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| 1 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 2 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 3 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 4 | Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers显示文摘背景 A 新 fluroquinolone 抗菌剂代理人, antofloxacin hydrochloride ,在中国发展了,学习的 levofloxacin.The 目的 8-NH2 derivant 是用汉语评估 antofloxacin hydrochloride 的单个、多重的口头的剂量的 pharmacokinetic 特征健康的男 volunteers.Methods 一开标签,非使随机化,单个、多重的剂量临床的试用是 conducted.In 单身者剂量学习, 12 个题目拿了 200 mg antofloxacin hydrochloride.In 多重剂量学习, 12 | LU Yuan KANG Zi-sheng ZHU Yan ZHANG Ming LIU Yan ZHANG Man LI Tian-yun XIAO Yong-hong | 2011 | Chinese Medical Journal2011，，2： | 6 |
| 5 | A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin Ⅱb显示文摘Dominance hierarchy is a fundamental phenomenon in grouped animals and human beings,however,the underlying regulatory mechanisms remain elusive.Here,we report that an antisense long non-coding RNA(lncRNA)of synapsinⅡ;named as AtLAS,plays a crucial role in the regulation of social hierarchy.AtLAS is decreased in the prefrontal cortical excitatory pyramidal neurons of dominant mice;consistently,silencing or overexpression of AtLAS increases or decreases the social rank,respectively.Mechanistically,we show that AtLAS regulates alternative polyadenylation of synapsinⅡgene and increases synapsin 2b(syn2b)expression.Syn2b reduces AMPA receptor(AMPAR)-mediated excitatory synaptic transmission through a direct binding with AMPAR at the postsynaptic site via its unique C-terminal sequence.Moreover,a peptide disrupting the binding of syn2b with AMPARs enhances the synaptic strength and social ranks.These findings reveal a novel role for lncRNA AtLAS and its target syn2b in the regulation of social behaviors by controlling postsynaptic AMPAR trafficking. | Mei Ma Wan Xiong Fan Hu Man-Fei Deng Xian Huang Jian-Guo Chen Heng-Ye Man Youming Lu Dan Liu Ling-Qiang Zhu | 2020 | Cell Research2020，30，2： | 3 |
| 6 | Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms显示文摘It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. | YUAN DeJian ZHU ZuoBin TAN XiaoHua LIANG Jie ZENG Chen ZHANG JieGen CHEN Jun MA Long DOGAN Ayca BROCKMANN Gudrun GOLDMANN Oliver MEDINA Eva RICE Amanda D. MOYER Richard W. MAN Xian YI Ke LI YanKe LU Qing HUANG YiMin HUANG Shi | 2014 | Science China(Life Sciences)2014，57，9： | 2 |
| 7 | Stromal cells attenuate the cytotoxicity of imatinib on Philadelphia chromosome-positive leukemia cells by up-regulating the VE-cadherin/β-catenin signal显示文摘 | Chong Chen Huan-Xin Zhang Man Wang Xuguang Song Jiang Cao Lin Wang Jian-Lin Qiao Xiao-Yun Lu Zheng-Xiang Han Ping Zhu Bin Pan Qing-Yun Wu Kai Zhao Zhi-Ling Yan Zhen-Yu Li Ling-Yu Zeng Kai-Lin Xu | 2014 | Leukemia Research2014，，： | 1 |
| 8 | 人Piwi基因泛素化修饰缺陷突变通过削弱精子形成过程中组蛋白-鱼精蛋白转换致男性不育显示文摘文章简介遗传学研究表明,Piwi蛋白对于动物生殖系细胞发育至关重要,Piwi基因敲除致动物不育。人Piwi(Hiwi)基因特异性地在雄性生殖细胞表达,但目前对其在人精子发生中的作用及其与男性不育的联系还知之甚少。 | Lan-Tao Gou Jun-Yan Kang Peng Dai Xin Wang Feng Li Shuang Zhao Man Zhang Min-Min Hua Yi Lu Yong Zhu Zheng Li Hong Chen Li-Gang Wu Dangsheng Li Xiang-Dong Fu Jinsong Li 施惠娟 刘默芳 | 2018 | 科学新闻2018，0，4： | 1 |
| 9 | Stimulated Brillouin scattering induced all-optical modulation in graphene microfiber显示文摘Graphene microfibers are burgeoning modulators with great potential in all-optical communication. One of the critical issues that remains to be understood is the dynamic mechanism of light–graphene interaction. Here, we propose a power dependent modulation by using 980 nm pump light and 1064 nm signal light via graphene microfiber, and the results show a strong transmission reduction and frequency blue shift with the increase of pump power. The experimental observation is attributed to a stimulated Brillouin scattering process induced by the pump light. Power and frequency variations are a result of energy transition of the scattered phonon in the fiber. This work reveals the nonlinear effect process in the light–graphene interaction and provides a new method for power and frequency control with graphene all-optical modulation. | JIWEN ZHU XUEMEI CHENG YALI LIU RUIDUO WANG MAN JIANG DIAO LI BAOLE LU ZHAOYU REN | 2019 | Photonics Research2019，7，1： | 1 |
| 10 | Author Correction: A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsp00b90ocp9wk6bvw.ffgz.tsg.suse.edu.cn/10.1038/s41422-020-0273-1 In the initial published version of this Article,there was an error in author information.Youming Lu(lym@hust.edu.cn)is a co-corresponding author.This correction does not affect the description of the results or the conclusions of this work. | Mei Ma Wan Xiong Fan Hu Man-Fei Deng Xian Huang Heng-Ye Man Youming Lu Dan Liu Ling-Qiang Zhu | 2021 | Cell Research2021，31，5： | 0 |
| 11 | Efficacy,safety and pharmacokinetics of Unecritinib(TQ-B3101)for patients with ROS1 positive advanced non-small cell lung cancer:a Phase I/II Trial显示文摘This phase I/II trial characterized the tolerability,safety,and antitumor activities of unecritinib,a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1,ALK,and c-MET,in advanced tumors and ROS1 inhibitor-naive advanced or metastatic non-small cell lung cancer(NSCLC)harboring ROS1 rearrangements.Eligible patients received unecritinib 100,200. | Shun Lu Hongming Pan Lin Wu Yu Yao Jianxing He Yan Wang Xiuwen Wang Yong Fang Zhen Zhou Xicheng Wang Xiuyu Cai Yan Yu Zhiyong Ma Xuhong Min Zhixiong Yang Lejie Cao Huaping Yang Yongqian Shu Wu Zhuang Shundong Cang Jian Fang Kai Li Zhuang Yu Jiuwei Cui Yang Zhang Man Li Xinxuan Wen Jie Zhang Weidong Li Jianhua Shi Xingxiang Xu Diansheng Zhong Tao Wang Jiajia Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
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