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| 1 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 2 | Realization of quantum discrete Fourier transform with NMR显示文摘The pulse sequences of the logic operations used in quantum discrete Fourier transform are designed for the experiment of nuclear magnetic resonance(NMR), and 2-qubit discrete Fourier transforms are implemented experimentally with NMR. The experimental errors are examined and methods for reducing the errors are proposed. | FANG Ximing ZHU Xiwen FENG Mang MAO Xi’an DU Fei | 2000 | Chinese Science Bulletin2000，45，12： | 7 |
| 3 | Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial显示文摘Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage.We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.Methods We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in China.Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom onset.Patients were randomly assigned(1:1)to receive either tranexamic acid or a matching placebo.The primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 hours.Clinical outcomes were assessed at 90 days.Results Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received placebo.The primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and dependency.Conclusions Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage growth.Larger studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients. | Jingyi Liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan Dacheng Liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping Liu Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 4 | Physiological response of natural C.taklimakanensis B.R.Pan et G.M.Shen to unconfined groundwater in the hinterland of the Taklimakan Desert显示文摘Calligonum. taklimakanensis B.R.Pan et G.M.Shen is an indigenous species that grows in the Taklimakan Desert. This study shows the relationship between C.taklimakanensis B.R.Pan et G.M.Shen and water conditions in the hinterland of the desert. The results show that: (1) Depth of water table is an important factor that affects water potential (ψp, ψA), osmotic potential (ψsat, ψtlp), relative water content (RWCtlp, ROWCtlp), and transpiration rate. (2) The degree of mineralization has a significant impact on the water potential of plants. A high degree of mineralization can strongly reduce plant productivity. (3) C. taklimakanensis B.R.Pan et G.M.Shen reduces the temperature of assimilation sticks through a high transpiration rate and maintains relatively high water content to adapt to drought and hot weather conditions in the hinterland of the desert. In addition, C. taklimakanensis B.R.Pan et G.M.Shen adapts to the water status in the desert through self-regulation or even sacrificing productivity. | LIANG ShaoMin YAN HaiLong ZHANG XiMing XIE TingTing ZHU JunTao ZHANG ZhongWu | 2008 | Chinese Science Bulletin2008，53，S2： | 2 |
| 5 | Photosynthesis responses of endemic shrubs of Taklimakan Desert to adverse temperature, humidity and radiation显示文摘Under the native habitat conditions, the seasonal gas exchange characteristics of two natural endemic plant species, Calligonum taklimakanensis B.R. Pan & G.M. Shen and Tamarix taklamakanensis M.T. Liu, which are located in the hinterland of the Taklimakan Desert, are measured and compared by Li-6400 photosynthesis system. The results indicate that temperature (℃), solar radiation (PAR), soil water content (SWC), and other environmental factors have obvious seasonal variations and the gas exchange characteristics of two plants have different changes in different growing seasons. For C. taklimakanensis, both in July and September, its daily changes of net photosynthetic rate tend to be obvious double peak curve, but in July its peak appeared earlier. Besides its maximum net photosynthetic rate (Pmax), apparent quantum efficiency (Φ ), range of effective photosynthetic radiation significantly less than that in September. Moreover, its water use efficiency (WUE) in July was also lower than that in September due to the higher transpiration rate (Tr ). For T. taklamakanensis, although its daily change of net photosynthetic rate is a single peak curve in September, its peak time has not changed, and except that its WUE is higher in September like C. taklimakanensis, the maximum net photosynthetic rate (Pmax), apparent quantum effi- ciency (Φ ), light saturation point, and range of effective photosynthetic radiation has not changed or slightly declined. That is to say C. taklimakanensis select a season that habitat was better (like September) to progress relative effectively photosynthesis accumulation, in contrast, T. taklamakanensis still keep a relatively stable photosynthesis rate in different growth seasons. The difference of gas exchange characteristics of the two plants in different seasons shows that adaptation strategies of the two plants to extreme conditions in desert are different. Besides, both the higher photosynthetic accumulation rate and the higher water use efficiency in September also indicate that these two endemic desert shrubs possess the abilities and strategies to make the best of limited natural resources. | YAN HaiLong LIANG ShaoMin ZHANG XiMing WANG WeiHua MA JianBing ZHU JunTao | 2008 | Chinese Science Bulletin2008，53，S2： | 2 |
| 6 | Diagnostic and modelling investigation on the ion acceleration and plasma throttling effects in a dualemitter hollow cathode micro-thruster显示文摘Hollow cathode discharges are widely used as neutralizers for the electric propulsion systems and recently developed into micro-thrusters for the small satellites.In this work,a dualemitter hollow cathode thruster is developed,which can be operated in two different modes—the neutralizer mode and the micro-thruster mode.For characterizing this kind of new device,the Langmuir probe,Faraday probe,and retarding potential analyzer are used to determine the electron temperature,electron density,ion flux,and ion energy distribution function.The operating parameters,including the thrust,and specific impulse,are also measured.A two-dimensional self-consistent extended fluid model is employed to calculate the spatial distribution of plasma parameters and the fluid field of electrons in the region around the emitters.By comparing the diagnostic and modelling results,it is found that the change in the electric field and ionization zone is the essential reason for the different performances of the device in the neutralizer and micro-thruster modes.Variation in the electric field leads to an ion acceleration effect in the micro-thruster mode;moving of the ionization zone raises the plasma pressure in the orifice region of the hollow cathode,and thus leads to enhanced plasma throttling and gas expanding effects.By analyzing the above mechanisms,the possible methods for improving this kind of hollow cathode micro-thruster are discussed. | Zhongxi NING Chenguang LIU Ximing ZHU Yanfei WANG Bingjian AN Daren YU | 2021 | Chinese Journal of Aeronautics2021，34，12： | 1 |
| 7 | Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Monlb显示文摘 | Ximing Shao Yi Liu Qian Yu Zhihao Ding Wenyu Qian Lei Zhang Jianchao Zhang Nan Jiang Linfei Gui Zhiheng Xu Yang Hong Yifan Ma Yanjie Wei Xiaoqing Liu Changan Jiang Minyan Zhu Hongchang Li Huashun Li | 2016 | Cell Research2016，26，5： | 1 |
| 8 | Experimental Implementa-tion of Dense Coding Using Nuclear Magnetic Reso-nance显示文摘 | Zhu Xiwen | 2000 | Phys Rev A2000，61，2： | 1 |
| 9 | Spatially Resolved Optieal Emission Spectroseopy Investigation of E and H Modes in Cylindrical Inductively Coupled Plasmas 显示文摘 | Yu Chen Guo Zhigang Zhu Ximing | 2007 | Journal of Physics D: Appllied Physics2007，40，7： | 1 |
| 10 | Gas temper ature,eleetron density and electron temperature measurement in a microwave excited microplasma显示文摘 | ZHU Ximing CHEN Wencong PU Yikang | 2008 | Journal of Physics D: Applied Physics2008，41，10： | 1 |
| 11 | Simple physical approach to reducing frictional and adhesive forces on a TiO2 surface via creating heterogeneous nanopores显示文摘 | An Rong Yu Qiuming Zhang Luzheng Zhu Yudan Guo Xiaojing Fu Shuangqin Li Licheng Wang Changsong Wu Ximing Liu Chang | 2012 | Langmuir2012，28，15： | 1 |
| 12 | Electron density and ion energy dependence on driving frequency in capacitively coupled argon plasmas 显示文摘 | Zhu Ximing Chen Wencong Zhang Shu | 2007 | J Phys D: Appl Phys2007，40，22： | 1 |
| 13 | Characteristics of atmospheric pressure plasma jets emerging into ambient air and helium显示文摘 | Zhu Wenchao Li Qing Zhu Ximing | 2009 | J Phys D:Appl Phys2009，42，20： | 1 |
| 14 | Electron density and ion energy dependence on driving frequency in capacitively coupled argon plasmas 显示文摘 | Zhu Ximing Chen Wencong Zhang Shu | 2007 | J Phys D : Appl Phys2007，40，： | 1 |
| 15 | Spatially resolved optical emission spectroseopy investigation of E and H Modes in cylindrical inductively coupled plasmas显示文摘 | Yu Chen Guo Zhigang Zhu Ximing | | 0，，： | 1 |
| 16 | Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation显示文摘Background:Nonalcoholic fatty liver disease(NAFLD)is a chronic condition characterized by a progressive decline in liver function,leading to disruptions in liver integrity and metabolic function,resulting in lipid deposition and excessive accumulation of extracellular matrix(ECM).The pathogenesis of NAFLD is complex and not yet fully understood,contributing to the absence of specific therapeutic strategies.Peroxisome proliferator-activated receptor gamma(PPARγ)is a ligand-activated transcription factor pivotal in regulating lipid and glucose metabolism.However,the impacts of PPARγon NAFLD remains insufficiently explored.Thus,this study aimed to investigate the role of PPARγin NAFLD and its underlying molecular mechanisms.Methods:Chemical detection kits were utilized to quantify collagen content,alanine aminotransferase(ALT),and aspartate aminotransferase(AST)level variations.Quantitative real-time polymerase chain reaction(qRT-PCR)was employed to assess alterations in extracellular matrix-related genes and inflammatory response genes in liver tissue and HepG2 cells,while western blotting was conducted to analyze the levels of both PPARγand the TGF-β/Smad signaling pathway.Results:Our findings unveiled significantly reduced PPARγexpression in a rat model of NAFLD,leading to subsequent activation of the TGF-β/Smad signaling pathway.Furthermore,PPARγactivation effectively mitigated NAFLD progression by inhibiting inflammation and fibrosis-related gene expression and collagen production.On a cellular level,PPARγactivation was found to inhibit the expression of extracellular matrix-related genes such as matrix metalloproteinase 2(MMP2)and matrix metalloproteinase 9(MMP9),along with inflammatory response genes interleukin(IL)-1βand IL-6.Additionally,PPARγactivation led to a significant decrease in the levels of ALT and AST.At the molecular level,PPARγnotably down-regulated the TGF-β/Smad signaling pathway,which is known to promote liver fibrosis.Conclusion:These groundbreaking findings underscore PPARγactivation as a promising therapeutic approach to delay NAFLD progression by targeting the TGF-β/Smad signaling pathway in hepatic cells.This highlights the potential of PPARγas a promising therapeutic target for NAFLD management in clinical settings. | Qingwei Zhang Wenjie Zhao Zeqi Sun Xinxin Dong Liwei Zhu Zhen Zhang Ximing Chen Yingying Hu Menghan Du Jiamin Li Yong Zhang | 2024 | Frigid Zone Medicine2024，4，1： | 0 |
| 17 | Visualizing nonlinear resonance in nanomechanical systems via single-electron tunneling显示文摘Numerous reports have elucidated the importance of mechanical resonators comprising quantum-dot-embedded carbon nanotubes(CNTs)for studying the effects of single-electron transport.However,there is a need to investigate the single-electron transport that drives a large amplitude into a nonlinear regime.Herein,a CNT hybrid device has been investigated,which comprises a gate-defined quantum dot that is embedded into a mechanical resonator under strong actuation conditions.The Coulomb peak positions synchronously oscillate with the mechanical vibrations,enabling a single-electron Chopper*1 mode.Conversely,the vibration amplitude of the CNT versus its frequency can be directly visualized via detecting the time-averaged single-electron tunneling current.To understand this phenomenon,a general formula is derived for this time-averaged single-electron tunneling current,which agrees well with the experimental results.By using this visualization method,a variety of nonlinear motions of a CNT mechanical oscillator have been directly recorded,such as Duffing nonlinearity,parametric resonance,and double-,fractional-,mixed-frequency excitations.This approach opens up burgeoning opportunities for investigating and understanding the nonlinear motion of a nanomechanical system and its interactions with electron transport in quantum regimes. | Xinhe Wang Lin Cong Dong Zhu Zi Yuan Xiaoyang Lin Weisheng Zhao Zaiqiao Bai Wenjie Liang Ximing Sun Guang-Wei Deng Kaili Jiang | 2021 | Nano Research2021，14，4： | 0 |
| 18 | Preliminary Study of a Hybrid Helicon-ECR Plasma Source显示文摘A new type of hybrid discharge is experimentally investigated in this work. A helicon source and an electron cyclotron resonance(ECR) source were combined to produce plasma. As a preliminary study of this type of plasma, the optical emission spectroscopy(OES) method was used to obtain values of electron temperature and density under a series of typical conditions. Generally,it was observed that the electron temperature decreases and the electron density increases as the pressure increased. When increasing the applied power at a certain pressure, the average electron density at certain positions in the discharge does not increase significantly possibly due to the high degree of neutral depletion. Electron temperature increased with power in the hybrid mode.Possible mechanisms of these preliminary observations are discussed. | A.M.HALA L.OKSUZ ZHU Ximing | 2016 | Plasma Science and Technology2016，18，8： | 0 |
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