|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage Ⅲ colon cancer显示文摘Background: The prognostic nutritional index(PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. Although a low PNI predicts poor prognosis in patients with colorectal cancer after tumor resection, the prognostic value remains unknown in patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy. This study aimed to investigate the prognostic value of PNI in patients with stage III colon cancer.Methods: Medical records of 274 consecutive patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy with oxaliplatin and capecitabine between December 2007 and December2013 were reviewed. The optimal PNI cutoff value was determined using receiver operating characteristic(ROC) curve analysis. The associations of PNI with systemic inflammatory response markers, including lymphocyte-to-monocyte ratio(LMR), neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and C-reactive protein(CRP)level, and clinicopathologic characteristics were assessed using the Chi square or Fisher's exact test. Correlation analysis was performed using Spearman's correlation coefficient. Disease-free survival(DFS) and overall survival(OS)stratified by PNI were analyzed using Kaplan-Meier method and log-rank test, and prognostic factors were identified by Cox regression analyses.Results: The preoperative PNI was positively correlated with LMR(r= 0.483, P < 0.001) and negatively correlated with NLR(r =-0.441, P < 0.001), PLR(r =-0.607, P < 0.001), and CRP level(r =-0.333, P < 0.001). A low PNI(≤49.22)was significantly associated with short OS and DFS in patients with stage ⅢC colon cancer but not in patients with stage ⅢA/ⅢB colon cancer.In addition, patients with a low PNI achieved a longer OS and DFS after being treated with6-8 cycles of adjuvant chemotherapy than did those with < 6 cycles. Multivariate analyses revealed that PNI was independently associated with DFS(hazard ratios 2.001; 95% confidence interval 1.157-3.462; P = 0.013).Conclusion: The present study identified preoperative PNI as a valuable predictor for survival outcomes in patients with stage Ⅲ colon cancer receiving curative tumor resection followed by adjuvant chemotherapy. | Jianhong Peng Rongxin Zhang Yixin Zhao Xiaojun Wu Gong Chen Desen Wan Zhenhai Lu Zhizhong Pan | 2017 | Chinese Journal of Cancer2017，36，11： | 11 |
| 2 | Ⅲ期结肠癌患者术前预后营养指数的预后价值及其与全身炎症反应标志物的相关性显示文摘背景与目的预后营养指数(prognostic nutritional index,PNI)已广泛应用于预测各种恶性肿瘤患者的生存结局。虽然低PNI预测肿瘤切除后的结直肠癌患者的预后不良,但对接受根治性肿瘤切除术后辅助化疗的Ⅲ期结肠癌患者的预后价值仍未知。本研究旨在探讨PNI对Ⅲ期结肠癌患者的预后价值。方法本文回顾了2007年12月至2013年12月期间,274例接受根治性肿瘤切除术后接受奥沙利铂和卡培他滨辅助化疗的Ⅲ期结肠癌的连续患者的医疗记录。采用受试者工作特征(receiver operating characteristic,ROC)曲线分析确定最佳PNI临界值。采用卡方检验或Fisher’s精确检验评估PNI与全身炎症反应标志物[包括淋巴细胞与单核细胞比值(lymphocyte-to-monocyte ratio,LMR)、中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)、C反应蛋白(C-reactive protein,CRP)水平]和临床病理特征的相关性。采用Spearman’s相关系数进行相关分析。采用Kaplan-Meier法和log-rank检验分析PNI分层的无病生存期(disease-free survival,DFS)和总生存期(overall survival,OS),并通过Cox回归分析确定预后因子。结果术前PNI与LMR呈正相关(r=0.483,P <0.001),与NLR(r=-0.441,P <0.001)、PLR(r=-0.607,P <0.001)和CRP水平(r=-0.333,P <0.001)呈负相关。在ⅢC期结肠癌患者中,低PNI(≤49.22)与短OS和DFS显著相关,而在ⅢA/ⅢB期结肠癌患者中则不相关。此外,在PNI低的患者中,接受6–8个疗程辅助化疗的患者比接受<6个疗程治疗的患者获得了更长的OS和DFS。多变量分析显示PNI与DFS独立相关(风险比=2.001;95%置信区间:1.157–3.462;P=0.013)。结论术前PNI是接受根治性肿瘤切除术后辅助化疗的Ⅲ期结肠癌患者生存结局的重要预测指标。 | Jianhong Peng Rongxin Zhang Yixin Zhao Xiaojun Wu Gong Chen Desen Wan Zhenhai Lu Zhizhong Pan | 2019 | 癌症2019，38，1： | 10 |
| 3 | Expression of voltage.gated sodium channel Nav1.5 in non.metastatic colon cancer and its associations with estrogen receptor(ER)-βexpression and clinical outcomes显示文摘Background: Voltage-gated sodium channel 1.5(Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes and estrogen receptor-β(ER-β)expression in non-metastatic colon cancer patients receiving radical resection.Methods: A total of 269 consecutive patients with pathologically confirmed stages Ⅰ-Ⅲ colon cancer who underwent radical resection were selected. Nav1.5 and ER-β expression was detected by using immunohistochemistry(IHC)on tissue microarray constructed from paraffin-embedded specimens. IHC score was determined according to the percentage and intensity of positively stained cells. Statistical analysis was performed with the X-tile method, k coefficient, Chi square test or Fisher's exact test, logistic regression, log-rank test, and Cox proportional hazards models.Results: We found that Nav1.5 was commonly expressed in tumor tissues with higher mean IHC score as compared with matched tumor-adjacent normal tissues(5.1 ± 3.5 vs. 3.5 ± 2.7, P < 0.001).The high expression of Nav1.5 in colon cancer tissues was associated with high preoperative carcinoembryonic antigen level [odds ratio(OR) = 2.980;95% confidential interval(CI)1.163-7.632; P = 0.023] and high ER-β expression(OR = 2.808; 95% CI 1.243-6.343;p = 0.00 3). Log-rank test results showed that high Nav1.5 expression contributed to a low 5-year disease-free survival(DFS) rate in colon cancer patients(77.2% vs. 92.1%, P = 0.048), especially in patients with high ER-β expression tumor(76.2% vs. 91.3%, P = 0.032). Analysis with Cox proportional hazards model demonstrated that high Nav1.5 expression[hazard ratio(HR) = 2.738; 95% CI 1.100-6.819;P = 0.030] and lymph node metastasis(HR = 2.633; 95% CI 1.632-4.248; P < 0.001) were prognostic factors for unfavorable DFS in colon cancer patients.Conclusions: High expression of Nav1.5 was associated with high expression of ER-β and indicated unfavorable oncologic prognosis in patients with non-metastatic colon cancer. | Jianhong Peng Qingjian Ou Xiaojun Wu Rongxin Zhang Qian Zhao Wu Jiang Zhenhai Lu Desen Wan Zhizhong Pan Yujing Fang | 2017 | Chinese Journal of Cancer2017，36，12： | 7 |
| 4 | Investigation on bubble dynamics characteristics and power spectral variation in acoustic field显示文摘Based on Keller-Miksis model,the influences of multiple control parameters,such as acoustic pressure amplitude,acoustic frequency and bubble radius at rest,on the complicated dynamics characteristics of nonlinear bubble oscillation driven by acoustic wave are discussed by utilizing a variety of numerical analysis methods,and the restrictive relationships among different parameters are analyzed.It is shown that chaotic state can occur only in the condition of all of the parameters in the suitable threshold,as the same time,chaotic state is the result of interaction of multiple control parameters.Furthermore,the power spectral expansion and energy conversion are existed in this nonlinear system.It is certified that the stronger acoustic pressure amplitude,the greater the sub-harmonic energy,besides,the energy attenuation of fundamental harmonic is also much greater. | YANG Desen SHI Jie SHI Shengguo ZHANG Haoyang JIANG Wei JIN Shiyuan | 2013 | Chinese Journal of Acoustics2013，32，2： | 1 |
| 5 | Genetic structure and domestication footprints of the tusk,coat color,and ear morphology in East Chinese pigs显示文摘The domestication and artificial selection of wild boars have led to dramatic morphological and behavioral changes,especially in East Chinese(ECN)pigs.Here,we provide insights into the population structure and current genetic diversity of representative ECN pig breeds.We identify a 500-kb region containing six tooth development-relevant genes with almost completely different haplotypes between ECN pigs and Chinese wild boars or European domestic pigs.Notably,the c.195A>G missense mutation in exon 2 of AMBN may cause alterations in its protein structure associated with tusk degradation in ECN pigs.In addition,ESR1 may play an important role in the reproductive performance of ECN pigs.A major haplotype of the large lop ear-related MSRB3 gene and eight alleles in the deafness-related GRM7 gene may affect ear morphology and hearing in ECN pigs.Interestingly,we find that the two-end black(TEB)coat color in Jinhua pigs is most likely caused by EDNRB with genetic mechanisms different from other Chinese TEB pigs.This study identifies key loci that may be artificially selected in Chinese native pigs related to the tusk,coat color,and ear morphology,thus providing new insights into the genetic mechanisms of domesticated pigs. | Sumei Zheng Pan Xu Zhongping Wu Hui Zhang Desen Li Shaojuan Liu Bingbing Liu Jun Ren Hao Chen Min Huang | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 6 | YBa_(2)Cu_(3)O_(7-x) Superconducting Thin Films Grown on CaNdA1O_(4)(100) Substrates显示文摘We report the fabrication of high temperature superconducting YBa_(2)Cu_(3)O_(7-x) thin films on CaNdA1O_(4)(100) substrate by pulsed laser deposition.Films have excellent features.X-ray diffraction patterns show that thin films are epitaxial with c-axis orientation normal to the surface of su bstrate.The four-terminal measurements indicate the zero resistance temperature of 92.1 K,and transition width of 0.7K,the critical current density of 3×10^(6)A/cm^(2)at 77K and under zero magnetic field. | XU Shifa ZHOU Yueliang LÜHuibin CUI Dafu CHEN Zhenghao YANG Guozhen TIAN Yongjun LIU Junzheng LI Lin CHANG Yingchuan HOU Desen FAN Hui ZHANG Zuren | 1994 | Chinese Physics Letters1994，11，5： | 0 |
| 7 | Genetic Mineralogy of the Pyrite and Quartz in Dongping Gold Deposit, Hebei Province: Implications for Gold Prospecting显示文摘Located at the boundary of Chongli county, Chicheng county and Xuanhua county of Heibei province, the Dongping gold deposit is genetically affiliated to the late Jurassic- early Cretaceous volcanics and intrusives. The ore body is quartz vein- and alteration-type and pyrite and quartz are the dominant gold-bearing minerals. | XU Hong YANG Lijun ZHANG Desen GAO Shen | 2013 | 矿物学报2013，33，S1： | 0 |
| 8 | Multipath matching pursuit using a cross-validation technique for sparse direction-of-arrival estimation with an acoustic vector array显示文摘High-resolution direction-of-arrival(DOA)estimations and the starboard ambiguity of moving underwater targets have always been key issues in underwater acoustic array signal processing.Compared with sound pressure arrays,vector arrays have natural advantages with respect to solving the starboard ambiguity problem and obtaining higher processing gains.Traditional high-resolution DOA estimation methods such as Capon have disadvantages such as being unable to resolve coherent sources,requiring multiple snapshot processing,and being sensitive to array manifold errors.High-resolution DOA estimation and the starboard ambiguity of moving underwater targets have always been challenging research topics.On one hand,maneuvering underwater targets reduce the coherence time of the received signals,which ultimately leads to poor performance when using high-resolution DOA estimation technologies based on the covariance matrix of the received signal.On the other hand,traditional DOA estimation technologies based on sound pressure arrays have the problem of port and starboard ambiguity,which can be solved by maneuvering the sonar platform.However,maneuvering the sonar platform can impair the coherence of the received signal,on which some algorithms rely.This approach greatly limits the combat effectiveness and performance of the platform.Given the aforementioned problems and taking advantage of the target sparsity,a cross-validation multipath matching pursuit technique based on the sparse DOA estimation of an acoustic vector array is proposed in this article for sonar observations.The proposed algorithm uses cross-validation technology to achieve a sparse DOA estimation with an unknown number of targets in a sonar observation scene.Compared with the conventional acoustic vector array-based Capon algorithm,the proposed algorithm can achieve a sparse DOA estimation and high-resolution capability with small numbers of snapshots or even single snapshots.The effectiveness of the proposed algorithm is verified via simulations and sea trial data processing. | TAN Peng HU Bo ZHANG Youwen WU Yuquan YANG Desen | 2023 | Chinese Journal of Acoustics2023，42，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员