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| 1 | Chloroplast phylogenomics of the New World grape species (Vitis, Vitaceae)显示文摘Vitis L。(葡萄类) 是经济地很重要的水果庄稼,葡萄和酒的来源。在类以内的种系发生的关系是高度争论的。此处,我们从整个 plastomes 采用顺序数据试图提高 Vitis 种系发生的分辨率。结果作为 monophyletic 支持新世界 Vitis 亚属 Vitis。在 clade 以内, V。californica 是到仍然保持新的姐妹世界 Vitis 亚属 Vitis。在亚属 Vitis 以内,而且,欧亚的 clade 要用体力地被支持并且是到新世界 clade 的姐妹。Vitis vinifera ssp 的 clade。vinifera 和 V。vinifera ssp。sylvestris 是到 Vitis 的核心亚洲人 clade 的姐妹。在北美洲的几普遍的种被发现例如,是在 plastome 树上的 nonmonophyletic 广泛地定义的 Vitis cinerea 和 V。aestivalis 各个需要被分成几种。可能也 nonmonophyly 某种类由于在北美的 Vitis 的杂交的普通出现。由进九个系列的 Munson 的北美的 Vitis 的分类基于种系发生的结果被讨论。分叉时间和系多样化的分析在在晚第三纪开始的北美洲支持 Vitis 的快速的放射。 | Jun Went AJ Harris Yash Kalburgi Ning Zhang Yuan Xu Wei Zheng Stefanie M. Ickert-Bondt Gabriel Johnson Elizabeth A. Zimmer | 2018 | Journal of Systematics and Evolution2018，56，4： | 14 |
| 2 | A high-quality genome sequence of alkaligrass provides insights into halophyte stress tolerance显示文摘Alkaligrass(Puccinellia tenuiflora) is a monocotyledonous halophytic forage grass widely distributed in Northern China. It belongs to the Gramineae family and shares a close phylogenetic relationship with the cereal crops, wheat and barley. Here, we present a high-quality chromosome-level genome sequence of alkaligrass assembled from Illumina, Pac Bio and 10× Genomics reads combined with genome-wide chromosome conformation capture(Hi-C) data. The ~1.50 Gb assembled alkaligrass genome encodes 38,387 protein-coding genes, and 54.9% of the assembly are transposable elements, with long terminal repeats being the most abundant. Comparative genomic analysis coupled with stress-treated transcriptome profiling uncovers a set of unique saline-and alkaline-responsive genes in alkaligrass. The high-quality genome assembly and the identified stress related genes in alkaligrass provide an important resource for evolutionary genomic studies in Gramineae and facilitate further understanding of molecular mechanisms underlying stress tolerance in monocotyledonous halophytes. The alkaligrass genome data is freely available at http://gffzz284c18d2de364501h6xqquqfcq5xb69wx.ffgz.tsg.suse.edu.cn/data/alkaligrass.html. | Wenting Zhang Jie Liu Yongxue Zhang Jie Qiu Ying Li Baojiang Zheng Fenhong Hu Shaojun Dai Xuehui Huang | 2020 | Science China(Life Sciences)2020，63，9： | 8 |
| 3 | GeoScope:Full 3D Geospatial Information System Case Study显示文摘Aiming at the integrative management and comprehensive applications of large-scale 3D geospatial information covering the full 3D space of a city,this paper briefly introduces the design and implementation of a full 3D GIS platform:GeoScope,which provides a professional solution for the massive full three-dimensional geospatial data integration,management,analysis,visualization,and applications.GeoScope is characterized by:(1) extendible software architecture based on the hierarchical message bus,facilitates multimodal integrative applications of 2D GIS and 3D GIS;(2) unified 3D city models,support multiscale semantic representation of outdoor & indoor and aboveground & underground 3D objects;(3) high-efficient 3D geospatial database engine,supports integrated management of massive 3D geospatial data for real-time applications;and (4) high-performance visualization engine exploiting the massively parallel computation architecture of modern GPUs,supports real-time realistic rendering of large-scale complicated 3D geospatial environments.The successful pilot application of GeoScope is also illustrated with the 3D city models of 8494 km2 of the whole Wuhan City,the largest city in middle China. | ZHANG Yeting ZHU Qing LIU Gang ZHENG Wenting LI Zhonghua DU Zhiqiang | 2011 | Geo-Spatial Information Science2011，14，2： | 7 |
| 4 | An Epidemic of Hepatitis A--Liaoning Province,2020显示文摘What is already known about this topic?Hepatitis A(HA)is caused by acute hepatitis A virus(HAV)infection and was once very common in China.Following the 2008 introduction of the HA vaccine into the national Expanded Program on Immunization(EPI),the incidence of reported HA in China decreased markedly.However,HA epidemics still occur in Liaoning Province every 3–5 years,although with far fewer cases than in the pre-HA-vaccination era.What is added by this report?Between January 1,2020 and March 18,2020,the number of reported cases of HA in Dalian and Dandong cities of Liaoning Province increased significantly compared with the same period in previous years.All cases were sporadic,and cases were seen in nearly every township.The increase in HA occurred one month after local fresh seafood became available with most cases being among adults.A casecontrol study showed that consuming raw or undercooked seafood,clams,snapping shrimp,and oysters were significantly associated with the increase in HA.What are the implications for public health practices?Strengthening health education for residents to avoid consumption of raw seafood and encouraging HAV vaccination of adults aged 20 to 54 years are important to prevent periodic HAV endemic outbreaks.Further multisectoral cooperation must be emphasized on HA surveillance in areas with a high prevalence of HA. | Jing Sun Yuanqiu Li Xing Fang Yan Wang Yinan Han Yang Liu Jingyuan Cao Wenting Zhou Hui Zheng Wenqing Yao | 2020 | China CDC weekly2020，2，30： | 7 |
| 5 | Core-shell fibrous vascular grafts with the nitric oxide releasing property显示文摘Small-diameter vascular grafts with the nitric oxide(NO) releasing property were designed and prepared.Diazeniumdiolated N,N'-dibutyl-1,6-hexanediamine(DBHD/N2O2) was first synthesized as the NO donor and doped into the biocompatible polymer poly(ε-caprolactone)(PCL).The fibrous vascular grafts were fabricated by electrospinning.Despite the reduced platelet adhesion observed on the NO releasing grafts,the cytotoxicity and burst release were apparent,especially at a higher loading level of the NO donor.In order to solve this problem,core-shell structured nanofibers,in which PCL or gelatin is the shell and PCL doped with the NO donor is the core,were fabricated via coaxial electrospinning.The core-shell structure made the NO release more steady and controllable,and the cell compatibility was improved. | ZHANG Lei,WANG Kai,ZHAO Qiang,ZHENG WenTing,WANG ZhiHong,WANG ShuFang & KONG DeLing Key Laboratory of Bioactive Materials,Ministry of Education College of Life Science,Nankai University,Tianjin 300071,China | 2010 | Science China Chemistry2010，53，3： | 6 |
| 6 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 7 | Construction and genetic analysis of mutator insertion mutant population in maize显示文摘A total of 26718 M1 plants were ob- tained by crossing the active mutator transposon donor parents (Q105, WW51, 115F, V26-2 and 919J) with the recipient parents (Hz85,W328 with Bz gene and S-Mo17Rf3Rf3). The phenotypes of M1 plants were observed in the field. M1 plants were self-pollinated to develop the mutator insertion-mutagenized M2 seeds. The transposition frequency of the mutator in the genome was calculated based on the spotted aleurone phenotype of the M2 seeds. The results showed that: (1) the mutation frequency of M1 phe- notypes in the field was 0.07 in the population of W328×Mu; (2) the mutation frequency of spotted aleurone seeds on the M2 ears was 0.122 in the population of W328×Mu; (3) five S-cytoplasm male-sterile plants were found among 22500 M1 plants of S-Mo17Rf3Rf3×Mu, with the transposition frequency about 2.2×10?4 per locus. 99 flanking se- quences of mutator transposition were amplified by the modified MuTAIL-PCR, and 59 non-redundant sequences with length around 400 bp were obtained. After bioinformatic analysis, 27 sequences of them could be annotated, using non-redundant nucleotide database of maize, rice, and Arabidopsis. 36 se- quences of them were located on the genetic map of maize by comparative genomics, and several flank- ing sequences of mutator insertion were mapped on the single marker locus. Hotspot sequences of mu- tator transposition were revealed by comparing the homologies between the 9-bp target site duplication of the mutator insertion. The putative functions of 8 flanking sequences of mutator transposition had identity with the functions of their correspondingmarker. The constructed mutator insertion mutant population in maize will facilitate the new gene discovery and functional genomics study in maize. | LIU Wenting GAO Youjun TENG Feng SHI Qing ZHENG Yonglian | 2006 | Chinese Science Bulletin2006，51，21： | 4 |
| 8 | Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma显示文摘Despite the advance in targeted therapy,lung adenocarcinoma(LUAD)remains one of the leading causes of death in patients with cancer.CD155,a member of poliovirus receptor–related(PRR)family,has been identified as the ligand of the Ig-like receptors tactile(CD96)and DNAM-1(CD226)on T cells.The interaction of CD155 with CD96 transmits an inhibitory signal and suppresses immune response.The interaction of CD155 with CD226 enhances the immune response.1,2,3 CD155 expression has been shown to be elevated in many types of cancers4,5 and is involved with immune suppression in melanoma.6 However,how CD155/CD96 is involved in immune response in the tumor microenvironment of LUAD remains unknown. | Hui Zhang Qianwen Liu Yiyan Lei Jianwen Zhou Wenting Jiang Yongmei Cui Qiong He Junfeng Zhu Zheng Zhu Yu Sun Zunfu Ke | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 9 | A path flux analysis method for the reduction of detailed chemical kinetic mechanisms显示文摘 | Wenting Sun Zheng Chen Xiaolong Gou Yiguang Ju | 2010 | Combustion and Flame2010，，7： | 3 |
| 10 | Association between TSHR gene polymorphism and the risk of Graves' disease:a meta-analysis显示文摘Thyroid stimulating hormone receptor(TSHR) is thought to be a significant candidate for genetic susceptibility to Graves' disease(GD).However,the association between TSHR gene polymorphism and the risk of GD remains controversial.In this study,we investigated the relationship between the two conditions by meta-analysis.We searched all relevant case-control studies in PubMed,Web of Science,CNKI and Wanfang for literature available until May2015,and chose studies on two single nucleotide polymorphisms(SNPs):rs 179247 and rsl2101255,within TSHR intron-1.Bias of heterogeneity test among studies was determined by the fixed or random effect pooled measure,and publication bias was examined by modified Begg's and Egger's test.Eight eligible studies with 15 outcomes were involved in this meta-analysis,including 6,976 GD cases and 7,089 controls from China,Japan,Poland,UK and Brazil.Pooled odds ratios(ORs) for allelic comparisons showed that both TSHR rsl79247A/G and rsl2101255T/C polymorphism had significant association with GD(OR=1.422,95%CI=1.353—1.495,P<0.001,P_(heterogeneity)=0.448;OR= 1.502,95%CI:1.410-1.600,P<0.001,P_(heterogeneity)=0.642),and the associations were the same under dominant,recessive and co-dominant models.In subgroup analyses,the conclusions are also consistent with all those in Asian,European and South America subgroups(P<0.001).Our meta-analysis revealed a significant association between TSHR rsl79247A/G and rsl2101255T/C polymorphism with GD in five different populations from Asia,Europe and South America.Further studies are needed in other ethnic backgrounds to independently confirm our findings. | Wei Qian Kuanfeng Xu Wenting Jia Ling Lan Xuqin Zheng Xueyang Yang Dai Cui | 2016 | The Journal of Biomedical Research2016，30，6： | 2 |
| 11 | Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects:fabrication,structural characterization and property evaluation显示文摘This study explored the potential of polysaccharides from Actium lappa(ALPs)as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid(OA)and ursolic acid(UA).Encapsulating OA+UA with ALPs(ALP:OA+UA,50:1;OA:UA,1:1)changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O groups.ALP-OA/UA nanoparticles had a particle size and zeta potential(in water)of 199.1 nm/-7.15 mV,with a narrow unimodal size distribution,and excellent pH,salt solution,temperature and storage stability.Compared with ALPs,ALPOA/UA nanoparticles showed enhanced anti-inflammatory activity(especially at a dose of 100μg/mL)in a CuSO-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines(TNF-α,IL-1βand IL-8).Therefore,ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules. | Shanshan Zhu Zhichang Qiu Xuguang Qiao Geoffrey I.N.Waterhouse Wenqing Zhu Wenting Zhao Qiuxia He Zhenjia Zheng | 2023 | Food Science and Human Wellness2023，12，2： | 2 |
| 12 | Joint iterative compressed sensing algorithm eliminating clipping noise in underwater acoustic communication system显示文摘Due to the intricacy characteristics of the Underwater Acoustic(UWA) channel especially the limited bandwidth, Orthogonal Frequency Division Multiplexing(OFDM) is used because of its high spectrum efficiency. However, relatively high Peak-to-Average-Power Ratio(PAPR) limits the efficiency of OFDM in UWA communication, leading to saturation in the power amplifier and consequent distortion of the signal. Clipping and C companding as the most classic and convenient algorithms, are widely applied to address the high PAPR issue. However clipping introduces additional noise which degrades the system's performance and traditional C companding is also not suitable for underwater acoustic field. Thus, an improved C companding combined with clipping is proposed here. Due to the sparseness of clipping noise, Compressed Sensing(CS) can be utilized to estimate it. The scheme exploits pilot tones and data tones as observations instead of reserve tones, which is different from the previous works and improves data rate. Furthermore, to minimize the effect of the underwater acoustic channel, the channel is also estimated using the CS technique, which provides more accurate channel characteristics than Least Square(LS) or Minimum Mean Square Error(MMSE) estimation algorithms. The effectiveness of the proposed algorithm is proved in computer simulations as well as in a pool experiment. | WU Jinqiu QIAO Gang ZEESHAN Babar ZHENG Wenting | 2017 | Chinese Journal of Acoustics2017，36，4： | 2 |
| 13 | Molecular genetic mapping of a high-lysine mulant gene (opaque-16) and the double recessive effect with opaque-2 in maize 显示文摘 | Wenpeng Yang Yonglian Zheng Wenting Zheng | 2005 | Molecular Breeding2005，15，： | 1 |
| 14 | Vertical distribution and migration of global fallout Pu in forest soils in southwestern China显示文摘 | Bu Wenting Zheng Jian Guo Qiuju | 2014 | Journal of Environmental Radioactivity2014，136，： | 1 |
| 15 | A path flux analysis method for the reduction of detailed chemical kinetic mechanisms 显示文摘 | Wenting Sun Zheng Chen Xiaolong Gou | 2010 | Combustion and Flame2010，157，7： | 1 |
| 16 | Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells显示文摘 | Shiyuan Liu Yumin Li Wei Chen Pengfei Zheng Tao Liu Wenting He Junqiang Zhang Xiangting Zeng | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 17 | Geographical influences on content of 10-hydroxy-trans-2-decenoic acid in royal jelly in China显示文摘 | WEI Wenting HU Yuanqiang ZHENG Huoqing | 2013 | Journal of Economic Entomology2013，106，5： | 1 |
| 18 | Gen- eralized Hyers Ulam Rassias stability of functional ine- qualities and functional equations显示文摘 | Gao Zhenxia Cao Huiaxin Zheng Wenting | 2009 | Journal of Mathe- matical Inequalities2009，3，1： | 1 |
| 19 | Super-sta- bility and stability of the exponential equations显示文摘 | Xu Lu Cao Huaixin Zheng Wenting | 2010 | Jour- nal of Mathematical Inequalities2010，4，1： | 1 |
| 20 | In vitro and in vivo studies on pure Mg, Mg-1Ca and Mg-2Sr alloys processed by equal channel angular pressing显示文摘In the present work,the biomedical as-cast pure Mg,Mg–1 Ca and Mg–2 Sr alloys were processed with equal channel angular pressing(ECAP)technique to develop ultrafine microstructure within the materials,and their microstructures,mechanical properties,degradation behavior,cytocompatibility in vitro and biocompatibility in vivo were studied comprehensively.Finer-gained microstructures and improved mechanical properties of these three materials after ECAP were confirmed compared to their as-cast counterparts.Moreover,after ECAP the degradation rate of pure Mg was increased while that of Mg–1 Ca or Mg–2 Sr alloys decreased compared to the ascast counterparts.Additionally,good in vitro cytocompatibility and in vivo biocompatibility of these three materials were revealed by cell cultural tests using osteoblastic MC3 T3-E1 and human mesenchymal stem cells(h MSC)and in vivo animal tests at the lateral epicondyle of SD-rats’femur.This study offers an alternative powerful avenue to achieve good comprehensive properties of magnesium-based biodegradable metals.It might also help to extend the applied range of magnesium-based biodegradable metals in orthopedic field. | Wenting Li Yunong Shen Jie Shen Danni Shen Xiao Liu Yufeng Zheng Kelvin W.K.Yeung Shaokang Guan Olga B.Kulyasova R.Z.Valiev | 2020 | Nano Materials Science2020，2，1： | 1 |
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