|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses显示文摘Patients with an influenza virus infection can be complicated by acute encephalopathy and encephalitis. To investigate the immune reactions involved in the neurocomplication,mouse microglia and astrocytes were isolated,infected with human H1N1 and avian H5N1 influenza viruses,and examined for their immune responses. We observed homogeneously distributed viral receptors,sialic acid (SA)-α2,3-Galactose (Gal) and SA-α2,6-Gal,on microglia and astrocytes. Both viruses were replicative and productive in microglia and astrocytes. Virus-induced apoptosis and cytopathy in infected cells were observed at 24 h post-infection (p.i.). Expression of IL-1β,IL-6 and TNF-α mRNA examined at 6 h and 24 h p.i. was up-regulated,and their expression levels were considerably higher in H5N1 infection. The amounts of secreted proinflammatory IL-1β,IL-6 and TNF-α at 6 h and 24 h p.i. were also induced,with greater induction by H5N1 infection. This study is the first demonstration that both human H1N1 and avian H5N1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis,cytopathy,and proinflammatory cytokine production in them in vitro. Our results suggest that the direct cellular damage and the consequences of immunopathological injury in the CNS contribute to the influenza viral pathogenesis. | Gefei Wang Juan Zhang Weizhong Li Yun Su Yuanli Gao Heng Zhang Guimei Lin Xiaoyang Jiao Kangsheng Li | 2008 | Cellular & Molecular Immunology2008，5，2： | 28 |
| 2 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 3 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 4 | Application of probabilistic risk assessment at a coking plant site contaminated by polycyclic aromatic hydrocarbons显示文摘概率的风险评价(PRA ) 和在一个 coking 植物地点的确定的风险评价(DRA ) 的申请被比较。由 DRA,跟随暴露到萘(小睡) 和跟随暴露到 Benzo (a) 分核(Bap ) 的增长生活癌症风险(ILCR ) 的危险商(HQ ) 是 1.87 和 2.12 ? 戠桥吗? | Tianxiang XIA | 2014 | Frontiers of Environmental Science & Engineering2014，8，3： | 7 |
| 5 | Intelligent identification of two-dimensional nanostructures by machine-learning optical microscopy显示文摘Two-dimensional (2D)materials and their heterostructures,with wafer-scale synthesis methods and fascinating properties,have attracted significant interest and triggered revolutions in corresponding device applications.However,facile methods to realize accurate,intelligent,and large-area characterizations of these 2D nanostructures are still highly desired.Herein,we report the successful application of machine-learning strategy in the optical identification of 2D nanostructures.The machine-leaming optical identification (MOI)method endows optical microscopy with intelligent insight into the characteristic color information of 2D nanostructures in the optical photograph.The experimental results indicate that the MOI method enables accurate,intelligent,and large-area characterizations of graphene,molybdenum disulfide,and their heterostructures, including identifications of the thickness,existence of impurities,and even stacking order.With the convergence of artificial intelligence and nanoscience,this intelligent identification method can certainly promote fundamental research and wafer-scale device applications of 2D nanostructures. | Xiaoyang Lin Zhizhong Si Wenzhi Fu Jianlei Yang Side Guo Yuan Cao Jin Zhang Xinhe Wang Peng Liu Kaili Jiang Weisheng Zhao | 2018 | Nano Research2018，11，12： | 5 |
| 6 | Heating graphene to incandescence and the measurement of its work function by the thermionic emission method显示文摘 | Feng Zhu | 2014 | Nano Research2014，7，4： | 5 |
| 7 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 8 | A VLIW Architecture Stream Cryptographic Processor for Information Security显示文摘As an important branch of information security algorithms,the efficient and flexible implementation of stream ciphers is vital.Existing implementation methods,such as FPGA,GPP and ASIC,provide a good support,but they could not achieve a better tradeoff between high speed processing and high flexibility.ASIC has fast processing speed,but its flexibility is poor,GPP has high flexibility,but the processing speed is slow,FPGA has high flexibility and processing speed,but the resource utilization is very low.This paper studies a stream cryptographic processor which can efficiently and flexibly implement a variety of stream cipher algorithms.By analyzing the structure model,processing characteristics and storage characteristics of stream ciphers,a reconfigurable stream cryptographic processor with special instructions based on VLIW is presented,which has separate/cluster storage structure and is oriented to stream cipher operations.The proposed instruction structure can effectively support stream cipher processing with multiple data bit widths,parallelism among stream cipher processing with different data bit widths,and parallelism among branch control and stream cipher processing with high instruction level parallelism;the designed separate/clustered special bit registers and general register heaps,key register heaps can satisfy cryptographic requirements.So the proposed processor not only flexibly accomplishes the combination of multiple basic stream cipher operations to finish stream cipher algorithms.It has been implemented with 0.18μm CMOS technology,the test results show that the frequency can reach 200 MHz,and power consumption is 310 mw.Ten kinds of stream ciphers were realized in the processor.The key stream generation throughput of Grain-80,W7,MICKEY,ACHTERBAHN and Shrink algorithm is 100 Mbps,66.67 Mbps,66.67 Mbps,50 Mbps and 800 Mbps,respectively.The test result shows that the processor presented can achieve good tradeoff between high performance and flexibility of stream ciphers. | Longmei Nan Xuan Yang Xiaoyang Zeng Wei Li Yiran Du Zibin Dai Lin Chen | 2019 | China Communications2019，16，6： | 4 |
| 9 | Distribution and sources of polycyclic aromatic hydrocarbons and phthalic acid esters in water and surface sediment from the Three Gorges Reservoir显示文摘After the impoundment of the Three Gorges Reservoir(TGR), the hydrological situation of the reservoir has changed greatly. The concentration and distribution of typical persistent organic pollutants in water and sediment have also changed accordingly. In this study, the concentration, distribution and potential sources of 16 polycyclic aromatic hydrocarbons(PAHs) and 6 phthalic acid esters(PAEs) during the water drawdown and impoundment periods were investigated in water and sediment from the TGR. According to our results, PAHs and PAEs showed temporal and spatial variations. The mean ΣPAH and ΣPAE concentrations in water and sediment were both higher during the water impoundment period than during the water drawdown period. The water samples from the main stream showed larger ΣPAH concentration fluctuations than those from tributaries. Both the PAH and PAE concentrations meet the Chinese national water environmental quality standard(GB 3838-2002). PAH monomers with 2–3 rings and 4 rings were dominant in water, and 4-ring and 5–6-ring PAHs were dominant in sediment. Di-n-butyl phthalate(DBP) and di-2-ethylhexyl phthalate(DEHP)were the dominant PAE pollutants in the TGR. DBP and DEHP had the highest concentrations in water and sediment, respectively. The main source of PAHs in water from the TGR was petroleum and emissions from coal and biomass combustion, whereas the main sources of PAHs in sediments included coal and biomass combustion, petroleum, and petroleum combustion. The main source of PAEs in water was domestic waste, and the plastics and heavy chemical industries were the main sources of PAEs in sediment. | Li Lin Lei Dong Xiaoyang Meng Qingyun Li Zhuo Huang Chao Li Rui Li Wenjun Yang John Crittenden | 2018 | Journal of Environmental Sciences2018，30，7： | 4 |
| 10 | Light gain amplification in microcavity organic semiconductor laser diodes under electrical pumping显示文摘Organic semiconductor is one of the most promising luminescent and lasing materials that can be chemically synthesized with a controllable performance and possess high cross-section of stimulated emission[1].Organic semiconductor laser diodes(OSLDs)can be prepared by simple processing technologies and integrated easily with other optoelectronic devices.As a result,OSLDs would | Jie Lin Yongsheng Hu Ying Lv Xiaoyang Guo Xingyuan Liu | 2017 | Science Bulletin2017，62，24： | 3 |
| 11 | Treatment of acid rose dye containing wastewater by ozonizing – biological aerated filter显示文摘 | Xiaojun Wang Xiaoyang Gu Dexian Lin Fang Dong Xiaofang Wan | 2006 | Dyes and Pigments2006，，3： | 3 |
| 12 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 13 | Combined processes of two-stage Fenton-biological anaerobic filter–biological aerated filter for advanced treatment of landfill leachate显示文摘 | Xiaojun Wang Jijun Han Zhiwei Chen Lei Jian Xiaoyang Gu Che-Jen Lin | 2012 | Waste Management2012，，12： | 1 |
| 14 | A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis显示文摘 | Yibin Deng Xiaoyang Ren Lin Yang Yahong Lin Xiangwei Wu | 2003 | Cell2003，，1： | 1 |
| 15 | Treatment of Acid Rose Dye Containing Wastewater by Ozonizing-Biological Aerated Filter显示文摘 | Wang Xiaojun Gu Xiaoyang Lin Dexian | 2007 | Dyes Pigments2007，74，3： | 1 |
| 16 | Metal-film-assisted ultra-clean transfer of single-walled carbon nanotubes显示文摘 | Yujun He Dongqi Li Tianyi Li Xiaoyang Lin Jin Zhang Yang Wei Peng Liu Lina Zhang Jiaping Wang Qunqing Li Shoushan Fan Kaili Jiang | 2014 | Nano Research2014，7，7： | 1 |
| 17 | Treatment of acid rose dye containing wastewater by ozonizing-bio- logical aerated filter 显示文摘 | WANG Xiaojun GU Xiaoyang LIN Dexian | 2007 | Dye and Pigments2007，74，3： | 1 |
| 18 | Treatment of acid rose dye containing wastewater by ozonizing-biologieal aerated filter显示文摘 | Wang Xiaojun Gu Xiaoyang Lin Dexian | 2007 | Dyes and Pigments2007，74，3： | 1 |
| 19 | Freestanding macroscopic metal-oxide nanotube films derived from carbon nanotube film templates显示文摘与非结晶的碳涂的排列的碳 nanotube 电影被原子层免职开发进新奇模板。独立宏观的金属氧化物 nanotube 电影然后被使用这些模板成功地综合。反应的非结晶的碳层极大地改进了原子核密度,它保证了这些电影的高质量并且允许 nanotubes 的墙厚度的精确控制。用综合模板的氧化铝 nanotube 电影,我们以高反应速度,一个传播电子显微镜学(TEM ) 格子,和催化剂支持表明一个湿度传感器。跨 stacked 汇编, ultrathin 厚度,化学不活泼,和氧化铝 nanotube 电影的高热的稳定性贡献了这些设备的优秀性能。另外,金属氧化物 nanotube 电影将由于他们的材料丰富,宏观的外观,灵活性,与半导体的技术的相容性,和大量生产的可行性有重要潜力,这被期望。 | He Ma Yang Wei Jiangtao Wang Xiaoyang Lin WenyunWu Yang Wu Ling Zhang Peng Liu Jiaping Wang Qunqing Li Shoushan Fan Kaili Jiang | 2015 | Nano Research2015，8，6： | 1 |
| 20 | Treatment of acid rose dye containing wastewater by ozonizing-biological aerated filter 显示文摘 | Wang Xiaojun Gu Xiaoyang Lin Dexian | 2007 | Dyes and Pigm2007，74，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员