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| 1 | Design and indoor simulated experiment of pneumatic rice seed metering device显示文摘In order to meet the agronomy demand for hybrid rice direct seeding,a novel precise pneumatic rice seed metering device was designed with groups of sucking holes plate,by which 3-4 seeds could be synchronously sucked and synchronously dropped into the paddy field.The plate was divided into five sections:seed sucking,seed clearing,seed carrying,seed dropping,and blank sections.The seeds were sucked in sucking section by the vacuum,carried and rotated to the dropping section with the plate,blown away in dropping section by the positive pressure air,and thrown into the dropping tube.The influences of the hole diameter,vacuum degree,and clear-up equipment on precision of metering device were discussed.Experiments were conducted to investigate the seeding precision and simulate the field emergence rates on the indoor seeding test-bed.The subjects were pregnant Indic hybrid Peizataifeng under two kinds of moisture content(23.43%and 26.07%).Other experiment conditions included the vacuum degree of 2.60 kPa,the rotation speed of seed sucking plate of 30 r/min,three sucking holes with a diameter of 1.6 mm,and the seed layer thickness of 25 mm.The seeding results showed that,in condition of no more than two seeds per hill,the emergence probabilities under the two moisture contents were 11.82%and 11.95%,respectively,and in condition of 3-4 seeds per hill,the results were 64.81%and 65.84%,respectively.With 2-5 seeds per hill,the results were 92.08%and 92.60%,respectively.If the emergence probability was 80%,under the two moisture contents,the no seed per hill probabilities were 1.33%and 0.80%respectively;the probabilities with 3-4 seeds per hill were 56.13%and 56.40%respectively;the probabilities with 5 or more seeds per hill were 10.67%and 10.13%respectively;the probabilities with 2-5 seeds per hill were 87.60%and 88.13%respectively.The results showed the simulated experiment was an efficient and economic method to assess the capability of pneumatic rice seed drilling metering device,and the precise pneumatic rice seed drilling metering device had a good prospect in practical application. | Zhang Guozhong Zang Ying Luo Xiwen Wang Zaiman Zhang Qiang Zhang Shasha | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 19 |
| 2 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 3 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 4 | Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice显示文摘有低浆液睾丸激素层次的 Twenty-four-month-old 男 C57BL/6 老鼠是被使用为在性功能和睾丸激素合成上检验丝绒鹿角多肽(VAP ) 的效果的一个迟了发作的性腺机能减退(LOH ) 动物模型。这些鼠标每天在 100, 200,或 300 mg kg −1 身体重量的剂量由每日的 gavage 收到了 VAP 5 个连续星期(n = 10 个鼠标每剂量) 。控制动物(n = 10 ) 收到了车辆的一样的基于重量的体积。在浆液和睾丸的空隙的织物的性行为和睾丸激素层次在 VAP 的最后管理以后被测量。而且,调查 VAP 怎么在 vivo 影响性行为和睾丸激素合成的机制, steroidogenic 的表示尖锐规章的蛋白质(星),细胞色素 P450 胆固醇方面链劈开酶( P450scc ),并且 3 β ; -hydroxysteroid 脱氢酶( 3 β ;在 Leydig 房间的-HSD)被染色的 immunofluorescence 和量的即时 PCR 也测量。作为结果, VAP 在这些变老的雄的鼠标的性函数生产了重要改进。浆液睾丸激素水平和 intratesticular 睾丸激素(ITT ) 集中也在对待 VAP 的组增加了。星, P450scc,和 3 β 的表示; -HSD 也被发现与控制组相比在对待 VAP 的组被提高。我们的结果建议 VAP 在在老化男性鼠标改进性功能是有效的。性功能上的丝绒鹿角的效果由于睾丸激素合成的几限制率的酶的增加的表示(星, P450scc,和 3 β在 vivo 的睾丸激素合成的 -HSD) 和下列提升。 | Zhi-Jun Zang Hong-Feng Tang Ying Tuo Wei-Jie Xing Su-Yun Ji Yong Gao Chun-Hua Deng | 2016 | Asian Journal of Andrology2016，18，4： | 13 |
| 5 | Microstructure,mechanical and corrosion properties of Mg-2Dy-xZn(x=0,0.1,0.5 and 1 at.%)alloys显示文摘Microstructure,mechanical and corrosion properties of as-cast Mg-2Dy-xZn(x=0,0.1,0.5,and 1)(at.%)alloys were investigated.The microstructures of the as-cast Mg-2Dy and Mg-2Dy-0.1Zn alloys mainly consisted ofα-Mg phase and Mg_(24)Dy_(5)eutectic phase.With 0.5 at.%Zn addition,Mg_(12)ZnDy phase with 18R-type long period stacking ordered(LPSO)structure and Mg_(2)Dy phase precipitated at the grain boundaries.When the content of Zn is 1 at.%,only the Mg_(3)Zn_(3)Dy_(2)phase formed in theα-Mg matrix.The electrochemical measurements and immersion testing results indicated that the Mg-2Dy-0.1Zn alloy exhibited the best corrosion resistance.It revealed that the morphology,scale,amount and distribution of the second phase have a great effect on the corrosion resistance of alloy.Additionally,the tensile testing results showed that the Mg-2Dy-0.5Zn alloy exhibited the higher tensile strength and good elongation,especially at 200℃.The improvement of mechanical properties was mainly due to the strengthening of LPSO phase and grain refinement of α-Mg. | Guangli Bi Yuandong Li Shijun Zang Jianbin Zhang Ying Ma Yuan Hao | 2014 | Journal of Magnesium and Alloys2014，2，1： | 13 |
| 6 | General structure design and field experiment of pneumatic rice direct-seeder显示文摘In order to meet the requirement of field direct seeding for super hybrid rice:1-3 seeds per hill,a pneumatic rice direct-seeder with six seeding metering devices was designed.Transmission system of pneumatic rice direct-seeder and seed metering device were analyzed in this study.And the pipeline structure and vortex pump were designed and selected.The pressure distribution of the pipeline was tested.The pressure value of each sub-pipeline under the conditions of different main pipeline pressure value was obtained and the reasons for pressure loss were analyzed.The results showed that the variation coefficient between sub-pipelines was less than 5%.The pipeline pressure could be evenly distributed.Further,the field experiments were carried out on super hybrid rice Peizataifeng using two-factor testing,by which the effects of different negative pressure and different forward speed(namely,rotational speed of suction plate)for seeding precision were studied.It found that:(1)the optimal negative pressure was 2 kPa;(2)under the optimal negative pressure,the probabilities of 1-3 seeds per hill for the direct-seeder were 93.41%,95.47%and 97.50%,respectively,when the forward speed of the direct-seeded was high,medium and low speed;(3)the probability of empty hole was less than 2%,which satisfied the field direct seeding requirements of super hybrid rice.Additionally,hill spacing was measured,and the factors affecting the hill spacing were analyzed.The results showed that the fluctuation of hill spacing in the small range will not affect the seeding effect.In this study,a new type of pneumatic rice direct-seeder was designed.The main working components were tested and analyzed.The best parameters of field work were obtained.It provides the basis for the field application of the pneumatic rice precision seeder. | Xing He Wang Zaiman Luo Xiwen Cao Xiaoman Liu Chunbo Zang Ying | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 10 |
| 7 | Initial experience of single-incision plus one port left-side approach totally laparoscopic distal gastrectomy with uncut Roux-en-Y reconstruction显示文摘BACKGROUND Single incision plus one port left-side approach(SILS+1/L)totally laparoscopic distal gastrectomy(TLDG)is an emerging technique for the treatment of gastric cancer.Reduced port laparoscopic gastrectomy has a number of potential advantages for patients compared with conventional laparoscopic gastrectomy:relieving postoperative pain,shortening hospital stay and offering a better cosmetic outcome.Nevertheless,there are no previous reports on the use of SILS+1/L TLDG with uncut Roux-en-Y(uncut R-Y)reconstruction.AIM To investigate the initial feasibility of SILS+1/L TLDG with uncut Roux-en-Y digestive tract reconstruction(uncut R-Y reconstruction)to treat distal gastric cancer.METHODS A total of 21 patients who underwent SILS+1/L TLDG with uncut R-Y reconstruction for gastric cancer were enrolled.All patients were treated at The Second Hospital of Shandong University.Reconstructions were performed intracorporeally with 60 mm endoscopic linear stapler and 45 mm no-knife stapler.The clinicopathological characteristics,surgical details,postoperative short-term outcomes,postoperative follow-up upper gastrointestinal radiography findings and endoscopy results were analyzed retrospectively.RESULTS All SILS+1/L operations were performed by SILS+1/L TLDG successfully.The patient population included 13 men and 8 women with a mean age of 48.2 years(ranged from 40 years to 70 years)and median body mass index of 22.8 kg/m^2.There were no conversions to open laparotomy,and no other port was placed.The mean operation time was 146 min(ranged 130-180 min),and the estimated mean blood loss was 54 mL(ranged 20-110 mL).The mean duration to flatus and discharge was 2.3(ranged 1-3.5)and 7.3(ranged 6-9)d,respectively.The mean number of retrieved lymph nodes was 42(ranged 30-47).Two patients experienced mild postoperative complications,including surgical site infection(wound at the navel incision)and mild postoperative pancreatic fistula(grade A).Follow-up upper gastrointestinal radiography and endoscopy were carried out at 3 mo postoperatively.No patients experienced moderate or severe food stasis,alkaline gastritis or bile reflux during the follow-up period.No recanalization of the biliopancreatic limb was found.CONCLUSION SILS+1/L TLDG with uncut R-Y reconstruction could be safely performed as a reduced port surgery. | Wei Zhou Chang-Zheng Dong Yi-Feng Zang Ying Xue Xing-Guo Zhou Yu Wang Yin-Lu Ding | 2020 | World Journal of Gastroenterology2020，26，31： | 7 |
| 8 | Multicenter Clinical Study for Evaluation of Efficacy and Safety of Transdermal Fentanyl Matrix Patch in Treatment of Moderate to Severe Cancer Pain in 474 Chinese Cancer Patients显示文摘Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life. | Yu-lin Zhu Guo-hong Song Duan-qi Liu Xi Zhang Kui-feng Liu Ai-hua Zang Ying Cheng Guo-chun Cao Jun Liang Xue-zhen Ma Xin Ding Bin Wang Wei-lian Li Zuo-wei Hu Gang Feng Jiang-jin Huang Xiao Zheng Shun-chang Jiao Rong Wu Jun Ren | 2011 | Chinese Journal of Cancer Research2011，23，4： | 6 |
| 9 | Optimization of variables for maximizing efficacy and efficiency in aerial spray application to cotton using unmanned aerial systems显示文摘Aerial spraying can support efficient defoliation without crop contact.With the recent introduction to unmanned aerial system(UAS)for aerial spraying in China,there is a need to determine the optimum application variables to achieve high efficacy and efficiency with low costs.The present research involved field studies across two annual cotton production seasons in North Xinjiang,China.Four factors,including volume rate(A),tank mix including spray adjuvants(B),flight altitude(C),flight speed(D)and three levels of L9(3^(4))orthogonal arrays were carried out to optimize the application parameters for three types of UASs.These included different numbers of rotors as follows:four-rotors,six-rotors and eight-rotors.Spray coverage,distribution uniformity(coefficient of variation(CV)of droplet coverage),rates of cotton defoliation and boll opening,application efficiency and cost were measured and assessed.Results showed that:(1)the rates of defoliation and boll opening by aerial cotton defoliant application could meet the requirement of cotton mechanized harvesting;(2)the optimal scenario for the three UASs was A_(3)B_(2)C_(1)D_(3),Volume rate(A3):48 L/hm^(2);Tank mix and concentration(B_(2)):(Tuotulong 225+Sujie 750+Ethephon 2250)mL/hm^(2),Flight altitude(C_(1)):1.5 m,and Flight speeds(D_(3))for unmanned helicopters with four-rotors,six-rotors and eight-rotors were 3.12 m/s,2.51 m/s and 3.76 m/s,respectively.These results can provide guidance for cotton defoliant aerial spraying in China using UAS. | Juan Liao Ying Zang Xiwen Luo Zhiyan Zhou Yubin Lan Yu Zang Xiuyan Gu Weiming Xu Andrew John Hewitt | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 6 |
| 10 | DNA cleavage mediated by water-soluble manganese corrole显示文摘水的 DNA 像核酸酶的活动可溶的锰 corrole 5, 10, 15-tris (N-methyl-4-pyridyl )- corrolatomanganese (III )(MnIIITMPyC ) 被调查了。MnIIITMPyC 可以经由由吸收系列,粘性大小和 CD 系列显示了的外面的沟绑定模式强烈绑在 DNA。MnIIITMPyC 面对 hydroperoxide 在 DNA 氧化劈开展出了优秀催化活动。 | Jun Lu Hai Yang Liu Lei Shi Xiang Li Wang Xiao Ying Lei Zhang Liang Nian Ji Lin Quan Zang Chi K. Chang | 2011 | Chinese Chemical Letters2011，22，1： | 6 |
| 11 | Review of precision rice hill-drop drilling technology and machine for paddy显示文摘Mechanized rice direct seeding is a cost-effective and efficient approach for rice cultivation.Recently,the use of rice direct seeding has been increasing rapidly owing to rural labour shortages and continuous increases in agricultural production costs.This article reviews the research and application progress of mechanized rice direct seeding including direct seeding technologies,precision rice seeding,precision rice seed-metering devices,key supporting agronomy technologies for mechanized rice direct seeding.South China Agricultural University developed precision rice hill-drop drilling(PRHDD)with synchronous furrowing and ridging technology and series machines for paddy that affords remarkable advantages in terms of saving time and labour,higher yield,and higher efficiency.In this approach,pre-germinated seeds are uniformly hill-dropped in the expected positions in puddled soil.It significantly improved the crop growth population and effectively solved the problems of high frequency of disease and pests caused by the irregular distribution of rice seeds with manual broadcasting,and generally reduces seed usage and increases the yield.Therefore,this technology has broad application prospects and great potential for promoting the development of mechanized rice direct seeding in China. | Minghua Zhang Zaiman Wang Xiwen Luo Ying Zang Wenwu Yang He Xing Baolong Wang Yizheng Dai | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 6 |
| 12 | CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer显示文摘(CEACAM6 ) Carcinoembryonic 抗原相关的房间粘附分子 6 证明在许多 humancancers 的增加的表示,和它的在表示上与提高的移植被联系,侵略,并且在 vivo 转移。这里,我们报导 CEACAM6 在房间衬里的胃的癌症(GC ) 和肿瘤纸巾是起来调整的。在 MKN-45 和 SGC-7901 GC 房间的 Over-expressionof CEACAM6 在 athymic 老鼠在 vitro 和转移支持了移植和侵略,而 MKN-28 和 SNU-16 GC 房间的移植和侵略被 knockdownof CEACAM6 压制。当 CEACAM6 是 over-expressedin SGC-7901 房间时,我们也观察到类固醇受体激活剂(C-SRC ) phosphorylation 被增加。一起拿,这些结果建议 CEACAM6 在 GC 作为 oncoprotein 工作并且可以是 importantmetastatic biomarker 和治疗学的目标。 | Yunqiang Zhang Mingde Zang Jianfang Li Jun Ji Jianian Zhang Xiaolei Liu Ying Qu Liping Su Chen Li Yinyan Yu Zhenggang Zhu Bingya Liu Min yan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 5 |
| 13 | Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a retrospective case study显示文摘Cyclospora cayetanensis 是引起世界范围的地方性、流行的人的腹泻的 foodborne 和水运的病原体。关于 C 的一些流行病学的研究。在中国的 cayetanensis 感染被进行了。在 2013 期间, 291 个凳子标本的一个总数在城市的上海在一所医院与腹泻从病人被收集。C。, cayetanensis 没被传统的显微镜学在任何凳子标本检测五个凳子标本(1.72% , 5/291 ) 由 PCR 是积极的。分子的技术证实的这些积极盒子都在成年的组(吝啬的年龄 27.8 年;2.94% , 5/170 ) 与水的腹泻。显著感染发生在 5 月和 7 月的雨季。顺序和 C 的部分 18S rRNA 基因的种系发生的分析。cayetanensis 孤立这个寄生虫的显示出的 intra 种类差异。第一次,这研究显示出那 C。cayetanensis 是在有在上海的腹泻的门诊病人的病原体,在底层的虽然。然而,在这些病人的这个寄生虫的传播动力学仍然保持不明确。 | Yanyan Jiang Zhongying Yuan Guoqing Zang Dan Li Ying Wang Yi Zhang Hua Liu Jianping Cao Yujuan Shen | 2018 | Frontiers of Medicine2018，12，1： | 5 |
| 14 | Development and experiment of rice hill-drop drilling machine for dry land based on proportional speed regulation显示文摘Rice precision hill-drop drilling technique in dry land uses fixed hill spacing to achieve orderly planting of crops and to attain good ventilating and day-lighting effects in rice fields.The technique is also beneficial in improving root growth and root structure and in increasing lodging resistance.The high-yield record of Xinjiang Production and Construction Corp’s first division for three consecutive years shows that rice precision hill-drop drilling technique in dry land is one of the important directions to developed rice cultivating mechanization technology.To further improve the quality of rice precision hill-drop drilling machine for dry land,a single profiling,electro-hydraulic proportional real-time adjustment of system was developed according to the agronomic requirements.This machine can simultaneously finish various kinds of seedbed leveling,furrowing and seeding operations,as well as soil covering and pressing.Electro-hydraulic proportional speed regulation makes an AMESim simulation test and analyzes the stability and error of hydraulic adjusting planting distance.Bench testing was carried out on the metering device by simultaneously employing high speed photography technology and analyzing the relationship of the high speed of hill distance and seed charge height.Finally,machine trial was completed.The two-year field experiments of Xinjiang Production and Construction Corp showed that when the machine operation speed is 2.8-3.2 km/h,the sowing depth percent of pass is 75%or higher,the qualified rate of row spacing is 80%or more,the pass rate of row spacing is 90%or higher,and the quantity per hill is 75%or higher.This machine met the various indicators of hill sowing quality requirements. | Fu Wei Zhang Zhiyuan Zang Ying Luo Xiwen Zeng Shan Wang Zaiman | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 5 |
| 15 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 16 | Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells显示文摘Idiopathic pulmonary fibrosis(IPF)is an aging-associated disease with a poor prognosis.Emerging evidence has revealed that targeting senescent cells may be a potential treatment for IPF.In this study,we aimed to explore whether roxithromycin(RXM)can improve lung fibrosis by targeting senescent cells.First,we confirmed the ability of RXM to selectively kill senescent cells by inducing apoptosis and inhibiting the expression of senescence-associated secretory phenotype(SASP)factors,suggesting the potential role of RXM as a“senolytic”and“senomorphic”drug.Next,we observed that TGF-β-and senescent cell-induced lung fibroblast activation was inhibited by RXM treatment,which prompted us to further investigate its effect in vivo.In a mouse model of bleomycin(BLM)-induced pulmonary fibrosis,RXM was shown to attenuate lung injury,inflammation,and fibrosis.Furthermore,the senescent phenotype of lung tissues induced by BLM was significantly diminished after RXM administration,indicating the potential of RXM as an antifibrotic and antisenescent agent.Interestingly,NADPH oxidase 4(NOX4),implicated in lung fibrosis and cell senescence,was shown to be inhibited by RXM treatments.The antifibroblast activation and antisenescent effects of RXM were abolished in NOX4 knockdown cells,demonstrating that RXM may ameliorate BLM-induced pulmonary fibrosis by targeting senescent cells mediated by the NOX4 pathway.Collectively,these data demonstrated that RXM may be a potential clinical agent for IPF and further supported the notion that targeting cellular senescence is a promising treatment for progressive age-related disease. | Xuan Zhang Ying Dong Wan-chen Li Bi-xi Tang Jia Li Yi Zang | 2021 | Acta Pharmacologica Sinica2021，42，12： | 3 |
| 17 | New Application of Stainless Steel显示文摘Several rigid substrates such as stainless steel, titanium alloy, aluminum alloy, nickel foil, silicon, and sodium lime glass have been employed for manufacturing high quality TiO2 films by metal organic chemical vapor deposition (MOCVD). The as-deposited TiO2 films have been characterized with SEM/EDX and XRD. The photocatalytic properties were investigated by decomposition of aqueous orangeⅡ. UV-VIS photospectrometer was employed to check the absorption characteristics and photocatalytic degradation activity. The results show that films synthesized on metal substrates display higher photoactivities than that on absolute substrates such as silicon and glass. It is found that solar light is an alternative to UV-light used for illumination during photodegradation of orange Ⅱ. TiO2 film on stainless steel substrate was regarded as the best one for photocatalysis. | YANG Jia-long LI Ying WANG Fu ZANG Zheng-gui LI Si-jun | 2006 | Journal of Iron and Steel Research(International)2006，13，1： | 3 |
| 18 | High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response显示文摘伪 - Galactosylceramide (伪 - GC ) 广泛地被知道激活不变的自然漂亮 T (iNKT ) 压制髓磷脂的房间抗原特定的 Th1 回答,保护易受影响的老鼠免于试验性的自体免疫的脑脊髓炎(EAE ) 。这里,我们表明那高加重,而非改善的伪 - GC 开 EAE 的意外发现。当与高剂量的伪 - GC 对待的 MOG35-55-specific T 房间被变成 na 时,类似的结果被观察 ? ve syngeneic 接受者老鼠。进一步的学习证明伪 - GC 的高剂量直接通过 STAT3 的 phosphorylation 和 NF-魏 B 的激活由 CD4+CD44+ 记忆 T 房间的激活提高 Th17 和 Th1 反应。不同于由伪 - GC 的低剂量的 iNKT 房间的激活,伪 - GC 的高剂量直接交往了, CD1d 在 T 房间上表示了并且激活 Th17 和 Th1 房间。而且,介绍抗原的房间(APC ) 主要表示 CD1d1,而 CD4+ T 房间快车 CD1d2 的多数。由 RNAi 的 CD1d1 或 CD1d2 基因表示击倒分别地防碍 iNKT 或 Th17/Th1 房间的激活。因此,伪 - GC 处理能改善或变得更坏由雇佣取决于剂量的 APC 或 Th17/Th1 房间的 EAE 使用了。 | Gaochao Qian Xia Qin Ying Qin Zang Baoxue Ge Taylor B Guo Bing Wan Lei Fang Jingwu Z Zhang | 2010 | Cell Research2010，20，4： | 3 |
| 19 | The Science Operations and Data Center (SODC) of the ASO-S mission显示文摘A ground data analysis center is very important to the success of a mission.We introduce the Science Operations and Data Center(SODC)for the ASO-S mission,which consists of a scientific operation subcenter,a data management subcenter,a data analysis subcenter and a user service subcenter.The mission planning process,instrument observation modes and the data volume are presented.We describe the data flow and processing procedures from spacecraft telemetry to high-level science data,and the long-term archival as well.The data policy and distributions are also briefly introduced. | Yu Huang Hui Li Wei-Qun Gan You-Ping Li Jiang-Tao Su Yuan-Yong Deng Li Feng Yang Su Wei Chen Shi-Jun Lei Ying Li Yun-Yi Ge Ying-Na Su Si-Ming Liu Jing-Jing Zang Zun-Lei Xu Xian-Yong Bai Jing-Wei Li | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 3 |
| 20 | Engineered tunneling layer with enhaneed impact ionization for detection improvement in graphene/silicon heterojunction photodetectors显示文摘Here,an engineered tunneling layer enhanced photocurrent multiplication through the impact ionization effect was proposed and experimentally demonstrated on the graphene/silic on heterojunction photodetectors.With con sidering the suitable band structure of the insulation material and their special defect states,an atomic layer deposition(ALD)prepared wide-bandgap insulating(WBI)layer of AIN was introduced into the interface of graphene/silicon heterojunction.The promoted tunneling process from this designed structure dem on strated that can effectively help the impact ionization with photogain not only for the regular minority carriers from silicon,but also for the novel hot carries from graphene.As a result,significantly enhanced photocurrent as well as simultaneously decreased dark current about one order were accomplished in this graphene/insulation/silicon(GIS)heterojunction devices with the optimized AIN thickness of〜15 nm compared to the conventional graphene/silicon(GS)devices.Specifically,at the reverse bias of-10 V,a 3.96-A W_1 responsivity with the photogain of~5.8 for the peak response under 850-nm light illumination,and a 1.03-A W_1 responsivity with~3.5 photogain under the 365 nm ultraviolet(UV)illumination were realized,which are even remarkably higher than those in GIS devices with either AI2O3 or the commonly employed SiO2 insulation layers.This work dem on strates a universal strategy to fabricate broad ba nd,low-cost and high-performance photo-detecting devices towards the graphene-silicon optoelectronic integration. | Jun Yin Lian Liu Yashu Zang Anni Ying Wenjie Hui Shusen Jiang Chunquan Zhang Tzuyi Yang Yu-Lun Chueh Jing Li Junyong Kang | 2021 | Light(Science & Applications)2021，10，6： | 3 |
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