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| 1 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 2 | Collaboration in R&D activities: Firm-specific decisions显示文摘 | Zehui Ge Qiying Hu | 2007 | European Journal of Operational Research2007，，2： | 2 |
| 3 | TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal显示文摘Dysregulation of gut homeostasis is associated with irritable bowel syndrome(IBS),a chronic functional gastrointestinal disorder affecting approximately 11.2%of the global population.The poorly understood pathogenesis of IBS has impeded its treatment.Here,we report that the E3 ubiquitin ligase tripartite motif-containing 27(TRIM27)is weakly expressed in IBS but highly expressed in inflammatory bowel disease(IBD),a frequent chronic organic gastrointestinal disorder.Accordingly,knockout of Trim27 in mice causes spontaneously occurring IBS-like symptoms,including increased visceral hyperalgesia and abnormal stool features,as observed in IBS patients.Mechanistically,TRIM27 stabilizesβ-catenin and thus activates Wnt/β-catenin signaling to promote intestinal stem cell(ISC)self-renewal.Consistent with these findings,Trim27 deficiency disrupts organoid formation,which is rescued by reintroducing TRIM27 orβ-catenin.Furthermore,Wnt/β-catenin signaling activator treatment ameliorates IBS symptoms by promoting ISC self-renewal.Taken together,these data indicate that TRIM27 is critical for maintaining gut homeostasis,suggesting that targeting the TRIM27/Wnt/β-catenin axis could be a potential treatment strategy for IBS.Our study also indicates that TRIM27 might serve as a potential biomarker for differentiating IBS from IBD. | Jing Wang Dongdong Zhao Zehui Lei Pupu Ge Zhe Lu Qiyao Chai Yong Zhang Lihua Qiang Yang Yu Xinwen Zhang Bingxi Li Shu Zhu Lingqiang Zhang Cui Hua Liu | 2023 | Cellular & Molecular Immunology2023，20，2： | 2 |
| 4 | Collaboration in R&D activities: Firm - specific decisions 显示文摘 | ZEHUI GE QIYING HU | 2008 | European Journal of Operational Research2008，185，2： | 1 |
| 5 | The circumferential mechanical properties of bamboo with uniaxial and biaxial com- pression tests显示文摘 | Jiang Zehui Chen Fuming Wang Ge | 2012 | BioResources2012，7，4： | 1 |
| 6 | Growth of ZnO nanofilmson wood with improved photostability显示文摘 | Yan Yu Zehui Jiang Ge Wang | 2009 | Holzforschung2009，64，： | 1 |
| 7 | Collaboration in R&zD activities: Firm-specific decisions显示文摘 | Ge Zehui Hu Qiying | 2008 | European Journal of Operational Re- search2008，185，2： | 1 |
| 8 | A Bounded Commitment in Vertical Collaborations of New Product Development显示文摘Uncertainty is a main source of opportunistic behaviors in research and development cooperations,which challenges strategic decisions ranging from investments to operations.To avoid opportunism arising in cooperations,commitments(either formal contracts or informal communications)are generally made in advance by members of an alliance.However,how does a commitment encourage R&D investments and ultimately enhance the total performance,without loss of flexibility in ex post operations?This study attempts to answer this by investigating a bounded commitment in the context of vertical collaborations in a supply chain.In this exploratory study,a 3-stage game model is used(by backward induction)to examine a two-echelon supply chain under a bounded commitment in NPD.Our analysis shows that upstream R&D investment is stimulated more and that both members are better off under the bounded commitment.At the same time,when the relative bargaining power between the supplier and the manufacturer falls into an appropriate area,it is possible to reach a bounded commitment,and the manufacturer is more sensitive to this relationship.Finally,the bounded commitment restrains opportunistic behaviors,but there is no strong sign that an increase in the ratio of the order outside the chain to the inside one can make firms better. | Zehui GE Zhengkun REN Qiying HU Yiheng JIA | 2021 | Journal of Systems Science and Information2021，9，2： | 0 |
| 9 | Visualization of Cellulose Microfibrils of Phyllostachys pubescens Fibers with Atomic Force Microscope显示文摘Atomic force microscope(AFM) was used to investigate the arrangement of cellulose microfibrils (CMF) in Moso bamboo (Phyllostachys pubescens) fibers. Two methods of sample preparation were used here for different purposes. The first method was chemical maceration with a mixture of hydrogen peroxide and glacial acetic acid, through which the obtained fibers were suitable for observing the orientation of CMF in the primary wal1. The other method was to prepare tangential microtomed sections with a thickness of approximately 30 μm, which was used to investigate the arrangement of CMF in the inner wall of cell cavity of bamboo fibers. The results indicated that the CMF are randomly oriented in the primary wall while in the inner wall of cell cavity they are nearly vertical to the long axis of fibers , which is similar to the arrangement of CMF in the corresponding layer of wood fibers. Meanwhile, the highly oriented arrangement of CMF is also observed in a certain layer of bamboo fibers, though it is incapable of determining which layer it is in this study. The pilot investigation demonstrates that AFM is a powerful tool for the high-resolution observation of CMF in bamboo fibers, meanwhile it has the advantages of simple procedure of sample preparation and easy operation compared to the traditional transmission electron microscopy. | YU Yan JIANG Zehui WANG Ge QIN Daochun CHENG Qiang International Centre for Bamboo and Rattan, Beijing 100102, P. R. China | 2008 | Chinese Forestry Science and Technology2008，7，3： | 0 |
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