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| 1 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 2 | Modeling investigation of geometric size effect on pervaporation dehydration through scaled-up hollow fiber NaA zeolite membranes显示文摘A mass transfer model in consideration of multi-layer resistances through Na A zeolite membrane and lumen pressure drop in the permeate side was developed to describe pervaporation dehydration through scaled-up hollow fiber supported NaA zeolite membrane. It was found that the transfer resistance in the lumen of the permeate side is strongly related with geometric size of hollow fiber zeolite membrane, which could not be neglected. The effect of geometric size on pervaporation dehydration could be more significant under higher vacuum pressure in the permeate side. The transfer resistance in the lumen increases with the hollow fiber length but decreases with lumen diameter. The geometric structure could be optimized in terms of the ratio of lumen diameter to membrane length. A critical value of dI/L(R_c) to achieve high permeation flux was empirically correlated with extraction pressure in the permeate side. Typically, for a hollow fiber supported Na A zeolite membrane with length of0.40 m, the lumen diameter should be larger than 2.0 mm under the extraction pressure of 1500 Pa. | Jiacheng Wang Peng Ye Xuechao Gao Yuting Zhang Xuehong Gu | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 4 |
| 3 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 4 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 5 | FeCe nanocomposite with high iron content as efficient catalyst for generation of COx-free hydrogen via ammonia decomposition显示文摘FeCe nanocomposite catalysts with different iron contents were synthesized by a facile co-precipitation method.The as-prepared materials were characterized by various techniques including powder X-ray diffraction(XRD),N2 adsorption/desorption and high-resolution transmission electron microscopy(HRTEM).Catalyst with the highest iron content(90 FeCe) shows the best activity for the hydrogen generation via ammonia decomposition.83% NH3 conversion is achieved at 550℃ and nearly full conversion of NH3 is realized at 600℃ with a GHSV of 24000 cm3/(gcat·h).The large content and small size crystal particles of iron species are responsible for the good catalytic performance.Temperatureprogrammed reduction by hydrogen(H2-TPR) was performed to investigate the interaction between cerium and iron species.It is found that slight cerium can exert strong interaction with iron compound thus effectively prevent the self-aggregation of active iron species,so as to improve the catalytic activity for ammonia decomposition. | Yingqiu Gu Xiaoya Chen Shuang Zhao Yuting Zhang | 2020 | Journal of Rare Earths2020，38，10： | 3 |
| 6 | Surface sulfur vacancies enhanced electron transfer over Co-ZnS quantum dots for efficient degradation of plasticizer micropollutants by peroxymonosulfate activation显示文摘Peroxymonosulfate(PMS)activation in heterogeneous processes is a promising water treatment technology.Nevertheless,the high energy consumption and low efficiency during the reaction are ineluctable,due to electron cycling rate limitation.Herein,a new strategy is proposed based on a quantum dots(QDs)/PMS system.Co-ZnS QDs are synthesized by a water phase coprecipitation method.The inequivalent lattice-doping of Co for Zn leads to the generation of surface sulfur vacancies(SVs),which modulates the surface of the catalyst to form an electronic nonequilibrium surface.Astonishingly,the plasticizer micropollutants can be completely degraded within only tens of seconds in the Co-Zn S QDs/PMS system due to this type of surface modulation.The interfacial reaction mechanism is revealed that pollutants tend to be adsorbed on the cobalt metal sites as the electron donors,where the internal electrons of pollutants are captured by the metal species and transferred to the surface SVs.Meanwhile,PMS adsorbed on the SVs is reduced to radicals by capturing electrons,achieving effective electron recovery.Dissolved oxygen(DO)molecules are also easily attracted to catalyst defects and are reduced to O_(2)^(·-),further promoting the degradation of pollutants. | Yuting Gu Tingting Gao Fagen Zhang Chao Lu Wenrui Cao Ziwei Fu Chun Hu Lai Lyu | 2022 | Chinese Chemical Letters2022，33，8： | 2 |
| 7 | Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways显示文摘 | Su Jing Ding Xiaoying Xu Ying Liu Rui Gu Mingyu Chen Yuting Yin Yanhua Wang Yufan Sun Haiyan Peng Yongde | 2014 | Clin Endocrinol2014，，6： | 1 |
| 8 | Size-dependent gene delivery of amine-modified silica nanoparticles显示文摘基于硅石的 nanoparticles 为基因交货应用正在答应搬运人。到进基因 transfection 效率上的粒子尺寸的效果的获得卓见,修改胺的 monodisperse 圣 ? ber 范围(有 125, 230, 330, 440,和 570 nm 的直径的 NH 2-SS) 被综合。在里面为交付编码绿色的 plasmid DNA 的 NH 2-SS 的 vitro transfection 效率荧光灯蛋白质(GFP )(pcDNA3-EGFP,作为 pcDNA 缩短了, 6.1 kbp ) 在 HEK293T 房间被学习。有 330 nm 的一条直径的 NH 2-SS (NH 2-SS330) 与另外的尺寸与 NH 2-SS 粒子相比显示出最高的 GFP transfection 水平。transfection 效率作为在有约束力的能力和 NH 2-SS330 的细胞的举起性能之间的妥协被发现, pcDNA 结合。NH 2-SS330 也与 8.9 kbp 的一种更大的尺寸为 plasmid DNA (pDNA ) 表明了最高的 transfection 效率。到我们的知识,这研究是第一在基于硅石的基因交货系统为基因 transfection 效率表明粒子尺寸的意义。我们的调查结果对为基因治疗的合成向量的合理设计关键。 | Meihua Yu Yuting Niu Jun Zhang Hongwei Zhang Yannan Yang Elena Taran Siddharth Jambhrunkar Wenyi Gu Peter Thorn Chengzhong Yu | 2016 | Nano Research2016，9，2： | 1 |
| 9 | Discovery of spirooxindole-ferrocene hybrids as novel MDM2 inhibitors显示文摘A series of spirooxindole-ferrocene hybrids bearing five or four contiguous chiral centers were designed and synthesized via organocatalysis.In vitro protein binding and cellular proliferation assays suggested that compound 5 d was the most potent mouse double minute 2 homolog(MDM2)inhibitor.In addition,mechanistic studies indicated that compound 5 d suppressed MDM2-mediated p53 degradation,induced apoptosis and promoted oxidative damage.Molecular docking studies have suggested that 5 d binds to MDM2 by mimicking the Trp23 and Leu26 residues of p53.This work can provide a basis for the development of novel multifunctional MDM2 inhibitors.The further exploration of more derivatives from this library and additional investigation of organocatalysis application in the development of new molecules may generate new potential lead compounds for cancer-targeted therapy. | Jun Mu Xin Xie Shanshan Xiong Yuehua Zhang Yuting Wang Qian Zhao Hongping Zhu Wei Huang Gu He | 2021 | Chinese Chemical Letters2021，32，6： | 1 |
| 10 | Fast-chargingand dendrite-free lithiummetal anodeeenabledby partial lithiation ofgraphene aerogel显示文摘The development of deeply cyclable lithium metal batteries with fast-charging capability offers a promising solution to relieve the“range anxiety”in driving electric vehicles.Conventional lithium metal anodes suffered from low operating current densities and shallow charge/discharge depths,owing to the intrinsic dendrite growth governed by Sand’s law.Herein,we come up with a novel design of heavy-duty lithium metal anode fabricated by partially infusing the three-dimensional(3D)porous graphene aerogel with molten Li.Both electroanalytical measurements and simulations show that the unique electrode architecture brings notable advantages in mediating smooth Li plating/stripping,including reduced local current density,inhibited dendrite growth,buffered volume fluctuation,as well as more efficient Li utilization.Consequently,a remarkable cycling performance in symmetric cells for over 400 cycles(800 h)with an ultrahigh cycling capacity of 15 mAh·cm^(−2) at 15 mA·cm^(−2) is achieved,which,to our best knowledge,has been never seen in literature.LiFePO4 full cells demonstrate a superb rate capability up to 10 C and a prolonged cycling of 1,600 cycles at 2 C with the per-cycle capacity decay of only 0.023%.This study paves the way for the ultimate deployment of lithium metal batteries in real-world applications that require fast charging and deep cycling. | Yong Ma Yuting Gu Ying He Le Wei Yuebin Lian Weiyi Pan Xinjian Li Yanhui Su Yang Peng Zhao Deng Zhongfan Liu | 2022 | Nano Research2022，15，11： | 1 |
| 11 | Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats显示文摘The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats. | Zhou Xiaoqin Liu Jia Dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan Xue | 2021 | Genes & Diseases2021，8，3： | 1 |
| 12 | A new pin-to-plate corona discharger with clean air protection for particulate matter removal显示文摘High concentration particulate matter(PM)has been a serious environmental problem in China and other devel-oping countries.Electrostatic-based purification technology is a method to remove airborne particles,and can reduce the energy consumption of ventilation fans in buildings because of its low pressure drop.In this study,we developed a new pin-to-plate corona discharger with particle-free external air protection to prevent particles polluting the surface of discharge pins.By using an optical microscope,we observed a certain number of parti-cles deposited on the non-protected(exposed pins)and few particles deposited on the protected pins after they operating for 3 weeks.We experimentally studied the long-term performances of the exposed and protected pins in single-pass PM removal efficiency and ozone production.The results showed that the protected pins produce less ozone and have higher breakdown voltage than the exposed pins.Experimental results indicated that the im-proved pin-to-plate corona discharger has better long-term performance and is safer than the exposed one.The results of the research can give an understanding of how to improve electrostatic-based purification technologies toward stable discharging for high removal efficiency of particles. | Yuting Gu Enze Tian Fanxuan Xia Tao Yu Alireza Afshari Jinhan Mo | 2020 | Energy and Built Environment2020，1，1： | 0 |
| 13 | Long-term outcomes of intraoperative radiotherapy for early-stage breast cancer in China: amulticenter real-world study显示文摘Dear Editor,Intraoperative radiotherapy(IORT)is an accelerated par-tial breast irradiation(APBI)treatment that is accom-plished intraoperatively.Numerous clinical trials indicate that IORT is safe and effective,non-inferior to standard whole-breast external beam radiotherapy(EBRT)for low-risk patients who receive breast-conserving surgery[1-3].Nevertheless,these studies mainly included non-Asians and thus lack adequate evidence to support the value of IORT in Asian patients with breast cancer. | Xin Wang Kexin Feng Wenyan Wang Xiangzhi Meng Jiaqi Liu Yang Yang Yuting Zhong Jingruo Li Shikai Wu Minghui Li Pan Ma Qinfu Feng Hongmei Zeng Yuanting Gu Xiru Li Zhaoqing Fan Xiang Wang | 2022 | Cancer Communications2022，42，3： | 0 |
| 14 | Peroxidase-like single Fe atoms anchored on Ti_(3)C_(2)T_(x)MXene as surface enhanced Raman scattering substrate for the simultaneous discrimination of multiple antioxidants显示文摘Single-atom nanozymes(SAzymes)are emerging as promising alternatives to mimic natural enzyme,which is due to high atomic utilization efficiency,well-defined geometric,and unique electronic structure.Herein,Fe single atoms supported on Ti_(3)C_(2)T_(x)(Fe-SA/Ti_(3)C_(2)T_(x))with intrinsic peroxidase activity is developed,further constructing a sensitive Raman sensor array for sensing of five antioxidants.Fe-SA/Ti_(3)C_(2)T_(x)shows excellent peroxidase-like performance in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine(TMB)with colorimetric reactions.X-ray adsorption fine structure(XAFS)reveals that the electron transport between the Ti_(3)C_(2)T_(x)and Fe atoms occurs along Fe-O-Ti ligands,meanwhile the density functional theory(DFT)calculations confirm the spontaneous dissociation of H_(2)O_(2)and the formation of OH radicals.Furthermore,the peroxidase-like Fe-SA/Ti_(3)C_(2)T_(x)was used as surface enhanced Raman scattering(SERS)substrate of oxidized TMB(TMB+)and achieved satisfied signal amplification performance.Using the blocking effects of free radical reactions,one-off identification of 5 antioxidants,including ascorbic acid(AA),uric acid(UA),glutathione(GSH),melatonin(Mel),and tea polyphenols(TPP),could be realized with this high identifiable catalytic property.This principle could realize 100%distinguish accuracy combined with linear discriminant analysis(LDA)and heat map data analysis.A wide detection concentration ranges from 10^(-8)to 10^(-3)M for five antioxidants was also achieved. | Hongyan Xi Hongfei Gu Yurui Han Tingting You Pengfei Wu Qingqing Liu Lirong Zheng Shuhu Liu Qiang Fu Wenxing Chen Yukun Gao Yuting Wang Penggang Yin | 2023 | Nano Research2023，16，7： | 0 |
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