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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | L_(1/2) regularization显示文摘In this paper we propose an L1 /2 regularizer which has a nonconvex penalty.The L 1/2 regularizer is shown to have many promising properties such as unbiasedness, sparsity and oracle properties.A reweighed iterative algorithm is proposed so that the solution of the L 1/2 regularizer can be solved through transforming it into the solution of a series of L 1 regularizers.The solution of the L 1/2 regularizer is more sparse than that of the L 1 regularizer, while solving the L 1/2 regularizer is much simpler than solving the L 0 regularizer.The experiments show that the L 1/2 regularizer is very useful and efficient, and can be taken as a representative of the Lp(0 < p < 1) regularizer. | XU ZongBen ZHANG Hai WANG Yao CHANG XiangYu LIANG Yong | 2010 | Science China(Information Sciences)2010，53，6： | 32 |
| 3 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 4 | Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer显示文摘Bone metastasis is the leading cause of death in prostate cancer patients,for which there is currently no effective treatment.Since the bone microenvironment plays an important role in this process,attentions have been directed to the interactions between cancer cells and the bone microenvironment,including osteoclasts,osteoblasts,and bone stromal cells.Here,we explained the mechanism of interactions between prostate cancer cells and metastasis-associated cells within the bone microenvironment and further discussed the recent advances in targeted therapy of prostate cancer bone metastasis.This review also summarized the effects of bone microenvironment on prostate cancer metastasis and the related mechanisms,and provides insights for future prostate cancer metastasis studies. | Xiangyu Zhang | 2019 | Cancer Communications2019，39，1： | 22 |
| 5 | Poxue Huayu and Tianjing Busui Decoction for cerebral hemorrhage Upregulation of neurotrophic factor expression显示文摘This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood.Rat models were intragastrically administered 5,10,20 g/kg Poxue Huayu and Tianjing Busui Decoction,supplemented with Hirudo,raw rhubarb,raw Pollen Typhae,gadfly,Fructrs Trichosanthis,Radix Notoginseng,Rhizoma Acori Talarinowii,and glue of tortoise plastron,once a day,for 14 consecutive days.Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage,and intracerebral hematoma volume markedly reduced after treatment.Immunohistochemical staining revealed that brain-derived neurotrophic factor,tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma.Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma.Neurologic impairment obviously reduced.These results indicated that Poxue Huayu and Tianjing Busui Decoction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor. | Jixiang Ren Xiangyu Zhou Jian Wang Jianjun Zhao Pengguo Zhang | 2013 | Neural Regeneration Research2013，8，22： | 19 |
| 6 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 7 | Stability control of surrounding rocks for a coal roadway in a deep tectonic region显示文摘In order to effectively control the deformation and failure of surrounding rocks in a coal roadway in a deep tectonic region, the deformation and failure mechanism and stability control mechanism were studied. With such methods as numerical simulation and field testing, the distribution law of the displacement, stress and plastic zone in the surrounding rocks was analyzed. The deformation and failure mechanisms of coal roadways in deep tectonic areas were revealed: under high tectonic stress, two sides will slide along the roof or floor; while the plastic zone of the two sides will extend along the roof or floor,leading to more serious deformation and failure in the corner of two sides and the bolt supporting the corners is readily cut off by the shear force or tension force. Aimed at controlling the large slippage deformation of the two sides, serious deformation and failure in the corners of the two sides and massive bolt breakage, a ‘‘controlling and yielding coupling support'' control technology is proposed. Firstly, bolts which do not pass through the bedding plane should be used in the corners of the roadway, allowing the two sides to have some degree of sliding to achieve the purpose of ‘‘yielding'' support, and which avoid breakage of the bolts in the corner. After yielding support, bolts in the corner of the roadway and which pass through the bedding plane should be used to control the deformation and failure of the coal in the corner. ‘‘Controlling and yielding coupling support'' technology has been successfully applied in engineering practice, and the stability of deep coal roadway has been greatly improved. | Xiao Tongqiang Wang Xiangyu Zhang Zhigao | 2014 | International Journal of Mining Science and Technology2014，24，2： | 16 |
| 8 | A Review of Colloid Transport in Fractured Rocks显示文摘Recent recognition of colloid and colloidassociated transport of strongly sorbing contaminants in fractured rocks highlights the importance of exploring the transport behavior of colloids under conditions prevailing in the field.The rapid transport of colloids through fractured rocks-as affected by the hydraulic properties of the flow system,the properties of fracture surface and the geochemical conditionshas not been sufficiently elucidated,and predictions of colloid transport through fractures have encountered difficulties,particularly at the field scale.This article reviews the current understanding of the mechanisms and modeling of colloid transport and retention in fractured rocks.Commonly used experimental techniques and approaches for conducting colloid transport experiments at different scales,ranging from the laboratory to the field scale,are summarized and commented upon.The importance of various interactions(e.g.,dissolution,colloid deposition,generation,mobilization and deposition of filling materials within fractures) between the flowing solution and the fracture walls(in many cases,with skin or coating on the host rock at the liquid-solid interface) has been stressed.Colloid transport through fractures of high heterogeneity has not yet been well understood and modeled at the field scale.Here,we summarize the current knowledge and understanding accumulated in the last two decades in regard to colloid and colloidassociated transport through fractures.Future research needs are also discussed. | ZHANG Wei TANG Xiangyu WEISBROD Noam GUAN Zhuo | 2012 | Journal of Mountain Science2012，9，6： | 12 |
| 9 | Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury显示文摘Pretreatment with scutellaria baicalensis stem-leaf total flavonoid has protective effects against ischemia and attenuates myocardial ischemia-reperfusion injury.In this study,rats were given scutellaria baicalensis stem-leaf total flavonoid intragastrically at 50,100,and 200 mg/kg per day for7 days before focal cerebral ischemia-reperfusion injury models were established using the suture method.We then determined the protective effects of scutellaria baicalensis stem-leaf tota flavonoid pretreatment on focal cerebral ischemia-reperfusion injury.Results showed that neurological deficit scores increased,infarct volumes enlarged,apoptosis increased and Bcl-2 and Bax protein expression were upregulated at 24 hours after reperfusion.Pretreatment with scutellaria baicalensis stem-leaf total flavonoid at any dose lowered the neurological deficit scores reduced the infarct volume,prevented apoptosis in hippocampal cells,attenuated neuronal and blood-brain barrier damage and upregulated Bcl-2 protein expression but inhibited Bax protein expression.Doses of 100 and 200 mg/kg were the most efficacious.Our findings indicate that pretreatment with scutellaria baicalensis stem-leaf total flavonoid at 100 and 200 mg/kg can improve the neurological functions and have preventive and protective roles after focal cerebra ischemia-reperfusion injury. | Shumin Zhao Wei Kong Shufeng Zhang Meng Chen Xiaoying Zheng Xiangyu Kong | 2013 | Neural Regeneration Research2013，8，34： | 11 |
| 10 | Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate显示文摘 | Jiezhao Zheng Zhujun Li Rui Tian Youming Lu Xiangyu Guo Yong-hui Jiang Xiao-Jiang Li Yong Q Zhang | 2017 | Cell Research2017，27，10： | 11 |
| 11 | Adaptive Walking of a Quadrupedal Robot Based on Layered Biological Reflexes显示文摘A multiple-legged robot is traditionally controlled by using its dynamic model.But the dynamic-model-based approach fails to acquire satisfactory performances when the robot faces rough terrains and unknown environments.Referring animals' neural control mechanisms,a control model is built for a quadruped robot walking adaptively.The basic rhythmic motion of the robot is controlled by a well-designed rhythmic motion controller(RMC) comprising a central pattern generator(CPG) for hip joints and a rhythmic coupler(RC) for knee joints.CPG and RC have relationships of motion-mapping and rhythmic couple.Multiple sensory-motor models,abstracted from the neural reflexes of a cat,are employed.These reflex models are organized and thus interact with the CPG in three layers,to meet different requirements of complexity and response time to the tasks.On the basis of the RMC and layered biological reflexes,a quadruped robot is constructed,which can clear obstacles and walk uphill and downhill autonomously,and make a turn voluntarily in uncertain environments,interacting with the environment in a way similar to that of an animal.The paper provides a biologically inspired architecture,with which a robot can walk adaptively in uncertain environments in a simple and effective way,and achieve better performances. | ZHANG Xiuli E Mingcheng ZENG Xiangyu ZHENG Haojun | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 10 |
| 12 | Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemiareperfusion injury in aged rats显示文摘Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury. | Xiangyu Ji Li'na Zhang Ran Liu Yingzhi Liu Jianfang Song He Dong Yanfang Jia Zangong Zhou | 2014 | Neural Regeneration Research2014，9，11： | 9 |
| 13 | Protective effects of Jiayan Kangtai granules on autoimmune thyroiditis in a rat model by modulating Th17/Treg cell balance显示文摘OBJECTIVE: To investigate the protective effects of Jiayan Kangtai(JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis(AIT), and the possible underlying mechanism.METHODS: Female Lewis rats(6-8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin(IL)-6,IL23 p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper(Th)17 cells and regulatory T cells(Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined via bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western blot.RESULTS: Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg activity.CONCLUSION: JYKT treatment appeared to be protective against AIT in rats, possibly via the regulation of the Th17 cell/Treg imbalance in AIT. | Hou Yi Wang Tieshan Guo Xiangyu Sun Wen Guo Xuan Wu Lili Qin Lingling Zhang Chengfei Liu Tonghua | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 9 |
| 14 | Genome-Wide Analysis and Expression Patterns of the YUCCA Genes in Maize显示文摘Auxin plays important roles in various aspects of plant growth and development(Zhao,2010).In Arabidopsis,a number of YUCCA(YUC)genes,which are involved in auxin biosynthesis,have been identified(Zhao et al.,2001;Woodward et al.,2005;Cheng et al.,2006,2007;Kim et al.,2007;Chen et al.,2014).YUC genes encode flavin monooxygenases(FMOs)that convert indole-3-pyruvate(IPA)to indole-3-acetic acid(IAA)(Zhao,2012).The Arabidopsis YUC family is comprised of 11 members(Zhao et al.,2001; | Wenlan Li Xiangyu Zhao Xiansheng Zhang | 2015 | Journal of Genetics and Genomics2015，42，12： | 8 |
| 15 | Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant显示文摘Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the implants.Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter.In this work,TiO2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of bacteria.The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo.More importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the TiO2 nanorod arrays improve the new bone formation around implants.In this protocol,besides the biocompatible TiO2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be released.Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation.The concept and antibacterial system described here have large clinical potential in orthopedic and dental applications. | Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu | 2021 | Bioactive Materials2021，6，1： | 7 |
| 16 | Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation:a multicenter study显示文摘The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation(HBMT) on hematological malignances are well established. Previous prospective single-center studies have demonstrated better survival after HBMT versus haploidentical rhG-CSF-mobilized peripheral blood stem cell transplantation(HPBSCT) for acute leukemia(AL) not in remission(NR) or in more than the second complete remission(>CR2). To test the hypothesis that HBMT is still superior to HPBSCT for patients with AL, multiple myeloma(MM), or non-Hodgkin lymphoma(NHL) in CR1/CR2 and for patients with chronic myeloid leukemia in the first and second chronic phase lacking a matched donor, we designed a propensity score method-based multicenter study.Hematopoietic recovery, acute graft-versus-host disease(aGVHD), and chronic GVHD were comparable between the HBMT group(n=168) and the HPBSCT group(n=42). No significant differences were found in non-relapse mortality rate(20.17%±3.58%and 27.24%±7.16%, P=0.18) or relapse rate(19.96%±3.72% and 28.49%±8.25%, P=0.32) between the HBMT group and the HPBSCT group. HBMT recipients had better overall survival(65.0%±4.2% and 54.2%±8.3%, P=0.037) and disease-free survival(59.9%±4.6% and 44.3%±8.7%, P=0.051). Multivariate analysis showed that HPBSCT was associated with poorer DFS(HR(95%CI), 1.639(0.995–2.699), P=0.052). Our comparisons showed that HBMT was superior to HPBSCT as a post-remission treatment for patients lacking an identical donor. | Xiangyu Zhao Feng Gao Xiaohui Zhang Yu Wang Lanping Xu Kaiyan Liu Xiaosu Zhao Yingjun Chang Han Wei Huan Chen Yuhong Chen Zhengfan Jiang Xiaojun Huang | 2016 | Science China(Life Sciences)2016，59，11： | 7 |
| 17 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 18 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 19 | INTERVENTIONAI DIAGNOSIS AND TREATMENT OF VASCULOGENEIC PULSATILE TINNITUS显示文摘Objective To retrospectively study clinical features and diagnostic imaging of vasculogeneic pulsatile tinnitus, and the feasibility and efficacy of transvascular interventional treatment for this condition. Methods Data from 82 cases of arterial or venous pulsatile tinnitus were reviewed. DSA characteristics and possible pathophysiological mechanisms of pulsatile tinnitus in these cases were studied. Diagnoses in this group included intracranial arterovenous fistula(AVF)(n=3), spontaneous skull base dural AVF(n=16), traumatic carotid-cavernous sinus fistula(n=5), subclavian artery stenosis(n=2), internal carotid artery stenosis(n=3), intracranial arterial stenosis(n=1), kinked and/or elongated vertebrobasilar artery(n=2), venous sinus diverticulum(n=2), venous sinus stenosis on the dominant drainage side(n=46) and occipital sinus stenosis(n=2).Treatments included embolization and stenting using coils, NBCA glue, Balt balloons, self-expansion stents and intracranial micro-stents via either the femoral artery or femoral vein. Results Procedures were successful in all cases with no surgery-related complications. Tinnitus disappeared within 2 days after the procedure in all cases. Follow up duration was 5-36 months. Recurrence occurred in 4 cases of arterial tinnitus within 3 months following the initial procedure, which improved after revision embolization or symptom management. There was no recurrence in venous tinnitus cases following stent plastic or stent-coiling embolization treatments. Conclusions Endovascular intervention provides a new approach to the diagnosis and treatment of intractable pulsatile tinnitus. It is also effective in differentiating and studying other types of tinnitus. | LI Baomin CAO Xiangyu LIU Xinfeng LI Sheng WANG Jun LIANG Yongping GE Aili ZHANG Alan FENG Huimin | 2014 | Journal of Otology2014，9，1： | 6 |
| 20 | A hypersonic target coherent integration detection algorithm based on Doppler feedback显示文摘The traversal search of multi-dimensional parameter during the process of hypersonic target echo signal coherent integration,leads to the problem of large amounts of calculation and poor real-time performance.In view of these problems,a modified polynomial Radon-polynomial Fourier transform(MPRPFT)hypersonic target coherent integration detection algorithm based on Doppler feedback is proposed in this paper.Firstly,the Doppler estimation value of the target is obtained by using the target point information obtained by subsequent non-coherent integration detection.Then,the feedback adjustment of the coherent integration process is performed by using the acquired target Doppler estimation value.Finally,the coherent integration is completed after adjusting the search interval of compensation.The simulation results show that the algorithm can effectively reduce the computational complexity and improve the real-time performance on the basis of the effective coherent integration of hypersonic target echo signals. | LI Lin WANG Guohong SUN Dianxing ZHANG Xiangyu | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 6 |
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