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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil显示文摘瞄准:有 docetaxel, flavopiridol,或 5 氟尿嘧啶(5-FU ) 的稳固的肿瘤的临床的治疗经常遇到不受欢迎的副作用和药抵抗。在 modulating chemosensitivity 并且更好与 docetaxel, flavopiridol,或 5-FU 评估联合治疗的潜在的角色的目的理解他们怎么可能临床上被使用的这研究。方法:HCT116 结肠癌房间在几不同行政时间表在试管内与 docetaxel, flavopiridol,和 5-FU 被对待,顺序或同时。房间幸存被 MTT 试金测量。caspase-3 的活动被 caspase-3 试金决定,软琼脂殖民地试金被用来在软琼脂测试 HCT116 房间的菌落形成。我们也建立了异种皮移植模型扩大在试管内观察到一个在活体内系统。结果:当人的结肠癌 HCT116 房间为 flavopiridol 为另一 24 h 为 24 h 和 5-FU 跟随的 1 h 与 docetaxel 被对待时,最大的细胞毒性被发现。这顺序的联合治疗不仅与另外的联合治疗相比更强烈禁止肿瘤细胞生长而且显著地在软琼脂减少菌落形成并且扩充 HCT116 细胞的 apoptosis。docetaxel 定序以后由 flavopiridol 跟随了 1 h,以后在异种皮移植模型由 5-FU 跟随了 24 h,也导致了推迟的肿瘤生长和更高的幸存率。结论:当把 docetaxel 与 flavopiridol 和 5-FU 相结合时,这些结果强调一张行政时间表的重要性,提供对它在临床的试用的发展的基本原理解释。 | Jun GUO An-wu ZHOU Yu-cai FW Udit N VERMA Debu TRIPATHY Eugene P FRENKEL Carlos R BECERRA | 2006 | Acta Pharmacologica Sinica2006，27，10： | 4 |
| 4 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 5 | A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication显示文摘 | Xiang R Mizutani N Luo Y Chiodoni C Zhou H Mizutani M | 2005 | Cancer Res2005，65，： | 1 |
| 6 | Modeling and simulation of drug release from multi-layer biodegradable polymer microstructure in three dimensions 显示文摘 | Yu R X Chen T N Zhou X Y | 2008 | Simulation Modeling Practice and Theory2008，16，1： | 1 |
| 7 | Progress in fretting maps显示文摘 | ZHOU Z R NAKAZAWA K ZHU M H MARUYAMA N KAPSA Ph VINCENT L | 2006 | Tribology International2006，39，10： | 1 |
| 8 | Oxidation behavior and breakdown of an aluminide coating on DZ40M alloy at high temperatures显示文摘 | Liu P S Liang K M Zhou H Y Guan H R Sun X F Jin T Yang K N | 2001 | Oxidation of Metals2001，55，56： | 1 |
| 9 | A molecular dynamics study of nikel vapor deposition:temperature,incident angle,and adatom energy effects显示文摘 | ZHOU X W JOHNSON R A WADLEY H N G | 1997 | Acta mater1997，45，4： | 1 |
| 10 | Corrosion fatigue behaviors of two biomedical Mg alloys-AZ9ID and WE43-in simulated body f1uid显示文摘 | Gu X N Zhou W R Zheng Y F | 2010 | Acta Biomaterialia2010，6，12： | 1 |
| 11 | Corrosion resistance and surface biocompatibility of a microarc oxidation coating on a Mg-Ca alloy显示文摘 | GU X N LI N ZHOU W R | 2011 | Acta Biomaterialia2011，，7： | 1 |
| 12 | Kinetics model for the growth of slicon carbide by the reation of liquid silicon with carbon显示文摘 | Zhou H Singh R N | 1995 | J Am Ceram Soc1995，78，5： | 1 |
| 13 | Nanotube molecular wires as chemical sensors显示文摘 | Kong J Franklin N R Zhou C | 2000 | Science2000，287，5453： | 1 |
| 14 | Electrodeposited Co-Ni-Al2O3 composite coatings 显示文摘 | WU G LI N ZHOU D R | 2004 | Surface and Coatings Technology2004，176，2： | 1 |
| 15 | Corrosion resist- ance and surface biocompatibility of a microarc oxidation coating on a Mg-Ca alloy 显示文摘 | Gu X N Li N Zhou W R | 2011 | Acta Bi- omaterialia2011，7，4： | 1 |
| 16 | Nanotube molecular wires as chemical sensors 显示文摘 | Kong Jing Franklin N R Zhou Chongwu | 2000 | Science2000，287，5453： | 1 |
| 17 | Misfit-Energy- Increasing Dislocations in Vapor-Deposited CoFe/NiFe Multilayers 显示文摘 | Zhou X W Johnson R A Wadley H N G | 2004 | Physical Review B2004，69，14： | 1 |
| 18 | Large area growth and electrical properties of p-type WSe2 atomic layers显示文摘 | Zhou H Wang C Shaw J C Cheng R Chen Y Huang X Liu Y Weiss N O Lin Z Huang Y Duan X | 2015 | Nano Letters2015，15，1： | 1 |
| 19 | The atmospheric input of trace species to the world ocean显示文摘 | Duce R A Liss P S Merrill J T Atlas L L Buat-Menard P Hicks B B Miller J M Prospero J M Arimoto R Church T M Ellis W Galloway F N Hansen L Jickells T D Knap A H Reinhardt K H Schneider B Soudine A Tokos J J Tsunogai S Wollast R Zhou M | 1991 | Global Biogeochemical Cycles1991，5，： | 1 |
| 20 | Preparation and characterization of nanocrystalline composite ( nanocomposite ) films of titanium dioxide and nickel by occlusion electrodeposition显示文摘 | Zhou M Tacconi N R Rajeshwar K | 1997 | J of Electroanalytical Chem1997，421，： | 1 |
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