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| 1 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 2 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 3 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 4 | Over-expression of hypoxia-inducible factor 1 alpha increases an-giogenesis of LNCaP cells显示文摘Objective: To evaluate the effect of HIF-1 αover-expression on angiogenesis in human prostate cancer cells. Methods:LNCaP cells(a human prostate cancer cell line) were transfected with the recombinant plasmid pcDNA3.1( -)-HIF-1αwith Lipo-fectamine 2000 system. The positive clones were selected by G418 being further confirmed by Western blot and immunofluores-cence. The expression levels of VEGF, iNOS and Ang-Ⅱ were determined. Results: The expression of HIF-1αin the LNCaP/HIF1αcells was significantly increased in transfected cells, which induced the up-regulation of VEGF, iNOS, whereas Ang-Ⅱexpression remained un- changed. Conclusion: Over-expression of HIF-1αcan induce angiogenesis proteins and may improve theangiogenesis potency of prostate cancer. | Yili Han Dalin He Yong Luo Hepeng Cheng Guangfeng Zhu | 2007 | Journal of Nanjing Medical University2007，21，4： | 2 |
| 5 | Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer显示文摘Background:Mitochondria are key regulators in cell proliferation and apoptosis.Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis.This study aimed to investigate whether mitochondrial transcription factor A(TFAM),a key regulator of mitochondrial DNA transcription and replication,is involved in the initiation and progression of colitis-associated cancer(CAC).Methods:TFAM expression was examined in tissue samples of inflammatory bowel diseases(IBD)and CAC by immunohistochemistry.Intestinal epithelial cell(IEC)-specific TFAM-knockout mice(TFAM^(△IEC))and colorectal cancer(CRC)cells with TFAM knockdown or overexpression were used to evaluate the role of TFAMin colitis and the initiation and progression ofCAC.The underlying mechanisms of TFAMwere also explored by analyzingmitochondrial respiration function and biogenesis.Results:The expression of TFAM was downregulated in active IBD and negatively associated with the disease activity.The downregulation of TFAM in IECs was induced by interleukin-6 in a signal transducer and activator of transcription 3(STAT3)/miR-23b-dependent manner.In addition,TFAM knockout impaired IECturnover to promote dextran sulfate sodium(DSS)-induced colitis inmice.Of note,TFAMknockout increased the susceptibility of mice to azoxymethane/DSSinduced CAC and TFAM overexpression protected mice from intestinal inflammation and colitis-associated tumorigenesis.By contrast,TFAM expression was upregulated in CAC tissues and contributed to cell growth.Furthermore,it was demonstrated that β-catenin induced the upregulation of TFAM through c-Myc in CRC cells.Mechanistically,TFAMpromoted the proliferation of both IECs and CRC cells by increasing mitochondrial biogenesis and activity.Conclusions:TFAM plays a dual role in the initiation and progression of CAC,providing a novel understanding of CAC pathogenesis. | Shirong Yang Xianli He Jing Zhao Dalin Wang Shanshan Guo Tian Gao Gang Wang Chao Jin Zeyu Yan Nan Wang Yongxing Wang Yilin Zhao Jinliang Xing Qichao Huang | 2021 | Cancer Communications2021，41，8： | 2 |
| 6 | Impact Analysis of Green Procurement Policy for Forest Products in France and Its Reference显示文摘In order to combat illegal logging and associated trade and promote sustainable forest management, major developed countries, including France, have implemented green procurement policy for forest products. This paper described the background of why France implements green procurement policy for forest products, analyzed the basic content of the policy, and made a comprehensive assessment of the impact of green procurement policy on suppliers, processors, eco-environment and competitiveness of forest products. Finally, with the experiences from French implementation of the green procurement policy for forest products, the paper put forward policy recommendations for China to implement green procurement policy for forest products. | Wang Xiuzhen Chen Jie He Youjun Zhou Dalin | 2011 | Chinese Forestry Science and Technology2011，10，3： | 1 |
| 7 | A novel antioxidant a- gent, astragalosides, prevents shock wave - induced renal oxida- tive in jury in rabbits显示文摘 | Xiang Li Dalin He Linlin Zhang | 2006 | Urol Res2006，34，： | 1 |
| 8 | Shock Wave Induces Biological Renal Damage by Activating Excessive Inflammatory Responses in Rat Model显示文摘 | Xiang Li Qingzhi Long Xinfa Cheng Dalin He | 2014 | Inflammation2014，，4： | 1 |
| 9 | A novel antioxidant agent, astragalosides, prevents shock wave- induced renal oxidative injury in rabbits 显示文摘 | Li Xiang He Dalin Zhang Linlin | 2006 | Urol Res2006，34，： | 1 |
| 10 | Realtime detection of survivin mRNA expression in cervical cancer cell lines using molecular beacon imaging显示文摘 | He Dalin Xue Yan | 2006 | Academic Journal of Xi''an Jiaotong University(English edition)2006，18，2： | 1 |
| 11 | Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties显示文摘 | Linlin Zhang Min Jiao Lei Li Dapeng Wu Kaijie Wu Xiang Li Guodong Zhu Qiang Dang Xinyang Wang Jer-Tsong Hsieh Dalin He | 2012 | Journal of Cancer Research and Clinical Oncology2012，，4： | 1 |
| 12 | Detection of survivin expression in cervical cancer cells using molecular beacon imaging: new strategy for the diagnosis of cervical cancer显示文摘 | Yan Xue Ruifang An Dong Zhang Jun Zhao Xinyang Wang Lili Yang Dalin He | 2011 | European Journal of Obstetrics and Gynecology2011，，1： | 1 |
| 13 | Primary application study in early diagnosis of bladder cancer by MBs显示文摘 | Jun Zhao He Dalin | 2007 | Urology2007，70，1： | 1 |
| 14 | Metagenomic analysis of two enhanced biological phosphorus removal (EBPR) sludge communities 显示文摘 | Martin HG Ivanova N Kunin V Warnecke F Barry KW McHardy AC Yeates C He S Salamov AA Szeto E Dalin E Putnam NH Shapiro HJ Pangilinan JL Rigoutsos I Kyrpides NC Blackall LL McMahon KD Hugenholtz P | 2006 | Nat Biotechnol2006，24，： | 1 |
| 15 | Erosion-Induced Inflammation on Coronary Plaque Stress/Strain and Flow Shear Stress Calculations Using OCT-Based FSI Computational Model显示文摘Plaque erosion,together with plaque rupture,is a common cause for acute coronary syndrome(ACS).Plaque erosion alone is responsible for about one third of the patients with ACS.Eroded plaque is defined as thrombosed,endothelium-absent and non-ruptured but often-inflamed plaques based on histological findings.Even though there is efficient imaging technologies to detect the eroded plaque in vivo and tailored treatment strategy has also been developed for ACScaused by erosion in clinics,the pathogenesis mechanisms that cause plaque erosion are not fully understood.It is widely postulated that thrombus formation and endothelial apoptosis(the precursors of plaque erosion)have closed association with biomechanical conditions in the coronary vessel.Revealing of the mechanical conditions in the eroded plaque could advance our knowledge in understanding the formation of plaque erosion.To this end,patient-specific OCT-based fluid-structure interaction(FSI)models were developed to investigate the plaque biomechanical conditions and investigate the impact of erosioninduced inflammation on biomechanical conditions.In vivo OCTand Biplane X-ray angiographic data of eroded coronary plaque were acquired from one male patient(age:64). OCT images were segmented manually with external elastic membrane contour and the trailing edge of the lipid-rich necrotic core(lipid)assumed to have positive remodeling ratio 1.1.Locations with luminal surface having direct contact with intraluminal thrombus on OCT images were identified erosion sites.Fusion of OCT and biplane X-ray angiographic data were performed to obtain the 3D coronary geometry.OCT-based FSI models with pre-shrink-stretch process and anisotropic material properties were constructed following previously established procedures.To reflect tissue weakening caused by erosion-induced inflammation,the material stiffness of plaque intima at the erosion site was adjust to one tenth of un-eroded fibrous plaque tissue.Three FSI models were constructed to investigate the impacts of inflammation and lipid component on plaque biomechanics:M1,without erosion(this means plaque intima at the erosion sites were not softened)and without inclusion of lipid component;M2,with erosion but no lipid;M3,with erosion and inclusion of lipid.FSI models were solved by ADINA to obtain the biomechanical conditions at peak blood pressure including plaque wall stress/strain(PWS/PWSn)and flow wall shear stress(WSS).The average values of three biomechanical conditions at the erosion sites and at the fibrous cap overlaying lipid component were calculated from three models for analysis.The results of M1 and M2 were compared to investigate the impact of erosion-induced inflammation on plaque biomechanics.Mean PWS value decreases from 49.98 kPa to 18.83 kPa(62.32%decrease)while Mean PWSn value increases from 0.123 1 to 0.138 4(12%increase)as the material stiffness becomes 10times soft.Comparing M2 and M3 at the cap sites,M3(with inclusion of lipid)will elevates mean PWS and PWSn values by48.59%and 16.09%,respectively.The impacts of erosion and lipid on flow shear stress were limited(<2%).To conclude,erosion-induced inflammation would lead to lower stress distribution but larger strain distribution,while lipid would elevate both stress and strain conditions.This shows the influence of erosion and lipid component has impacts on stress/strain cal-culations which are closely related to plaque assessment. | Liang Wang Luping He Rui Lv Xiaoya Guo Chun Yang Haibo Jia Dalin Tang | 2019 | 医用生物力学2019，34，A01： | 1 |
| 16 | TiO_(2)@C catalyzed hydrogen storage performance of Mg-Ni-Y alloy with LPSO and ternary eutectic structure显示文摘A designed Mg_(88.7)Ni_(6.3)Y_(5)hydrogen storage alloy containing 14H type LPSO(long-period stacking ordered)and ternary eutectic structure was prepared by regulating the alloy composition and casting.The hydrogen storage performance of the alloy was improved by adding nano-flower-like TiO_(2)@C catalyst.The decomposition of the LPSO structure during hydrogenation led to the formation of plenty of nanocrystals which provided abundant interphase boundaries and activation sites.The nanoscale TiO_(2)@C catalyst was uniformly dispersed on the surface of alloy particles,and the'hydrogen overflow''effect of TiO_(2)@C accelerated the dissociation and diffusion of hydrogen on the surface of the alloy particles.As a result,the in-situ endogenous nanocrystals of the LPSO structure decomposition and the externally added flower-like TiO_(2)@C catalyst uniformly dispersed on the surface of the nanoparticles played a synergistic catalytic role in improving the hydrogen storage performance of the Mg-based alloy.With the addition of the TiO_(2)@C catalyst,the beginning hydrogen desorption temperature was reduced to 200℃.Furthermore,the saturated hydrogen absorption capacity of the sample was 5.32 wt.%,and it reached 4.25 wt.%H_(2) in 1 min at 200℃and 30 bar. | Wenjie Song Wenhao Ma Shuai He Wei Chen Jianghua Shen Dalin Sun Qiuming Wei Xuebin Yu | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
| 17 | Development of a high-power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia显示文摘This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing tissue removal methods.Energy platform for BPH should balance a range of factors,such as operative time,patient conditions,urinary functions,complications,durability,accessibility,and cost,all while prioritizing patient care.Blueray Medical's innovation of high-power blue diode laser systems for BPH surgery is explored,with emphasis on achieving a balance among these considerations.By illustrating the biomedical effects of lasers and their interaction with soft tissues,particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior,this study outlines the advantages of the highpower blue diode laser system.The initial laboratory experiments and clinical results consistently align with our theoretical predictions,especially in terms of tissue vaporization efficiency,tissue coagulation,and bleeding control.In conclusion,blue diode lasers hold potential to enhance surgical outcomes for BPH.Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages.Integrating blue laser technology into BPH protocols could lead to shorter hospital stays,cost savings,and expanded patient eligibility,although rigorous clinical studies are needed to fully understand their benefits and limitations. | Liyue Mu Xiang Zhu Bing Yang Lin Yang Xiaofeng Xu Yongwei Zhao Dalin He | 2023 | UroPrecision2023，1，3： | 0 |
| 18 | Diagnostic accuracy of cystoscopic biopsy for tumour grade in outpatients with urothelial carcinoma of the bladder and the risk factors of upgrading显示文摘Objective:To assess the concordance of tumour grade in specimens obtained from diagnostic cystoscopic biopsy and transurethral resection of bladder tumour(TURBT)and explore the risk factors of upgrading.Methods:The medical records of 205 outpatients who underwent diagnostic cystoscopic biopsy before initial TURBT were retrospectively reviewed.Comparative analysis of the tumour grade of biopsy and operation specimens was performed.Tumour grade changing from low-grade to high-grade with or without variant histology was defined as upgrading.Logistic regression an-alyses were performed to identify the risk factors of upgrading.Results:For the 205 patients,the concordance of tumour grade between specimens obtained from biopsy and operation was 0.639.The concordance for patients who were preoperatively diagnosed with low-grade and high-grade was 0.504 and 0.912,respectively.Univariate and multivariate logistic regression analyses showed that older age,tumour multifocality,high neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and low lymphocyte-to-monocyte ratio(LMR)were significantly associated with upgrading(odds ratio ranging from 0.412 to 4.364).The area under the curve of the different multivariate models was improved from 0.752 to 0.821,and decision curve analysis demonstrated a high net benefit when NLR,LMR,and PLR were added.Conclusion:Diagnostic cystoscopic biopsy may not accurately represent the true grade of primary bladder cancer,especially for outpatients with low-grade bladder cancer.Moreover,older age,tumour multifocality,high NLR,PLR,and low LMR are risk factors of upgrading,and systemic inflammatory markers improve the predictive ability. | Junjie Fan Hua Liang Jinhai Fan Lei Li Guanjun Zhang Xinqi Pei Tao Yang Dalin He Kaijie Wu | 2023 | Asian Journal of Urology2023，10，1： | 0 |
| 19 | Immunoexpression and prognostic role of p53 in different subtypes of epithelial ovarian carcinoma显示文摘We sought to investigate the significance of p53 expression for epithelial ovarian carcinoma.In this study,we used immunohistochemical method to investigate the expression patterns of p53 in different subtypes of epithelial ovarian carcinoma.We found that the expressions of p53 protein in epithelial ovarian cancer(pituita,serosity and intima) were 88.9%,75% and 100%,respectively,while the recurrence rates among three cancer subtypes were significantly different(33.3%,12.5% and 0%,respectively;P < 0.05).Compared with patients without lymph node metastasis,the expression of p53 in patients with lymph node metastasis was significantly strong(68.75% and 100%,respectively;P < 0.05).However,the recurrence rate in the patients with lymph node metastasis(40%) was higher than that without lymph node metastasis(6.25%,P < 0.05).The expressions of p53 protein in ovarian cancer betweenⅠ-Ⅱ(25%) stage and Ⅱ-Ⅳ stage(100%) were significantly different(P < 0.05),and the recurrence rates between the two groups were significantly different(0% and 31.25%,respectively,P < 0.05).Therefore,p53 protein has an intimate relationship with the malignant degree and the prognosis of ovarian cancer. | Lihong Chen Lianxiang Li Feng Chen Dalin He | 2012 | The Journal of Biomedical Research2012，26，4： | 0 |
| 20 | 全基因组关联研究发现中国人群前列腺癌两个新易感位点9q31.2和19q13.4显示文摘0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。 | Jianfeng Xu Zengnan Mo Dingwei Ye Meilin Wang Fang Liu Guangfu Jin Chuanliang Xu Xiang Wang Qiang Shao Zhiwen Chen Zhihua Tao Jun Qi Fangjian Zhou Zhong Wang Yaowen Fu Dalin He Qiang Wei Jianming Guo Denglong Wu Xin Gao Jianlin Yuan Gongxian Wang Yong Xu Guozeng Wang Haijun Yao Pei Dong Yang Jiao Mo Shen Jin Yang Jun Ou-Yang Haowen Jiang Yao Zhu Shancheng Ren Zhengdong Zhang Changjun Yin Xu Gao Bo Dai Zhibin Hu Yajun Yang Qijun Wu Hongyan Chen Peng Peng Ying Zheng Xiaodong Zheng Yongbing Xiang Jirong Long Jian Gong Rong Na Xiaoling Lin Hongjie Yu Sha Tao Junjie Feng Jishan Sun Wennuan Liu Ann Hsing Jianyu Rao Qiang Ding Fredirik Wiklund Henrik Gronberg Xiao-Ou Shu Wei Zheng Hongbing Shen Li Jin Rong Shi Daru Lu Xuejun Zhang Jielin Sun S Lilly Zheng Yinghao Sun | 2013 | 第二军医大学学报2013，34，4： | 0 |
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