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| 1 | Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China:a decision analysis and implications for practice显示文摘Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.Methods: A decision tree model with three scenarios(low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort(100,000 smokers aged45-80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality(primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables.Results: Among the 100,000 subjects, there were 448,541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively(17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, lowdose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths(relative numbers) with low-dose CT screening in the worst and optimal cases were16(5.4%) and 288(40.2%) over no screening, respectively.Conclusions: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China.However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed. | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2017 | Chinese Journal of Cancer2017，36，8： | 9 |
| 2 | Light-Written Reversible 3D Fluorescence and Topography Dual-Pattern with Memory and Self-Healing Abilities显示文摘To achieve the dynamical dual-pattern with multiplex information of complex topography and 3D fluorescence is challenging yet promising for wide applications ranging from visual bioassays,memory,smart devices to smart display.Here,we develop a convenient,reliable,and versatile method to realize the well-ordered dual-pattern with reversible topography and 3D fluorescence via a light direct-writing approach based on the wrinkle mechanism.By introducing the charge transfer(CT)interaction betweenπ-electron-rich anthracene(AN)andπ-electron-poor naphthalene diimide(NDI)into the polymer system,both modulus and fluorescence of the polymer films can be spatially regulated through the photodimerization of AN,which is controlled in-plane by photomasks,and becomes gradient in the vertical direction due to the filter effect of light.Therefore,the exposed sample displays a well-ordered complex pattern with the same topography as the applied photomask and 3D gradient change of fluorescence from red to green laterally across the layers simultaneously.The spatial cross-linking and CT interaction of the gradient layer can be controlled independently,which not only provides the reliability and reversibility of the topographical and fluorescence dual-pattern but also endows the possibility for tailoring the pattern with memory and selfhealing.These characters of the dual-pattern with reversible topography and 3D fluorescence declare the clear applications in smart multiplex displays,memory,anticounterfeiting,visual detections,and so on. | Jing Bai Luzhi Zhang Honghao Hou Zixing Shi Jie Yin Xuesong Jiang | 2019 | Research2019，，1： | 4 |
| 3 | 中国城市人群低剂量计算机断层扫描筛查肺癌的死亡率结果:决策分析和实践意义显示文摘背景与目的不同低剂量计算机断层扫描(computed tomography,CT)筛查肺癌试验得出的死亡率结果不一致。本研究旨在评价中国城市CT筛查是否能够降低肺癌死亡率,并探讨影响筛查效果的因素。方法建立了3种场景(低剂量CT筛查、胸部X线筛查和无筛查)的决策树模型来比较模拟的中国城市人群(100,000例年龄45–80岁的吸烟者)的筛查结果。从国家登记和流行病学调查中获得了参与者特征数据并估算了肺癌患病比例。根据文献调研选择了低剂量CT和胸部X线筛查的灵敏度和特异度等其他树变量。计算了3种筛查方法间肺癌死亡率(主要结局)、误诊和误诊导致死亡的差异。通过敏感性分析找出了与筛查结果相关的因素,并确定了在变量可能范围内的最差和最优筛查效果。结果 100,000例研究对象中,低剂量CT、胸部X线和无筛查场景分别有448例、541例和591例肺癌死亡(低剂量CT筛查比胸部X线筛查死亡人数减少17.2%,比无筛查减少24.2%)。100,000例研究对象中,2种筛查场景的代价分别为9387例和2497例误诊及7例和2例误诊导致的死亡。低剂量CT筛查比无筛查的死亡数降低,影响最大的因素是筛查人群的肺癌患病比例、低剂量CT的灵敏度和低剂量CT检出肺癌中早期癌的比例。综合了所有可能性,低剂量CT筛查肺癌的死亡人数(相对数)在最坏和最好情况下分别比无筛查降低了16例(5.4%)和288例(40.2%)。结论就死亡率结局而言,我们的研究结果支持在中国城市人群中进行低剂量CT筛查。然而,急需策略来减少误诊和优化纳入标准等重要筛查条件。 | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2018 | 癌症2018，37，8： | 3 |
| 4 | Graphene oxide/polybenzimidazole composites fabricated by a solvent- exchange method显示文摘 | Wang Yan Shi Zixing Fang Jianhua | 2011 | Carbon2011，49，4： | 1 |
| 5 | Preparation and char-acterization of sulfonated graphene- enhanced poly (vinyl alco-hol) composite hydrogel and its application as dye absorbent显示文摘 | Li Hong Fan Jinchen Shi Zixing | 2015 | Polymer2015，，60： | 1 |
| 6 | Three-dimensional graphene network assisted high performance dye sensitized solar cells显示文摘 | Bo Tang Guoxin Hu Hanyang Gao Zixing Shi | 2013 | Journal of Power Sources2013，，： | 1 |
| 7 | Kevlar oligomer functionalized graphene for polymer composites 显示文摘 | Wang Yan Shi Zixing Yin Jie | 2011 | Polymer2011，52，16： | 1 |
| 8 | One pot syn- thesis of multiwalled carbon nanotubes reinforced polybenzimid- azole hybrids : Preparation, characterization and properties 显示文摘 | Shao Huanzhen Shi Zixing Fang Jianhua | 2009 | Polymer2009，50，25： | 1 |
| 9 | Halogenated Thermally Activated Delayed Fluorescence Materials for Efficient Scintillation显示文摘Organic scintillators,materials with the ability to exhibit luminescence when exposed to X-rays,have aroused increasing interest in recent years.However,the enhancement of radioluminescence and improving X-ray absorption of organic scintillators lie in the inherent dilemma,due to the waste of triplet excitons and weak X-ray absorption during scintillation.Here,we employ halogenated thermally activated delayed fluorescence materials to improve the triplet exciton utilization and X-ray absorption simultaneously,generating efficient scintillation with a low detection limit,which is one order of magnitude lower than the dosage for X-ray medical diagnostics.Through experimental study and theoretical calculation,we reveal the positive role of X-ray absorption,quantum yields of prompt fluorescence,and intersystem crossing in promoting the radioluminescence intensity.This finding offers an opportunity to design diverse types of organic scintillators and expands the applications of thermally activated delayed fluorescence. | Xiao Wang Guowei Niu Zixing Zhou Zhicheng Song Ke Qin Xiaokang Yao Zhijian Yang Xiaoze Wang He Wang Zhuang Liu Chengzhu Yin Huili Ma Kang Shen Huifang Shi Jun Yin Qiushui Chen Zhongfu An Wei Huang | 2023 | Research2023，，4： | 1 |
| 10 | Curing kinetics of benzoxazine resin by torsional braid analysis显示文摘 | Yu Dingsheng Chen Hong Shi Zixing | 2002 | Polymer2002，43，11： | 1 |
| 11 | Solvent exfoliatedgraphene for reinforcement of PMMA composites prepared byin situ polymerization显示文摘 | Wang Jialiang Shi Zixing Ge Yu | 2012 | Materials Chemistry & Physics2012，136，1： | 1 |
| 12 | Graphene ox- ide/polybenzimidazole composites fabricated by a solvent- exchange method 显示文摘 | Wang Yan Shi Zixing Fang Jianhua etal | 2011 | Carbon2011，49，4： | 1 |
| 13 | Investigation of isothermal curing behaviour during the synthesis of polybenzoxazine-layered silicate nanocomposites via cyclic monomer显示文摘 | ZIXING SHI DINTG SHENG YU YIZHONG WANG | 2002 | European Polymer Journal2002，，38： | 1 |
| 14 | DSC investigation of the hindered effect on curing behavior for epoxy-phenol/ MMT nanocomposites based on the acidic octadecylamine modifier 显示文摘 | LIU Dian SHI Zixing MATSUNAGA M | 2006 | Polymer2006，47，8： | 1 |
| 15 | Investigation of isothermal curing behaviour during the synthesis of polybenzoxazine-layered silicate nanocomposites via cyclic monomer显示文摘 | Shi Zixing Yu Dingsheng Wang Yizhong | 2002 | European Polymer Journal2002，38，4： | 1 |
| 16 | Noniso- thermal cure kinetics in the synthesis of polybenzoxazine-clay nanocomposites 显示文摘 | Shi Zixing Yu Dingsheng Wang Yizhong | 2003 | Journal of Applied Polymer Science2003，88，1： | 1 |
| 17 | Investigation of Isothermal Curing Behaviour during the Synthesis of Polybenzoxazine-layered Silicate Nanocomposites Via Cyclic Monomer显示文摘 | Zixing Shi Dintg Sheng Yu Yizhong Wang | 2002 | European Polymer Journal2002，38，： | 1 |
| 18 | Curing Kinetics of Benzoxazine Resin by Torsional Braid Analysis 显示文摘 | Yu Dingsheng Chen Hong Shi Zixing | 2002 | Polymer2002，43，11： | 1 |
| 19 | Synthesis and evaluation of peptide-fentanyl analogue conjugates as dualμ/δ-opioid receptor agonists for the treatment of pain显示文摘Novel peptide-fentanyl analogue conjugates were synthesized by the covalent coupling of carfentanyl derivatives to the C-terminus or N-terminus of the conformationally constrained dermorphin tetrapeptide BVD03 via a chemical linker.The carfentanyl-related analogues displayed distinct binding and functional activities atμ/δopioid receptors(MOR/DOR)and antinociceptive effects when conjugated to the peptide.The most potent compound,SW-LJ-11,displayed mixed MOR/DOR agonist properties in the low nanomolar range and significant analgesic efficacy in vivo in four classic mouse models of pain.Interestingly,SW-LJ-11 did not exhibit any physical dependence or respiratory depression,in contrast to an equipotent analgesic dose of morphine or BVD03,indicating that the use of opioid peptide-fentanyl analogue conjugates as dual MOR/DOR agonists may be a promising strategy for obtaining safer opioids. | Jing Li Tao Zhang Jialin Sun Fengxia Ren Hongxin Jia Zixing Yu Jingchao Cheng Weiguo Shi | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 20 | Study of rotational bands of ^(129)La using the projectedshell model显示文摘The projected shell model is applied to the nucleus 129La. The present results of theoretical calculations about the one-quasiproton bands are compared with experimental data. The agreement with both the yrast πh11/2 band πg7/2 band is satisfactory. We also assign the πg7/2 [νh11/2]2 configuration with an oblate shape for one of bands in 129La. | WANG Zixing SHEN Shuifa SHI Shuanghui GU Jiahui LIU Jingyi ZHU Zhiyuan (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) | 1999 | Nuclear Science and Techniques1999，10，3： | 0 |
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