6篇
您的检索式：作者名="Yvonne Cheng"
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| 1 | Silencing ofα-complex protein-2 reverses alcohol-and cytokine-induced fibrogenesis in hepatic stellate cells显示文摘Background and aim:a-complex protein-2(aCP2)encoded by the poly(rC)binding protein 2(PCBP2)gene is responsible for the accumulation of type I collagen in fibrotic livers.In this study,we silenced the PCBP2 gene using a small interfering RNA(siRNA)to reverse alcohol-and cytokine-induced profibrogenic effects on hepatic stellate cells(HSCs).Methods:Primary rat HSCs and the HSC-T6 cell line were used as fibrogenic models to mimic the initiation and perpetuation stages of fibrogenesis,respectively.We previously found that a PCBP2 siRNA,which efficiently silences expression of aCP2,reduces the stability of type I collagen mRNA.We investigated the effects of the PCBP2 siRNA on cell proliferation and migration.Expression of type I collagen in HSCs was analyzed by quantitative real-time PCR and western blotting.In addition,we evaluated the effects of the PCBP2 siRNA on apoptosis and the cell cycle.Results:PCBP2 siRNA reversed multiple alcohol-and cytokine-induced profibrogenic effects on primary rat HSCs and HSC-T6 cells.The PCBP2 siRNA also reversed alcohol-and cytokine-induced accumulation of type I collagen as well as cell proliferation and migration.Moreover,the combination of LY2109761,a transforming growth factor-b1 inhibitor,and the PCBP2 siRNA exerted a synergistic inhibitive effect on the accumulation of type I collagen in HSCs.Conclusions:Silencing of PCBP2 using siRNA could be a potential therapeutic strategy for alcoholic liver fibrosis. | Hao Liu Zhijin Chen Wei Jin Ashutosh Barve Yu-Jui Yvonne Wan Kun Cheng | 2017 | Liver Research2017，1，1： | 2 |
| 2 | Hydrogen sulphide regulates intra- cellular pH in vascular smooth muscle cells显示文摘 | Shiau Wei Lee Yvonne Cheng Philip K Moore | 2007 | Biochem Biophys Res Commun2007，358，4： | 1 |
| 3 | Velamentous cord insertion: is it associated with adverse perinatal outcomes?*显示文摘 | Tania F. Esakoff Yvonne W. Cheng Jonathan M. Snowden Susan H. Tran Brian L. Shaffer Aaron B. Caughey | 2014 | The Journal of Maternal-Fetal & Neonatal Medicine2014，，： | 1 |
| 4 | Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments显示文摘 | Sun Kun Jiang Peiyong Chan K. C. Allen Wong John Cheng Yvonne K. Y. Liang Raymond H. S. Chan Wai-kong Ma Edmond S. K. Chan Stephen L. Cheng Suk Hang Chan Rebecca W. Y. Tong Yu K. Ng Simon S. M. Wong Raymond S. M. Hui David S. C. Leung Tse Ngong Leung Tak | 2015 | Proceedings of the National Academy of Sciences2015，，40： | 1 |
| 5 | Nonremoval of an abnormally invasive placenta at cesarean section with postoperative uterine artery embolization显示文摘 | Man Y. Chung Yvonne K.Y. Cheng Simon C.H. Yu Daljit S. Sahota Tak Y. Leung | 2013 | Acta Obstet Gynecol Scand2013，，11： | 1 |
| 6 | Fundal height: a useful screening tool for fetal growth?显示文摘 | Teresa N. Sparks Yvonne W. Cheng Blake McLaughlin Tania F. Esakoff Aaron B. Caughey | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，4： | 1 |
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