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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 3 | Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta)显示文摘 | Lifang Jin Shaohui Ji Xianghui Tang Xiangyu Guo Yongqing Lu Hongwei Chen Hongkui Deng Qi Zhou Weizhi Ji | 2009 | Cell Research2009，19，2： | 2 |
| 4 | Effects of different amino acid levels and a carvacrol-thymol blend on growth performance and intestinal health of weaned pigs显示文摘Background:Over the past years,antibiotic growth promoter had been restricted in animal husbandry production in many countries because of antimicrobial resistance and foodborne antibiotic residues.However,the problems of poor intestinal health and low growth efficiency of piglets have not been solved completely in an antibiotic-free diet,and it is urgent to explore alternatives to antimicrobial growth promoters.Methods:Here,a total of 532 weaned pigs were assigned to one of 4 treatments,the low amino acid(AA)level diet(d 1 to d 14 is 1.35%,d 15 to d 42 is 1.25%)(Low AA),the low AA level diet supplementation with a carvacrol-thymol blend(50 mg carvacrol and 50 mg thymol/kg of diet)(CB)(Low AA+CB),the high AA level diet(d 1 to d 14 is 1.50%,d 15 to d 42 is 1.40%)(High AA),and the high AA level diet supplementation with a CB(High AA+CB),respectively.Then we measured growth performance and intestinal health indicators of weaned pigs.Results:Results showed that high AA level significantly reduced plasma urea nitrogen,plasma Interleukin-6(IL-6)and fecal lipocalin-2 contents(P<0.05),significantly increased the relative abundance of fecal Lactobacillus and Enterococcus,and had a trend to increase the fecal secretory immunoglobulin A(sIgA)and mucin 2(MUC 2)contents(P<0.05)in piglets,thereby alleviating the diarrhea of piglets and reducing the feed conversion ratio(FCR)of piglets during d 1~14 after weaning.Dietary supplementation with CB significantly increased the activity of plasma antioxidant enzymes T-SOD and GSH-px(P<0.05),while significantly reduced plasma malondialdehyde(MDA),plasma interleukin-1β(IL-1β),plasma endotoxin and D-lactic acid contents(P<0.05).Meanwhile,CB significantly decreased fecal lipocalin-2 contents and the abundance of fecal Escherichia coli(P<0.05).Thus,we hypothesis that dietary supplementation with CB significantly increased the average daily gain(ADG)of piglets(P<0.05)during d 1~14 after weaning through promoting intestinal health.Conclusion:These results suggest that high AA level and dietary supplementation with CB improved the growth performance of weaned pigs in an antibiotic-free diet by improving AA metabolism and intestinal antioxidant capacity. | Yanan Wang Zhipeng Yang Yuanfei Zhou Jiajian Tan Haiqing Sun Defa Sun Yuyun Mu Jian Peng Hongkui Wei | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 2 |
| 5 | Transcriptional response of porcine skeletal muscle to feeding a linseed-enriched diet to growing pigs显示文摘Background: To investigate the effect of feeding a linseed-enriched diet to growing-finishing pigs on gene expression in skeletal muscle, pigs were fed with a linseed-enriched diet for 0, 30, 60 and 90 d. Transcriptional profiles of longissimus dorsi muscle were measured using Affymetrix Genechip.Results: Results showed that 264 genes were identified as differentially expressed genes(DEGs). The strongest transcriptional response was clearly observed at 30 d. DEGs were assigned to several main functional terms,including transcription, apoptosis, intracellular receptor-mediated signaling, muscle organ development, fatty acid metabolic process, cell motion, regulation of glucose metabolic process, spermatogenesis and regulation of myeloid cell differentiation. We also found that transcriptional changs of several transcription cofactors might contribute to n-3 PUFAs regulated gene expression. In addition, the increased expression of IGF-1, insulin signaling pathway and the metabolism of amino acids might involve in the muscle growth induced by feeding a linseedenriched diet. The results also provide the new evidence that the expression changes of PTPN1, HK2 and PGC-1αmight contribute to the regulation of insulin sensitivity by n-3 PUFAs.Conclusions: Our finding provided correlative evidence that feeding the linseed enriched diet affact expression of genes involved in insulin signaling pathway and the metabolism of amino acids. | Hongkui Wei Yuanfei Zhou Shuzhong Jiang Feiruo Huang Jian Peng Siwen Jiang | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 2 |
| 6 | 妊娠109d母猪背膘过厚导致脂毒性胎盘环境且使繁殖性能下降显示文摘研究探讨了妊娠109日龄母猪背膘厚对母猪和仔猪生产性能的影响。从种猪场收集了846头3~5胎次的经产大白母猪的相关数据。根据妊娠109 d时母猪的背膘厚(≤16,17~18,19~20,21~22,23~24和≥25 mm)分为6组。对母猪繁殖性能的评价包括窝产仔数、初生窝重和21日龄断奶窝重、分娩胎盘重、胎盘效率和母猪泌乳日采食量。测量与血脂和胎盘脂质浓度相关的参数,对数据进行分析,以确定背膘厚、胎盘脂质和仔猪性能之间的关系。各组间的出生仔猪数、产活仔猪数、寄养仔猪数和断奶仔猪数差异不显著(P> 0.05)。初生窝重和断奶窝重、仔猪初生重、断奶重、胎盘效率以及出生体重<800 g的仔猪数量和比例与背膘厚呈显著的二次效应(P> 0.05)。在泌乳期,母猪的日采食量在妊娠109 d时随背膘厚度的增加而线性降低(P> 0.05)。虽然甘油三酯和低密度脂蛋白胆固醇(LDL-C)无显著差异,但随着母猪背膘厚的增加,母猪和脐带血中胆固醇、高密度脂蛋白胆固醇(HDL-C)和游离脂肪酸(FFA)浓度均显著升高(P <0.05)。随着母猪背膘厚的增加,胎盘脂质浓度也显著增加(P <0.05)。此外,背膘厚和胎盘脂质浓度与体重<800 g的仔猪数呈正相关(P <0.01),而与初生重、窝产仔重和断奶仔猪重呈负相关(P <0.01)。综上所述,妊娠末期母猪背膘厚与仔猪出生和断奶体重相关。胎盘异位脂质堆积引起的脂毒性可能是造成这种相关性的原因。 | 孙义姗 Yuanfei Zhou Tao Xu Anle Cai Yinghui Wu Hongkui Wei Siwen Jiang Jian Peng | 2019 | 猪业科学2019，36，11： | 1 |
| 7 | Global vulnerability to agricultural drought and its spatial characteristics显示文摘As an important part of agricultural drought risk, agricultural drought vulnerability helps effectively prevent and alleviate drought impacts by quantifying the vulnerability as well as identifying its spatial distribution characteristics. In this study, global agricultural cultivation regions were chosen as the study area; six main crops(wheat, maize, rice, barley, soybean,sorghum) were selected as the hazard-affected body of agricultural drought. Then, global vulnerability to agricultural drought was assessed at a 0.5° resolution and finally, its distribution characteristics were revealed. The results indicated that the area percentages of different grades of global vulnerability to agricultural drought from low to very high were 38.96%, 28.41%,25.37%, and 7.26%, respectively. This means that the total area percentage of high and very high vulnerability zones exceeded30% of the study area. Although high and very high vulnerability zones were mainly distributed in arid and semi-arid regions,approximately 40% of those above were distributed in humid and semi-humid regions. In addition, only about 15% of the population in this study was located in the high vulnerability regions. Among the vulnerability factors, water deficit during the growing season and the irrigation area ratio are the key factors affecting regional vulnerability. Therefore, the vulnerability could be reduced by adjusting crop planting dates and structures as well as by improving irrigation level and capacity. | WU JianJun GENG GuangPo ZHOU HongKui LIU JingHui WANG QianFeng YANG JianHua | 2017 | Science China Earth Sciences2017，60，5： | 1 |
| 8 | A Numerical Study on Hydraulic Fracturing Problems via the Proper Generalized Decomposition Method显示文摘The hydraulic fracturing is a nonlinear,fluid-solid coupling and transient problem,in most cases it is always time-consuming to simulate this process numerically.In recent years,although many numerical methods were proposed to settle this problem,most of them still require a large amount of computer resources.Thus it is a high demand to develop more efficient numerical approaches to achieve the real-time monitoring of the fracture geometry during the hydraulic fracturing treatment.In this study,a reduced order modeling technique namely Proper Generalized Decomposition(PGD),is applied to accelerate the simulations of the transient,non-linear coupled system of hydraulic fracturing problem,to match this extremely tight response time constraint.The separability of the solution in space and time dimensions is studied for a simplified model problem.The solid and fluid equations are coupled explicitly by inverting the solid discrete problem,and a simple iterative procedure to handle the non-linear characteristic of the hydraulic fracturing problem is proposed in this work.Numeral validation illustrates that the results of PGD match well with these of standard finite element method in terms o f fracture opening and fluid pressure in the hydro-fracture.Moreover,after the off-line calculations,the numerical results can be obtained in real time. | Daobing Wang Sergio Zlotnik Pedro Díez Hongkui Ge Fujian Zhou Bo Yu | 2020 | Computer Modeling in Engineering & Sciences2020，，2： | 1 |
| 9 | The effect of military training on anxiety symptoms in Chinese recruits显示文摘Objective To investigate the prevalence of anxiety symptoms in army recruits and the effect of military training on anxiety.Methods A cluster sampling of 1431 new army recruits was conducted.The anxiety level of recruits was determined by Beck Anxiety Inventory(BAI) and Adult EPQ questionnaires prior to,one month after,and two months after entering basic military training.Self compiled biographic variables of the recruits were collected before the training.Results The highest BAI score(32.71±7.87) was observed 2 days before training,followed by 1 month after training(31.49±7.75) and 2 months after training(29.87±6.95).BAI score before training correlated with neuroticism and extraversion of recruits,the psychological trauma,suicide feeling and frequency of exercise before recruiting.A significant decrease in the percentage of severe symptom of wobbliness in legs,instability to relax,racing heart,dizziness,fear of the worst happening and trembling hands was observed after 1 month and/or 2 months of military training.Conclusion A higher BAI score and percentage of severe anxiety symptoms were observed before the training which correlated with psychological characteristics of recruits as well as the psychological experience before entering training.A combination of early psychological interference and physical exercise could reduce the anxiety. | Li Hongzheng Lei Meiying Zhao Donghai Zhao Liqiong Ye Changqing Zhou Hongkui Liu Gen Qin Mei Li Jiefeng Wen Jian Huang Pinde | 2012 | 重庆医学2012，41，36： | 0 |
| 10 | Optimizing feeding regimen of replacement gilts to improve their reproductive performance and retention rate of their first 2 parities显示文摘The effects of age,body weight(BW),and backfat thickness(BF)of replacement gilts at first estrus and first mating on their subsequent reproductive performance and retention of their first 2 parities as sows was evaluated.A total of 3,025 Danish replacement gilts were categorized by farm(allocated to 4 farms),cross combination,age,BW and BF at first estrus and first mating,estrous cycle number at first mating,and flush feeding before first mating.The result shows that all the factors mentioned above were significantly associated with reproductive performance and retention rates of the first 2 parities.Farm 3 had more piglets born alive per litter(BA)(P<0.05).Farms 3 and 4 had more healthy piglets per litter(HP)(P<0.05).Farm 4 had the most piglets weaned per litter(PW)(P<0.05).Landrace×Landrace×Yorkshire(L×L×Y)replacement gilts had the most total piglets born per litter(TB),BA,HP,PW and a higher retention rate of the 2 parities than Landrace×Yorkshire(L×Y)replacement gilts(P<0.05).In addition,flush feeding before first mating had the most TB,BA,HP,PW,and a higher retention rate of the 2 parities than no flush feeding(P<0.05).Because the effects of replacement gilts rearing parameters on reproductive performance traits differed,we used 100 replacement gilts as a unit and the total number of weaned piglets from the first 2 parities as a new index.Replacement gilts undergoing their first estrus between 180 and 210 d of age at 115 to 124.9 kg BW and 14 to 15 mm BF had significantly higher reproductive indexes for their first 2 parities per 100 replacement gilts.Replacement gilts that mated between 210 and 230 d of age at 140 to 149.9 kg BW and 15 to 16 mm BF had optimal reproductive indexes.These results provide a new insight into the complex relationships among these reproductive performance traits and may help guide successful management of replacement gilts as a pivotal starting point for future fertility and longevity of rearing herds. | Jiajian Tan Miaomiao Wang Haiqing Sun Chao Wang Hongkui Wei Siwen Jiang Yuanfei Zhou Jian Peng | 2023 | Animal Nutrition2023，，1： | 0 |
| 11 | Using Recurrent Neural Network Structure and Multi-Head Attention with Convolution for Fraudulent Phone Text Recognition显示文摘Fraud cases have been a risk in society and people’s property security has been greatly threatened.In recent studies,many promising algorithms have been developed for social media offensive text recognition as well as sentiment analysis.These algorithms are also suitable for fraudulent phone text recognition.Compared to these tasks,the semantics of fraudulent words are more complex and more difficult to distinguish.Recurrent Neural Networks(RNN),the variants ofRNN,ConvolutionalNeuralNetworks(CNN),and hybrid neural networks to extract text features are used by most text classification research.However,a single network or a simple network combination cannot obtain rich characteristic knowledge of fraudulent phone texts relatively.Therefore,a new model is proposed in this paper.In the fraudulent phone text,the knowledge that can be learned by the model includes the sequence structure of sentences,the correlation between words,the correlation of contextual semantics,the feature of keywords in sentences,etc.The new model combines a bidirectional Long-Short Term Memory Neural Network(BiLSTM)or a bidirectional Gate Recurrent United(BiGRU)and a Multi-Head attention mechanism module with convolution.A normalization layer is added after the output of the final hidden layer.BiLSTM or BiGRU is used to build the encoding and decoding layer.Multi-head attention mechanism module with convolution(MHAC)enhances the ability of the model to learn global interaction information and multi-granularity local interaction information in fraudulent sentences.A fraudulent phone text dataset is produced by us in this paper.The THUCNews data sets and fraudulent phone text data sets are used in experiments.Experiment results show that compared with the baseline model,the proposed model(LMHACL)has the best experiment results in terms of Accuracy,Precision,Recall,and F1 score on the two data sets.And the performance indexes on fraudulent phone text data sets are all above 0.94. | Junjie Zhou Hongkui Xu Zifeng Zhang Jiangkun Lu Wentao Guo Zhenye Li | 2023 | Computer Systems Science & Engineering2023，46，8： | 0 |
| 12 | Experimental Study of the Main Influencing Factors in Mechanical Properties of Conglomerate显示文摘In recent years,with the success of exploration and development of conglomerate reservoirs in Mahu Depression,Junggar Basin,China,it is urgent to study the mechanical properties and its influencing factors of conglomerate which is considered as a new oil and gas reservoir.Based on the investigations of petrologic characteristics,heterogeneity and mechanical properties of conglomerate in Baikouquan formation,the content and geometric characteristics of gravel in conglomerate,the main factors in heterogeneity and the mechanical behavior in the triaxial compression experiment of conglomerate are analyzed in this paper.The results show that the size and content of gravel in conglomerate varies greatly,and conglomerate has strong heterogeneity under the influence of gravel content and size.An analysis of mechanical properties of conglomerate shows that conglomerate is characterized by plasticity.Besides,the sphericity is negatively correlated to the gravel content,while the heterogeneity increases with the increase of conglomerate plasticity.Due to the existence of heterogeneous gravel,local stress may concentrate in conglomerate when the stress is loaded.Consequently,a large number of micro-cracks appear at the edge of gravel,demonstrating the strong plasticity of conglomerate.This paper is of referential significance to the study of rock mechanical properties and the evaluation of engineering properties in conglomerate development. | ZHOU Bo GE Hongkui ZHOU Wei WANG Jianbo HAO Hongyong WANG Xiaoqiong LIU Pengyu | 2020 | Earthquake Research in China2020，34，3： | 0 |
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