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| 1 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | On ferroelectric domain polarization switching mechanism subject to an external electric field by simulations with the phase-field method显示文摘The ferroelectric domain formation(FDF) and polarization switching(FDPS) subjected to an external electric field are simulated using the phase-field(PF) method,and the FDPS mechanism under different external electric fields is discussed.The results show that the FDF is a process of nucleation and growth in ferroelectric without applying any external stress.Four kinds of parallelogram shaped ferroelectric domains are formed at the steady state,in which the 180° anti-phase domains regularly align along the 45° direction and the 90° anti-phase domains regularly distribute like a stepladder.Steady electric fields can rotate domain polarization by 90° and 180°,and force the orientation-favorite domains and the average polarization to grow into larger ones.The greater the steady electric field,the larger the average polarization at the steady state.In ferroelectrics subject to an alternating electric field,domain polarization switches to cause a hysteresis loop and an associated butterfly loop with the alternating electric field.The coercive field and remnant field are enhanced with the increase of the electric field frequency or strength,or with the decrease of temperature. | ZHOU GuangZhao WANG YongXin LIU Chong CHEN Zheng | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 3 | Investigation into Spatter Particles and Their Effect on the Formation Quality During Selective Laser Melting Processes显示文摘During the selective laser melting process,a high-energy laser beam acts on the powder,a molten pool is rapidly generated and the characteristic parameters are constantly changing.Among them,temperature is one of the important parameters in the forming process.Due to the generation of splash particles,there will be defects in the microstructure,which will seriously affect the formation quality of the prepared parts.Therefore,it is necessary to study the relationships between the splash behavior,molten pool characteristics and product quality.The finite element simulation of the transient temperature field was performed by ANSYS software.Time-series images at different frame rates were obtained with a high-speed camera,and the dynamic process of splashing was observed.Using IN718 alloy powder,the influence of the laser energy density on the light intensity of the molten pool was studied.The appearance of splash particles and the deviation of the powder chemical elements caused by the splash were analyzed.The results show that the transient temperature field with drastic change is easy to cause spatter,which is consistent with the experimental results.There are large differences in the splash at different shooting frame rates.Increasing the frame rate can allow the observation of details such as the shape,size and number of splash particles,which is beneficial for studying the process of splash formation.At the moment when the splash occurs,the light intensity of the molten pool always first increases and then decreases,depending on the energy input.The higher the energy input is,the more intense the light intensity of the molten pool and the higher the peak interval distribution.Compared with fresh powder,the contents of Al and Ti in powder reused 5 times were reduced by 0.15%and 0.02%,respectively.The increases of these two elements in the splash were 16.18%and 29.62%,respectively,and the content of Nb even exceeded the standard range.When the energy density decreased from 229.17 J/mm3 to 130.95 J/mm3,the relative density of the part increased from 91.82%to 99.83%.This shows that reducing the energy input can reduce the splash to suppress the generation of defects,along with the weakening of the overall light intensity of the molten pool.These results can provide a basis for feature extraction of the molten pool,which is of great significance for real-time monitoring and online control in manufacturing processes and ensuring product quality. | Zhiqiang Wang Xuede Wang Xin Zhou Guangzhao Ye Xing Cheng Peiyu Zhang | 2020 | Computer Modeling in Engineering & Sciences2020，，7： | 3 |
| 4 | Slipping detection and control in gripping fruits and vegetables for agricultural robot显示文摘The minimum gripping force applied is expected to prevent objects from mechanical damage when an agricultural robot is applied to handle and manipulate fruits and vegetables.In this research,a sensitive slipping sensor was developed with a piezo resistor to control the griping force of the agricultural robot.Firstly,an output of the slipping sensor was analyzed in a frequency domain by using a short time Fourier transform.Then rules for discriminating slipping signal from the output of a slipping sensor were proposed based on detail coefficients of discrete wavelet transform.Finally,a controller based on adaptive Neuro-Fuzzy inference system was developed to adjust the grasping force of the agricultural robot in real time.The detail coefficients and the normal gripping force were applied as input of the controller,and Fuzzy rules were simplified through subtractive clustering.With a two-finger end-effector of the agricultural robot,the experimental results showed that the slipping signal could be effectively extracted regardless of change in the normal gripping force,and the gripping force had been controlled successfully when grasping tomatoes and apples.This method was a promising way to optimize the gripping force of the agricultural robot grasping the fruits and vegetables. | Guangzhao Tian Jun Zhou Baoxing Gu | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 2 |
| 5 | A possible unification model for all basic forces显示文摘 | Yueliang Wu Guangzhao Zhou | 1998 | Science in China Series A: Mathematics1998，，3： | 1 |
| 6 | HEAVY RESPONSIBILITIES & GREAT EXPECTATIONS显示文摘Forty years have elapsed since the founding of the CAS Academic Divisions on June 1, 1955. The beginning of the 1950s, when the People’s Republic had just come into being, was a period of time in which thousands of things were to be done in the newlyborn country. As early as in 1953, however, the Government was considering the introduction of a system | Zhou Guangzhao(The Chinese Academy of Sciences) | 1995 | Bulletin of the Chinese Academy of Sciences1995，9，4： | 0 |
| 7 | 4–λ hybrid InGaAsP-Si evanescent laser array with low power consumption for on-chip optical interconnects显示文摘A 4 –λ hybrid InGaAsP-Si evanescent laser array is obtained by bonding III–V distributed feedback lasers to a silicon on insulator(SOI) substrate using a selective area metal bonding technique. Multiple wavelengths are realized by varying the width of the III–V ridge waveguide. The threshold current is less than 10 mA for all wavelength channels under continuous-wave(CW) operation at room temperature, and the lowest threshold current density is 0.76 kA∕cm2. The side mode suppression ratio(SMSR) is higher than 40 dB for all wavelength channels when the injection current is between 20 mA and 70 mA at room temperature, and the highest SMSR is up to 51 dB. A characteristic temperature of 51 K and thermal impedance of 144°C/W are achieved on average.The 4 –λ hybrid InGaAsP-Si evanescent laser array exhibits a low threshold and high SMSR under CW operation at room temperature. The low power consumption of this device makes it very attractive for on-chip optical interconnects. | YAJIE LI HONGYAN YU WENGYU YANG CHAOYANG GE PENGFEI WANG FANGYUAN MENG GUANGZHEN LUO MENGQI WANG XULIANG ZHOU DAN LU GUANGZHAO RAN JIAOQING PAN | 2019 | Photonics Research2019，7，6： | 0 |
| 8 | A SPEECH AT THE GATHERING TO COMMEMORATE THE 45TH ANNIVERSARY OF THE CAS FOUNDING显示文摘Forty-five years ago today the Chinese Academy of Sciences was founded. Over the past 45 years, the CAS has experienced several significant historical stages: establishment, initial development, a decade of chaos before the end of the 'Cultural Revolution' and the readjustment, restoration and reform and opening since 1978.CAS has accompanied the country through a zigzag journey and is poised to triumph in the future. Throughout the CAS’s course of development, it has always enjoyed the warm solicitude and support of the Party, | Zhou Guangzhao(CAS President) | 1995 | Bulletin of the Chinese Academy of Sciences1995，9，3： | 0 |
| 9 | DEVELOPING SCIENCE AND TECHNOLOGY TO INVIGORATE THE CHINESE NATION显示文摘Owing to the rapid and vigorous development of science and technology,the world today is entering a period of profound changes in both the economy and society. The information society and intelligent age are approaching.Information is being communicated by computers,optical fibers and satellites to every comer of the world,breaking down all the barriers and restrictions and involving individuals, enterprises, regions and countries into the world market, which is intensely competitive, turbulent and fluctuating. Operation at | Zhou Guangzhao(The Chinese Academy of Sciences) | 1995 | Bulletin of the Chinese Academy of Sciences1995，9，2： | 0 |
| 10 | WELCOMING THE CONVENTION OF THE 18TH PACIFIC SCIENCE CONGRESS IN CHINA显示文摘The 18th Pacific Science Congress is to convene in Beijing on June 6-12,1995.This will be a large-scale and comprehensive meeting of international academic circles. Its theme is 'population,resources & environment: prospects & countermeasures'.At the time when today’s world, and the Pacific Rim in particular,is being challenged by many vital problems,such as the population explosion,depleting natural resources and ecological deterioration in its sustained and steady development, the scheduled content of this session will discuss those problems, exchange research results,analyze | Zhou Guangzhao(The Chinese Academy of Sciences) | 1995 | Bulletin of the Chinese Academy of Sciences1995，9，2： | 0 |
| 11 | A GIANT OF OUR ERA AND BOSOM FRIEND OF CHINESE SCIENTISTS-Mourning with deep grief over the death of comrade Deng Xiaoping显示文摘One of great leaders of our era, comrade Deng Xiaoping has passed away and left us forever.Chinese circles of science and technology were especially filled with the deepest sorrow when we heard the sad news of his death because we since then lost a leader of foresight and sagacity, a venerable elder as well as a good teacher and a helpful friend. But his enduring contribution to Chinese science, and his earnest teachings to Chinese scientists have been, and will be, a far-reaching and unflagging influence in the years to come. | Zhou Guangzhao(The Chinese Academy of Sciences) | 1997 | Bulletin of the Chinese Academy of Sciences1997，11，2： | 0 |
| 12 | WORKING REPORT AT THE 7TH GENERAL ASSEMBLY OF THE CAS显示文摘Members and comrades: The Seventh General Assembly of the CAS opened here today together with the meeting for the establishment of the Chinese Academy of Engineering (the CAE).The establishment of the CAE is an important event for the S&.T community in this country.Please allow me.on behalf of the CAS.to extend my congratulations to the CAE on its official founding. | Zhou Guangzhao( CAS President and Chairman of Executive Committee of the CAS Presidium ) | 1995 | Bulletin of the Chinese Academy of Sciences1995，9，1： | 0 |
| 13 | Electric-controlled tunable thermal switch based on Janus monolayer MoSSe显示文摘The high-performance,wide-range tunable thermal switches play a significant role in the thermal management,high-power-density intelligent devices,energy systems,etc.However,traditional thermal switch components,such as thermal diodes,suffer from poor stability,small adjustability,low time efficiency,and difficult implementation.Herein,we propose the superior electric-controlled thermal switch(ECTS)based on Janus monolayer MoSSe.The high-effective and asymmetric regulation of the thermal conductivity driven by electric field demonstrates a wide-range adjustable thermal switch ratio,where the peak value reaches 2.09 under the electric field of 0.04 VÅ^(−1).The underlying mechanism is revealed by electronic structures that the interactions between electrons and phonons are renormalized due to the electric field driving charge density redistribution,which ultimately modulates the phonon anharmonicity.The high-efficiency adjustable ECTS component is expected to provide new inspiration for next-generation thermal management and information processing. | Donghai Wei E Zhou Xiong Zheng Huimin Wang Chen Shen Hongbin Zhang Zhenzhen Qin Guangzhao Qin | 2022 | npj Computational Materials2022，，1： | 0 |
| 14 | A SPEECH AT THE NEWS CONFERENCE FOR THE 1995 BY-ELECTION OF CAS MEMBERSHIP DELIVERED ON SEPTEMBER 3,1995显示文摘Today, the Chinese Academy of Sciences is holding a news conference under this roof to publicize the results of the 1995 by-election of CAS members.Taking this opportunity,I would like to extend a cordial welcome to you, present at this meeting,and thank you for your long-term support and unflagging concern for our Academy’s work in various aspects. In line with the stipulations of the Constitution of | Zhou Guangzhao(Executive Chairman of CAS Presidium & CAS President) | 1996 | Bulletin of the Chinese Academy of Sciences1996，10，1： | 0 |
| 15 | SOME OF MY UNDERSTANDING ON THE LAW REGARDING S&T DEVELOPMENT显示文摘Science, technology and engineering expertise form a treasurehouse of knowledge acquired by man in striving to understand and change nature.They respond respectively to different links of this endless endeavour.So they differ greatly from each other but are closely associated.Science refers to various principles, basic theories and concepts summed up from man’s cognition of natural phenomena,exploration of material movements and related objective laws; technology is the applicable methods and practical means developed from scien- | Zhou Guangzhao(Chinese Academy of Sciences) | 1996 | Bulletin of the Chinese Academy of Sciences1996，10，1： | 0 |
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