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| 1 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 2 | Microbial D-amino acids and marine carbon storage显示文摘In nature, there are two conformational types of amino acids: L- and D-isomers. The L-amino acids are the predominant form and are used mainly for protein synthesis, while the D-amino acids are few in quantity but more diverse in terms of their biological functions. D-amino acids are produced by many marine microbes, which are important players in carbon and energy cycles in the ocean. As the major constituent of the marine organic carbon pool, D-amino acids can persist in the water column for a long time before being further transformed by chemical or biological processes or transported through physical processes(such as absorption and aggregation). This article reviews the microbial synthesis of D-amino acids, their physiological function and metabolism in microbes, and the contribution of D-amino acids as a carbon source to the oceanic carbon reservoir. | ZHANG Zi Lian ZHENG Qiang JIAO Nian Zhi | 2016 | Science China Earth Sciences2016，59，1： | 9 |
| 3 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 4 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 5 | Cis-2-dodecenoic Acid Mediates Its Synergistic Effect with Triazoles by Interfering with Efflux Pumps in Fluconazole-resistant Candida albicans显示文摘Objective To evaluate the synergy of the Burkholderia signaling molecule cis-2-dodecenoic acid(BDSF) and fluconazole(FLU) or itraconazole(ITRA) against two azole-resistant C. albicans clinical isolates in vitro and in vivo. Methods Minimum inhibitory concentrations(MICs) of antibiotics against two azole-resistant C. albicans were measured by the checkerboard technique, E-test, and time-kill assay. In vivo antifungal synergy testing was performed on mice. Analysis of the relative gene expression levels of the strains was conducted by quantitative reverse-transcription polymerase chain reaction(qR T-PCR). Results BDSF showed highly synergistic effects in combination with FLU or ITRA with a fractional inhibitory concentration index of ≤ 0.08. BDSF was not cytotoxic to normal human foreskin fibroblast cells at concentrations of up to 300 μg/mL. The qR T-PCR results showed that the combination of BDSF and FLU/ITRA significantly inhibits the expression of the efflux pump genes CDR1 and MDR1 via suppression of the transcription factors TAC1 and MRR1, respectively, when compared with FLU or ITRA alone. No dramatic difference in the mR NA expression levels of ERG1, ERG11, and UPC2 was found, which indicates that the drug combinations do not significantly interfere with UPC2-mediated ergosterol levels. In vivo experiments revealed that combination therapy can be an effective therapeutic approach to treat candidiasis. Conclusion The synergistic effects of BDSF and azoles may be useful as an alternative approach to control azole-resistant Candida infections. | YANG Dong Liang HU Yan Ling YIN Zi Xin ZENG Gui Sheng LI Dan ZHANG Yu Qian XU Zhen Hua GUAN Xiao Ming WENG Li Xing WANG Lian Hui | 2019 | Biomedical and Environmental Sciences2019，32，3： | 2 |
| 6 | Environmental and tectonic significance of Late Permian reefs in the Linxi and adjacent areas in Inner Mongolia of China显示文摘Many plateau-edge reefs and reef mounds of the Late Permian have been discovered in Linxi County and adjacent areas of Inner Mongolia, China. These reefs verify that the Hinggan-Inner Mongolia Area was an open and unobstructed sea-trough in Late Permian. Facies and sequences of reef strata in Member 4 and Member 5 of the Linxi Formation were studied for information to reconstruct the closing process of the Linxi-Jiutai chasm in the sea-trough, i.e., to constrain subsidence, uplift, and final closing. Ages of the reef-bearing strata have been determined to be late and end of Late Permian, based on ranges or abundances of diverse fossils. Six reef-building organic assemblages were distinguished, representing different ecologic conditions, according to morphological functions and paleoecological adaptations of organisms including primarily sponges, bryozoans, and calcareous algae. Two types of shelf slopes, the gentle slope and the steep slope, have been interpreted for Member 4 and Member 5 of the Linxi Formation, based on the assemblages. The locations of outcrops, and types of these reefs delineate the north margin of Sino-Korea Platform, and define uplift and final closing of the Linxi-Jiutai chasm at the end of Late Permian. | TIAN Shu Gang ZHANG Yong Sheng GONG Yue Xuan LI Zi Shun GAO Lian Da ZHAI Da Xing ZHU Chang Wei | 2016 | Science China Earth Sciences2016，59，7： | 2 |
| 7 | Is the Trial of Labor after Two Previous Cesarean Sections Contraindicated in China?显示文摘The cesarean section(CS) rate has risen rapidly worldwide. In high-income countries, national studies have revealed that more than a quarter of births are performed by CS, while in China the rate increased from 28.8% in 2008 to 34.9% in2014[1]—far above the World Health Organization(WHO)-recommended rate of 10%–15%. Due to the high global cesarean rates, the promotion of trial of labor after cesarean(TOLAC) may be an option that can be used to reduce the overall number of CSs. | BI Shi Lei ZHANG Li Zi LIANG Xin Yue HUANG Li Jun ZENG Shan Shan LIANG Ying Yu LI Yu Lian HUANG Min Shan JIA Jin Ping WEN Sui Wen FENG Ling DU Li Li WANG Zhi Jian CHEN Dun Jin | 2021 | Biomedical and Environmental Sciences2021，34，12： | 0 |
| 8 | Leukocyte Telomere Length and Lacunar Stroke:A Mendelian Randomization Study显示文摘Lacunar stroke is a cerebral small vessel disease that accounts for nearly 25%of cases of ischemic stroke.As an age-related disease,the incidence of lacunar stroke increases with age.Generally,biological age is equal to chronological age.However,under the influence of a range of chronic diseases and circumstances,the biological age can accelerate,which may contribute to the variation in risk of illness and death between individuals. | DANG Mei Juan LI Tao ZHAO Li Li LI Ye WANG Xiao Ya WU Yu Lun LU Jia Liang LU Zi Wei YANG Yang FENG Yu Xuan WANG He Ying JIAN Ya Ting FAN Song Hua JIANG Yu ZHANG Gui Lian | 2023 | Biomedical and Environmental Sciences2023，36，4： | 0 |
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