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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 3 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 4 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 5 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 6 | Alzheimer's disease and gut microbiota显示文摘Alzheimer's disease(AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior.Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the 'hygiene hypothesis'. All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD. | Xu Hu Tao Wang Feng Jin | 2016 | Science China(Life Sciences)2016，59，10： | 49 |
| 7 | Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents显示文摘The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction(PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. However, most known Nrf2 activators/ARE inducers are indirect inhibitors of Keap1–Nrf2PPI and they are electrophilic species that act by modifying the sulfhydryl groups of Keap1's cysteine residues. The electrophilicity of these indirect inhibitors may cause 'off-target' side effects by reacting with cysteine residues of other important cellular proteins. Efforts have recently been focused on the development of direct inhibitors of Keap1–Nrf2 PPI. This article reviews these recent research efforts including the development of high throughput screening assays, the discovery of peptide and small molecule direct inhibitors, and the biophysical characterization of the binding of these inhibitors to the target Keap1 Kelch domain protein. These non-covalent direct inhibitors of Keap1–Nrf2 PPI could potentially be developed into effective therapeutic or preventive agents for a variety of diseases and conditions. | Dhulfiqar Ali Abed Melanie Goldstein Haifa Albanyan Huijuan Jin Longqin Hu | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 46 |
| 8 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 9 | Hydrothermal recrystallization of the Lower Ordovician dolomite and its significance to reservoir in northern Tarim Basin显示文摘Discovered in S15 and some other wells, the Lower Ordovician in the northern Tarim Basin consists mainly of brown gray-dark gray very fine-fine crystalline dolomite, with a minor portion of locally light gray-white medium-coarse crystalline dolomite. Silicification can be observed in the medium-coarse dolomite, and some euhedral drusy quartz can also be found in pores and fractures of the dolomite. The homogenization temperature of the fluid inclusions in the medium-coarse dolomite is between 110 and 200°C with maximum between 140 and 190°C, and the salinity is between 10.7 and 18.5 wt.% NaCl Eq. The homogenization temperature and salinity of the fluid inclusions in the medium-coarse dolomite are similar to those in the drusy quartz. Compared with the very fine-fine dolomite, the medium-coarse phase contains relatively high Fe and Mn. The average concentration of FeO and MnO in the medium-coarse dolomite is 1.917% and 0.323%, respectively. The medium-coarse dolomite has a remarkable negative Eu anomaly, consistent with the REE pattern of the intermediate-felsic igneous rocks in the Tarim Basin. The oxygen isotopic composition of the medium-coarse dolomite is relatively lighter than that of the very fine-fine dolomite. The δ18OPDB values of the medium-coarse dolomite are between -10.35‰ and -7.31‰. The δ18OSMOW values of the fluid associated with the medium-coarse dolomite can be calculated according to homogenization temperature and oxygen isotope fractionation factor between dolomite and fluid, and the calculated values are between +4‰ and +10‰, consistent with those of the hydrothermal fluid. The medium-coarse dolomite has relatively high 87Sr/86Sr ratios as well, indi- cating an origin associated with intermediate-felsic igneous rock. The homogenization temperature, element composition, REE pattern, oxygen and strontium isotopes demonstrate that the medium-coarse dolomite is the result of recrystallization of very fine-fine dolomite under hydrothermal environment. The hydrothermal dolomite recrystallization is a special event but exists extensively in the Tarim Basin. The recrystallized dolomite becomes well reservoir bed for many intercrystalline pores and dissolution pores are produced in this event, so that more attention should be paid to the altered dolomite during the petroleum exploration in the lower Paleozoic in the Tarim Basin. | ZHU DongYa JIN ZhiJun HU WenXuan | 2010 | Science China Earth Sciences2010，53，3： | 34 |
| 10 | Extracellular matrix gel is necessary for in vitro cultivation of insulin producing cells from human umbilical cord blood derived mesenchymal stem cells显示文摘背景胰腺的小岛房间移植是一条有效途径治疗类型 1 糖尿病。然而,因为可移植的施主小岛的严重缺乏,这治疗广泛地没被使用。这研究调查了从人的脐的绳索血(UCB ) 导出的间充质的干细胞(MSC ) 是否能是进胰岛素生产的 transdifferentiated 在 vitro 和在这 procedure.Methods 人 UCB 的胶化取样的细胞外的矩阵(ECM ) 的角色的房间是镇定的, MSC 被孤立。MSC 特定的标记蛋白质被流动 cytometer 分析。造骨细胞和 adipocyte 的能力被测试区分。进象房间一样的小岛的区别被一个 15 天的协议导致与或没有 ECM 胶化。胰腺的特征与 immunofluorescence,反向的抄写聚合酶链反应(RT-PCR ) 和流动 cytometry 被评估。响应葡萄糖刺激的胰岛素内容和版本与 chemiluminescent 免疫分析 system.Results 被检测十六 MSC 从 42 个术语人 UCB 单位(38%) 被孤立。人的 UCB-MSCs 表示 MSC 特定的标记并且能在 vitro 被导致进造骨细胞和 adipocyte。小岛相似房间簇出现了在在有 ECM 的导致的系统的胰腺的区别以后的大约 9 天胶化。胰岛素积极房间说明了(25. | GAO Feng WU De-quan HU Yan-hua JIN Guang-xin | 2008 | Chinese Medical Journal2008，，9： | 31 |
| 11 | EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women显示文摘 | Wang, Y. | 2008 | 南京医科大学学报(自然科学版)2008，28，12： | 32 |
| 12 | Impact of different clinical pathways on outcomes of patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the RAPID-AMI study显示文摘背景当前的指南作为选择的第一治疗支持主要经皮的冠的干预(主要一种总线标准)( 与 thrombolytic 治疗对比) 为有尖锐圣片断举起的病人心肌的梗塞(STEMI ) 特别当在 12 小时症状发作以内交付了时。我们试图从 2005 年 11 月与 STEMI.Methods 在病人在结果在灌注延期和随后的改进的减小上评估不同临床的小径的影响到 2007 年 11 月,有明确的 STEMI 的 546 个连续病人,在在紧急情况房间的到达之上是 triaged 经历主要一种总线标准,被包括。他们, 271 个病人直接被带到 catheterization 实验室(快速的组) ,并且 275 个病人首先进入冠的照顾单位(CCU ) 或心脏的病房,然后转了到 catheterization 实验室(非快速的组) 。主要端点是 door-to-balloon ( D28 )时间,并且第二等的端点包括了山峰 CK-MB 水平和主要心脏的不利事件(向)的率在住院期间并且在30天的临床的 follow-up.Results 基线临床的特征包括死亡,梗塞,或目标容器 revascularization 估计的梗塞尺寸, angiographic 特征和程序的成功率在二个组之间是可比较的,除了更多的病人以前收到了 glycoprotein b/a 受体禁止者之外一D2B 时间被弄短((108 ? ㈨ ? 洠污 ???? 畯 ? 晡整 ? 桴 ? 灯牥瑡潩 ? 慷 ? 楳湧晩捩湡汴 ? 楨桧牥琠慨 ? 桴瑡漠 ? 桴 ? 湫 ' 覞煬潠 P 潲灵吗?? | ZHANG Qi ZHANG Rui-yan QIU Jian-ping JIN Hui-gen ZHANG Jun-feng WANG Xiao-long JIANG Li LIAO Min-lei HU Jian DING Feng-hua ZHANG Jian-sheng SHEN Wei-feng | 2009 | Chinese Medical Journal2009，，6： | 32 |
| 13 | Seed priming with chitosan improves maize germination and seedling growth in relation to physiological changes under low temperature stress显示文摘低温度应力在萌芽和早幼苗生长期间是玉米的全球生产的重要限制。有 0.25% , 0.50% ,和 0.75% 的种子 priming (w/v ) 的效果在生长和生理的变化上的 15 ° C 的 chitosan 答案用二玉米(Zea mays L.) 被调查生来的线, HuangC (寒心容忍) 并且 Mo17 (寒心敏感) 。当有 chitosan 的种子 priming 没在低温度应力下面在萌芽百分比上有重要效果时,它提高了萌芽索引,减少了吝啬的萌芽时间(MGT ) ,并且增加了射击高度,根长度,和射击和根在两根玉米线的干燥重量。 malondialdehyde ( MDA )的衰落内容和血浆膜的相对渗透和可溶的糖和脯氨酸的集中的增加, peroxidase (邮政部门)活动,并且过氧化氢酶(猫)活动与 chitosan 的三集中在 priming 以后在寒心敏感、寒心容忍的玉米幼苗两个都被检测。HuangC 对对 chitosan 的不同集中作出回应不太敏感。有为大约 60 ∼64 h 的 0.50% chitosan 的 Priming 似乎有最好的效果。因此,它建议有 chitosan 的种子 priming 可以在低温度应力下面为幼苗生长改进玉米种子和利益的萌芽的速度。 | Ya-jing GUAN Jin HU Xian-ju WANG Chen-xia SHAO | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，6： | 31 |
| 14 | The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients显示文摘Objective Evidence suggests that type 2 diabetes (T2DM) is associated with an increased risk of dementia and that glucose variability is an independent risk factor for diabetic complications.This study investigated the relationship between glucose excursion and cognitive function in aged T2DM patients.Methods A total of 248 aged T2DM patients wore a continuous glucose monitoring system (CGMS) for 3 days in order to evaluate glucose excursion,including mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD).All subjects were evaluated with a number of accepted cognitive function tests,including themini‐mental status examination (MMSE).The relationship between MAGE and MODD and performance on these cognitive tests was assessed.Results The MAGE and MMSE score were negatively correlated,likewise with the correlation between MODD and MMSE.Liner multivariate regression analysis showed that MAGE and MODD were also negatively related to MMSE independent of age,sex,glycemic control,hypertension,smoking,or coronary heart disease history.Conclusion Glucose excursion is related to cognitive function in aged T2DM patients.Elevated glucose excursion decreased the MMSE score,which reflects general cognitive function.Thus,therapy aimed at controlling glucose excursion may be beneficial for maintaining cognitive function in aged T2DM patients. | ZHONG Yuan ZHANG Xiao Yan MIAO Ya ZHU Jie Hua YAN Hong WANG Bei Yun JIN Jun HU Ting Jun JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 34 |
| 15 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 16 | National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016显示文摘Hand, foot and mouth disease(HFMD) is a major public health concern in China. The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71(EVA71) and coxsackievirus A16(CVA16). Since its first large outbreak in 2008, the dominant HFMD pathogens are constantly changing. In 2013 and 2015, CVA6 exceeded both EVA71 and CVA16 to become the leading cause of HFMD in some provinces. However, there still lacks a comprehensive overview on the molecular epidemiology and evolution of HFMD-related enteroviruses at the national level. In this study, we performed systematic epidemiological analyses of HFMD-related enteroviruses using the data of 64 published papers that met the inclusion criteria, and conducted phylogenetic analyses based on 12,080 partial VP1 sequences identified in China before 31 st June 2018. We found that EVA71 prevalence has decreased sharply but other enteroviruses have increased rapidly from 2008 to 2016 and that one subtype of each enterovirus is represented during the epidemic. In addition, four genotypes EVA71_C4, CVA16_B1, CVA6_D and CVA10_C are the most predominant enterovirus strains and collectively they cause over 90% of all HFMD cases in China according to the phylogenetic trees using representative partial VP1 sequences. These four major enterovirus genotypes have different geographical distributions, and they may cocirculate with other genotypes and serotypes. These results suggest that more molecular epidemiological studies should be performed on several enteroviruses simultaneously, and such information should have implications for virological surveillance, disease management, vaccine development and policy-making on the prevention and control of HFMD. | Xuemin Fu Zhenzhou Wan Yanpeng Li Yihong Hu Xia Jin Chiyu Zhang | 2020 | Virologica Sinica2020，35，1： | 31 |
| 17 | A review of recent advances in tribology显示文摘The reach of tribology has expanded in diverse fields and tribology related research activities have seen immense growth during the last decade.This review takes stock of the recent advances in research pertaining to different aspects of tribology within the last 2 to 3 years.Different aspects of tribology that have been reviewed including lubrication,wear and surface engineering,biotribology,high tem perature tribology,and computational tribology.This review attempts to highlight recent research and also presents future outlook pertaining to these aspects.It may however be noted that there are limitations of this review.One of the most important of these is that tribology being a highly multidisciplinary field,the research results are widely spread across various disciplines and there can be omissions because of this.Secondly,the topics dealt with in the field of tribology include only some of the salient topics(such as lubrication,wear,surface engineering,biotribology,high tem perature tribology,and computational tribology)but there are many more aspects of tribology that have not been covered in this review.Despite these limitations it is hoped that such a review will bring the most recent salient research in focus and will be beneficial for the growing community of tribology researchers. | Yonggang MENG Jun XU Zhongmin JIN Braham PRAKASH Yuanzhong HU | 2020 | Friction2020，8，2： | 31 |
| 18 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 19 | Photovoltaic and Solar Power Forecasting for Smart Grid Energy Management显示文摘Due to the challenge of climate and energy crisis,renewable energy generation including solar generation has experienced significant growth.Increasingly high penetration level of photovoltaic(PV)generation arises in smart grid.Solar power is intermittent and variable,as the solar source at the ground level is highly dependent on cloud cover variability,atmospheric aerosol levels,and other atmosphere parameters.The inherent variability of large-scale solar generation introduces significant challenges to smart grid energy management.Accurate forecasting of solar power/irradiance is critical to secure economic operation of the smart grid.This paper provides a comprehensive review of the theoretical forecasting methodologies for both solar resource and PV power.Applications of solar forecasting in energy management of smart grid are also investigated in detail. | Can Wan Jian Zhao Yonghua Song Zhao Xu Jin Lin Zechun Hu | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 29 |
| 20 | Randomized comparison of intracoronary tirofiban versus urokinase as an adjunct to primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: results of the ICTUS-AMI trial显示文摘 | ZHU Tian-qi ZHANG Qi DING Feng-hua QIU Jian-ping JIN Hui-geng JIANG Li LU Lin ZHANG Rui-yan HU Jian YANG Zhen-kun SHEN Ying SHEN Wei-feng | 2013 | Chinese Medical Journal2013，，16： | 27 |
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