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| 1 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 2 | Provenance of Lower Carboniferous Bauxite Deposits in Northern Guizhou,China:Constraints from Geochemistry and Detrital Zircon U-Pb Ages显示文摘The Lower Carboniferous Jiujialu Formation bauxite deposits of northern Guizhou Province,China,are a Kazakhstan subtype of karst bauxite deposits.The provenance of the Jiujialu Formation has long been debated,with uncertainty about the formation of the bauxite deposits.Here we report new geochemical data that indicate the affinity between the Lower-Middle Ordovician clastic rocks and argillaceous dolostones and the overlying Carboniferous bauxite deposits,all of which are characterized by high Al_(2)0_(3),K2_(O),and∑REE contents,flat post-Archean Australian shale(PAAS)-normalized REE patterns,and uniform immobile element ratios(TiO2/Al_(2)0_(3),Nb/TiO2,and Zr/TiO2).Their similar detrital zircon age distributions further indicate the link between the bauxite deposits and the clastic rocks and argillaceous dolostones.Zircon age spectra of clastic rocks of the Lower Silurian Hanchiatien Formation in northern Guizhou match those of the bauxite deposits,with a maximum age peak at-980 Ma and other secondary age peaks,suggesting these clastic rocks may represent the provenance of the bauxite deposits.The youngest detrital zircons(-445 Ma)occur only in the bauxite deposits and are probably sourced from K-bentonite beds of the Ordovician-Silurian tran-sition.Our analyses indicate that the source materials of the bauxite deposits in the Jiujialu Formation are of mixed provenance:Lower-Middle Ordovician aluminosilicate rocks and argillaceous dolostones of the underlying strata,and Lower Silurian clastic rocks and K-bentonite from adjacent areas.A comparison of Early Carboniferous bauxitic provenances in northern and central Guizhou indicates that paleotopography was the major factor controlling the provenance of these bauxite deposits. | Guolin Xiong Wenchao Yu Yuansheng Du Shenfu Weng Dawei Pang Xusheng Deng Jintao Zhou | 2021 | Journal of Earth Science2021，32，1： | 3 |
| 3 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 4 | Aerodynamic Characteristics of Isolated Loaded Tires with Different Tread Patterns: Experiment and Simulation显示文摘The current research of tire aerodynamics mainly focus on the isolated and simplified tread tire.Compared with the real complex pattern tire,the tread pattern structure and deformed profile of a loaded tire has a greatly influence on tire aerodynamic drag.However,the mechanisms of the isolated loaded tires with different tread patterns effects on the aerodynamic drag are subjects worthy of discussion.The purpose of this study is to experimentally and compu-tationally investigate the aerodynamic characteristics of three tires 185/65 R14 with different patterns under loaded.A wind tunnel test model was first established using three-dimensional(3D)printing with a ratio of 1:1,and the pres-sure coefficients C_(p) of the three tires with different patterns are measured.The paper then conducted computational fluid dynamics(CFD)simulations for analyzing the pressure and flow characteristics.The accuracy of CFD simulation is verified by comparing the simulation results with the test results of pressure coefficients C_(p),and they are of good consistency.While,the general analysis of pressure coefficients C_(p) results of the three tires indicates high-pressure area on the windward surface,and occurrence of low-pressure area on the leeward surface,the pressure coefficients C_(p) of all three tires decreased firstly and then increased along in the air flow direction.The authors finally analyzed the effect of tread patterns on the flow field around the tire and revealed the differences between flow characteristics and aerodynamic drag.The results show that,angle of tire lateral groove has great effect on the flow field characteristics such that;the more the angle of lateral groove agrees with the air flow direction,the less the flow separation and flow vortices,and a minimum observable aerodynamic drag.The research provides a guidance for the design of low aerodynamic drag tires,and helps to illustrate the impact of tire aerodynamics on the car body in the future. | Haichao Zhou Zhen Jiang Guolin Wang Shupei Zhang | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 2 |
| 5 | Let there be light: a bright future for Ca2+ signaling显示文摘Calcium ion(Ca^(2+))is a ubiquitous second messenger in eukaryotic cells.In response to electrical,hormonal,or mechanical stimulation,cytosolic Ca^(2+)levels increase due to Ca^(2+) influxes through ion channels embedded in the plasma membrane or Ca^(2+) releases from intracellular Ca^(2+) stores,such as the endoplasmic | Guolin Ma Jindou Liu Nhung T. Nguyen Yubin Zhou Youjun Wang | 2018 | Science Bulletin2018，63，16： | 1 |
| 6 | SAGE is far more sensitive than EST for detecting low - adundance transerlpts 显示文摘 | Miao Sun Guolin Zhou Sanggyu Lee | 2004 | BMC Genomics2004，5，： | 1 |
| 7 | Generation of high quality and quantity of tag/ditag for SAGE analysis 显示文摘 | LEE S CHEN Jianjun ZHOU Guolin | 2001 | BioTechniques2001，31，： | 1 |
| 8 | High- throughput GLGI procedure for converting a large number of serial analysis of gene expression tag sequence into 3' complementary DNAs 显示文摘 | CHEN Jianjun LEE S ZHOU Guolin | 2002 | Genes Chromosomes Cancer2002，33，3： | 1 |
| 9 | Isolation and complete nucleotide sequence of a Chinese Sindbis-like virus 显示文摘 | Liang Guodong Lilei Zhou Guolin Fu Shihong | 2000 | J Gen Virol2000，81，： | 1 |
| 10 | Retroperitoneal cystic ectopic adrenal gland in woman显示文摘To the editor:Ectopic adrenal tissue is common in male surgery,especially near the gonadal area;however,it is extremely rare in adult females.1,2 In this study,we present a 46-year-old woman with a mass of ectopic adrenal tissue in the retroperitoneal region. | Gui Shunping Zhang Yanyan Luo Guolin Ni Shanshan Xiao Xue Zhou Rong | 2014 | Chinese Medical Journal2014，，7： | 0 |
| 11 | 用有限元模拟分析优化宽基轮胎的成型工艺和设计显示文摘宽基轮胎是近年来应用和发展较快的一种新型轮胎。在载重汽车用宽基轮胎替代并装双胎的普通轮胎,具有改善车辆与地面的附着性和耐磨性等多项性能的潜在优势。但是,宽基轮胎在成型制造过程中,很容易出现胎面变形和应力分布不均匀的现象。本文研究的目的是应用数值分析技术仿真模拟宽基载重汽车充气轮胎的成型制造过程,进而指导优化轮胎的施工设计。首先,应用有限元分析技术模拟385/55R22.5规格轮胎的成型制造过程,包括四个阶段:分别是成型主鼓部件贴合、辅助成型鼓部件贴合、半成品胎坯成型和最后的胶囊硫化机硫化定型过程。其次,为了解决435/50R19.5规格轮胎生产中存在的实际轮胎结构与理论设计的轮胎结构在材料分布方面的差别,根据轮胎施工设计仿真模型的分析结果,提出曲面鼓成型半成品胎坯的方法,并且确定了曲面鼓的设计参数。在本文中,我们给出了收集轮胎材料的方法、测试过程、分析方法、试验结果和相关数据的统计。最后,通过试验检测结果对仿真模拟模型的准确性进行了验证。 | 赵冬梅(编译) Haichao Zhou Guolin Wang Yuming Wang | 2019 | 现代橡胶技术2019，45，5： | 0 |
| 12 | A Square Wave Based Electrical Method for Human Skin Moisture Assessment显示文摘The moisture content measurement of human skin is a significant way to assess skin conditions and diagnose diseases that influence skin function.The necessity of evaluating the efficacy of a cosmetic product makes it important to improve the accuracy and reproducibility of the measurement.A pair of interdigitated gold electrodes was fabricated on the printed circuit board (PCB) substrate and utilized directly in contact with the measured skin.A square-wave voltage at a single frequency was applied to the electrodes and the corresponding response current was measured to get the equivalent impedance of human skin.Since it's easy to generate and control a square-wave signal by digital electric circuits,this method is suitable to be used in the portable application.The experimental results indicate that good repeatability and satisfied accuracy can be obtained by this method. | Guolin Zhou Yonggui Dong | 2006 | 稀有金属材料与工程2006，35，A03： | 0 |
| 13 | Controllable growth of wafer-scale PdS and PdS_(2) nanofilms via chemical vapor deposition combined with an electron beam evaporation technique显示文摘Palladium(Pd)-based sulfides have triggered extensive interest due to their unique properties and potential applications in the fields of electronics and optoelectronics.However,the synthesis of large-scale uniform PdS and PdS_(2)nanofilms(NFs)remains an enormous challenge.In this work,2-inch wafer-scale PdS and PdS_(2) NFs with excellent stability can be controllably prepared via chemical vapor deposition combined with electron beam evaporation technique.The thickness of the pre-deposited Pd film and the sulfurization temperature are critical for the precise synthesis of PdS and PdS_(2) NFs.A corresponding growth mechanism has been proposed based on our experimental results and Gibbs free energy calculations.The electrical transport properties of PdS and PdS_(2) NFs were explored by conductive atomic force microscopy.Our findings have achieved the controllable growth of PdS and PdS_(2) NFs,which may provide a pathway to facilitate PdS and PdS_(2) based applications for next-generation high performance optoelectronic devices. | Hui Gao Hongyi Zhou Yulong Hao Guoliang Zhou Huan Zhou Fenglin Gao Jinbiao Xiao Pinghua Tang Guolin Hao | 2023 | Journal of Semiconductors2023，44，12： | 0 |
| 14 | Petrogenesis Significance of Chromian Spinels from Northeastern Jiangxi Province Ophiolite(NEJXO), China: Paleogeodynamic Implications显示文摘1 Introduction The northeastern Jiangxi Province ophiolite is located in the SE margin of the Yangtze Block,along the Zhangshudun(Yiyang)-Xingangshan(Dexing),ophiolite belt extending northeast for about 100km(Zhou,1989;Li et al.,1997).The original sequence of the NE Jiangxi ophiolite suite has been structurally disrupted | GUO Guolin FAN Xiujun YANG Jingsui LIU Xiaodong ZHANG Yong ZHOU Wenting | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 0 |
| 15 | Transcriptome based high-throughput SSRs and SNPs discovery in the medicinal plant Lagenaria siceraria显示文摘Lagenaria siceraria(Molina)Standley has unique biological characteristics with high nutritional and medicinal values.It is an important pharmaceutical plant with various biologically active ingredients.Genetic improvement and deeper genomic studies require a rich resource of molecular markers.The application of next-generation sequencing technology,especially for transcriptome profiling,has greatly facilitated high throughput single nucleotide polymorphism(SNP)and simple sequence repeat(SSR)discovery.In this study,we sequenced the transcriptome of three major cultivars of L.siceraria and obtained 64.88 GB of clean data.The assembled high-quality reads were clustered into 89,347 unigenes,which were annotated by non-redundant protein database,Swiss-Port,Eukaryotic Ortholog Groups,Kyoto Encyclopedia of Genes and Genomes,and gene ontology databases.A total of 8,891 SSR and 35,873 SNP markers were predicted from unigenes by MISA and SAM tools,respectively.Characterization of the predicted markers in L.siceraria showed that the SSR and SNP densities were 60 and 243 markers per Mb of genome,respectively,and the estimated ratio of transition to transversion of SNP was 2.016.These markers will be very useful for genetic studies in L.siceraria,especially for the high-density linkage map construction and genome-wide association studies.Further genomic studies based on these results will facilitate the identification of novel genes or alleles of pharmaceutical importance. | HONGYUAN ZHANG MIN ZHANG JIE TAN SHUPING HUANG GUOLIN ZHOU XIA CHEN | 2021 | BIOCELL2021，45，2： | 0 |
| 16 | Variable stiffness wires based on magnetorheological liquid metals显示文摘Magnetorheological fluid(MRF)has shown its great potential in the development of large mechanical devices,such as dampers,shock absorbers,rotary brakes,clutches,and prosthetic joints.Recently,more research focus has been invested on using MRF to develop soft,stretchable,and miniaturized devices with variable stiffness for realizing functionalities that cannot be achieved using solid smart materials.Here,based on liquid metal magnetoactive slurries(LMMS),a variable stiffness wire with excellent electrical conductivity is demonstrated.Without exposure to a magnetic field,the LMMS wire has an extremely low stiffness,and can be easily stretched while maintaining an excellent electrical conductivity.When applying a magnetic field,the wire becomes much stiffer and can retain its shape even under a load.The combination of properties of flexibility,high electrical conductivity,and variable stiffness of the wire is harnessed to make a flexible gripper that can grasp objects of various shapes.Moreover,by using gallium instead of its liquid metal alloys,the tunable stiffness range of the LMMS wire is signifi-cantly enhanced and can be controlled using both external magnetic fields and temperature-induced phase change.The presented LMMS wire has the potential to be applied in flexible electronics,soft robotics and so on. | Xiangbo Zhou Jian Shu Hu Jin Hongtai Ren Gang Ma Ning Gong Duan Ge Juan Shi Shi-Yang Tang Guolin Yun Hongda Lu Shuai Dong Xiangpeng Li Shiwu Zhang Weihua Li | 2022 | International Journal of Smart and Nano Materials2022，13，2： | 0 |
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