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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | A Simulation of Dynamic Recrystallization by Coupling a Cellular Automaton Method With a Topology Deformation Technique 显示文摘 | Xiao N M Zheng C W Li D Z | 2008 | Computational Materials Science2008，41，3： | 1 |
| 5 | Treatment with vector-expressed small hairpin RNAs against Ki67 RNA- induced eell growth inhibition and apoptosis in human re- nal eareinoma cells 显示文摘 | ZHENG J N SUN Y F PEI D S | 2006 | Aeta Bioehim Biophys Sin (Shanghai)2006，38，： | 1 |
| 6 | Direct catalytic conversion of cellulose into ethylene glycol using nickel-promoted tungsten carbide catalysts显示文摘 | JI N ZHANG T ZHENG M Y WANG A Q WANG H WANG X D CHENG J G | 2008 | Angew Chem2008，120，44： | 1 |
| 7 | Modified grid algorithm for noisy all-sky autonomous star identification显示文摘 | Na M Zheng D N Jia P F | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，2： | 1 |
| 8 | What ' s the difference between CD80 and CD86? 显示文摘 | SANSOM D M MANZOTTI C N ZHENG Y | 2003 | Trends Immunol2003，24，6： | 1 |
| 9 | Epitaxial BiFe03 multiferroic thin film heterostructures 显示文摘 | WANG J NEATON J B ZHENG H NAGARAJAN V OGALE S B LID B VIEHLAND D VAITHYANAATHAN V SCHLOM D G WAGHMARE U V SPALDIN N A RABE K M WUTTIG M RAMESH R | 2003 | Science2003，299，： | 1 |
| 10 | Coumarins from Cnidium monnieri and their antiosteoporotic activity显示文摘 | Zhang Q Qin L He W Van Puyvelde L Maes D Adams A Zheng H De Kimpe N | 2007 | Planta Med2007，73，1： | 1 |
| 11 | An integrated fat grafting technique for cosmetic facial contouring显示文摘 | XIE Y ZHENG D N LI Q F | 2010 | J Plast Reconstr Aesthet Surg2010，63，2： | 1 |
| 12 | Effect of carbon content on microstructure and mechanical properties of hot-rolled low carbon 12Cr-Ni stainless steel显示文摘 | Zheng H Ye X N Li J D | 2010 | Mater Sci Eng A2010，527，2728： | 1 |
| 13 | Increased vascular endothelial growth factor and receptors:relationship to angiogenesis in asthma显示文摘 | Feltis B N Wignarajah D Zheng L | 2006 | Am J Respir Crit Care Med2006，173，11： | 1 |
| 14 | Effects of recombinant human endostatin and its synergy with eisplatin on circulating endothelial cells and tumor vascular normalization in A549 xenograft murine model显示文摘 | Li N Zheng D Li K | 2012 | J Cancer Res Clin Oncol2012，138，7： | 1 |
| 15 | Non-flat function estimation with a multi-scale support vector regression显示文摘 | Zheng D N Wang J X Zhao Y N | 2006 | Neurocomputing2006，70，： | 1 |
| 16 | Evaluation of a DNA vaccine candidate expressing prM-E-NS1 antigens of dengue virus serotype 1 with or without granulocyte- macrophage colony-stimulating factor (GM-CSF) in immunogenicity and protection 显示文摘 | Zheng Q Fan D Y Gao N | 2011 | Vaccine2011，29，4： | 1 |
| 17 | Potential energy savings and CO2 emissions reduction of China's cement industry显示文摘 | Ke J Zheng N Fridley D | 2012 | Energy Policy2012，45，： | 1 |
| 18 | Extraction/conversion of geometric dimensions and tolerances for machining features 显示文摘 | Gao J Zheng D T Gindy N | 2005 | Advanced Manufacturing Technology2005，26，4： | 1 |
| 19 | Blow-up rate and profile for a degenerate parabolic system coupled via nonlocal sources显示文摘 | Zheng S N Wang L D | 2006 | Comput Math Appl2006，52，1011： | 1 |
| 20 | Health risk of Hg, Pb, Cd, Zn and Cu to the inhabitants around Huludao zinc plant in China via consumption of veg- etables显示文摘 | Zheng N Wang Q Zheng D | 2007 | The Science of the Total Environment2007，383，： | 1 |
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