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| 1 | Co-occurrence of nitrite-dependent anaerobic methane oxidizing and anaerobic ammonia oxidizing bacteria in two Qinghai-Tibetan saline lakes显示文摘亚硝酸根依赖者厌氧氧化甲烷(n-damo ) 氧化的细菌和厌氧的氨(anammox ) 细菌是涉及全球碳并且氮骑车的二组微生物。为了测试 n-damo 和 anammox 细菌是否在自然盐的环境, DNA 和 cDNA 共同发生,样品从二个盐的湖的地表的沉积获得了(与 32 和 84 g/L 的咸度,分别地)与 anammox-damo-specific 和 n-damo-specific 教材集合的使用在西藏的高原上是 放大PCR 的,由克隆图书馆建设和种系发生的分析列在后面。DNA 和基于 cDNA 的克隆与 n-damo 结盟了, anammox 细菌成功地从二件样品被检索,显示这些二组细菌能象 84 g/L 一样高在有咸度的自然盐的环境共同发生。我们发现在自然为我们全球碳和氮周期的理解有大含意[出版摘要] | Jian YANG Hongchen JIANG Geng WU Weiguo HOU Yongjuan SUN Zhongping LAI Hailiang DONG | 2012 | Frontiers of Earth Science2012，6，4： | 12 |
| 2 | Radiative forcing and global warming potential of perfluorocarbons and sulfur hexafluoride显示文摘We developed two radiation parameterizations with different resolutions(17-band and 998-band) for perfluorocarbons(PFCs) and sulfur hexafluoride(SF6) using the updated High-resolution Transmission Molecular Absorption(HITRAN) 2004 database and the correlated k-distribution method.We analyzed the impacts of the two radiation schemes on heating rates.Then we studied their instantaneous radiative efficiency,stratospheric adjusted radiative efficiency,global warming potential(GWP),and global temperature potential(GTP),for both clear-and all-sky conditions using a high-resolution radiation scheme.We found that the stratosphere-adjusted radiative efficiencies of C2F6,CF4,and SF6 for the whole sky were 0.346,0.098,and 0.680 W m-2 ppbv-1,respectively.Radiative forcing from the industrial revolution to 2005 was 0.001,0.007,and 0.004 W m-2,re-spectively;and was predicted to rise to 0.008,0.036,and 0.037 W m-2,respectively,by 2100,according to emission scenarios provided by the IPCC.The GWPs of C2F6,CF4,and SF6 are 17035,7597,and 31298,respectively,for a time horizon of 100 years relative to CO2.Their GTPs of pulse and sustained emissions,GTPP and GTPS,are 22468,10052,and 40935 and 16498,7355,and 30341,respectively,for a 100-year time horizon. | ZHANG Hua WU JinXiu SHEN ZhongPing | 2011 | Science China Earth Sciences2011，54，5： | 8 |
| 3 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 4 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 5 | Preparation and structure of microarc oxidation ceramic coatings containing ZrO2 grown on LY12 Al alloy显示文摘Ceramic coatings containing ZrO2 were prepared in situ on LY12 aluminum alloy by microarc oxidation(MAO) in the mixed solution of zirconate and phosphate solution.The phase composition and morphology of the coatings were studied by XRD and SEM,respectively.The growing mechanism of ceramic coatings was discussed in a preliminary manner.The results show that with an increase in MAO time,the compactness of the coating improved and the thickness increased.From the inner layer to the coating surface,the content of Zr increased,while the content of Al decreased.In addition,the coating was composed of m-ZrO2,t-ZrO2,and a little amount of γ-Al2O3.With an increase in reaction time,the relative content of t-ZrO2 within the coating sharply decreased while the relative content of m-ZrO2 sharply increased,and then both generally kept at a constant level after 60 min. | WU Zhendong YAO Zhongping JIANG Zhaohua | 2008 | Rare Metals2008，27，1： | 6 |
| 6 | A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes显示文摘Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi's sarcoma-associated herpesvirus (KSHV) is capable of regulating cellular gene transcription by miRNA. We demonstrate that a miRNA, hsv1-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24) that inhibits transcriptional efficiency of viral immediate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. Our discovery reveals an effective viral strategy for evading host cell defenses and supporting the efficient replication and proliferation of HSV-1. | WU WenJuan GUO ZhongPing ZHANG XueMei GUO Lei LIU LongDing LIAO Yun WANG JingJing WANG LiChun LI QiHan | 2013 | Science China(Life Sciences)2013，56，4： | 6 |
| 7 | Comparative Study of Hydrogen and Carbon Isotopic Composition of Gases Generated from the Pyrolysis of a Peat under Saltwater and Freshwater Conditions显示文摘To understand the influence of the diagenetic water medium on the isotopic compositions of thermogenic coalbed gas, both hydrous and anhydrous closed-system pyrolyses were performed at temperatures of 250°C to 650°C on an herbaceous marsh peat. Compared to the results of anhydrous pyrolysis, the hydrocarbon gases generated from hydrous pyrolyses have very different hydrogen isotopic compositions. However, the carbon isotopic compositions of the hydrocarbon gases became only slightly heavier in hydrous pyrolysis, compared to that from anhydrous pyrolysis. With the progress of thermal evolution from peat to a more advanced thermal maturity of vitrinite reflectance values(Ro) of 5.5% during the pyrolysis, the difference in the average δD value increased from 52‰ to 64‰ between the hydrous pyrolysis with saltwater and anhydrous pyrolysis and increased from 18‰ to 29‰ between the hydrous pyrolysis with freshwater and anhydrous pyrolysis, respectively. The difference in the average δ^(13)C value was only 1‰–2‰ between the hydrous and anhydrous pyrolysis. The relationships between the δD values of the generated hydrocarbon gases and Ro values as well as among δD values of the hydrocarbon gas species are established. The close relationships among these parameters suggest that the water medium had a significant effect on the hydrogen isotopic composition and a minimal effect on the carbon isotopic composition of the hydrocarbon gases. The results of these pyrolyses may provide information for the understanding of the genesis of coalbed gas from herbaceous marsh material with the participation of different diagenetic water media. | WU Yingzhong DUAN Yi ZHAO Yang CAO Xixi MA Lanhua QIAN Yaorong LI Zhongping XING Lantian | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 3 |
| 8 | A preliminary study of the variation of phytoplankton absorption coefficients in the northern South China Sea显示文摘The temporal and spatial variabilities of phytoplankton absorption coefficients (a ph (λ)) and their relationships with physical processes in the northern South China Sea were examined, based on in situ data collected from two cruise surveys during May 14 to 25, 2001 and November 2 to 21, 2002. Significant changes in the surface water in a ph values and B/R ratios (a ph (440)/a ph (675)) were observed in May, which were caused by a phytoplankton bloom on the inner shelf stimulated by a large river plume due to heavy precipitation. This is consistent with the observed one order of magnitude elevation of chlorophyll a and a shift from a pico/nano dominated phytoplankton community to one dominated by micro-algae. Enhanced vertical mixing due to strengthened northeast monsoon in November has been observed to result in higher surface a ph (675) (0.002–0.006 m-1 higher) and less pronounced subsurface maximum on the outer shelf/slope in November as compared with that in May. Measurements of a ph and B/R ratios from three transects in November revealed a highest surface a ph (675) immediately outside the mouth of the Zhujiang (Pearl) River Estuary, whereas lower a ph (675) and higher B/R ratios were featured in the outer shelf/slope waters, demonstrating the respective influence of the Zhujiang River plume and the oligotrophic water of the South China Sea. The difference in spectral shapes of phytoplankton absorption (measured by B/R ratios and bathochromic shifts) on these three transects infers that picoprocaryotes are the major component of the phytoplankton community on the outer shelf/slope rather than on the inner shelf. A regional tuning of the phytoplankton absorption spectral model (Carder et al., 1999) was attempted, demonstrating a greater spatial variation than temporal variation in the lead parameter a 0 (λ). It was thus implicated that region-based parameterization of ocean color remote sensing algorithms in the northern South China Sea was mandatory. | WU Jingyu HONG Huasheng SHANG Shaoling DAI Minhan LEE Zhongping LI Shaojing | 2009 | Acta Oceanologica Sinica2009，28，5： | 2 |
| 9 | Composition and Evolution of Hydrogen Isotopes of n-Akanes Generated from Anhydrous Pyrolysis of Sediments from Lake Gahai,Gannan,China显示文摘To understand the thermal evolution of lacustrine sedimentary n-alkane hydrogen isotopic composition(δD),especially bacterially derived n-alkanes,anhydrous thermal simulation experiments were performed with sediments from Lake Gahai(Gannan,China).We analyzed the original and pyrolysis-generated n-alkanes and theirδD values.The results showed that thermal maturity and n-alkane origins significantly affected the distribution of pyrolysis-generated n-alkanes.In immature to post-mature sediments,the bacterial-derived medium-chain n-alkanes generally had depletedδD values.The maximum difference in averageδD values between the bacterial-and herbaceous plant-derived medium-chain n-alkanes was 32‰,and the maximum difference in δD values among individual n-alkanes was 59‰.We found that the averageδD value of pyrolysis-generated n-alkanes from different latitude was significantly different in immature to highly mature sediments,but similar in post-mature ssediments.The hydrogen isotopes of sedimentary n-alkanes can be used as indicators for paleoclimate/paleo-environment conditions only when sediments are immature to highly mature.During thermal evolution,the δD value of generated individual n-alkanes and the averageδD value increased with thermal maturity,indicating that hydrogen isotopes of sedimentary n-alkanes can be used as an index of organic matter maturity.We established mathematical models of average δD values of generated n-alkanes from immature to post-mature sediments using n C_(21)^(-)/nC_(21)^(+)and average chain lengths.These results improve our understanding of the distribution andδD value of sedimentary n-alkanes derived from herbaceous plants in mid-latitude plateau cold regions. | DUAN Yi WU Yingzhong XING Lantian LI Zhongping ZHANG Ting | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 2 |
| 10 | Ni3S2 nanorods growing directly on Ni foam for all-solid-state asymmetric supercapacitor and efficient overall water splitting显示文摘Transition metal compounds are attractive for their significant applications in supercapacitors and as non-noble metal catalysts for electrochemical water splitting.Herein,we develop Ni3 S2 nanorods growing directly on Ni foam,which act as multifunctional additive-free Ni3 S2@Ni electrode for supercapacitor and overall water splitting.Based on PVA-KOH gel electrolyte,the assembled all-solid-state Ni3 S2@Ni//AC asymmetric supercapacitor delivers a high areal energy density of 0.52 mWh cm^-2 at an areal power density of 9.02 MW cm^-2,and exhibits an excellent cycling stability with a capacitance retention ratio of 89%after 10000 GCD cycles at a current density of 30 mA cm^-2.For hydrogen evolution reaction and oxygen evolution reaction in 1 M KOH,Ni3 S2@Ni electrode achieves a benchmark of 10 mA cm^-2at overpotentials of 82 mV and 310 mV,respectively.Furthermore,the assembled Ni3 S2@Ni‖Ni3 S2@Ni electrolyzer for overall water splitting attains a current density of 10 mA cm^-2 at 1.61 V.The in-situ synthesis of Ni3 S2@Ni electrode enriches the applications of additive-free transition metal compounds in high-performance energy storage devices and efficient electrocatalysis. | Baoxin Wu Hao Qian Zhongwu Nie Zhongping Luo Zixu Wu Peng Liu Hao He Jianghong Wu Shuguang Chen Feifei Zhang | 2020 | Journal of Energy Chemistry2020，29，7： | 2 |
| 11 | ASYMPTOTIC SURROGATE CONSTRAINT METHOD AND ITS CONVERGENCE FOR A CLASS OF SEMI-INFINITE PROGRAMMING显示文摘A class of constrained semi\|infinite minimax problem is transformed into a simple constrained problem, by means of discretization decomposition and maximum entropy method, making use of surrogate constraint. The paper deals with the convergence of this asymptotic approach method. | Wan Zhongping\ Wu Guoming | 1999 | Applied Mathematics(A Journal of Chinese Universities)1999，14，4： | 2 |
| 12 | Clinical Practice of Nebulized Therapy in China:A National Questionnaire Survey显示文摘 | Zheng Zhu Jinping Zheng Zhongping Wu | 2014 | J Aerosol Med Pulm Drug Deliv2014，27，5： | 1 |
| 13 | Pscudoephedrine/ephed- rine shows potent anti - inflammatory activity against TNF - ct - media- ted acute liver failure induced by lipopolysaccharide/D - galactosamine 显示文摘 | Zhongping Wu Jin Ye Tong Zhang ct al | 2014 | European journal of pharmacology2014，，： | 1 |
| 14 | Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1‐modulated P53 activity显示文摘 | Saifeng Wang Lipeng Qiu Xiaoli Yan Wensong Jin Yanzhong Wang Lizhao Chen Erjie Wu Xin Ye George F. Gao Fusheng Wang Yu Chen Zhongping Duan Songdong Meng | 2012 | Hepatology2012，，3： | 1 |
| 15 | Wide-angle seismic imaging of the high velocity subbasalt显示文摘 | Hu Zhongping Wu Dali Guan Luping | 2003 | Expanded Abstracts of 73th Annual Internat SEG Mtg2003，11，421： | 1 |
| 16 | Single-wavelength-excited fluorogenic nanoprobe for accurate realtime ratiometric analysis of broad pH fluctuations in mitophagy显示文摘Mitophagy has a critical role in maintaining cellular homeostasis through acidic lysosomes engulfing excess or impaired mitochondria,thereby pH fluctuation is one of the most significant indicators for tracking mitophagy.Then such precise pH tracking demands the fluorogenic probe that has tailored contemporaneous features,including mitochondrial-specificity,excellent biocompatibility,wide pH-sensitive range of 8.0–4.0,and especially quantitative ability.However,available molecular probes cannot simultaneously meet all the requirements since it is extremely difficult to integrate multiple functionalities into a single molecule.To fully address this issue,we herein integrate two fluorogenic pH sensitive units,a mitochondria-specific block,cellpenetrating facilitator,and biocompatible segments into an elegant silica nano scaffold,which greatly ensures the applicability for real-time tracking of pH fluctuations in mitophagy.Most significantly,at a single wavelength excitation,the integrated pHsensitive units have spectra-distinguishable fluorescence towards alkaline and acidic pH in a broad range that covers mitochondrial and lysosomal pH,thus enabling a ratiometric analysis of pH variations during the whole mitophagy.This work also provides constructive insights into the fabrication of advanced fluorescent nanoprobes for diverse biomedical applications. | Xin Zhang Juan Chen Jiwen Hu Anna du Rietz Xiongyu Wu Ruilong Zhang Zhongping Zhang Kajsa Uvdal Zhangjun Hu | 2022 | Nano Research2022，15，7： | 1 |
| 17 | The progress of laser ranging technology at Shanghai Astronomical Observatory显示文摘As an important station of International Laser Ranging Service(ILRS),Shanghai Astronomical Observatory(SHAO)has upgraded Satellite Laser Ranging(SLR)system with high repetition rate and achieved some technological progress,There are a lot of improvements for overall system performance,such as annual observation passes,measurement precision and quality of observation data.SLR technology with repetition rate of 10 kHz is accomplished firstly in China,and space debris laser ranging technology with200 Hz laser is promoted and proved to be more detective for weak echo,which lead to successful measurement for 40,000 km satellites and space debris within 3000 km.At the same time,SLR based on multi-telescopes and 1064 nm wavelength are planned to make a breakthrough of detection capabilities,and also to expand its application fields.These progresses will be introduced in this paper in detail. | Zhibo Wu Haifeng Zhang Huarong Deng Mingliang Long Zhien Cheng Zhongping Zhang Wendong Meng | 2019 | Geodesy and Geodynamics2019，10，6： | 1 |
| 18 | A Novel Hybrid Vortex Search and Artificial Bee Colony Algorithm for Numerical Optimization Problems显示文摘Though vortex search(VS) algorithm has good performance in solving global numerical optimization problems, it cannot fully search the whole space occasionally. Combining the vortex search algorithm and the artificial bee colony algorithm(ABC) which has good performance in exploration, we present a HVS(hybrid vortex search) algorithm to solve the numerical optimization problems. We first use the employed bees and onlooker bees of ABC algorithm to find a solution, and then adopt the VS algorithm to find the best solution. In the meantime, we cannot treat the best solution so far as the center of the algorithm all the time. The algorithm is tested by 50 benchmark functions. The numerical results show the HVS algorithm has superior performance over the ABC and the VS algorithms. | WANG Zhaowei WU Guomin WAN Zhongping | 2017 | Wuhan University Journal of Natural Sciences2017，22，4： | 1 |
| 19 | Methane sensor based on nanocomposite of palladium/multi-walled carbon nanotubes grafted with 1,6-hexanediamine显示文摘 | Li Zhongping Li Junfen Wu Xu | 2009 | Sensors and Actuators B2009，139，： | 1 |
| 20 | Synthesis of high quality and stability CdS quantum dots with overlapped nucleation-growth process in large scale显示文摘 | Xinmei Liu Yang Jiang Xinzheng Lan Shanying Li Di Wu Tingting Han Honghai Zhong Zhongping Zhang | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
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