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| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 3 | Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl- d -aspartate receptor 2B subunit显示文摘 | YaGuo Zheng SongQing Cui Yue Liu Juan Zhang Wei Zhang Jing Zhang XiaoPing Gu ZhengLiang Ma | 2012 | Brain Research Bulletin (-)2012，，4： | 1 |
| 4 | Exfoliation corrosion of extruded 2024-T4 in the coastal environments in China显示文摘 | Shuangqing Sun Qifei Zheng Defu Li Songqing Hu Junguo Wen | 2011 | Corrosion Science2011，，8： | 1 |
| 5 | Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl- d -aspartate receptor 2B subunit显示文摘 | YaGuo Zheng SongQing Cui Yue Liu Juan Zhang Wei Zhang Jing Zhang XiaoPing Gu ZhengLiang Ma | 2012 | 2012 (4-5)2012，，4： | 1 |
| 6 | DYNAMIC BUCKLING OF STATICALLY PRELOADED RING-STIFFENED CYLINDRICAL SHELLS UNDER AXIAL FLUID-SOLID IMPACT LOADING显示文摘The Initial Imperfection Amplified Criterion is applied to investigate the geometric nonlineardynamic buckling of statically preloaded ring-stiffened cylindrical shells under axial fluid-solid impact.Tak-ing account of the effects of large deformation and initial geometric imperfection,the governing equations areobtained by the Galerkin method and solved by the Runge-Kutta method.The effects of static preloading(uniform external radial pressure)on the buckling features and the load-carrying ability of ring-stiffened cy-lindrical shells against axial impact are discussed. | Jiang Songqing Li Yongchi Hu Xiuzhang Zheng Jijia | 2000 | Acta Mechanica Solida Sinica2000，13，3： | 1 |
| 7 | Aberrant expression of β -catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer显示文摘 | Lina Xu Yi Jiang Jun Zheng Guiyuan Xie Jiao Li Lei Shi Songqing Fan | 2013 | Human Pathology2013，，7： | 1 |
| 8 | Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc显示文摘Actin filament associated protein 1 antisense RNA 1(named AFAP1-AS1)is a long non-coding RNA and overexpressed in many cancers.This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer.The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells.To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer,we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses.AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients'poor prognosis.In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis.AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1(named SNIP1),which inhibited ubiquitination and degradation of c-Myc protein.Upregulation of c-Myc molecule in turn promoted the expression of ZEB1,ZEB2,and SNAIL gene,which ultimately enhanced epithelial to mesenchymal transition(EMT)and lung cancer metastasis.Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer's migration and invasion may provide novel therapeutic targets for lung cancer patients'early diagnosis and therapy. | Yu Zhong Liting Yang Fang Xiong Yi He Yanyan Tang Lei Shi Songqing Fan Zheng Li Shanshan Zhang Zhaojian Gong Can Guo Qianjin Liao Yujuan Zhou Ming Zhou Bo Xiang Xiaoling Li Yong Li Zhaoyang Zeng Guiyuan Li Wei Xiong | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 9 | Experiments on the influences of well pattern on water flooding characteristics of dissolution vug-cave reservoir显示文摘Based on the similarity criterion, volcanic rock samples were taken from outcrops to make experimental models. Water flooding experiments of five-spot well pattern, nine-spot well pattern, five-spot to nine-spot well pattern, the relationship between relative well and fracture positions, and injection rate in dissolution vug-cave reservoirs with/without fractures were carried out to analyze variation regularities of development indexes, find out development characteristics of water flooding with different well patterns and sort out the optimal water flooding development mode. For dissolution vug-cave reservoirs without fractures, five-spot well pattern waterflooding has very small sweeping area, serious water channeling and low oil recovery. When the well pattern was adjusted from five-spot to nine-spot well pattern, oil recovery could be largely improved, but the corner well far from the injector is little affected. In dissolution vug-cave reservoirs with fractures, when the injector and producer are not connected by fractures, the fractures could effectively connect the poorly linked vugs to improve the development effect of water flooding. Whether there are fractures or not in dissolution vug-cave reservoirs, the development effect of nine-spot well-pattern is much better than that of five-spot well pattern and five-spot to nine-spot well pattern, this is more evident when there are fractures, and the edge well has better development indexes than corner well. At the high-water cut stage of water flooding with nine-spot well pattern, the oil recovery can be further improved with staggered line-drive pattern by converting the corner well into injection well. It is helpful to increase the oil production of corner well of nine-spot well pattern by increasing the injection rate, and improve ultimate oil recovery, but the water-free production period would be greatly shortened and water-free recovery would decrease. | WANG Jing LIU Huiqing ZHANG Jing ZHAO Wei HUANG Yitao KANG Zhijiang ZHENG Songqing | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 10 | Controlling factors of remaining oil distribution after water flooding and enhanced oil recovery methods for fracturecavity carbonate reservoirs in Tahe Oilfield显示文摘Based on comprehensive analysis of core, well logging, seismic and production data, the multi-scale reservoir space, reservoir types, spatial shape and distribution of fractures and caves, and the configuration relationship with production wells in fracture-cavity carbonate reservoirs were studied systematically, the influence of them on the distribution of residual oil was analyzed, and the main controlling factors mode of residual oil distribution after water flooding was established. Enhanced oil recovery methods were studied considering the development practice of Tahe oilfield. Research shows that the main controlling factors of residual oil distribution after water flooding in fracture-cavity carbonate reservoirs can be classified into four categories: local high point, insufficient well control, flow channel shielding and weak hydrodynamic. It is a systematic project to improve oil recovery in fracture-cavity carbonate reservoirs. In the stage of natural depletion, production should be well regulated to prevent bottom water channeling. In the early stage of waterflooding, injection-production relationship should be constructed according to reservoir type, connectivity and spatial location to enhance control and producing degree of waterflooding and minimize remaining oil. In the middle and late stage, according to the main controlling factors and distribution characteristics of remaining oil after water flooding, remaining oil should be tapped precisely by making use of gravity differentiation and capillary force imbibition, enhancing well control, disturbing the flow field and so on. Meanwhile, backup technologies of reservoir stimulation, new injection media, intelligent optimization etc. should be developed, smooth shift from water injection to gas injection should be ensured to maximize oil recovery. | ZHENG Songqing YANG Min KANG Zhijiang LIU Zhongchun LONG Xibin LIU Kunyan LI Xiaobo ZHANG Shiliang | 2019 | Petroleum Exploration and Development2019，46，4： | 0 |
| 11 | Theories and practices of carbonate reservoirs development in China显示文摘Carbonate reservoirs in China have the characteristics of diversified accumulation pattern, complex structure and varying reservoir conditions. Concerning these characteristics, this article tracks the technical breakthroughs and related practices since the 1950 s, summarizes the developed theory and technologies of carbonate reservoir development, analyzes their adaptability and problems, and proposes their development trend. The following theory and technologies have come into being:(1) carbonate reservoir formation mechanisms and compound flow mechanisms in complex medium;(2) reservoir identification and description technologies based on geophysics and discrete fracture-vuggy modeling method;(3) well testing analysis technology and numerical simulation method of coupling free flow and porous media flow;(4) enhanced oil recovery techniques for nitrogen single well huff and puff, and water flooding development techniques with well pattern design in spatial structure, changed intensity water injection, water plugging and channel blocking as the core;(5) drilling and completion techniques, acid fracturing techniques and its production increasing techniques. To realize the efficient development of carbonate oil and gas reservoirs, researches in four aspects need to be done:(1) complex reservoir description technology with higher accuracy;(2) various enhanced oil recovery techniques;(3) improving the drilling method and acid fracturing method for ultra-deep carbonate reservoir and significantly cutting engineering cost;(4) strengthening the technological integration of information, big data, cloud computation, and artificial intelligence in oilfield development to realize the smart development of oilfield. | LI Yang KANG Zhijiang XUE Zhaojie ZHENG Songqing | 2018 | Petroleum Exploration and Development2018，45，4： | 0 |
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