|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Piper sarmentosum as an antioxidant on oxidative stress in human umbilical vein endothelial cells induced by hydrogen peroxide显示文摘Endothelial cell death due to increased reactive oxygen species(ROS) may contribute to the initial endothelial injury,which promotes atherosclerotic lesion formation.Piper sarmentosum(PS),a natural product,has been shown to have an antioxidant property,which is hypothesized to inhibit production of ROS and prevent cell injury.Thus,the present study was designed to determine the effects of PS on the hydrogen peroxide(H2O2)-induced oxidative cell damage in cultured human umbilical vein endothelial cells(HUVECs).In this experiment,HUVECs were obtained by collagenase perfusion of the large vein in the umbilical cord and cultured in medium M200 supplemented with low serum growth supplementation(LSGS).HUVECs were treated with various concentrations of H2O2(0-1000 μmol/L) and it was observed that 180 μmol/L H2O2 reduced cell viability by 50% as denoted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay.Using the above concentration as the positive control,the H2O2-induced HUVECs were concomitantly treated with various concentrations(100,150,250 and 300 μg/ml) of three different extracts(aqueous,methanol and hexane) of PS.Malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX) levels showed a significant increase(P<0.05) in HUVECs compared to the negative control.However,PS extracts showed a protective effect on HUVECs from H2O2-induced cell apoptosis with a significant reduction in MDA,SOD,CAT and GPX levels(P<0.05).Furthermore,PS had exhibited ferric reducing antioxidant power with its high phenolic content.Hence,it was concluded that PS plays a beneficial role in reducing oxidative stress in H2O2-induced HUVECs. | Abdul Hamid HAFIZAH Zakaria ZAITON Amom ZULKHAIRI Adenan MOHD ILHAM Megat Mohd Nordin NOR ANITA Abdullah Mahdy ZALEHA | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，5： | 13 |
| 2 | Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats显示文摘 | Abdulrashid Umar Qamar U. Ahmed Bala Y. Muhammad Bashar Bello S. Dogarai Siti Zaiton Bt. Mat Soad | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 3 | Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats显示文摘 | Abdulrashid Umar Qamar U. Ahmed Bala Y. Muhammad Bashar Bello S. Dogarai Siti Zaiton Bt. Mat Soad | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 4 | The application of the digital signature law in securing internet banking: Some preliminary evidence from Malaysia显示文摘 | Hartini S Zaiton H | 2011 | Proce-dia CompuleT Science2011，3，： | 1 |
| 5 | Detection of genetically modified soy in processed foods sold commercially in Malaysia by PCR-based method显示文摘 | Tosiah Abdullalla Son Radub Zaiton Hassanc | 2006 | Food Chemistry2006，98，3： | 1 |
| 6 | Characterization of Vibrio vulnificus isolated from cockles (Anadara granosa): antimicrobial resistance, plasmid profiles and random amplification of polymorphic DNA analysis 显示文摘 | Son Radu Nasreldin Elhadi Zaiton Hassan | 1998 | FEMS Microbiology Letters1998，，165： | 1 |
| 7 | Raw starch-degrading enzyme from newly isolated strains of enduphytic fungi显示文摘 | Yetti M arlida Nazamid Saari Zaiton Hassan | 2000 | World Journal of Microbiology & Biotechnology2000，16，： | 1 |
| 8 | O- verview of PSO for optimizing process parameters of machining显示文摘 | Norfadzlan Yusup Azlan Mohd Zain Siti Zaiton Mohd Hashim | 2012 | Procedia Engineering2012，29，： | 1 |
| 9 | Complication of gall stone lost during laparoscopic cholecystectomy显示文摘 | Ammari FF Abu -Zaiton A | 2000 | Saudi Med J2000，21，10： | 1 |
| 10 | Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: role of iNOS and VEGF显示文摘 | Sawsan A Zaitone Noha M | 2012 | Eur J Pharmacol2012，691，13： | 1 |
| 11 | Antioxidant potential ofmelatonin enhances the response to L-dopa in 1-methyl 4-phenyl1,2,3,6-tetrahydropyridine-parkinsonian mice显示文摘 | Zaitone S A Hammad L N Farag N E | 2013 | Pharmacol Rep2013，65，5： | 1 |
| 12 | Characterization of Vibrio vulnificus isolated from cockles (Anadara granosa):antimicrobial resistance,plasmid profiles and random amplification of polymorphic DNA analysis显示文摘 | Son Radu Nasreldin Elhadi Zaiton Hassan | 1998 | FEMS Microbiology Letters1998，165，： | 1 |
| 13 | Raw starch- degrading enzyme from newly isolated strains of endophytic fungi 显示文摘 | Yetti Marlida Nazamid Saari Zaiton Hassan Son Radu | 2000 | World Journal of Microbiology and Biotechnology2000，16，： | 1 |
| 14 | Acetyl-L- carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy 显示文摘 | Zaitone SA Abo-Elmatty DM Shaalan AA | 2012 | Pharmacol Biochem Be- hay2012，100，3： | 1 |
| 15 | Enzyme Hydrolysates from Stichopus horrens as a New Source for Angiotensin-Converting Enzyme Inhibitory Peptides显示文摘 | Bita Forghani Afshin Ebrahimpour Jamilah Bakar Azizah Abdul Hamid Zaiton Hassan Nazamid Saari Raffaele Capasso | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 16 | Rosuvastatin promotes angiogenesis and reverses isoproterenolinduced acute myocardial infarction in rats: role of iNOS and VEGF显示文摘 | Zaitone SA AboGresha NM | 2012 | Eur J Pharmacol2012，691，13： | 1 |
| 17 | Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myo- cardial infarction in rats: role of iNOS and VEGF显示文摘 | ZAITONE SA ABO-GRESHA NM | 2012 | Eur J Pharmacol2012，691，13： | 1 |
| 18 | Piper Sarmentosum increases nitric oxide production in oxidative stress: a study on human umbilical vein endothelial cells显示文摘 | Azizah Ugusman Zaiton Zakaria Chua Kien Hui | 2010 | Clinics2010，65，7： | 1 |
| 19 | Multiplication of oil palm suspension culture in a bench-top(2-1itre)bioreactor显示文摘 | Tarmizi A H Norjihan M A Zaiton R | 2004 | Journal of Oil Palm Research2004，16，2： | 1 |
| 20 | Antioxidant potential of melatonin enhances the response to L-dopa in 1- methyl 4-phenyl 1,2,3,6-tetrallydropyridine-parkinsonian mice 显示文摘 | ZAITONE S A HAMMAD L N FARAG N E | 2013 | Pharmacol Rep2013，65，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员