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| 1 | Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis显示文摘Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed. | Licia Polimeni Maria Del Ben Francesco Baratta Ludovica Perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico | 2015 | World Journal of Hepatology2015，7，10： | 23 |
| 2 | Modern approach to the clinical management of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common and emerging form of chronic liver disease worldwide.It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis,which may progress to cirrhosis,liver cancer,and liver mortality.Common metabolic diseases,which are well established cardiovascular risk factors,have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population.The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration.Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide.First-line management focuses on lifestyle modifications.Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended.Several therapeutic interventions have been proposed.These include insulin sensitizer agents,lipid lowering drugs,antioxidants such as vitamin E and supplementation of vitamin D3.However,therapeutic strategies have been largely empirical so far,and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes.Metabolic conditions such as diabetes mellitus,obesity,hypertension and hyperlipidemia,should be strongly considered and a multidisciplinary approach should be personalized for individual patients.Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients.The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease. | Maria Del Ben Licia Polimeni Francesco Baratta Daniele Pastori Lorenzo Loffredo Francesco Angelico | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 3 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 4 | Advanced oxidation and adsorption technologies for organic micropollutant removal from lake water used as drinkingwater supply 显示文摘 | Guzzella Licia Feretti Donatella Monarca Silvano | 2002 | Water Res2002，36，17： | 1 |
| 5 | Analysis of gene environment interaction in coronary heart disease:fibrinogen polymorphisms as an example显示文摘 | Michela Vischetti Francesco Zito Maria Benedetta Donati Licia Iacoviello | 2002 | Ital Heart J2002，3，： | 1 |
| 6 | Validating the Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ) in Italian inpatients with chronic migraine with a history of medication overuse显示文摘 | Alberto Raggi Ambra Mara Giovannetti Silvia Schiavolin Matilde Leonardi Gennaro Bussone Licia Grazzi Susanna Usai Marcella Curone Paola Fiore Domenico D’Amico | 2014 | Quality of Life Research2014，，4： | 1 |
| 7 | The use of thermal analusis in assessing the effect of temperature on a cement paste显示文摘 | Licia Alarcon Ruiz | 2005 | Cem Concr Res2005，，35： | 1 |
| 8 | The Wnt signalling pathway and rheumatoid arthritis 显示文摘 | FRANCIELI S R LICIA M H RODRIGO A C | 2010 | Autoimmunity Rev2010，9，4： | 1 |
| 9 | CARLSMA:Context-aware reflective middleware system for mobile applications显示文摘 | Licia Capra Wolfgang Emmerich Ceilia Mascolo | 2003 | IEEE Transactions on Software Engineering2003，29，10： | 1 |
| 10 | Are the IKKs and IKK-related kinases TBK1 and IKK-? similarly activated?显示文摘 | Tieu-Lan Chau Romain Gioia Jean-Stéphane Gatot Félicia Patrascu Isabelle Carpentier Jean-Paul Chapelle Luke O’Neill Rudi Beyaert Jacques Piette Alain Chariot | 2008 | Trends in Biochemical Sciences2008，，4： | 1 |
| 11 | The efficacy and safety of statins for the treatment of non - alcoholic fatty liver disease 显示文摘 | Daniele P Licia P Francesco B | 2015 | Digestive & Liver Disease Official Journal of the Italian Society of Gastroenterology & the Italian Association for the Study of the Liver2015，47，1： | 1 |
| 12 | Influence of manganese on cell morphology, protoplasts formation and β-D-glu-cosidase activity in Phaffia rhodozyma 显示文摘 | Licia M Pera Rubinstein Laura | 1999 | FEMS Microbiology Letters1999，177，： | 1 |
| 13 | Halomonas alkaliantarctica sp. nov., isolated from saline lake Cape Russell in Antarctica, an alkalophilic moderately halophilic, exopolysaccharide-producing bacterium显示文摘 | Annarita Poli Enrico Esposito Pierangelo Orlando Licia Lama Assunta Giordano Francesca de Appolonia Barbara Nicolaus Agata Gambacorta | 2006 | Systematic and Applied Microbiology2006，，1： | 1 |
| 14 | Relation of Nonalcoholic Fatty Liver Disease and Framingham Risk Score to Flow-Mediated Dilation in Patients With Cardiometabolic Risk Factors显示文摘 | Daniele Pastori Lorenzo Loffredo Ludovica Perri Francesco Baratta Laura Scardella Licia Polimeni Arianna Pani Monica Brancorsini Fabiana Albanese Elisa Catasca Maria Del Ben Francesco Violi Francesco Angelico | 2015 | The American Journal of Cardiology2015，，10： | 1 |
| 15 | Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer显示文摘 | Chiara Castelli Licia Rivoltini Francesca Rini Filiberto Belli Alessandro Testori Michele Maio Vincenzo Mazzaferro Jorgelina Coppa Pramod K. Srivastava Giorgio Parmiani | 2004 | Cancer Immunology Immunotherapy2004，，3： | 1 |
| 16 | Prognostic Value of diffusion-weighted imaging summation scores or apparent diffusion coefficient maps in new borns with hypoxic-ischemic encephalopathy显示文摘 | Francescan Cavalleri Licia Lugli Marisa Pugliese | 2014 | Pediatr Radiol2014，44，9： | 1 |
| 17 | Recent advances on the role of tumor exosomes in immunosuppression and disease progression显示文摘 | Paola Filipazzi Maja Bürdek Antonello Villa Licia Rivoltini Veronica Huber | 2012 | Seminars in Cancer Biology2012，，4： | 1 |
| 18 | Trends in mortality, complications, and demographics for primary hip arthroplasty in the United States显示文摘 | Spencer S. Liu Alejandro González Della Valle Melanie C. Besculides Licia K. Gaber Stavros G. Memtsoudis | 2009 | International Orthopaedics2009，，3： | 1 |
| 19 | Toxicity identification evaluation of Lake Orta (Northern Italy) sediments using the microtoxsystem显示文摘 | Licia G Cristina B Philippe R | 1996 | Ecotoxicology and Environmental Safety1996，35，： | 1 |
| 20 | Defect cluster formation in M2O3-doped cubic ZrO2 显示文摘 | Matthew O Z Licia M | 2000 | Soild State Ionics2000，128，： | 1 |
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