|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transplantation of Human Bone Marrow Mesenchymal Stem Cell Ameliorates the Autoimmune Pathogenesis in MRL/lpr Mice显示文摘Recent evidence indicates that mesenchymal stem cells (MSC) possess immunosuppressive properties both in vitro and in vivo. We previously demonstrated the functional abnormality of bone marrow derived MSC in patients with systemic lupus erythematosus (SLE). In this study, we aimed to investigate whether transplantation of human bone marrow derived MSC affects the autoimmune pathogenesis in MRL/lpr mice. We found that human MSC from healthy donors reduced the proliferation of T lymphocytes from MRL/lpr mice in a dose-dependent fashion. Two weeks after in vivo transfer of MSC, we detected significantly reduced serum levels of anti ds-DNA antibodies and 24 hour proteinuria in MRL/lpr mice as compared with control groups without MSC transplantation. Moreover, flow cytometric analysis revealed markedly reduced number of CD4+ T cells while increased Th1 subpopulation in MSC group and MSC + CTX group when compared with controls. Histopathological examination showed significantly reduced renal pathology in MSC-treated mice. Immunohistochemical studies further revealed reduced expression of TGF-β, FN, VEGF and the deposition of complement C3 in renal tissue after MSC and MSC + CTX treatment. Taken together, we have demonstrated that transplantation of human MSC can significantly inhibit the autoimmune progression in MRL/lpr mice. | Kangxing Zhou Huayong Zhang Ouyang Jin Xuebing Feng Genhong Yao Yayi Hou Lingyun Sun | 2008 | Cellular & Molecular Immunology2008，5，6： | 59 |
| 2 | A Pilot Study of the Therapeutic Efficacy and Mechanism of Artesunate in the MRL/lpr Murine Model of Systemic Lupus Erythematosus显示文摘Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease.In this study,we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model.MRL/lpr mice were divided into control,cyclophosphamide(CTX)and artesunate treatment groups.Blood was collected to measure serum levels of creatinine,antinuclear antibody(ANA)and anti-double-stranded DNA(anti-dsDNA)antibody.Twenty-four-hour urine was collected to measure levels of proteinuria.The concentration of monocyte chemotactic protein-1(MCP-1)in serum and urine was measured.The expression of MCP-1 in kidney was detected by Western blot and immunohistochemistry assay,respectively.The expression of B cell activating factor(BAFF)in spleen was determined by real time-PCR and immunoblotting.We found that artesunate significantly increased the survival rate,body weight and blood leukocyte counts,and reduced the serum levels of ANA and anti-dsDNA antibody titer,24 h urinary protein,and serum creatinine.Our results indicated that artesunate could decrease MCP-1,major pro-inflammation cytokine,in serum,urine and kidney.We also found that the level of BAFF,the major B cell activation factor,was decreased in artesunate treated MRL/lpr mice.Its efficacy was comparable with that of CTX in this study.Taken together,we have demonstrated that artesunate can inhibit the progression of disease and reverse the pathologic lesion of lupus nephritis. | Ouyang Jin Huayong Zhang Zhifeng Gu Shengnan Zhao Ting Xu Kangxing Zhou Bo Jiang Jie Wang Xiaofeng Zeng Lingyun Sun | 2009 | Cellular & Molecular Immunology2009，6，6： | 20 |
| 3 | MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus显示文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus. | Linyu Geng Xiaojun Tang Kangxing Zhou Dandan Wang Shiying Wang Genhong Yao Weiwei Chen Xiang Gao Wanjun Chen Songtao Shi Nan Shen Xuebing Feng Lingyun Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 16 |
| 4 | A Study of Weak Laser-DNA Molecule Interaction and Its Chaotic Behaviour显示文摘The motion equations with the effect of laser-deoxyribonucleic acid(DNA)molecule interaction are advanced.The chaotic behaviour about these equations were studied by Afelnikov’s method.It is found that DNA molecule system can turn into chaotic state under the weak laser action.This result is helpful for the explanation of laser-induced biological genetic variation effect. | ZHOU Lingyun | 1993 | Chinese Physics Letters1993，10，7： | 13 |
| 5 | CD4^(+)CD25^(+)but not CD4^(+)Foxp3^(+) T cells as a regulatory subset in primary biliary cirrhosis显示文摘Increasing evidence indicates a role for regulatory T cells(Tregs)in the immune response and in autoimmune diseases,but the role of Tregs and cytokines in autoimmune hepatic diseases remains largely unclear and controversial,especially in patients with primary biliary cirrhosis(PBC).This study was undertaken to investigate Tregs and different cytokines in the liver and peripheral blood of PBC patients.We found that these patients demonstrated a reduction of CD4^(+)CD25^(+) T cells but elevated CD4^(+)Foxp3^(+) T cells in peripheral blood mononuclear cells(PBMCs)and CD41 T cells.The percentage of CD4^(+)CD25^(+) T cells in PBMCs was negatively correlated with elevated plasma interferon(IFN)-c levels.A liver-specific analysis showed that the frequency of Foxp31 Tregs,transforming growth factor(TGF)-b1 and IFN-c were increased in PBC patients.Our findings suggest that an imbalance between CD4^(+)CD25^(+) Tregs and cytotoxic cytokines plays a crucial role in the pathogenesis of PBC while the role of Foxp3 needs further investigation. | Dandan Wang Huayong Zhang Jun Liang Zhifeng Gu Qiang Zhou Xiangshan Fan Yayi Hou Lingyun Sun | 2010 | Cellular & Molecular Immunology2010，7，6： | 9 |
| 6 | Bph30confers resistance to brown planthopperby fortifying sclerenchyma in rice leaf sheaths显示文摘Phloem-feeding insects cause massive losses in agriculture and horticulture.Host plant resistance to phloem-feeding insects is often mediated by changes in phloem composition,which deter insect settling and feeding and decrease viability.Here,we report that rice plant resistance to the phloem-feeding brown planthopper(BPH)is associated with fortification of the sclerenchyma tissue,which is located just beneath the epidermis and a cell layer or two away from the vascular bundle in the rice leaf sheath.We found that BPHs prefer to feed on the smooth and soft region on the surface of rice leaf sheaths called the long-cell block.We identified Bph30 as a rice BPH resistance gene that prevents BPH stylets from reaching the phloem due to the fortified sclerenchyma.Bph30 is strongly expressed in sclerenchyma cells and enhances cellulose and hemicellulose synthesis,making the cell walls stiffer and sclerenchyma thicker.The structurally fortified sclerenchyma is a formidable barrier preventing BPH stylets from penetrating the leaf sheath tissues and arriving at the phloem to feed.Bph30 belongs to a novel gene family,encoding a protein with two leucine-rich domains.Another member of the family,Bph40,also conferred resistance to BPH.Collectively,the fortified sclerenchyma-mediated resistance mechanism revealed in this study expands our understanding of plant-insect interactions and opens a new path for controlling planthoppers in rice. | Shaojie Shi Huiying Wang Lingyun Nie Di Tan Cong Zhou Qian Zhang YiLi Bo Du Jianping Guo Jin Huang DiWu Xiaohong Zheng Wei Guan Junhan Shan Lili Zhu Rongzhi Chen Longjian Xue Linda L.Walling Guangcun He | 2021 | Molecular Plant2021，14，10： | 7 |
| 7 | A new type of damper with friction-variable characteristics显示文摘Professor T.T.Soong is one of the early pioneers in fi eld of earthquake response control of structures.A new type of smart damper,which is based on an Energy Dissipating Restraint(EDR),is presented in this paper.The EDR by Nims and Kelly,which has a triangle hysteretic loop,behaves like an active variable stiffness system(AVS) and possesses the basic characteristics of a linear viscous damper but has diffi culty in capturing the output and large stroke simultaneously needed for practical applicataions in engineering structures.In order to overcome this limitation,the friction surface in the original Sumitomo EDR is divided into two parts with low and high friction coeffi cients in this paper.The results of f inite element analysis studies show that the new type of smart friction damper enables large friction force in proportion to relative displacement between two ends of the damper and has a large allowable displacement to fi t the demands of engineering applications.However,unlike the EDR by Nims and Kelly,this type of friction variable damper cannot self re-center.However,the lateral stiffness can be used to restore the structure.The nonlinear time history analysis of earthquake response for a structure equipped with the proposed friction variable dampers was carried out using the IDARC computer program.The results indicate that the proposed damper can successfully reduce the earthquake response of a structure. | Zhou Xiyuan Peng Lingyun | 2009 | Earthquake Engineering and Engineering Vibration2009，8，4： | 7 |
| 8 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 9 | Proteomic analysis of long-term salinity stress-responsive proteins in Thellungiella halophila leaves显示文摘Salinity is one of the most severe environmental factors that may impair crop productivity. A proteomic study based on two-dimensional gel electrophoresis is performed in order to analyze the long-term salinity stress response of Thellungiella halophila, an Arabidopsis-related halophyte. Four-week-old seedlings are exposed to long-term salinity treatment. The total crude proteins are extracted from leaf blades, separated by 2-DE, stained with Coomassie Brilliant Blue, and differentially displayed spots are identified by MALDI-TOF MS or QTOF MS/MS. Among 900 protein spots reproducibly detected on each gel, 30 spots exhibit significant change and some of them are identified. The identified proteins include not only some previously characterized stress-responsive proteins such as TIR-NBS-LRR class disease resistance protein, ferritin-1, and pathogenesis-related protein 5, but also some proteins related to energy pathway, metabolism, RNA processing and protein degradation, as well as proteins with unknown functions. The possible functions of these proteins in salinity tolerance of T. halophila are discussed and it is suggested that the long-term salinity tolerance of T. halophila is achieved, at least partly, by enhancing defense system, adjusting energy and metabolic pathway and maintaining RNA structure. | GAO Fei ZHOU YiJun HUANG LingYun HE DaChengt ZHANG GenFa | 2008 | Chinese Science Bulletin2008，53，22： | 6 |
| 10 | Neural Mechanisms of Mental Fatigue Revisited: New Insights from the Brain Connectome显示文摘Maintaining sustained attention during a prolonged cognitive task often comes at a cost: high levels of mental fatigue. Heuristically, mental fatigue refers to a feeling of tiredness or exhaustion, and a disengagement from the task at hand;it manifests as impaired cognitive and behavioral performance. In order to effectively reduce the undesirable yet preventable consequences of mental fatigue in many real-world workspaces, a better understanding of the underlying neural mechanisms is needed, and continuous efforts have been devoted to this topic. In comparison with conventional univariate approaches, which are widely utilized in fatigue studies, convergent evidence has shown that multivariate functional connectivity analysis may lead to richer information about mental fatigue. In fact, mental fatigue is increasingly thought to be related to the deviated reorganization of functional connectivity among brain regions in recent studies. In addition, graph theoretical analysis has shed new light on quantitatively assessing the reorganization of the brain functional networks that are modulated by mental fatigue. This review article begins with a brief introduction to neuroimaging studies on mental fatigue and the brain connectome, followed by a thorough overview of connectome studies on mental fatigue. Although only a limited number of studies have been published thus far, it is believed that the brain connectome can be a useful approach not only for the elucidation of underlying neural mechanisms in the nascent field of neuroergonomics, but also for the automatic detection and classification of mental fatigue in order to address the prevention of fatigue-related human error in the near future. | Peng Qi Hua Ru Lingyun Gao Xiaobing Zhang Tianshu Zhou Yu Tian Nitish Thakor Anastasios Bezerianos Jinsong Li Yu Sun | 2019 | Engineering2019，5，2： | 5 |
| 11 | An in situ ATR-FTIR study of mixed collectors BHA/DDA adsorption in ilmenite-titanaugite flotation system显示文摘This paper researched the enhanced flotation separation performance of ilmenite and titanaugite using the mixed collector benzhydroxamic acid/dodecylamine(BHA/DDA).The interface assembly mechanism was mainly investigated through in situ attenuated total reflectance Fourier transform infrared(ATRFTIR)spectroscopy combined with the two-dimensional correlation spectroscopy(2D-COS)and X-ray photoelectron spectroscopy(XPS).It has been found that BHA/DDA mixed collectors successfully separate ilmenite from titanaugite at a molar ratio of 8:1.Zeta potential experiments suggested that,in the presence of mixed collector system,the BHA-DDA complex adsorbed on the ilmenite surface via the chemically adsorbed BHA and the electrostatically adsorbed DDA,however,the complex adsorbed on the surface of titanaugite unstably.According to in situ ATR-FTIR combined with 2D-COS and XPS results,the interface assembly mechanism of BHA/DDA is summarized as:the function group of BHA molecules first binds to the metal sites on minerals to form bidentate ligand,then DDA co-adsorbed with BHA on the surface of minerals through hydrogen bonding.DDA may change the adsorption modes of some BHA on the ilmenite surface from four-membered ring to five-membered ring,while the modes on the titanaugite surface is true opposite.Finally,recommended adsorption configurations of the BHA/DDA complex on the two mineral surfaces are proposed. | Liping Luo Houqin Wu Longhua Xu Jinping Meng Jiahui Lu Huan Zhou Xiaomei Huo Lingyun Huang | 2021 | International Journal of Mining Science and Technology2021，31，4： | 4 |
| 12 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 13 | Patterns and dietary intake of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in food products in China显示文摘The health risk of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs) and dioxin-like PCBs(d1-PCBs) to human being should be assessed regularly.To evaluate the contamination levels in various food products in the Chinese market and to assess the dietary exposure of the Chinese population,11 varieties of food groups totaling 534 samples including beef and mutton,chicken and duck,pork,fish and seafood,milk and dairy products were evaluated.The average concentrations of PCDD/Fs in all groups ranged from0.291 to 8.458 pg/g whole weight(w.w.).The average toxic equivalency concentrations were from 0.012 pg TEQ/g w.w.for cereal to 0.357 pg TEQ/g fat for marine oil.OCDD and2,3,7,8-TCDF were the dominant congeners in foodstuffs.The dietary estimated mean intake for the Chinese rural and urban populations were 0.555 and 0.514 pg TEQ/kg body weight/day,respectively,however,the cereal group exposure were higher to the estimate daily intake and contributed 81%for rural and 48%for urban population,followed by fish and seafood which contributed 4%and 15%to the estimate daily intake.The estimated dietary intakes were compared with the toxicological reference values and showed that both rural and urban populations were well below those values. | Lingyun Wang Gangdou Ding Zhiguang Zhou Xun Liu Yixiao Wang Heidi Qunhui Xie Tuan Xu Pu Wang Bin Zhao | 2017 | Journal of Environmental Sciences2017，29，1： | 3 |
| 14 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 15 | Intestinal uptake of barley protein-based nanoparticles for β-carotene delivery显示文摘Our previous study introduced a barley protein microparticle for encapsulation of hydrophobic drug/nutraceutical, which could release nanoparticles upon gastric digestion and deliver encapsulated compound to a simulated intestinal environment intact. This work focused on evaluating the potential of liberated nanoparticles to improve the absorption of encapsulated compounds(e.g., β-carotene) using in vitro Caco-2 cell and ex vivo small intestine models. Nanoparticles obtained from gastric digestion of barley protein microparticles had a spherical shape and an average size of 351 nm. Nanoparticles showed low cytotoxicity in Caco-2 cells and their cellular uptake was dependent on time, concentration and temperature. In a Caco-2 cell monolayer model, significantly greater uptake and transport of β-carotene were observed when it was delivered by nanoparticles(15%), compared to free β-carotene suspension(2.6%). In an ex vivo rat jejunum model, nanoparticles showed the capacity to retain in small intestinal tissue. Approximately 2.24 and 6.04 μg nanoparticle were able to permeate through each cm2 intestinal tissue and translocate to the serosal side after 60 and 90 min, respectively. Results from this study demonstrated the absorption improving effect of the barley protein nanoparticles and suggested their potential as vehicles for hydrophobic compounds. | Guangyu Liu Ying Zhou Lingyun Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 3 |
| 16 | Level and characteristics of polychlorinated dibenzo-p-dioxins and dibenzofurans in feed and feed additives显示文摘Feed security is a prerequisite for safe animal food products.In this study,13 groups of feed and feed ingredients,totaling 2067 samples,were collected in the period of 2011 to 2014 from China.The highest mean level of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs) was found in fish meals and shell powders,with a concentration of 60.35 ng/kg,followed by mineral origin materials.In terms of the toxicity equivalent concentration,the fish oil group showed the highest PCDD/F levels because of their bio-accumulation through the aquatic food chain,with an average concentration of 1.26 ng WHO-TEQ/kg,while the lowest level was observed in compound feed for chickens and pigs,with an average value of0.16 ng WHO-TEQ/kg.OCDD and OCDF were the predominant congeners in all groups except fish oils,in which the primary congeners were 2,3,4,7,8-PeCDF and 2,3,7,8-TCDF.For zinc chloride samples,different from other zinc-based compound samples,the main congeners were 1,2,3,4,6,7,8-HpCDF(17%),1,2,3,4,7,8,9-HpCDF(15%),1,2,3,4,7,8-HxCDF(12%) and OCDF(30%).Considering toxicity equivalency factors,the dominant congeners were 2,3,4,7,8-PeCDF,1,2,3,4,7,8-HxCDF,2,3,7,8-TCDF and 1,2,3,7,8-PeCDD,and the contribution to the total TEQwas29%,16%,14%and 12%,respectively.Overall,2.1%(43 out of 2067) of all the analyzed samples exceeded the different individual 'European Union maximum limited levels for PCDD/Fs.This study is beneficial for the determination of the status of contamination levels of feed and feed ingredients. | Lingyun Wang Gangdou Ding Zhiguang Zhou Xun Liu Yixiao Wang HeidQunhui Xie Tuan Xu Pu Wang Bin Zhao | 2017 | Journal of Environmental Sciences2017，29，1： | 2 |
| 17 | Forming of magnesium alloy microtubes in the fabrication of biodegradable stents显示文摘Magnesium alloys have, in recent years, been recognized as highly promising biodegradable materials, especially for vascular stent applications. Forming of magnesium alloys into high-precision thin-wall tubes has however presented a technological barrier in the fabrication of vascular stents, because of the poor workability of magnesium at room temperature. In the present study, the forming processes, i.e., hot indirect extrusion and multi-pass cold drawing were used to fabricate seamless microtubes of a magnesium alloy. The magnesium alloy ZM21 was selected as a representative biomaterial for biodegradable stent applications. Microtubes with an outside diameter of 2.9 mm and a wall thickness of 0.2 mm were successfully produced at the fourth pass of cold drawing without inter-pass annealing. Dimensional evaluation showed that multipass cold drawing was effective in correcting dimensional non-uniformity arising from hot indirect extrusion. Examinations of the microstructures of microtubes revealed the generation of a large number of twins as a result of accumulated work hardening at the third and fourth passes of cold drawing, corresponding to the significantly raised forming forces. The work demonstrated the viability of the forming process route selected for the fabrication of biodegradable magnesium alloy microtubes. | Lixiao Wang Gang Fang Lingyun Qian Sander Leeflang Jurek Duszczyk Jie Zhou | 2014 | Progress in Natural Science:Materials International2014，24，5： | 2 |
| 18 | Pullulan Acetate Coated Magnetite Nanoparticles for Hyper-Thermia:Preparation,Characterization and In Vitro Experiments显示文摘Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMNs) had spherical morphology. Dynamic light scattering (DLS) showed that the size distribution of PAMNs was unimodal,with an average diameter of 25.8 nm ± 6.1 nm. The presence of the adsorbed layer of PA on the magnetite surface was confirmed by Fourier transform infrared (FTIR) spectroscopy. Magnetic measurements revealed that the saturation magnetization of the PAMNs reached 51.9 emu/g and the nanoparticles were superparamagnetic. Thermogravimetric analysis (TGA) showed that the Fe_(3)O_(4) particles constituted 75 wt% of the PAMNs. The PAMNs had good heating properties in an alternating magnetic field. Cytotoxicity assay showed that PAMNs exhibited no significant cytotoxicity against L929 cells. TEM results showed that a large number of PAMNs were internalized into KB cells. PAMNs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia. These novel magnetic nanoparticles have great potential as magnetic hyperthermia mediators. | Fuping Gao Yuanyuan Cai Jing Zhou Xiaoxue Xie Weiwei Ouyang Yuhui Zhang Xufei Wang Xiaodong Zhang Xiaowen Wang Lingyun Zhao Jintian Tang | 2010 | Nano Research2010，3，1： | 2 |
| 19 | Balancing selection and wild gene pool contribute to resistance in global rice germplasm against planthopper显示文摘Interactions and co-evolution between plants and herbivorous insects are critically important in agriculture.Brown planthopper(BPH)is the most severe insect of rice,and the biotypes adapt to feed on different rice genotypes.Here,we present genomics analyses on 1,520 global rice germplasms for resistance to three BPH biotypes.Genome-wide association studies identified 3,502 single nucleotide polymorphisms(SNPs)and 59 loci associated with BPH resistance in rice.We cloned a previously unidentified gene Bph37 that confers resistance to BPH.The associated loci showed high nucleotide diversity.Genome-wide scans for trans-species polymorphisms revealed ancient balancing selection at the loci.The secondarily evolved insect biotypes II and III exhibited significantly higher virulence and overcame more rice varieties than the primary biotype I.In response,more SNPs and loci evolved in rice for resistance to biotypes II and III.Notably,three exceptional large regions with high SNP density and resistance-associated loci on chromosomes 4 and 6 appear distinct between the resistant and susceptible rice varieties.Surprisingly,these regions in resistant rice might have been retained from wild species Oryza nivara.Our findings expand the understanding of long-term interactions between rice and BPH and provide resistance genes and germplasm resources for breeding durable BPH-resistant rice varieties. | Cong Zhou Qian Zhang Yu Chen Jin Huang Qin Guo Yi Li Wensheng Wang Yongfu Qiu Wei Guan Jing Zhang Jianping Guo Shaojie Shi Di Wu Xiaohong Zheng Lingyun Nie Jiaoyan Tan Chaomei Huang Yinhua Ma Fang Yang Xiqin Fu Bo Du Lili Zhu Rongzhi Chen Zhikang Li Longping Yuan Guangcun He | 2021 | Journal of Integrative Plant Biology2021，63，10： | 2 |
| 20 | Comparative proteomic analysis of a Haemophilus parasuis SC096 mutant deficient in the outer membrane protein P5显示文摘 | Bin Zhang Chenggang Xu Suming Zhou Saixiang Feng Lingyun Zhang Yanbin He Ming Liao | 2011 | Microbial Pathogenesis2011，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员