-brane Science2007，294，12： | 1 |
| 8 | Oriented zeolite MFI monolayer films on metal substrates by in situ crys- tallization 显示文摘 | Wang Zhengbao Yan Yushan | 2001 | Microporous and Mesoporous Materi- als2001，48，13： | 1 |
| 9 | Methanol resistant cathodic catalyst for direct methanol fuel cells显示文摘 | Wang Xin Waje Mahesh Yan Yushan | 2004 | J Electro- chem Soc2004，151，12： | 1 |
| 10 | Chaos synchronization of semiconductor lasers over 1040-km fiber relay transmission with hybrid amplification显示文摘Optical chaos communication and key distribution have been extensively demonstrated with high-speed advantage but only within the metropolitan-area network range of which the transmission distance is restricted to around 300 km.For secure-transmission requirement of the backbone fiber link,the critical threshold is to realize long-reach chaos synchronization.Here,we propose and demonstrate a scheme of long-reach chaos synchronization using fiber relay transmission with hybrid amplification of an erbium-doped fiber amplifier(EDFA)and a distributed fiber Raman amplifier(DFRA).Experiments and simulations show that the hybrid amplification extends the chaos-fidelity transmission distance thanks to that the low-noise DFRA suppresses the amplified spontaneous emission noise and self-phase modulation.Optimizations of the hybrid-relay conditions are studied,including launching power,gain ratio of DFRA to EDFA,single-span fiber length,and number of fiber span.A 1040-km chaos synchronization with a synchronization coefficient beyond 0.90 is experimentally achieved,which underlies the backbone network-oriented optical chaos communication and key distribution. | LONGSHENG WANG JUNLI WANG YUSHAN WU YUEHUI SUN SONGSUI LI LIANSHAN YAN YUNCAI WANG ANBANG WANG | 2023 | Photonics Research2023，11，6： | 1 |
| 11 | Interfacial polymerization of thin film nanocompo-sites:a new concept for reverse osmosis membranes显示文摘 | JEONG Byeong-Heon HOEK Eric M V YAN Yushan | 2007 | Journal of Membrane Science2007，294，12： | 1 |
| 12 | Bactericidal and ammonia removal activity of silver ion-exchanged zeolite显示文摘 | K.K. Krishnani Yu Zhang Laj Xiong Yushan Yan Raj Boopathy Ashok Mulchandani | 2012 | Bioresource Technology2012，，： | 1 |
| 13 | Bactericidal and ammonia removal activity of silver ion-exchanged zeolite显示文摘 | Krishnani K K Zhang Yu Yan Yushan | | 0，，： | 1 |
| 14 | Electrochemical Deposition of Mesoporous Crystalline Oxide Semiconductor Films from Lyotropic Liquid Crystalline Phases 显示文摘 | Hongmei Luo Junfeng Zhang Yushan Yan | 2003 | Chem Mater2003，15，20： | 1 |
| 15 | Syn- thesis of template-free zeolite nanocrystals by using in situ thermoreversible polymer hydrogels 显示文摘 | Wang Huanting Holmberg B A Yan Yushan | 2003 | J Am Chem Soc2003，，125： | 1 |
| 16 | Synthesis, morphology control, and properties of porous metal–organic coordination polymers显示文摘 | Limin Huang Huanting Wang Jinxi Chen Zhengbao Wang Jinyu Sun Dongyuan Zhao Yushan Yan | 2002 | Microporous and Mesoporous Materials2002，，2： | 1 |
| 17 | Interfacial polymerization of thin film nanocomposites: A new concept for reverse osmosis membranes显示文摘 | Byeong-Heon Jeong Eric M.V. Hoek Yushan Yan Arun Subramani Xiaofei Huang Gil Hurwitz Asim K. Ghosh Anna Jawor | 2007 | Journal of Membrane Science2007，，1： | 1 |
| 18 | Synthesis of tem- plate free zeolite nanocrystals by reverse microemulsion microwave method 显示文摘 | Chen Zhongwei Li Shuang Yan Yushan | 2005 | Chem Mater2005，17，9： | 1 |
| 19 | Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia:targeted immunotherapy for acute lymphoblastic leukemia显示文摘The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.However,several studies showed that blinatumomab has a short plasma half-life due to its low molecular weight,and thus its clinical use is limited.Furthermore,multiple trials have shown that approximately 30%of blinatumomab-relapsed cases are characterized by CD19 negative leukemic cells.Here,we design and characterize two novel antibodies,A-319 and A-2019.Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures,and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.Our in vitro,ex vivo,and in vivo experiments demonstrated that A-319 and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells,enhancing T-cell function,mediating B-cell depletion,and eventually inhibiting tumor growth in Raji xenograft models.The two molecules are complementary in terms of efficacy and specificity profile.The activity of A-319 demonstrated superior to that of A-2019,whereas A-2019 has an additional capability to target CD20 in cells missing CD19,suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells. | Sisi Wang Lijun Peng Wenqian Xu Yuebo Zhou Ziyan Zhu Yushan Kong Stewart Leung Jin Wang Xiaoqiang Yan Jian-Qing Mi | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 20 | Three-Dimensional sp^(2) Carbon-Linked Covalent Organic Frameworks as a Drug Carrier Combined with Fluorescence Imaging显示文摘Three-dimensional(3D)covalent organic frameworks(COFs)are crystalline porous polymers with potential in numerous high-tech applications,but the linkages involved in their synthesis are still rather limited.Herein,we report novel 3D sp^(2) carbon-linked COFs fabricated by the formation reaction of C=C bonds and their application in fluorescence imaging.These new COFs,namely JUC-580 and JUC-581,show high stability and excellent light-emitting properties in solid state and dispersed in various solvents.Furthermore,we investigate the potential application of JUC-581 as a drug carrier combined with fluorescence imaging.These results indicate that 3D sp^(2) carbon-linked COFs are not only potential drug-loaded and sustained release materials but also promising cell fluorescent stains.This study thus expands the structural categories of 3D COFs based on different linkages,and promotes their prospective applications for biomedicine and fluorescent materials. | Li Liao Zerong Zhang Xinyu Guan Hui Li Yaozu Liu Minghao Zhang Bin Tang Valentin Valtchev Yushan Yan Shilun Qiu Xiangdong Yao Qianrong Fang | 2022 | Chinese Journal of Chemistry2022，40，17： | 1 |
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