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| 1 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 2 | Pulmonary tumor thrombotic microangiopathy of hepatocellular carcinoma: A case report and review of literature显示文摘BACKGROUND Pulmonary tumor thrombotic microangiopathy(PTTM)is a rare condition in patients with hepatocellular carcinoma(HCC);to date,few cases have been reported.While hepatic dysfunction has been focused on the later stages of HCC,the management of symptoms in PTTM is important for supportive care of the cases.For the better understanding of PTTM in HCC,the information of our recent case and reported cases have been summarized.CASE SUMMARY A patient with HCC exhibited acute and severe respiratory failure.Radiography and computed tomography of the chest revealed the multiple metastatic tumors and a frosted glass–like shadow with no evidence of infectious pneumonia.We diagnosed his condition as acute respiratory distress syndrome caused by the lung metastases and involvement of the pulmonary vessels by tumor thrombus.Administration of prednisolone to alleviate the diffuse alveolar damages including edematous changes of alveolar wall caused by the tumor cell infiltration and ischemia showed mild improvement in his symptoms and imaging findings.An autopsy showed the typical pattern of PTTM in the lung with multiple metastases.CONCLUSION PTTM is caused by tumor thrombi in the arteries and thickening of the pulmonary arterial endothelium leading to the symptoms of dyspnea in terminal staged patients.Therefore,supportive management of symptoms is necessary in the cases with PTTM and hence we believe that the information presented here is of great significance for the diagnosis and management of symptoms of PTTM with HCC. | Shinichi Morita Kenya Kamimura Hiroyuki Abe Yukari Watanabe-Mori Chiyumi Oda Takamasa Kobayashi Yoshihisa Arao Yusuke Tani Riuko Ohashi Yoichi Ajioka Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，48： | 4 |
| 3 | Damage Level of Road Infrastructure and Road Traffic Performance in the Mid Niigata Prefecture Earthquake of 2004 显示文摘 | Tokida Ken-Ichi Oda Kazuhiro Nabeshima Yasuyuki Egawa Yusuke | 2007 | Structural Engineering & earthquake Engineering2007，24，1： | 1 |
| 4 | A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy显示文摘 | Ryo Suzuki Yusuke Oda Naoki Utoguchi Eisuke Namai Yuichiro Taira Naoki Okada Norimitsu Kadowaki Tetsuya Kodama Katsuro Tachibana Kazuo Maruyama | 2008 | Journal of Controlled Release2008，，3： | 1 |
| 5 | miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition显示文摘Glioblastoma is the most aggressive and invasive brain tumor and has a poor prognosis;elucidating the underlying molecular mechanisms is essential to select molecular targeted therapies.Here,we investigated the effect of microRNAs on the marked invasiveness of glioblastoma.U373 glioblastoma cells were infected with 140 different microRNAs from an OncomiR library,and the effects of the invasion-related microRNAs and targeted molecules were investigated after repeated Matrigel invasion assays.Screening of the OncomiR library identified miR-23a as a key regulator of glioblastoma invasion.In six glioblastoma cell lines,a positive correlation was detected between the expression levels of miR-23a and invasiveness.A luciferase reporter assay demonstrated that homeobox D10(HOXD10)was a miR-23a-target molecule,which was verified by high scores from both the PicTar and miRanda algorithms.Forced expression of miR-23a induced expression of invasion-related molecules,including uPAR,RhoA,and RhoC,and altered expression of glial-mesenchymal transition markers such as Snail,Slug,MMP2,MMP9,MMP14,and E-cadherin;however,these changes in expression levels were reversed by HOXD10 overexpression.Thus,miR-23a significantly promoted invasion of glioblastoma cells with polarized formation of focal adhesions,while exogenous HOXD10 overexpression reversed these phenomena.Here,we identify miR-23a-regulated HOXD10 as a pivotal regulator of invasion in glioblastoma,providing a novel mechanism for the aggressive invasiveness of this tumor and providing insight into potential therapeutic targets. | Kazuhiro Yachi Masumi Tsuda Shinji Kohsaka Lei Wang Yoshitaka Oda Satoshi Tanikawa Yusuke Ohba Shinya Tanaka | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 1 |
| 6 | Randomized phase II trial of first-line treatment with tailored irinotecan and S-1 therapy versus S-1 monotherapy for advanced or recurrent gastric carcinoma (JFMC31-0301)显示文摘 | Yoshito Komatsu Yutaka Takahashi Yutaka Kimura Hisashi Oda Yusuke Tajima Shigeyuki Tamura Jo Sakurai Takehiro Wakasugi Shigeru Tatebe Masahiro Takahashi Yuh Sakata Masaki Kitajima Junichi Sakamoto Shigetoyo Saji | 2011 | Anti-Cancer Drugs2011，，6： | 1 |
| 7 | Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles显示文摘 | Ryo Suzuki Yusuke Oda Naoki Utoguchi Kazuo Maruyama | 2010 | Journal of Controlled Release2010，，1： | 1 |
| 8 | Histological and prognostic importance of CD 44+/ CD 24+/ E p CAM + expression in clinical pancreatic cancer显示文摘 | Yusuke Ohara Tatsuya Oda Masato Sugano Shinji Hashimoto Tsuyoshi Enomoto Keiichi Yamada Yoshimasa Akashi Ryoichi Miyamoto Akihiko Kobayashi Kiyoshi Fukunaga Yukio Morishita Nobuhiro Ohkohchi | 2013 | Cancer Sci2013，，8： | 1 |
| 9 | Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report显示文摘BACKGROUND Hepatocellular carcinoma(HCC)accompanied by portal vein tumour thrombus(PVTT)presents an aggressive disease course,worsening liver function reserve,and a high recurrence rate.Clinical practice guidelines recommend systemic therapy as the first-line option for HCC with portal invasion.However,to achieve longer survival in these patients,the treatment strategy should be concluded with removal of the tumour by locoregional therapy.We experienced a case of initially unresectable HCC with main PVTT converted to radical hepatectomy after lenvatinib treatment.CASE SUMMARY A 59-year-old male with chronic hepatitis C infection visited our clinic as a regular post-surgery follow-up.Contrast-enhanced abdominal computed tomography revealed a liver mass diffusely located at the lateral segment with a massive PVTT extending from the umbilical portion to the main and contralateral third-order portal branches.With the diagnosis of unresectable HCC with Vp4(main trunk/contralateral branch)PVTT,lenvatinib was started at 12 mg/d.The computed tomography taken 3 mo after starting lenvatinib showed regression of the PVTT,which had retreated to the contralateral first-order portal branch.He tolerated the full dose without major adverse effects.With cessation of lenvatinib for 7 d,radical left lobectomy and PVTT thrombectomy were conducted.The patient’s postoperative course was uneventful.Microscopically,the primary lesion showed fibrotic changes,with moderately to poorly differentiated tumour cells surrounded by granulation tissues in some areas.The majority of the PVTT showed necrosis.He was alive without recurrence for 8 mo.CONCLUSION This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment. | Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda | 2021 | World Journal of Hepatology2021，13，3： | 1 |
| 10 | Development of cell-targeting bubble liposome for effective gene delivery with ultrasound显示文摘Previously,we developed a gene delivery system using Bubble liposomes(perfluoropropane gas-entrapping liposomes;BLs)and ultrasound(US)[1].The combination of BLs and US can deliver plasmid DNA into the cytoplasm via the formation of transient membrane pores by cavitation.To enhance the efficiency of gene delivery,it is important to induce the cavitation of BLs at the vicinity of cells.In brief,cell-binding BLs would be useful for gene delivery to induce the cavitation on the cell membrane. | Mutsumi Sugii Ryo Suzuki Yusuke Oda Johan Unga Daiki Omata Hitoshi Uruga Yoichi Negishi Kazuo Maruyama | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
| 11 | Development of tissue-selective gene delivery system with ultrasound显示文摘Gene therapy is applied into cardiovascular diseases,cancer and diseases that are due to genomic causes.Viral vectors are efficient carriers of genes for transduction,but some problems have become evident.Delivery vectors that are highly potent in terms of gene transduction efficiency should also be safe and easy to apply.Non-viral vectors have recently received focus as gene carriers,but their transduction efficiency is very low and not suitable for in vivo gene delivery.In addition,it is important to develop tissue-specific or selective gene delivery system to avoid side effects in gene therapy. | Ryo Suzuki Daiki Omata Yusuke Oda Mutsumi Sugii Hitoshi Uruga Johan Unga Yoichi Negishi Sanae Oda Kazuo Maruyama | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
| 12 | Ion-beam treatment in Hyogo Ion Beam Medical Center (HIBMC)显示文摘 | Yoshio Hishikawa Daisuke Miyawaki Yasue Oda Yusuke Demizu Masao Murakami | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 13 | Rocket Propulsion Powered Using a Gyrotron显示文摘 | Masafumi Fukunari Kimiya Komurasaki Yusuke Nakamura Yasuhisa Oda Keishi Sakamoto | 2017 | Journal of Energy and Power Engineering2017，11，6： | 0 |
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