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| 1 | Alcoholic disease: Liver and beyond显示文摘The harmful use of alcohol is a worldwide problem.It has been estimated that alcohol abuse represents the world’s third largest risk factor for disease and disability;it is a causal factor of 60 types of diseases and injuries and a concurrent cause of at least 200 others.Liver is the main organ responsible for metabolizing ethanol,thus it has been considered for long time the major victim of the harmful use of alcohol.Ethanol and its bioactive products,acetaldehyde-acetate,fatty acid ethanol esters,ethanol-protein adducts,have been regarded as hepatotoxins that directly and indirectly exert their toxic effect on the liver.A similar mechanism has been postulated for the alcohol-related pancreatic damage.Alcohol and its metabolites directly injure acinar cells and elicit stellate cells to produce and deposit extracellular matrix thus triggering the'necrosis-fibrosis'sequence that finally leads to atrophy and fibrosis,morphological hallmarks of alcoholic chronic pancreatitis.Even if less attention has been paid to the upper and lower gastrointestinal tract,ethanol produces harmful effects by inducing:(1)direct damaging of the mucosa of the esophagus and stomach;(2)modification of thesphincterial pressure and impairment of motility;and(3)alteration of gastric acid output.In the intestine,ethanol can damage the intestinal mucosa directly or indirectly by altering the resident microflora and impairing the mucosal immune system.Notably,disruption of the intestinal mucosal barrier of the small and large intestine contribute to liver damage.This review summarizes the most clinically relevant alcohol-related diseases of the digestive tract focusing on the pathogenic mechanisms by which ethanol damages liver,pancreas and gastrointestinal tract. | Alba Rocco Debora Compare Debora Angrisani Marco Sanduzzi Zamparelli Gerardo Nardone | 2014 | World Journal of Gastroenterology2014，20，40： | 27 |
| 2 | Expression of cell cycle regulated proteins pRb2/pl30,p107,p27(kip1),p53,Mdm-2,and Ki-67(MIB-1)in prostatic gland adenocarcinoma显示文摘 | Claudio P P Zamparelli A Garcia F U | 2002 | Clin Cancer Res2002，8，6： | 1 |
| 3 | Results and complications of laparoscopic surgery for pediatric varicocele显示文摘 | C. Esposito G. Monguzzi M.A. Gonzalez-Sabin R. Rubino L. Montinaro A. Papparella G. Esposito A. Settimi L. Mastroianni M. Zamparelli R. Sacco G. Amici R. Damiano N. Innaro | 2001 | Journal of Pediatric Surgery2001，，5： | 1 |
| 4 | Activated Akt as an indicator of prognosis in gastric cancer显示文摘 | Caterina Cinti Carla Vindigni Alessandra Zamparelli Dario Sala Maria Carmela Epistolato Daniele Marrelli Gabriele Cevenini Piero Tosi | 2008 | Virchows Archiv2008，，5： | 1 |
| 5 | Strategic Employer Branding: Brand and Image Management as a Tool of Attractiveness for Talented Capital显示文摘 | Valentina Della Corte Gianluigi Mangia Roberto Micera Giuseppina Zamparelli | 2011 | China-USA Business Review2011，10，12： | 1 |
| 6 | Facies and biota of Anisian to Carnian carbonate platforms in the Northern Calcareous Alps (Tyrol and Bavaria)显示文摘 | Dr. Thomas Rüffer Dr. Valeria Zamparelli | 1997 | Facies1997，，1： | 1 |
| 7 | Expression of cell-cycle-associated proteins pRB2/p130 and p27kip in vulvar squamous cell carcinomas显示文摘 | Masciullo V Bovicelli A | 2001 | Hum Pathol2001，32，1： | 1 |
| 8 | Expression and localisation of annexin Ⅶ (synexin) isoforms in differentiating myoblasts显示文摘 | Clemen CS Hofmann A Zamparelli C | 1999 | Muscle Res Cell Motil1999，20，7： | 1 |
| 9 | The-174G/C interleukin-6 poly-morphism influences post-operative interleukin-6 levels and post-operative atrial fibrillation:Is atrialfibrillation an inflammatory complication?显示文摘 | Gaudino M Andreotti F Zamparelli R | 2003 | Circulation2003，108，： | 1 |
| 10 | Structure-function relationships in sorcin,a member of the penta EF-hand family显示文摘 | ZAMPARELLI C LLARI A VERZILI D | 2000 | Biochemistry2000，39，4： | 1 |
| 11 | Treatment of colorectal cancer current guidelines and future prospects for drug therapy 显示文摘 | Labianca R Pessitt MA Zamparelli G | 1997 | Drugs1997，53，4： | 1 |
| 12 | The ?174G/C Interleukin-6 Polymorphism Influences Postoperative Interleukin-6 Levels and Postoperative Atrial Fibrillation. Is Atrial Fibrillation an Inflammatory Complication?显示文摘 | Mario Gaudino Felicita Andreotti Roberto Zamparelli Augusto Di Castelnuovo Giuseppe Nasso Francesco Burzotta Licia Iacoviello Maria Benedetta Donati Rocco Schiavello Attilio Maseri Gianfederico Possati | 2003 | Circulation: Journal of the American Heart Association . 2003 (10 S)2003，，： | 1 |
| 13 | Activated Akt as an indicator of prognosis in gastric cancer显示文摘 | Cinti C Vindigni C Zamparelli A | 2008 | Virchows Arch2008，453，5： | 1 |
| 14 | Right ventricular bifocal DDD pacing as primary choice for cardiac resynchronization in heart failure patients with severe mitral regurgitation显示文摘 | Zamparelli L Martiniello AR | 2005 | Heart Rhythm2005，，： | 1 |
| 15 | One - trocar surgery: a less invasive videosurgical approach in childhood显示文摘 | Martino A Zamparelli M Cobellis G | 2001 | J Pediatr Surg2001，36，5： | 1 |
| 16 | Expression of cell-cycle-regulated proteins pRb2/p130,p107,p27 (kip 1),p53,mdm-2,and Ki-67 (MIB-1) in prostatic gland adenocarcinoma显示文摘 | Claudio PP Zamparelli A Garcia FU | | 0，，06： | 1 |
| 17 | Normothermia does not improve postoperative hemostasis nor does it reduce inflammatory activation in patients undergoing primary isolated coronary artery bypass显示文摘 | Zamparelli R Andreotti F | 2002 | J Thorac Cardiovasc Surg2002，123，： | 1 |
| 18 | Inflammatory and fibrinoytic activation after coronary aetery bypass with extracorporeal circulation显示文摘 | Gaudino M Nasso G Zamparelli R | 2002 | Ital heart I Suppl2002，3，6： | 1 |
| 19 | Inflammatory and fibrinoytic activation after coronary aetery bypass with extracorporeal circulation显示文摘 | Gaudino M Nasso G Zamparelli R | 2002 | Ital heart I Suppl2002，3，6： | 1 |
| 20 | Genetically Trained Cellular Neural Networks 显示文摘 | ZAMPARELLI M | 1997 | Neural Networks1997，10，6： | 1 |
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