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| 1 | The development and function of follicular helper T cells in immune responses显示文摘小囊的助手 T 房间(Tfh ) 作为提供帮助让 B 房间增殖并且在幼芽的中心经历抗体亲密关系成熟的一个系被提交了。证据支持了那个 Tfh 子集开发象另外的系一样,依赖于一个特别 transcriptional 节目被开始的微型环境。它为 Tfh 房间的开发和函数作为主人管理者被看了那 Bcl-6 和 IL-21 行为。Tfh dysregulation 涉及自体免疫的病理的发展,例如全身的豺狼座 erythematosus,风湿性关节炎和另外的自体免疫的疾病。现在的评论在在他们的开发和函数的 Tfh 房间和焦点的域里加亮最近的进展。 | Maogen Chen Zhiyong Guo Weiqiang Ju Bernhard Ryffel Xiaoshun He Song Guo Zheng | 2012 | Cellular & Molecular Immunology2012，9，5： | 18 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Effect of Heat Treatment on Cu Distribution,Antibacterial Performance and Cytotoxicity of Ti-6Al-4V-5Cu Alloy显示文摘A copper-bearing Ti-6AI-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure,antibacterial performance,and cytocompatibility.Characterization of microstructure revealed that the solution treated alloy consisted of α phase,α' phase and(3 phase,while besides these phases,the aged alloy also contained the precipitations of intermetallic Ti_2Cu compound.The solution treated alloy showed better antibacterial performance with increasing the solution temperature.The Cu ions released from Ti—6AI—4V—5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy,and do not induce any cytotoxicity.The optimal heat treatment for Ti-6Al-4V-5Cu alloy was solution treated at 930 C,at which it could exhibit both promising antibacterial performance and no cytotoxicity. | Zheng Ma Ling Ren Rui Liu Ke Yang Yu Zhang Zhenhua Liao Weiqiang Liu Min Qi R.D.K.Misra | 2015 | Journal of Materials Science & Technology2015，31，7： | 10 |
| 4 | Long-distance ranging with high precision using a soliton microcomb显示文摘Laser-based light detection and ranging(lidar)plays a significant role in both scientific and industrial areas.However,it is difficult for existing lidars to achieve high speed,high precision,and long distance simultaneously.Here,we demonstrate a high-performance lidar based on a chip-scaled soliton microcomb(SMC)that can realize all three specialties simultaneously.Aided by the excellent properties of ultrahigh repetition rate and the smooth envelope of the SMC,traditional optical frequency comb(OFC)-based dispersive interferometry is heavily improved and the measuring dead zone induced by the mismatch between the repetition rate of the OFC and resolution of the optical spectrum analyzer is totally eliminated.Combined with an auxiliary dual-frequency phase-modulated laser range finder,the none-dead-zone measurable range ambiguity is extended up to 1500 m.The proposed SMC lidar is experimentally implemented in both indoor and outdoor environment.In the outdoor baseline field,real-time,high-speed(up to 35 k Hz)measurement of a long distance of^1179 m is achieved with a minimum Allan deviation of 5.6μm at an average time of 0.2 ms(27 nm at an average time of 1.8 s after high-pass filtering).The present SMC lidar approaches a compact,fast,high-precision,and none-dead zone long-distance ranging system,aimed at emerging applications of frontier basic scientific research and advances in industrial manufacturing. | JINDONG WANG ZHIZHOU LU WEIQIANG WANG FUMIN ZHANG JIAWEI CHEN YANG WANG JIHUI ZHENG SAI T.CHU WEI ZHAO BRENT E.LITTLE XINGHUA QU WENFU ZHANG | 2020 | Photonics Research2020，8，12： | 8 |
| 5 | Antibacterial Properties of Ti-6Al-4V-xCu Alloys显示文摘Surgical implant-associated bacterial infection is becoming a serious clinical problem.A series of copper-bearing titanium alloy,Ti—6AI—4V—xCu(x = 1,3,5 wt%),were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element.The metallography,X-ray diffraction,antibacterial ability,corrosion resistance and cytotoxicity of Ti—6AI—4V—xCu alloys were preliminarily studied with comparison to the commercial medical Ti—6AI—4V alloy.The Ti—6AI—4V—xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility,and the antibacterial role was enhanced with increasing Cu content,which has significant potential for clinical applications as surgical implant materials. | Ling Ren Zheng Ma Mei Li Yu Zhang Weiqiang Liu Zhenhua Liao Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，7： | 5 |
| 6 | Dynamic analysis of heat extraction rate by supercritical carbon dioxide in fractured rock mass based on a thermal-hydraulic-mechanics coupled model显示文摘Heat production from geothermal reservoirs is a typical heat transfer process involving a cold working fluid contacting a hot rock formation.Compared to the thermal-physical characteristics of water,supercritical CO_(2)(scCO_(2))has a higher heat storage capacity over a wide temperature-pressure range and may be favored as a heat transfer fluid.Singularly characteristic of scCO_(2)-based heat extraction is that the hydraulic-thermal properties of the scCO_(2) vary dramatically and dynamically with the spatial pressure gradient during unsteady-state flow along fracture.This highly nonlinear behavior presents a challenge in the accurate estimation of heat extraction efficiency in scCO_(2)-based EGS.In this paper,a thermal-h ydraulic-mechanical(THM)coupled model is developed by considering deformation of the fractured reservoir,non-Darcy flow and the varying thermal-physical properties of scCO_(2).The proposed model is validated by matching the modeling temperature distribution with published data.The results show that during continuous injection of scCO_(2),the fracture first widens and then narrows,ultimately reopening over the long term.The sequential fracture deformation behaviors are in response to the combined impacts of mechanical compression and thermally-induced deformation.By controlling the injection parameters of the scCO_(2),it is found that the heat extraction rate is positively correlated to its pore pressure or mass flow rate.The heat extraction rate can be significantly enhanced,when the inlet temperature of scCO_(2) is below its critical temperature.As a result,the heat increment recovered per unit mass of scCO_(2) decreases as the hot rock is gradually cooled.Meanwhile,the heat increment recovered per unit mass of scCO_(2) decreases by increasing the inlet temperature of scCO_(2) or its mass flow rate,but increases as the outlet pressure rises.Furthermore,multi-linear regression indicates that controlling the inlet temperature of the scCO_(2) can significantly improve the thermodynamic efficiency of heat extraction. | Chunguang Wang Xingkai Shi Wei Zhang Derek Elsworth Guanglei Cui Shuqing Liu Hongxu Wang Weiqiang Song Songtao Hu Peng Zheng | 2022 | International Journal of Mining Science and Technology2022，32，2： | 3 |
| 7 | Photon momentum transfer in inhomogeneous dielectric mixtures and induced tractor beams显示文摘The determination of optical force as a consequence of momentum transfer is inevitably subject to the use of the proper momentum density and stress tensor.It is imperative and valuable to consider the intrinsic scheme of photon momentum transfer,particularly when a particle is embedded in a complex dielectric environment.Typically,we consider a particle submerged in an inhomogeneous background composed of different dielectric materials,excluding coherent illumination or hydrodynamic effects.A ray-tracing method is adopted to capture the direct process of momentum transfer from the complex background medium,and this approach is validated using the modified Einstein–Laub method,which uses only the interior fields of the particle in the calculation.In this way,debates regarding the calculation of the force with different stress tensors using exterior fields can be avoided.Our suggested interpretation supports only the Minkowski approach for the optical momentum transfer to the embedded scatterer while rejecting Peierls’s and Abraham’s approaches,though the momentum of a stably moving photon in a continuous background medium should be considered to be of the Abraham type.Our interpretation also provides a novel method of realizing a tractor beam for the exertion of negative force that offers an alternative to the use of negative-index materials,optical gain,or highly non-paraxial or multiple-light interference. | Cheng-Wei Qiu Weiqiang Ding MRCMahdy Dongliang Gao Tianhang Zhang Fook Chiong Cheong Aristide Dogariu Zheng Wang Chwee Teck Lim | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 8 | Derivation and characterization of human embryonic stem cell lines from poor quality embryos显示文摘Poor quality embryos discarded from in vitro fertilization (IVF) laboratories are good sources for deriving human embryonic stem cell (hESC) lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses (ICMs) could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM at- tachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods (P>0.05). As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories. | Weiqiang Liu, Yifei Yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China | 2009 | Journal of Genetics and Genomics2009，36，4： | 3 |
| 9 | The Application of Artificial Neural Networks in the Study of Quantitative Structure-Retention Relationships for Saturated Alcohols显示文摘 | GUO WEIQIANG LU YANG ZHENG XIAOMING | 2000 | Talanta2000，51，： | 1 |
| 10 | Effect of bis (3-tr iethoxysi ly ipropyl) tetrasulfide on the crosslink structure, interfacial adhesion, and mechanical properties of natural rubber/cotton fiber composites显示文摘 | Zeng Zheng Ren Weiqiang Zhang Yong Zhang Wentan Xu Chi Lu Yinxi | 2009 | Journal of Applied Polymer Science2009，111，1： | 1 |
| 11 | Polar Coded Iterative Multiuser Detection for Sparse Code Multiple Access System显示文摘Polar coded sparse code multiple access(SCMA) system is conceived in this paper. A simple but new iterative multiuser detection framework is proposed, which consists of a message passing algorithm(MPA) based multiuser detector and a soft-input soft-output(SISO) successive cancellation(SC) polar decoder. In particular, the SISO polar decoding process is realized by a specifically designed soft re-encoder, which is concatenated to the original SC decoder. This soft re-encoder is capable of reconstructing the soft information of the entire polar codeword based on previously detected log-likelihood ratios(LLRs) of information bits. Benefiting from the soft re-encoding algorithm, the resultant iterative detection strategy is able to obtain a salient coding gain. Our simulation results demonstrate that significant improvement in error performance is achieved by the proposed polar-coded SCMA in additive white Gaussian noise(AWGN) channels, where the performance of the conventional SISO belief propagation(BP) polar decoder aided SCMA, the turbo coded SCMA and the low-density parity-check(LDPC) coded SCMA are employed as benchmarks. | Hang MU Youhua Tang Li Li Zheng Ma Pingzhi Fan Weiqiang Xu | 2018 | China Communications2018，15，11： | 1 |
| 12 | Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway显示文摘Mesenchymal stromal cells(MSCs)have been considered a promising alternative for treatment of acute respiratory distress syndrome(ARDS).However,there is significant heterogeneity in their therapeutic efficacy,largely owing to the incomplete understanding of the mechanisms underlying the therapeutic activities of MSCs.Here,we hypothesize that the cholinergic antiinflammatory pathway(CAP),which is recognized as a neuroimmunological pathway,may be involved in the therapeutic mechanisms by which MSCs mitigate ARDS.Using lipopolysaccharide(LPS)and bacterial lung inflammation models,we found that inflammatory cell infiltration and Evans blue leakage were reduced and that the expression levels of choline acetyltransferase(ChAT)and vesicular acetylcholine transporter(VAChT)in lung tissue were significantly increased 6 hours after MSC infusion.When the vagus nerve was blocked orα7 nicotinic acetylcholine(ACh)receptor(α7nAChR)-knockout mice were used,the therapeutic effects of MSCs were significantly reduced,suggesting that the CAP may play an important role in the effects of MSCs in ARDS treatment.Our results further showed that MSC-derived prostaglandin E2(PGE2)likely promoted ACh synthesis and release.Additionally,based on the efficacy of nAChR andα7nAChR agonists,we found that lobeline,the nicotinic cholinergic receptor excitation stimulant,may attenuate pulmonary inflammation and alleviate respiratory symptoms of ARDS patients in a clinical study(ChiCTR2100047403).In summary,we reveal a previously unrecognized MSC-mediated mechanism of CAP activation as the means by which MSCs alleviate ARDS-like syndrome,providing insight into the clinical translation of MSCs or CAP-related strategies for the treatment of patients with ARDS. | Xiaoran Zhang Xuxia Wei Yiwen Deng Xiaofeng Yuan Jiahao Shi Weijun Huang Jing Huang Xiaoyong Chen Shuwei Zheng Jieying Chen Keyu Chen Ruiming Xu Hongmiao Wang Weiqiang Li Shiyue Li Huimin Yi Andy Peng Xiang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 13 | Antibacterial and antiparasitic activities analysis of a hepcidinlike antimicrobial peptide from Larimichthys crocea显示文摘As an economically important marine fish,the large yellow croaker Larimichthys crocea suffered from marine white spot disease caused by the ectoparasite Cryptocaryon irritans in recent years.This disease not only could result in physiological damage,but also lead to secondary bacterial invasion.Reports indicated some AMPs(antimicrobial peptides)were of antiparasitic activity to C.irritans.Hepcidin-like(Lc-HepL)was one of the significant differential expression genes excavated from the transcriptome following a challenge with C.irritans.In this study,we characterized this AMP’s bioactivity based on the levels of mRNA and protein.After challenged by C.irritans,qRT-PCR showed Lc-HepL was significantly upregulated in six tissues,including gill,muscle,liver,head kidney and spleen during theront infection,trophont falling off,and secondary bacterial invasion stages,which implicated a role Lc-HepL played in the immune defense against C.irritans and secondary bacterial infection.Recombinant Lc-HepL(rLc-HepL)was induced and purified successfully.rLc-HepL exhibited antibacterial activity to certain bacteria in a dose-and time-dependent manners.Anti-C.irritans activity was explored for the first time and found it could cause the theronts membrane rupture and contents leakage.These results provided the first evidence that Lc-HepL had strong antiparasitic activity against marine fish ectoparasites C.irritans theronts.Together,data indicated that Lc-HepL might be an important component in the innate immune system against C.irritans and has the potential to be employed in future drug development. | Libing Zheng Yuan Li Jun Wang Ying Pan Jia Chen Weiqiang Zheng Longshan Lin | 2020 | Acta Oceanologica Sinica2020，39，10： | 1 |
| 14 | A retrospective analysis of the clinicopathologic characteristics of uterine cellular leiomyomas in China显示文摘 | Rui Guan Weiqiang Zheng Mingjuan Xu | 2012 | International Journal of Gynecology and Obstetrics2012，，： | 1 |
| 15 | Styrene epoxidation catalyzed by polyoxometalate/quaternary ammonium phase transfer catalysts: The effect of cation size and catalyst deactivation mechanism显示文摘Catalytic epoxidation of alkenes is an important type of organic reaction in chemical industry,and the deep insight into catalyst deactivation will help to develop new epoxidation process.In this work,series of quaternary ammoniums bearing different cationic sizes,i.e.MTOA+(methyltrioctylammonium,[(C_(8)H_(17))_(3)CH_(3)N]+),HTMA+(hexadecyltrimethylammonium,[(C_(16)H_(33))(CH_(3))_(3)N]+) and DMDOA+(dimethyldioctadecylammonium,[(C_(18)H_(37))_(2)(CH_(3))_(2)N]+) were incorporated with polyoxometalate (POM) anions to prepare phase transfer catalysts (PTCs),which were used in the styrene epoxidations.Among them,(MTOA)_(3)PW_(4)O_(24)exhibits the best catalytic performance judged from the highest styrene conversion rate(52%) and styrene oxide selectivity (93%),during which the styrene epoxidation conditions were optimized.Meanwhile,the deactivation mechanism of this kind of PTCs was proposed firstly,i.e.in the case of low H_(2)O_(2) content,the oxidant can only be used in the styrene epoxidation,in which the catalyst can transform into stable Keggin-type POM.But when the content of H_(2)O_(2) is higher,the excess H_(2)O_(2) can reactivate the Keggin-type POM into active (PW_(4)O_(24))_(3)-anions,which can trigger the ring-opening polymerization of styrene oxide.Consequently,the catalyst is deactivated by adhered poly(styrene oxide)irreversibly,which was determined by NMR spectra.In this situation,the active moiety{PO_(4)[WO(O_(2))_(2)]_(4)}_(3)-in phase-transfer catalytic system can break into some unidentified species with low W/P ratio with the presence of epoxides.This work will be beneficial for the design of new PTCs in alkene epoxidation in fine chemical industry. | Qiongna Xiao Yuyan Jiang Weiqiang Yuan Jingjing Chen Haohong Li Huidong Zheng | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 0 |
| 16 | Surface distribution of alkalinity and specific alkalinity and their application to water mass tracing in Kuroshio area of the East China Sea显示文摘Surface distribution and seasonal variation of alkalinity and specific alkalinity in Kuroshio area of the East ChinaSea and their application to the water mass tracing are discussed in this paper. Results show a distinct seasonal variation of the alkalinity, which is concerned with the process of vertical mixing. Different specific alkalinity in various water masses has been found. On the basis of the difference of the specific alkalinity and the distribution of alkalinity, two water fronts in summer season, located at 27°-30°N and 124°-1 27°E, (Ⅰ), and at the northern waters about one latitude from the Taiwan Island, (Ⅱ); one in winter season at about one longitude from coast of mainland of China and 26°-30°N were found. In summer season, about 1-2 longitudes eastward shift of front (Ⅰ) is found by comparison of data in May and August. And the high alkalinity of the northern East China Sea in summer season may be caused by the Huanghe River runoff flowing southward along with the Huanghai | Zheng Jiancheng, Huang Shuilong and Wang Weiqiang Third Institute of Oceanography, State Oceanic Administration, Xiamen, China | 1991 | Acta Oceanologica Sinica1991，10，1： | 0 |
| 17 | A 3D sliced-soil-beam model for settlement prediction of tunnelling using the pipe roofing method in soft ground显示文摘The pipe roofing method is widely used in tunnel construction because it can realize a flexible section shape and a large section area of the tunnel,especially under good ground conditions.However,the pipe roofing method has rarely been applied in soft ground,where the prediction and control of the ground settlement play important roles.This study proposes a sliced-soil-beam(SSB)model to predict the settlement of ground due to tunnelling using the pipe roofing method in soft ground.The model comprises a sliced-soil module based on the virtual work principle and a beam module based on structural mechanics.As part of this work,the Peck formula was modified for a square-section tunnel and adopted to construct a deformation mechanism of soft ground.The pipe roofing system was simplified to a threedimensional Winkler beam to consider the interaction between the soil and pipe roofing.The model was verified in a case study conducted in Shanghai,China,in which it provided the efficient and accurate prediction of settlement.Finally,the parameters affecting the ground settlement were analyzed.It was clarified that the stiffness of the excavated soil and the steel support are the key factors in reducing ground settlement. | Yu DIAO Yiming XUE Weiqiang PAN Gang ZHENG Ying ZHANG Dawei ZHANG Haizuo ZHOU Tianqi ZHANG | 2023 | Frontiers of Structural and Civil Engineering2023，17，12： | 0 |
| 18 | Research on mineral processing of low quality kalium-natrium feldspar显示文摘In light of characteristic of low quality feldspar ores in Wanzai County,Jiangxi Province,steel ball was taken as grinding medium,and selective grinding could make impurity separate from feldspar effectively. Through the flow of flotation-desliming-high gradient magnetic separation,the feldspar Concentration 1 was obtained with the yield of 70.19 %,containing Fe2O3 0.17 % and TiO2 0.07 %. The feldspar Concentrate 1 could meet the quality requirement of high-grade construction ceramic. And the slime that was deslimed in the flow was also separated and recovered; the feldspar Concentration 2 was obtained with the yield of 13.18 %,containing Fe2O3 0.31 % and TiO2 0.17 %. The feldspar Concentrate 2 can be used for raw material of low-end ceramic. And gangue,with the yield of 16.63 %,was thrown away in this flow,the separating efficiency was high. Employing this flow could also bring high economy benefit and low influence of pollution to environment. | Zhang Lingyan Bu Junfen Lai Weiqiang Tang Huawei Zheng Guangjun | 2008 | Engineering Sciences2008，6，4： | 0 |
| 19 | The MAX2-KAI2 module promotes salicylic acid-mediated immune responses in Arabidopsis显示文摘Arabidopsis MORE AXILLARY GROWTH2 MAX2)is a key component in the strigolactone(SL)and karrikin(KAR)signaling pathways and regulates the degradation of SUPPRESSOR OF MAX21/SMAX1-like(SMAX1/SMXL)proteins,which are transcriptional co-repressors that regulate plant architecture,as well as abiotic and biotic stress responses.The max2 mutation reduces resistance against Pseudomonas syringae pv.tomato(Pst).To uncover the mechanism of MAX2-mediated resistance,we evaluated the resistance of various SL and KAR signaling pathway mutants.The resistance of SL-deficient mutants and of dwarf 14(d14)was similar to that of the wild-type,whereas the resistance of the karrikin insensitive 2(kai2)mutant was compromised,demonstrating that the KAR signaling pathway,not the SL signaling pathway,positively regulates the immune response.We measured the resistance of smaxl and smxl mutants,as well as the double,triple,and quadruple mutants with max2,which revealed that both the smax1 mutant and smx16/7/8 triple mutant rescue the low resistance phenotype of max2 and that SMAX1 accumulation diminishes resistance.The susceptibility of smax1D,containing a degradation-insensitive form of SMAX1,further confirmed the SMAX1 function in the resistance.The relationship between the accumulation of SMAX1/SMXLs and disease resistance suggested that the inhibitory activity of SMAX1 to resistance requires SMXL6/7/8.Moreover,the exogenous application of KAR2 enhanced resistance against Pst,but KAR-induced resistance depended on salicylic acid(SA)signaling.Inhibition of karrikin signaling delayed SA-mediated defense responses and inhibited pathogen-induced protein biosynthesis.Together,we propose that the MAX2-KAI2-SMAX1 complex regulates resistance with the assistance of SMXL6/7/8 and SA signaling and that SMAX1/SMXLs possibly form a multimeric complex with their target transcription factors to fine tune immune responses. | Xiujuan Zheng Fangqian Liu Xianfeng Yang Weiqiang Li Sique Chen Xinwu Yue Qi Jia Xinli Sun | 2023 | Journal of Integrative Plant Biology2023，65，6： | 0 |
| 20 | Future research needs for environmental science in China显示文摘Environmental science is an interdisciplinary science developed in the process of understanding and solving ecolog-ical and environmental problems.In order to tackle these problems,environmental science research is expected to reveal the source,behavior,fate,exposure,and risks of pollutants in the environment and develop potential solutions to control pollution.It provides the scientific basis for decision-makers to establish environmental and economic poli-cies,and promote concerted efforts for the sustainable development of society.Here,we articulate the development patterns,challenges,and future research needs of environmental science in China based on literature review and expert panel discussion.Environmental science research has evolved significantly in the past decade with an increas-ing diversity of environmental pollutants and health impacts,new technologies and methods,deepening fusion of multiple disciplines,and emerging solutions for pollution control.Its future development relies on the advances in our knowledge on the fate and transport of pollutants,regional environmental processes,ecotoxicological effects,environmental exposure and health effects,environmental analysis and monitoring,source control and reduction,environmental remediation,as well as environmental risk management.For each of these fields,we summarize the significant challenges and highlight the research demands for China.Based on the status quo of China’s environmen-tal science research and future needs,we provide recommendations to promote its future development,including encouraging innovation and interdisciplinary research,providing decision support for national needs,encouraging international collaboration,and improving collaboration mechanisms. | Dongqiang Zhu Weiqiang Chen Xiaolei Qu Yuming Zheng Jun Bi Haidong Kan Yongming Luo Guangguo Ying Eddy Y.Zeng Fangjie Zhao Lingyan Zhu Yongguan Zhu Shu Tao | 2021 | Geography and Sustainability2021，2，3： | 0 |
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