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| 1 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 2 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 3 | SEMIPARAMETRIC ANALYSIS OF ISOTONIC ERRORS-IN-VARIABLES REGRESSION MODELS WITH RANDOMLY RIGHT CENSORED RESPONSE显示文摘This paper considers the estimation of a semiparametric isotonic regression model when the covariates are measured with additive errors and the response is randomly right censored by a censoring time.The authors show that the proposed estimator of the regression parameter is rootn consistent and asymptotically normal.The authors also show that the isotonic estimator of the functional component,at a fixed point,is cubic root-n consistent and converges in distribution to the slope at zero of the greatest convex minorant of the sum of a two-sided standard Brownian motion and the square of the time parameter.A simulation study is carried out to investigate the performance of the estimators proposed in this article. | SUN Zhimeng ZHANG Zhongzhan DU Jiang | 2013 | Journal of Systems Science & Complexity2013，26，3： | 3 |
| 4 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics显示文摘 | Wei Lei Sun Xudong Xiu Zhimeng | 2004 | J Eur Ceram Soc2004，24，9： | 1 |
| 5 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics 显示文摘 | Wen Lei Sun Xudong Xiu Zhimeng | 2004 | J Eur Ceram Soc2004，24，9： | 1 |
| 6 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics 显示文摘 | WEN Lei SUN Xudong XIU Zhimeng | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 7 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics显示文摘 | Lei Wen Xudong Sun Zhimeng Xiu Shaowei Chen Chi-Tay Tsai | 2003 | Journal of the European Ceramic Society2003，，9： | 1 |
| 8 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics显示文摘 | WEN Lei SUN Xedong XIU Zhimeng | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 9 | VARIABLE SELECTION FOR PARTIALLY LINEAR VARYING COEFFICIENT QUANTILE REGRESSION MODEL显示文摘 | JIANG DU ZHONGZHAN ZHANG ZHIMENG SUN | 2013 | International Journal of Biomathematics2013，6，3： | 1 |
| 10 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics显示文摘 | WEN Lei SUN Xudong XIU Zhimeng | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 11 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics 显示文摘 | WEN Lei SUN Xudong XIU Zhimeng | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 12 | Synthesis of nanocrystalline yttria powder and fabrication of transparent YAG ceramics显示文摘 | Wen Lei Sun Xudong Xiu Zhimeng | 2004 | J Eur Ceram Soc2004，24，9： | 1 |
| 13 | Molecular sieve based Janus separators for Li-ions redistribution to enable stable lithium deposition显示文摘During operation of a lithium metal battery,uneven lithium deposition often results in the growth of lithium dendrites and causes a rapid decay in battery performance and even leads to safety issues.This is still the main hurdle hindering the practical application of lithium metal anodes.We report a new type of Janus separator fabricated by introducing a molecular sieve coating on the surface of the polypropylene separator that serves as a redistribution layer for lithium ions.Our results show that using this layer,the growth of lithium dendrites can be largely inhibited and the battery performance greatly improved.In a typical Li||Cu half-cell with the Janus separator,the Coulombic efficiency of the lithium metal anode can be maintained at>98.5%for over 500 cycles.The cycling life span is also extended by a factor of 8 in the Li||Li symmetric cell.Furthermore,the high-strength coating improves the mechanical properties of the separator,thus enhancing safety.The effectiveness of our strategy is demonstrated by both the inhibited growth of lithium dendrites and the improved battery performance.Our methodology could eventually be generalized for electrode protection in other battery systems. | Huanyu Xie Zhimeng Hao Shuai Xie Yadong Ye Wei Zhang Zhaowei Sun Song Jin Hengxing Ji Jun Chen | 2022 | Nano Research2022，15，6： | 0 |
| 14 | Fast Fourier Transform-based Support Vector Machine for Subcellular Localization Prediction Using Different Substitution Models显示文摘有约 10 ~ 在生物信息学的热点是怎么识别蛋白质的潜水艇的在 cell.A 的 9 蛋白质细胞的本地化,如果它的顺序被知道。在这篇论文,基于变换的支持向量机器被开发预言潜水艇的用 fastFourier 的一个方法从他们的物理化学的性质和结构的参数的蛋白质的细胞的本地化。预言精确性在原核生物的有机体到达了 83% 并且 84% c-p-v 矩阵在有替换的真核细胞的有机体当模特儿(c,作文; p,极性;并且 v,分子的体积) 。全面预言精确性也用“ leave-one-out ”被评估预言精确性上的替换模型的大折刀 procedure.The 影响也在新程序的 work.The 源代码被讨论了在从作者的请求以后是可得到的。 | Zhimeng WANG Lin JIANG Menglong LI Lina SUN Rongying LIN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 0 |
| 15 | Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst显示文摘Deoxycholic acid(DCA)has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat.The hydroxylated product(6β-OH DCA)was developed to improve the solubility and pharmaceutic properties of DCA for further applications.Herein,a combinatorial catalytic strategy was applied to construct a powerful Cytochrome P450 biocatalyst(CYP107D1,OleP)to convert DCA to 6β-OH DCA.Firstly,the weak expression of OleP was significantly improved using pRSFDuet-1 plasmid in the E.coli C41(DE3)strain.Next,the supply of heme was enhanced by the moderate overexpression of crucial genes in the heme biosynthetic pathway.In addition,a new biosensor was developed to select the appropriate redox partner.Furthermore,a cost-effective whole-cell catalytic system was constructed,resulting in the highest reported conversion rate of 6β-OH DCA(from 4.8%to 99.1%).The combinatorial catalytic strategies applied in this study provide an efficient method to synthesize high-value-added hydroxylated compounds by P450s. | Chixiang Sun Baodong Hu Yanchun Li Zhimeng Wu Jingwen Zhou Jianghua Li Jian Chen Guocheng Du Xinrui Zhao | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 16 | The effects of amino groups and open metal sites of MOFs on polymer-based electrolytes for all-solid-state lithium metal batteries显示文摘Metal-organic frameworks(MOFs) are becoming more and more popular as the fillers in polymer electrolytes in recent years. In this study, a series of MOFs(NH_(2)-MIL-101(Fe), MIL-101(Fe), activated NH_(2)-MIL-101(Fe) and activated MIL-101(Fe)) were synthesized and added to PEO-based solid composite electrolytes(SCEs). Furthermore, the role of the —NH_(2) groups and open metal sites(OMSs) were both examined. Different ratios of MOFs vs polymers were also studied by the electrochemical characterizations. At last, we successfully designed a novel solid composite electrolyte containing activated NH_(2)-MIL-101(Fe),PEO, Li TFSI and PVDF for the high-performance all-solid-state lithium-metal batteries. This work might provide new insight to understand the interactions between polymers and functional groups or OMSs of MOFs better. | Jiahao Lu Zhimeng Wang Qi Zhang Cheng Sun Yanyan Zhou Sijia Wang Xiangyun Qiu Shoudong Xu Rentian Chen Tao Wei | 2023 | Chinese Journal of Chemical Engineering2023，60，8： | 0 |
| 17 | Constitutive expression of codon optimized Trichoderma reesei TrCel5A in Pichia pastoris using GAP promoter显示文摘To address the deficient activity of TrCel5A in naturally secreted cellulase preparation,this study used the GAP promoter to induce constitutive expression of Trichoderma reesei TrCel5A in Pichia pastoris.A recombinant TrCel5A was screened out after gene optimization,synthesis,and expression.The biochemical and enzymatic properties of the new recombinant were characterized.As a result,optimization of shake-flask fermentation of the recombinant was obtained at 28℃,2%inoculum volume,an initial pH of 6.0,as well as glycerol and Tween-80 additions of 30 g/L and 6 g/L,respectively.Under the above-optimized conditions,the recombinant produced 14.8 U/mL of the enzyme activity at 96 h of fermentation.To further enhance enzyme production,pilot-scale cultivation was evaluated using 5-L bioreactors.Using high-cell-density fermentation,the recombinant strain increased enzyme activity to 130.4 U/ml and protein content to 2.49 g/L.In addition,the kinetic factors,including K_(m) and V_(max) values for TrCel5A,were detected to be 5.1 mg/mL and 265.9μmol/(min.mg),respectively.Thus,TrCel5A was effectively expressed in P.pastoris under the GAP promoter,and it demonstrated its potential in commercially relevant enzyme hydrolysis of lignocellulosic biomass. | Yun Hu Renhui Bai Shaohua Dou Zhimeng Wu Ali Abdulkhani Mohammad Ali Asadollahi Abd El-Fatah Abomohra Fubao Sun | 2022 | Systems Microbiology and Biomanufacturing2022，2，3： | 0 |
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