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| 1 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 2 | Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation显示文摘Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death. | Yufang Wang Peiliang Shi Qin Chen Zan Huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin | 2019 | Journal of Molecular Cell Biology2019，11，12： | 23 |
| 3 | Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats显示文摘在糖尿病的可勃起的机能障碍(编辑) 的高发生为有效处理策略加亮需要。Resveratrol,沉默信息管理者 2-related 酶的使活跃之物 1 (sirtuin1, SIRT1 ) ,在癌症, neurodegenerative 疾病,长寿和心血管的疾病为它的珍贵效果收到了注意。在导致糖尿病的编辑探索 resveratrol 的效果, resveratrol 与 streptozocin 予老鼠被以(65 mg kg −1)-induced 糖尿病。可勃起的功能,多孔的结构,沉默信息管理者 2-related 酶的织物蛋白质表示 1 (sirtuin1, SIRT1 ) , p53 和 O 3a (FOXO3a )(MDA ) , superoxide dismutase (草皮) 活动和 malondialdehyde 在阴茎海绵体铺平的 forkhead 抄写因素被学习。我们发现 SIRT1 在 cavernosal 组织被表示,并且它是在糖尿病的老鼠的宫体的 downregulated。resveratrol upregulated 的管理 SIRT1 和恢复可勃起的功能的表示。相反, resveratrol downregulated p53 和 FOXO3a 的表示,调整 apoptosis 和氧化应力。而且,对待 resveratrol 的组在光滑的肌肉内容,草皮活动和 MDA 层次看了改进什么时候与糖尿病患者相比组织。因此, resveratrol 的能力改进导致糖尿病的编辑与它 SIRT1 表示的激活有关是可能的,因此向氧化应力引起 apoptosis 和抵抗的抑制。 | Wen Yu Zan Wan Xue-Feng Qiu Yun Chen Yu-Tian Dai | 2013 | Asian Journal of Andrology2013，15，5： | 15 |
| 4 | Potato/Maize intercropping reduces infestation of potato tuber moth, Phthorimaea operculella(Zeller) by the enhancement of natural enemies显示文摘The potato tuber moth(PTM),Phthorimaea operculella(Zeller),is one of the most economically significant insect pests for potato in both field and storage worldwide.To evaluate the infestation,reduction of potato yield and the control efficacy for PTM,field tests were conducted in two seasons by intercropping of potato as the host plant with maize as a non-host plant of PTM.Three intercropping patterns were tested,which were 2 rows of potatoes with either 2,3,or 4 rows of maize(abbreviated 2 P:2 M,2 P:3 M,and 2 P:4 M),and the monocropped potato as the control,2 rows of potatoes,without maize,(abbreviated 2 P:0 M).Results showed that the population and infestation of PTM in the 2 P:3 M intercropping pattern was significantly lower than those in 2 P:2 M,2 P:4 M and the monocropping pattern of 2 P:0 M,due to the enhancement of natural enemies.Cumulative mines and tunneling in potato leaves in 2 P:3 M intercropping were significantly lower than those in 2 P:2 M and 2 P:4 M patterns.The population of parasitoids and the parasitism rate of PTM in intercropping pattern of 2 P:3 M were significantly higher than that in intercropping pattern of 2 P:2 M,2 P:4 M and monocropping pattern of 2 P:0 M.We conclude that the potato intercropped with maize reduced the adult and larva populations,and reduced the damage from PTM by enhancing the number of parasitoids and the level of parasitism.The greatest population density of parasitoids and parasitism rate were in the intercropping pattern of 2 rows of potatoes with 3 rows of maize.These data indicate that the host/non-host intercropping patterns can be used as a biological control tactic against PTM by enhancing the density of natural enemies in the agro-ecosystems. | ZHENG Ya-qiang ZHANG Li-min CHEN Bin YAN Nai-sheng GUI Fu-rong ZAN Qing-an DU Guang-zu HE Shu-qi LI Zheng-yue GAO Yu-lin XIAO Guan-li | 2020 | Journal of Integrative Agriculture2020，19，2： | 8 |
| 5 | Recovery of novel bacterial diversity from mangrove sediment显示文摘 | Liang JB Chen YQ Lan CY Tan NFY Zan QJ Huang LN | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 6 | A New Basal Neoceratopsian Dinosaur from the Middle Cretaceous of Jilin Province,China显示文摘一条新基础 neoceratopsian 恐龙, Helioceratops brachygnathus 情报。et sp。nov,在 Liufangzi 地区从 Quantou 形成(晚早的白垩纪或早迟了的白垩纪) 被描述(吉林省,中国) 。Helioceratops 与它的深齿骨分支不同于另外的基础 neoceratopsians,它的使陡峭地倾向的腹的 predentary 方面,它的异构的齿骨王冠,并且由小齿和第二等的山脉一在它的齿骨牙齿上的主要山脉的任何一个方面上相称性地分布式。与 Auroraceratops 和 Yamaceratops 一起, Helioceratops 代表大多数导出的 non-coronosaurian neoceratopsians 之一。基础 neoceratopsians 的 palaeogeographical 分发处于我们的知识的当前的国家显得限于北中国和南部的蒙古。这个区域为更先进的、迟了的白垩纪 Coronosauria 组成了出生地,因此是可能的。 | JIN Liyong CHEN Jun ZAN Shuqin Pascal GODEFROIT | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 7 |
| 7 | Determining reference conditions for TN,TP,SD and Chl-a in eastern plain ecoregion lakes,China显示文摘Establishing the nutrient reference condition(baseline environmental condition) of lakes in an ecoregion is a critical consideration in the development of scientifically defensible aquatic nutrient criteria.Three methods were applied to determine reference conditions in the Eastern plain ecoregion lakes with respect to total phosphorus(TP),total nitrogen(TN),planktonic chlorophyll a(Chl-a) and Secchi depth(SD).The reference condition value for the lakes in the Eastern plain ecoregion by the trisection method is TP of 0.029 mg/L,TN of 0.67 mg/L,Chl-a of 3.92 mg/m 3,SD of 0.85 m,and the reference condition range by the lake population distribution approach is TP of 0.014-0.043 mg/L,TN of 0.360-0.785 mg/L,Chl-a of 1.78-4.73 mg/m 3,SD of 0.68-1.21 m.Additionally,empirical models were developed for estimating the reference Chl-a concentration and SD successfully for lakes in the Eastern plain ecoregion.Overall,the data suggest that multiple methods can be used to determine reference conditions and that in Eastern plain ecoregion lakes the reference condition corresponds to a mesotrophic status. | Shouliang Huo Beidou Xi Jing Su Fengyu Zan Qi Chen Danfeng Ji Chunzi Ma | 2013 | Journal of Environmental Sciences2013，25，5： | 7 |
| 8 | Progress in green and efficient enrichment of rare earth from leaching liquor of ion adsorption type rare earth ores显示文摘Ion adsorption type rare earth ores(IATREOs)are a valuable strategic mineral resource in China,which feature a complete composition of fifteen rare earth elements and are rich in medium and heavy rare earth(RE)elements.In the leaching process for recovering rare earth elements from IATREOs,many impurities will be leached together with rare earth elements and enter the leaching liquor.An impurity removal-precipitation enrichment technique is currently applied to selectively recovery rare earth elements from the leaching liquor with the high content of impurities and low concentration of rare earth elements by using ammonium bicarbonate in the industry.However,a high loss of rare earth elements and severe ammonia nitrogen pollution are caused by this process.Therefore,more beneficial impurities removal technologies,mainly for aluminum,and green enrichment technologies with lower pollution are now urgently needed.For this purpose,this paper analyzed two aspects of research progress in recent decades:the green separation of rare earth elements and aluminum from leaching liquor and the green and efficient enrichment of rare earth elements.Finally,an approach for the high-efficiency and green enrichment of rare earth elements from leaching liquor of the IATREOs is proposed in several aspects,including impurity inhibition leaching,neutralization and impurity removal,alkaline calcium and magnesium salt precipitation enrichment,and centrifugal extraction enrichment. | Qiang He Jiang Qiu Jinfa Chen Miaomiao Zan Yanfei Xiao | 2022 | Journal of Rare Earths2022，40，3： | 5 |
| 9 | Cell behaviors on surface of pure tantalum with nano-dimpled structure显示文摘Tantalum exhibits excellent biocompatibility and good chemical stability, which has been employed in dental and orthopedic applications.The local microenvironment of the surface of implants influence determines the surrounding cell responses.In this work, nano-dimpled structure on the surface of pure tantalum was fabricated by electrochemical anodization.The surface morphology of the nano-dimpled structure was observed, and the dimensions of the nano-dimpled structure were measured by scanning electron microscopy(SEM).The surface roughness of the sample with nano-dimpled structure was measured by atomic force microscopy(AFM).The results show that the diameter of nano-dimpled ranges from 40 to 180 nm, and the higher the applied voltage, the larger the diameter.Moreover, nano-dimpled structure has good hydrophilicity.In vitro results show that nano-dimpled structure can promote the adhesion and proliferation of mouse cranial anterior bone(MC-3T3-E1) cells.The filopodia of MC-3T3-E1 cells can be fully extended on this nano-dimpled structure.On the surface of the nano-dimpled structure with a dimple size of 40 nm, the cells have the longest aspect ratio.The small dimple size of the nanodimpled structure is beneficial to cell proliferation and osteogenic differentiation. | Jun-Wei Ma Rui Zan Wen-Zhi Chen Jia-Hua Ni Xiao-Nong Zhang | 2019 | Rare Metals2019，38，6： | 4 |
| 10 | A Fuzzy PID Algorithm for a Novel Miniature Spherical Robots with Three-dimensional Underwater Motion Control显示文摘We proposed and developed a small bionic amphibious spherical robot system for tasks such as coastal environment monitoring and offshore autonomous search and rescue.Our third-generation bionic small amphibious spherical robots have many disadvantages,such as the lack of maneuverability and a small operating range.It is difficult to accomplish underwater autonomous motion control with these robots.Therefore,we proposed a fourth-generation amphibious spherical robot.However,the amphibious spherical robot developed in this project has a small and compact design,with limited sensors and external sensing options.This means that the robot has weak external information collection capabilities.We need to make the real time operation of the robot's underwater motion control system more reliable.In this paper,we mainly used a fuzzy Proportional-Integral-Derivative(PID)control algorithm to design an underwater motion control system for a novel robot.Moreover,we compared PID with fuzzy PID control methods by carrying out experiments on heading and turning bow motions to verify that the fuzzy PID is more robust and exhibits good dynamic performance.We also carried out experiments on the three-dimensional(3D)motion control to validate the design of the underwater motion control system. | Liwei Shi Yao Hu Shuxiang Su Shuxiang Guo Huiming Xing Xihuan Hou Yu Liu Zhan Chen Zan Li Debin Xia | 2020 | Journal of Bionic Engineering2020，17，5： | 4 |
| 11 | Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair显示文摘Peripheral nerve regeneration requires stepwise and well-organized establishment of microenvironment.Since local delivery of VEGF-A in peripheral nerve repair is expected to promote angiogenesis in the microenvironment and Schwann cells(SCs)play critical role in nerve repair,combination of VEGF and Schwann cells may lead to efficient peripheral nerve regeneration.VEGF-A overexpressing Schwann cells were established and loaded into the inner wall of hydroxyethyl cellulose/soy protein isolate/polyaniline sponge(HSPS)conduits.When HSPS is mechanically distorted,it still has high durability of strain strength,thus,can accommodate unexpected strain of nerve tissues in motion.A 10 mm nerve defect rat model was used to test the repair performance of the HSPS-SC(VEGF)conduits,meanwhile the HSPS,HSPS-SC,HSPS-VEGF conduits and autografts were worked as controls.The immunofluorescent co-staining of GFP/VEGF-A,Ki67 and MBP showed that the VEGF-A overexpressing Schwann cells could promote the proliferation,migration and differentiation of Schwann cells as the VEGF-A was secreted from the VEGF-A overexpressing Schwann cells.The nerve repair performance of the multifunctional and flexible conduits was examined though rat behavioristics,electrophysiology,nerve innervation to gastrocnemius muscle(GM),toluidine blue(TB)staining,transmission electron microscopy(TEM)and NF200/S100 double staining in the regenerated nerve.The results displayed that the effects on the repair of peripheral nerves in HSPS-SC(VEGF)group was the best among the conduits groups and closed to autografts.HSPS-SC(VEGF)group exhibited notably increased CD31+endothelial cells and activation of VEGFR2/ERK signaling pathway in the regenerated nerve tissues,which probably contributed to the improved nerve regeneration.Altogether,the comprehensive strategy including VEGF overexpressing Schwann cells-mediated and HSPS conduit-guided peripheral nerve repair provides a new avenue for nerve tissue engineering. | Ping Wu Zan Tong Lihua Luo Yanan Zhao Feixiang Chen Yinping Li Céline Huselstein Qifa Ye Qingsong Ye Yun Chen | 2021 | Bioactive Materials2021，6，10： | 4 |
| 12 | 骨转换标志物在非小细胞肺癌骨转移临床应用价值的研究(英文)显示文摘Objective:The purpose of this study was to assess the clinical application value of bone turnover markers in non-small-cell lung cancer(NSCLC) patients with bone metastases.Including diagnosing bone metastases,detecting bone metastatic spread.Methods:Alkaline phosphatase(AKP),β-C-terminal telopeptide of type I collagen(β-CTx),osteocalcin(OST) and bone alkaline phosphatase(BALP) were measured in 76 patients with bone metastases from NSCLC and 44 normal people.Results:The level of AKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the normal people.Significant correlation was observed among bone turnover markers.The levels of BALP and OST were significantly correlated with the extent of bone metastasis.The patients with high-level CTx and low-level BALP had higher risk of pathologic fracture.Conclusion:In NSCLC patients with bone metastases,bone turnover markers can help to make diagnosis and evaluate the severity.It will have a wide range of use in clinical practice. | Zhiyu Wang Chen Yang Yumei Yang Zan Shen Hui Zhao Yang Yao | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 3 |
| 13 | Plant species coexistence alleviates the impacts of lead on Zea mays L.显示文摘Whether plant coexistence can reduce the impacts of lead (Pb) on crops in agroecosystems has not been well understood. We conducted a factorial experiment to investigate the effects of weeds coexisting with maize (Zea mays L.) on Pb accumulation in maize and soil microbes at two Pb levels (ambient and 300 mg/kg). Elevated Pb tended to increase the Pb concentration in maize and decreased soil microbial activity (indicated by the average well color development, AWCD), functional group diversity, as well as arbuscular mycorrhizal (AM) colonization and vesicle number of maize. Compared to the monoculture, weeds coexisting with maize reduced the Pb concentrations in the root, leaf, sheath and stem of maize at both seedling and mature stages. In maize-weed mixtures, soil microbial activity and functional group diversity tended to increase for both Pb treatments relative to the monoculture. Furthermore, principal component analysis revealed that the soil microbial community structure changed with the introduction of weeds. The highest Pb accumulation in weeds occurred for the elevated Pb treatment in a three species mixture. The results suggest that multiple plant species coexistence could reduce lead accumulation in crop plants and alleviate the negative impacts on soil microbes in polluted land, thereby highlighting the significance of plant diversity in agroecosystems. | Ruyi Yang Ling Liu Shuting Zan Jianjun Tang Xin Chen | 2012 | Journal of Environmental Sciences2012，24，3： | 2 |
| 14 | Nano-silica-decorated Poly(m-Phenylene Isophthalamide)Separator with Enhanced Mechanical and Electrolyte Wetting Properties for Lithium-Ion Batteries显示文摘Heat-resistant poly(m-phenylene isophthalamide)(PMIA)has attracted considerable attention as a novel separator for application in lithium-ion batteries(LIBs);however,its mechanical strength and electrolyte wettability are not ideal.Herein,a nano-silica-decorated poly(m-phenylene isophthalamide)(PMIA@SiO2)separator was fabricated with SiO2 nanoparticles uniformly attached to the pores and pore walls of the PMIA separator.The as-prepared PMIA@SiO2 separator has good mechanical strength(a 16%improvement compared with pristine PMIA)and wettability toward the electrolyte(the contact angle decreases from 34.0°to 23.1°).The PMIA@SiO2 separator also had a high ionic conductivity(0.75 mS/cm)and low interfacial electric resistance(75Ω).The assembled LiCoO2/PMIA@Si O2-liquid electrolyte/Li cell displays good cycle performance with a capacity retention of 88.1%after 50 cycles.Furthermore,the cycling performance and rate capacity rarely changed after high-temperature treatment.Therefore,the nano-silica-decorated PMIA separator is a potential candidate for application in LIBs with high safety. | Jianjie Wang Biao Yuan Fusheng Pan Lina Qiao Jun Guo Cuijia Duan Wei Wu Zan Chen anlei Su | 2020 | Transactions of Tianjin University2020，26，4： | 2 |
| 15 | Boosting electrocatalytic activity for CO_(2) reduction on nitrogen-doped carbon catalysts by co-doping with phosphorus显示文摘Electrochemical reduction of CO_(2)(CERR)to value-added chemicals is an attractive strategy for greenhouse gas mitigation,and carbon recycles utilization.Conventional metal catalysts suffered from low durability and sluggish kinetics impede the practical application.On the other hand,doped carbon materials recently demonstrate superior catalytic performance in CERR,which shows the potential to diminish the problems of metal catalysts to some extent.Herein,we present the design and fabrication of nitrogen(N),phosphorus(P)co-doped metal-free carbon materials as an efficient and stable electrocatalyst for reduction of CO_(2) to CO,which exhibits an excellent performance with a high faradaic efficiency of 92%(-0.55 V vs.RHE)and up to 24 h stability.A series of characterizations including TEM and XPS verified that nitrogen and phosphorous are successfully incorporated into the carbon matrix.Moreover,the comparisons between co-doping and single doping catalysts reveal that co-doping can significantly increase CERR performance.The improved catalytic activity is attributed to the synergetic effects between nitrogen and phosphorous dopants,which effectively modulate properties of the active site.The density functional theory(DFT)calculations were also performed to understand the synergy effects of dopants.It is revealed that the phosphorous doping can significantly lower the Gibbs free energy of COOH^(*)formation.Moreover,the introduction of the second dopants phosphorous can reduce the reaction barrier along the reaction path and cause polarization of density of states at the Fermi level.These changes can greatly enhance the activity of the catalysts.From a combined experimental and computational exploration,current work provides valuable insights into the reaction mechanism of CERR on N,P co-doped carbon catalysts,and the influence from synergy effects between dopants,which paves the way for the rational design of novel metal-free catalysts for CO2 electro-reduction. | Shuo Chen Tianfu Liu Samson O.Olanrele Zan Lian Chaowei Si Zhimin Chen Bo Li | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 16 | CD4+T cells memorize obesity and promote weight regain显示文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain. | Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 17 | A new complexity metric for FH/SS sequences using fuzzy entropy显示文摘This paper presents a new complexity metric to evaluate the unpredictability of a frequencyhopping/spread-spectrum (FH/SS) sequence based on fuzzy entropy (FuzzyEn).According to the property of the FS/SS sequence,the definition of a fuzzy membership function for a complexity metric is presented and a basic theorem for FuzzyEn complexity is proved.Simulation and analytical results show that the proposed FuzzyEn works and can effectively discern the changing complexities of the FH/SS sequences,which are compared with a complexity metric based on approximate entropy (ApEn).The FuzzyEn scheme has obvious advantages in robustness to resolution parameters and sensitivity to vector dimensions. | CHEN XiaoJun SI JiangBo LI Zan CAI JuePing BAI BaoMing | 2011 | Science China(Information Sciences)2011，54，7： | 2 |
| 18 | Tourism expansion, tourism uncertainty and economic growth : New evidence from Taiwan and Korea 显示文摘 | Ching - Fu Chen Song Zan Chiou - Wei | 2009 | Tourism Management2009，，30： | 1 |
| 19 | Chemical ingredients isolated from the aerial paret of Artemisia anomala 显示文摘 | ZAN Ke CHEN Xiao-qing FU Qiang | 2010 | Journal of Chinese Pharmaceutical Scientes2010，19，2： | 1 |
| 20 | Credit rating analysis with support vector machines and neural networks显示文摘 | Huang Zan Chen Hsinchun | 2004 | Decision Support Systems2004，37，4： | 1 |
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