|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Galectin-3 gene silencing inhibits migration and invasion of human tongue cancer cells in vitro via downregulating β-catenin显示文摘 | Dong ZHANG Zheng-gang CHEN Shao-hua LIU Zuo-qing DONG Martin DALIN Shi-san BAO Ying-wei HU Feng-cai WEI | 2013 | Acta Pharmacologica Sinica2013，34，1： | 10 |
| 2 | Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer显示文摘地岬相当或相同的事物基因家庭成员 A (RhoA ) 作为肿瘤的一个批评管理者被识别了好攻击的行为。在 thisstudy,我们在位于有鳞的细胞 carcinomaof 舌头(TSCC ) 的生长,移植,和侵略下面的机制估计了 RhoA 的角色。TSCC 房间线 SCC-4 和 CAL27 击倒的稳定的 RhoA 用 Lentiviral transfection 被完成。房间移植,侵略,和房间增长上的 RhoA 弄空的 Theeffects 是坚定的。TSCC 房间线上的可能的位于决定 Galectin-3 (Gal-3 ) 的表示下面 mechanismof RhoA 弄空被也评估,在 vivo 的 -catenin, andmatrix metalloproteinase-9 (MMP-9 ) 。同时, TSCC 生长的内在的机制被 cyclin D1/2 的分析学习, p21 CIP1/WAF1 , 和 p27 Kip1 蛋白质层次。Immunohistochemical 评价被执行进一步证明 Gal-3 和 -catenin expression.We 的改变发现了那,在与在舌头的人的 TSCC 房间注射的老鼠, RhoA 层次与在正常纸巾的那些相比在主要肿瘤和 metastasizedlymph 节点是更高的。RhoA 的 Silencing 显著地减少了肿瘤生长, Gal-3 的 decreasedthe 层次, -catenin, MMP-9,和 cyclin D1/2,并且增加了 p21 CIP1/WAF1 和 p27 Kip1 。在 vitro, RhoA 击倒也导致了房间移植,侵略,和增长的抑制。我们的数据建议 RhoA 由通过分别地通过房间周期规定表明小径 andcell 增长的 Wnt/-catenin 调整房间移植和侵略在 TSCC 前进起 asignificant 作用。RhoA 可能是 TSCC 的一个新奇治疗学的目标。 | Guoxin Yan Ronghai Zou Zhenggang Chen Bing Fan Zhaoyan Wang Ying Wang Xiaonan Yin Dong Zhang Lei Tong Fang Yang Weina Jiang Wensheng Fu Jiwei Zheng Martin O. Bergo Martin Dalin Jiawei Zheng Shulan Chen Jianhua Zhou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 7 |
| 3 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 4 | Effects of folic acid on in vitro astrocytic differentiation of neural stem cells from neonatal rats显示文摘BACKGROUND:Folic acid is essential for normal functioning of the nervous system.Previous studies have focused on the effects of folic acid on astrocyte proliferation. OBJECTIVE:To explore the effects of folic acid on astrocyte differentiation of neural stem cells (NSCs) and the related mechanisms in vitro. DESIGN,TIME AND SETTING:A randomized,controlled,grouping experiment was performed in Tianjin Medical University between August 2007 and October 2008. MATERIALS:Folic acid and 5-bromo-2-deoxyuridine(BrdU) were obtained from Sigma,MO,USA. Primary antibodies[rabbit anti-rat nestin,β-tubulin-Ⅲ,glial fibrillary acidic protein,and neurogenin1 (Ngn1);mouse anti-rat BrdU andβ-actin monoclonal antibodies]were purchased from Santa Cruz Biotechnology,USA. METHODS:At 6 days of NSC proliferation from 24-hour-old neonatal rats,BrdU incorporation assay was performed.Seven days after primary culture,NSCs were induced to differentiate with medium containing 5%fetal bovine serum.Cultured NSCs were assigned to three groups:control,low-dose (liquid media with 8 mg/L folic acid),and high-dose folic acid(liquid media with 44 mg/L folic acid). MAIN OUTCOME MEASURES:At day 7 after primary culture,the cells were identified as NSCs by immunocytochemical methods.Double-label immunofluorescence technique for glial fibrillary acidic protein/BrdU detected differentiated cells 7 days after induction.Western blot was used to analyze expression of Ngn1 protein in NSCs. RESULTS:In serum-free suspension medium,neurospheres comprised a large number of Nestin-, glial fibrillary acidic protein-,β-tubulin-Ⅲ-,and BrdU-positive cells.Compared with the control group, high-dose folic acid supplementation led to an marked increase in the percentage of glial fibrillary acidic protein/BrdU-positive cells(P<0.05),and significantly decreased Ngn1 protein expression (P<0.05). CONCLUSION:Folic acid promotes astrocytic differentiation of NSCs,which might be related to downregulation of Ngn1 protein expression. | Xumei Zhang Guowei Huang Zhihong Tian Guanglei Wang Dalin Ren | 2009 | Neural Regeneration Research2009，4，8： | 4 |
| 5 | Design and Experimental Evaluation of PID Controller for Digital Electro-Pneumatic Cabin Pressure Control System显示文摘The performance of the designed digital electro-pneumatic cabin pressure control system for the cabin pressure schedule of transport aircraft is investigated.For the purpose of this study,an experimental setup consisting of a simulated hermetic cabin and altitude simulation chamber is configured for cabin pressure control system operation.A series of experimental tests are executed to evaluate the performance of the cabin pressure control system.The parameters of the PID controller are optimized.In the optimization process,the variation regularity of the rate of cabin pressure change under various conditions is considered.An approach to prioritize the control of the rate of change of cabin pressure based on the flight status model is proposed and verified experimentally.The experimental results indicate that the proposed approach can be adopted for the designed digital electro-pneumatic cabin pressure control system to obtain a better cabin pressure schedule and rate of cabin pressure change. | Nie Jinfang Pan Quan Shen Hao Song Zhitao Zhang Dalin | 2016 | Transactions of Nanjing University of Aeronautics and Astronautics2016，33，5： | 3 |
| 6 | Steady thermal hydraulic analysis for a molten salt reactor显示文摘The Molten Salt Reactor (MSR) can meet the demand of transmutation and breeding. In this study, theoretical calculation of steady thermal hydraulic characteristics of a graphite-moderated channel type MSR is conducted. The DRAGON code is adopted to calculate the axial and radial power factor firstly. The flow and heat transfer model in the fuel salt and graphite are developed on basis of the fundamental mass, momentum and energy equations. The results show the detailed flow distribution in the core, and the temperature profiles of the fuel salt, inner and outer wall in the nine typical elements along the axial flow direction are also obtained. | ZHANG Dalin QIU Suizheng LIU Changliang SU Guanghui | 2008 | Nuclear Science and Techniques2008，19，3： | 3 |
| 7 | An application of the LTP_DSEF model to heavy precipitation forecasts of landfalling tropical cyclones over China in 2018显示文摘Recently, a track-similarity-based Dynamical-Statistical Ensemble Forecast(LTP_DSEF) model has been developed in an attempt to predict heavy rainfall from Landfalling Tropical cyclones(LTCs). In this study, the LTP_DSEF model is applied to predicting heavy precipitation associated with 10 LTCs occurring over China in 2018. The best forecast scheme of the model with optimized parameters is obtained after testing 3452 different schemes for the 10 LTCs. Then, its performance is compared to that of three operational dynamical models. Results show that the LTP_DSEF model has advantages over the three dynamical models in predicting heavy precipitation accumulated after landfall, especially for rainfall amounts greater than 250 mm. The model also provides superior or slightly inferior heavy rainfall forecast performance for individual LTCs compared to the three dynamical models. In particular, the LTP_DSEF model can predict heavy rainfall with valuable threat scores associated with certain LTCs, which is not possible with the three dynamical models. Moreover, the model can reasonably capture the distribution of heavier accumulated rainfall, albeit with widespread coverage compared to observations. The preliminary results suggest that the LTP_DSEF model can provide useful forecast guidance for heavy accumulated rainfall of LTCs despite its limited variables included in the model. | Zuo JIA Fumin REN Dalin ZHANG Chenchen DING Mingjen YANG Tian FENG Boyu CHEN Hui YANG | 2020 | Science China Earth Sciences2020，63，1： | 3 |
| 8 | Genomic variations in the counterpart normal controls of lung squamous cell carcinomas显示文摘 | Dalin Zhang Liwei Qu Bo Zhou Guizhen Wang Guangbiao Zhou | 2018 | Frontiers of Medicine2018，12，3： | 2 |
| 9 | Dynamic simulation of a space gas-cooled reactor power system with a closed Brayton cycle显示文摘Space nuclear reactor power(SNRP)using a gas-cooled reactor(GCR)and a closed Brayton cycle(CBC)is the ideal choice for future high-power space missions.To investigate the safety characteristics and develop the control strategies for gas-cooled SNRP,transient models for GCR,energy conversion unit,pipes,heat exchangers,pump and heat pipe radiator are established and a system analysis code is developed in this paper.Then,analyses of several operation conditions are performed using this code.In full-power steady-state operation,the core hot spot of 1293 K occurs near the upper part of the core.If 0.4$reactivity is introduced into the core,the maximum temperature that the fuel can reach is 2059 K,which is 914 K lower than the fuel melting point.The system finally has the ability to achieve a new steady-state with a higher reactor power.When the GCR is shut down in an emergency,the residual heat of the reactor can be removed through the conduction of the core and radiation heat transfer.The results indicate that the designed GCR is inherently safe owing to its negative reactivity feedback and passive decay heat removal.This paper may provide valuable references for safety design and analysis of the gas-cooled SNRP coupled with CBC. | Chenglong WANG Ran ZHANG Kailun GUO Dalin ZHANG Wenxi TIAN Suizheng QIU Guanghui SU | 2021 | Frontiers in Energy2021，15，4： | 2 |
| 10 | Embedding ZnSe nanodots in nitrogen-doped hollow carbon architectures for superior lithium storage显示文摘转变金属 chalcogenides 由于他们的高理论的能力为高效的锂离子电池(解放) 代表最有希望的其他的电极材料的一个班。然而,他们在控告 / 解除进程期间受不了大卷扩大,粒子凝块,和低电导率,导致不能令人满意的精力存储性能。以便处理这些期,我们讲道理地设计了三维(3D ) 由一致地在一个做 N 的多孔的碳网络(ZnSe ND@NPC ) 以内限制的 ZnSe nanodots 组成的混合 composites 经由一个方便热分解过程获得了。当为解放用作阳极时, composites 展出了突出的电气化学的性能,与一个高可逆的能力( 1,134 妈瑩?楬楰獤?桴祥眠牥?業數?楷桴瀠潨灳慨楴祤'褲湗H敮??睯瀠灥楴敤挠湯散瑮慲楴湯?ㄨ?洠?椠摮'讚_敨映牯慭楴湯漠??敨整潲敧敮畯?業瑸牵?景瘠獥捩汵牡猠牴'壮肭??牡敧洠汵楴慬敭汬牡瘠獥捩敬??噌??灳捡湩???渠?挠敯楸瑳摥眠瑩?汯杩?漠?湵汩浡汥慬?敶楳汣獥??‰浮椠?楤浡瑥牥?湡?楢散汬?楬敫猠牴'壮肭???渠?敬杮桴?ㄠ?浮眠摩桴??杩?数瑰摩?潣据湥牴瑡潩獮??洠?氠摥琠?湵汩浡汥慬?敶楳汣獥???搠慩敭整?? | Ziliang Chen Renbing Wu Hao Wang Kelvin H. L. Zhang Yun Song Feilong Wu Fang Fang Dalin Sun | 2018 | Nano Research2018，11，2： | 2 |
| 11 | Zeolite templated carbon nanodots for broadband ultrafast pulsed fiber laser generation显示文摘Carbon nanodots(C-dots) with a uniform size of about 2 nm are synthesized via in situ pyrolysis of n-propylamine that is confined in the nanochannels of zeolite Linde Type A(LTA). The as-synthesized C-dots@LTA composite shows nonlinear optical saturable absorption properties in a broad wavelength band and can be used as saturable absorber(SA) to generate ultrafast pulsed fiber lasers. By inserting a zeolite LTA single crystal hosting C-dots into the fiber laser cavity, mode-locked fiber lasers with long-term operation stability at 1.5 μm and 1 μm are achieved. These results show that the C-dots@LTA are a promising SA material for ultrafast pulsed fiber laser generation in a broad wavelength band. To the best of our knowledge, this is the first demonstration of a C-dots@LTA-based mode-locked fiber laser. | XINTONG XU JIAQI CHEN WENTAO SHI DALIN SUN SHAOWEN CHU LANG SUN WENFEI ZHANG YANPING CHEN JIANPANG ZHAI SHUANGCHEN RUAN ZIKANG TANG | 2019 | Photonics Research2019，7，10： | 2 |
| 12 | A multiscale numerical study of hurricane Andrew(1992) partⅠ:explicit simulation and verification显示文摘 | Lui Yubao Zhang Dalin | 1997 | Monthly Weather Review1997，125，12： | 1 |
| 13 | A novel antioxidant a- gent, astragalosides, prevents shock wave - induced renal oxida- tive in jury in rabbits显示文摘 | Xiang Li Dalin He Linlin Zhang | 2006 | Urol Res2006，34，： | 1 |
| 14 | Use of the advanced microwave sounding unit data to improve typhoon prediction显示文摘The effects of incorporating the advanced microwave sounding unit (AMSU-A) data with a modified Zhu-Zhang-Weng vortex- bogussing algorithm on typhoon prediction are examined through the use of the PSU/NCAR Mesoscale Model version 5 (MM5). The AMSU-A data contain the vertical distribution of the retrieved temperature from satellite brightness temperature, with the geopo- tential height and wind fields derived through a series of statistical and diagnostic calculations. The advantages of the modified vortex- bogussing algorithm include the incorporation of realistic asymmetric typhoon structures, the balanced dynamics with the background field, the easiness to implement and the effcient computations. To test the effciency of this vortex-bogussing algorithm, the Typhoon Dan event in 1999 is simulated by incorporating the derived AMSU-A fields into the initial conditions of the MM5 modeling system. Results show significant improvements in the track and intensity of the storm, as compared to the simulation without the AMSU-A data. Therefore, this modified vortex-bogussing algorithm can be easily implemented on any typhoon modeling system, which will improve the real-time forecast of tropical cyclones. | Guo Deng Dalin Zhang Tong Zhu Angsheng Wang | 2009 | Progress in Natural Science:Materials International2009，19，3： | 1 |
| 15 | Numerical simulation of an intense squall line during 10-11 June 1985 PRE-STORM Part Ⅱ: rear inflow surface pressure perturbations and stratiform pre- cipitation 显示文摘 | Zhang Dalin Gao Kun | 1989 | Mon Wea Rev1989，117，9： | 1 |
| 16 | A novel antioxidant agent, astragalosides, prevents shock wave- induced renal oxidative injury in rabbits 显示文摘 | Li Xiang He Dalin Zhang Linlin | 2006 | Urol Res2006，34，： | 1 |
| 17 | Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties显示文摘 | Linlin Zhang Min Jiao Lei Li Dapeng Wu Kaijie Wu Xiang Li Guodong Zhu Qiang Dang Xinyang Wang Jer-Tsong Hsieh Dalin He | 2012 | Journal of Cancer Research and Clinical Oncology2012，，4： | 1 |
| 18 | Detection of survivin expression in cervical cancer cells using molecular beacon imaging: new strategy for the diagnosis of cervical cancer显示文摘 | Yan Xue Ruifang An Dong Zhang Jun Zhao Xinyang Wang Lili Yang Dalin He | 2011 | European Journal of Obstetrics and Gynecology2011，，1： | 1 |
| 19 | A numerical investigation of a moderate coastal storm with intense Precipitation显示文摘 | Zhang Dalin | 1997 | ATMOSPHERE-OCEAN1997，1997，： | 1 |
| 20 | Fundamental solution of nuclear solitary wave显示文摘 | Xue-Nong Chen Edgar Kiefhaber Dalin Zhang Werner Maschek | 2012 | Energy Conversion and Management2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员